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Protein

Chlorophyll a-b binding protein 6, chloroplastic

Gene

LHCA1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

The light-harvesting complex (LHC) functions as a light receptor, it captures and delivers excitation energy to photosystems with which it is closely associated.1 Publication

Cofactori

Note: Binds at least 14 chlorophylls (8 Chl-a and 6 Chl-b) and carotenoids such as lutein and neoxanthin.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi48Magnesium (chlorophyll-b 1 axial ligand); via carbonyl oxygenBy similarity1
Binding sitei68Chlorophyll-a 1; via amide nitrogenBy similarity1
Metal bindingi87Magnesium (chlorophyll-a 1 axial ligand)By similarity1
Metal bindingi90Magnesium (chlorophyll-a 2 axial ligand)By similarity1
Binding sitei92Chlorophyll-b 2By similarity1
Binding sitei129Chlorophyll-a 3; via amide nitrogenBy similarity1
Metal bindingi133Magnesium (chlorophyll-b 2 axial ligand); via carbonyl oxygenBy similarity1
Metal bindingi153Magnesium (chlorophyll-b 3 axial ligand)By similarity1
Binding sitei156Chlorophyll-b 4By similarity1
Binding sitei190Chlorophyll-a 5By similarity1
Metal bindingi191Magnesium (chlorophyll-a 3 axial ligand)By similarity1
Metal bindingi194Magnesium (chlorophyll-a 4 axial ligand)By similarity1
Binding sitei196Chlorophyll-a 1By similarity1
Metal bindingi208Magnesium (chlorophyll-a 5 axial ligand)By similarity1
Metal bindingi224Magnesium (chlorophyll-a 6 axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

  • photosynthesis, light harvesting in photosystem I Source: UniProtKB
  • protein-chromophore linkage Source: UniProtKB-KW
  • response to blue light Source: TAIR
  • response to cold Source: UniProtKB
  • response to far red light Source: TAIR
  • response to high light intensity Source: UniProtKB
  • response to low light intensity stimulus Source: UniProtKB
  • response to red light Source: TAIR
Complete GO annotation...

Keywords - Biological processi

Photosynthesis

Keywords - Ligandi

Chlorophyll, Chromophore, Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chlorophyll a-b binding protein 6, chloroplastic
Alternative name(s):
LHCI-730
LHCII type III CAB-6
Light-harvesting complex protein Lhca11 Publication
Gene namesi
Name:LHCA11 Publication
Synonyms:CAB6
Ordered Locus Names:At3g54890
ORF Names:F28P10.130
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

TAIRiAT3G54890.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei93 – 113HelicalSequence analysisAdd BLAST21
Transmembranei132 – 152HelicalSequence analysisAdd BLAST21
Transmembranei197 – 217HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • chloroplast Source: TAIR
  • chloroplast envelope Source: TAIR
  • chloroplast thylakoid Source: TAIR
  • chloroplast thylakoid membrane Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: TAIR
  • photosystem I Source: UniProtKB-KW
  • plastoglobule Source: TAIR
  • thylakoid Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Chloroplast, Membrane, Photosystem I, Plastid, Thylakoid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 35ChloroplastSequence analysisAdd BLAST35
ChainiPRO_000040136236 – 241Chlorophyll a-b binding protein 6, chloroplasticAdd BLAST206

Post-translational modificationi

Photoregulated by reversible phosphorylation of its threonine residues.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ01667.
PRIDEiQ01667.

Expressioni

Inductioni

Induced by low light (LL) but repressed by high light (HL). Inhibited by cold.1 Publication

Gene expression databases

ExpressionAtlasiQ01667. baseline and differential.
GenevisibleiQ01667. AT.

Interactioni

Subunit structurei

The LHC complex consists of chlorophyll a-b binding proteins. Red-emitting heterodimer with LHCA4 (PubMed:21083539). Interacts with LHCA5 (PubMed:21806943, PubMed:15563470).3 Publications

Protein-protein interaction databases

BioGridi9970. 2 interactors.
DIPiDIP-59003N.
STRINGi3702.AT3G54890.1.

Structurei

Secondary structure

1241
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi51 – 53Combined sources3
Beta strandi67 – 69Combined sources3
Helixi73 – 75Combined sources3
Helixi77 – 97Combined sources21
Helixi99 – 106Combined sources8
Turni112 – 118Combined sources7
Beta strandi119 – 123Combined sources5
Beta strandi129 – 131Combined sources3
Beta strandi133 – 137Combined sources5
Helixi138 – 157Combined sources20
Helixi162 – 166Combined sources5
Helixi170 – 172Combined sources3
Beta strandi174 – 176Combined sources3
Helixi181 – 211Combined sources31
Helixi217 – 226Combined sources10
Turni228 – 230Combined sources3
Helixi234 – 237Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2O01X-ray3.40149-235[»]
2WSCX-ray3.3011-241[»]
2WSEX-ray3.4911-241[»]
2WSFX-ray3.4811-241[»]
4XK8X-ray2.801/646-240[»]
ProteinModelPortaliQ01667.
SMRiQ01667.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ01667.

Family & Domainsi

Domaini

The N-terminus of the protein extends into the stroma where it is involved with adhesion of granal membranes and post-translational modifications; both are believed to mediate the distribution of excitation energy between photosystems I and II.

Sequence similaritiesi

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHXH. Eukaryota.
ENOG410XVD6. LUCA.
HOGENOMiHOG000238033.
InParanoidiQ01667.
KOiK08907.
OMAiGDIVIPF.
OrthoDBiEOG09360J56.
PhylomeDBiQ01667.

Family and domain databases

Gene3Di1.10.3460.10. 1 hit.
InterProiIPR001344. Chloro_AB-bd_pln.
IPR022796. Chloroa_b-bind.
IPR023329. Chlorophyll_a/b-bd_dom.
[Graphical view]
PANTHERiPTHR21649. PTHR21649. 1 hit.
PfamiPF00504. Chloroa_b-bind. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced. According to EST sequences.
Isoform 1 (identifier: Q01667-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASNSLMSCG IAAVYPSLLS SSKSKFVSAG VPLPNAGNVG RIRMAAHWMP
60 70 80 90 100
GEPRPAYLDG SAPGDFGFDP LGLGEVPANL ERYKESELIH CRWAMLAVPG
110 120 130 140 150
ILVPEALGYG NWVKAQEWAA LPGGQATYLG NPVPWGTLPT ILAIEFLAIA
160 170 180 190 200
FVEHQRSMEK DPEKKKYPGG AFDPLGYSKD PKKLEELKVK EIKNGRLALL
210 220 230 240
AFVGFCVQQS AYPGTGPLEN LATHLADPWH NNIGDIVIPF N
Length:241
Mass (Da):25,996
Last modified:November 1, 1996 - v1
Checksum:i2F5EE06B55A979CE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti11I → K in AAG40043 (PubMed:14593172).Curated1
Sequence conflicti43R → K in AAG40043 (PubMed:14593172).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M85150 Genomic DNA. Translation: AAA32759.1.
X56062 mRNA. Translation: CAA39534.1.
AL049655 Genomic DNA. Translation: CAB41095.1.
CP002686 Genomic DNA. Translation: AEE79306.1.
AF324692 mRNA. Translation: AAG40043.2.
AF325016 mRNA. Translation: AAG40368.1.
AF326866 mRNA. Translation: AAG41448.1.
AF339688 mRNA. Translation: AAK00370.1.
AF361847 mRNA. Translation: AAK32859.1.
AY070473 mRNA. Translation: AAL49939.1.
AY094437 mRNA. Translation: AAM19809.1.
BT000852 mRNA. Translation: AAN38689.1.
AK317555 mRNA. Translation: BAH20219.1.
PIRiS25435.
RefSeqiNP_191049.1. NM_115346.4. [Q01667-1]
UniGeneiAt.23982.
At.67867.

Genome annotation databases

EnsemblPlantsiAT3G54890.1; AT3G54890.1; AT3G54890. [Q01667-1]
GeneIDi824654.
GrameneiAT3G54890.1; AT3G54890.1; AT3G54890.
KEGGiath:AT3G54890.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M85150 Genomic DNA. Translation: AAA32759.1.
X56062 mRNA. Translation: CAA39534.1.
AL049655 Genomic DNA. Translation: CAB41095.1.
CP002686 Genomic DNA. Translation: AEE79306.1.
AF324692 mRNA. Translation: AAG40043.2.
AF325016 mRNA. Translation: AAG40368.1.
AF326866 mRNA. Translation: AAG41448.1.
AF339688 mRNA. Translation: AAK00370.1.
AF361847 mRNA. Translation: AAK32859.1.
AY070473 mRNA. Translation: AAL49939.1.
AY094437 mRNA. Translation: AAM19809.1.
BT000852 mRNA. Translation: AAN38689.1.
AK317555 mRNA. Translation: BAH20219.1.
PIRiS25435.
RefSeqiNP_191049.1. NM_115346.4. [Q01667-1]
UniGeneiAt.23982.
At.67867.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2O01X-ray3.40149-235[»]
2WSCX-ray3.3011-241[»]
2WSEX-ray3.4911-241[»]
2WSFX-ray3.4811-241[»]
4XK8X-ray2.801/646-240[»]
ProteinModelPortaliQ01667.
SMRiQ01667.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi9970. 2 interactors.
DIPiDIP-59003N.
STRINGi3702.AT3G54890.1.

Proteomic databases

PaxDbiQ01667.
PRIDEiQ01667.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G54890.1; AT3G54890.1; AT3G54890. [Q01667-1]
GeneIDi824654.
GrameneiAT3G54890.1; AT3G54890.1; AT3G54890.
KEGGiath:AT3G54890.

Organism-specific databases

TAIRiAT3G54890.

Phylogenomic databases

eggNOGiENOG410IHXH. Eukaryota.
ENOG410XVD6. LUCA.
HOGENOMiHOG000238033.
InParanoidiQ01667.
KOiK08907.
OMAiGDIVIPF.
OrthoDBiEOG09360J56.
PhylomeDBiQ01667.

Miscellaneous databases

EvolutionaryTraceiQ01667.
PROiQ01667.

Gene expression databases

ExpressionAtlasiQ01667. baseline and differential.
GenevisibleiQ01667. AT.

Family and domain databases

Gene3Di1.10.3460.10. 1 hit.
InterProiIPR001344. Chloro_AB-bd_pln.
IPR022796. Chloroa_b-bind.
IPR023329. Chlorophyll_a/b-bd_dom.
[Graphical view]
PANTHERiPTHR21649. PTHR21649. 1 hit.
PfamiPF00504. Chloroa_b-bind. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCAB6_ARATH
AccessioniPrimary (citable) accession number: Q01667
Secondary accession number(s): B9DHK2, Q9C5R7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 30, 2010
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

Light emission at 684 nm upon excitation at 410 and 470 nm.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.