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Protein

Transcription factor AP-4

Gene

TFAP4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor that activates both viral and cellular genes by binding to the symmetrical DNA sequence 5'-CAGCTG-3'.

GO - Molecular functioni

  • DNA binding Source: UniProtKB
  • E-box binding Source: UniProtKB
  • histone deacetylase binding Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: Ensembl
  • sequence-specific DNA binding Source: UniProtKB
  • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding Source: Ensembl
  • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Source: UniProtKB
  • transcription regulatory region DNA binding Source: UniProtKB

GO - Biological processi

  • cellular response to dexamethasone stimulus Source: Ensembl
  • DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator Source: UniProtKB
  • negative regulation by host of viral transcription Source: UniProtKB
  • negative regulation of cell cycle arrest Source: UniProtKB
  • negative regulation of cell proliferation Source: UniProtKB
  • negative regulation of cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB
  • negative regulation of DNA binding Source: UniProtKB
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation by host of viral transcription Source: UniProtKB
  • positive regulation of apoptotic process Source: UniProtKB
  • positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway Source: Ensembl
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • protein complex assembly Source: UniProtKB
  • regulation of mitotic cell cycle phase transition Source: UniProtKB

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SIGNORiQ01664.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor AP-4
Alternative name(s):
Activating enhancer-binding protein 4
Class C basic helix-loop-helix protein 41
Short name:
bHLHc41
Gene namesi
Name:TFAP4
Synonyms:BHLHC41
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000090447.11.
HGNCiHGNC:11745. TFAP4.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7023.
OpenTargetsiENSG00000090447.
PharmGKBiPA36462.

Polymorphism and mutation databases

BioMutaiTFAP4.
DMDMi1729833.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001274581 – 338Transcription factor AP-4Add BLAST338

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei123PhosphoserineCombined sources1
Modified residuei124PhosphoserineCombined sources1
Modified residuei139PhosphoserineCombined sources1
Cross-linki147Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki187Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki189Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki285Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ01664.
MaxQBiQ01664.
PaxDbiQ01664.
PeptideAtlasiQ01664.
PRIDEiQ01664.

PTM databases

iPTMnetiQ01664.
PhosphoSitePlusiQ01664.

Expressioni

Gene expression databases

BgeeiENSG00000090447.
CleanExiHS_TFAP4.
ExpressionAtlasiQ01664. baseline and differential.
GenevisibleiQ01664. HS.

Organism-specific databases

HPAiHPA001912.

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein. Homodimer.

Binary interactionsi

Show more details

GO - Molecular functioni

  • histone deacetylase binding Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB

Protein-protein interaction databases

BioGridi112881. 114 interactors.
DIPiDIP-53627N.
IntActiQ01664. 22 interactors.
STRINGi9606.ENSP00000204517.

Structurei

3D structure databases

ProteinModelPortaliQ01664.
SMRiQ01664.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini48 – 99bHLHPROSITE-ProRule annotationAdd BLAST52

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni100 – 120Leucine-zipper 1Add BLAST21
Regioni151 – 179Leucine-zipper 2Add BLAST29

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi193 – 222Gln-richAdd BLAST30
Compositional biasi225 – 244Pro-richAdd BLAST20

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0561. Eukaryota.
ENOG4111JPE. LUCA.
GeneTreeiENSGT00390000015189.
HOGENOMiHOG000294087.
HOVERGENiHBG061473.
InParanoidiQ01664.
KOiK09108.
OMAiHHVNVVT.
OrthoDBiEOG091G194I.
PhylomeDBiQ01664.
TreeFamiTF316489.

Family and domain databases

CDDicd00083. HLH. 1 hit.
Gene3Di4.10.280.10. 1 hit.
InterProiView protein in InterPro
IPR011598. bHLH_dom.
PfamiView protein in Pfam
PF00010. HLH. 1 hit.
SMARTiView protein in SMART
SM00353. HLH. 1 hit.
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiView protein in PROSITE
PS50888. BHLH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q01664-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEYFMVPTQK VPSLQHFRKT EKEVIGGLCS LANIPLTPET QRDQERRIRR
60 70 80 90 100
EIANSNERRR MQSINAGFQS LKTLIPHTDG EKLSKAAILQ QTAEYIFSLE
110 120 130 140 150
QEKTRLLQQN TQLKRFIQEL SGSSPKRRRA EDKDEGIGSP DIWEDEKAED
160 170 180 190 200
LRREMIELRQ QLDKERSVRM MLEEQVRSLE AHMYPEKLKV IAQQVQLQQQ
210 220 230 240 250
QEQVRLLHQE KLEREQQQLR TQLLPPPAPT HHPTVIVPAP PPPPSHHINV
260 270 280 290 300
VTMGPSSVIN SVSTSRQNLD TIVQAIQHIE GTQEKQELEE EQRRAVIVKP
310 320 330
VRSCPEAPTS DTASDSEASD SDAMDQSREE PSGDGELP
Length:338
Mass (Da):38,726
Last modified:October 1, 1996 - v2
Checksum:i540C008658596B83
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059346218Q → H1 PublicationCorresponds to variant dbSNP:rs251732Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S73885 mRNA. Translation: AAB32235.1.
AC004653 Genomic DNA. Translation: AAC17116.1.
BC010576 mRNA. Translation: AAH10576.1.
X57435 mRNA. Translation: CAA40683.1.
CCDSiCCDS10510.1.
PIRiI56893.
RefSeqiNP_003214.1. NM_003223.2.
UniGeneiHs.513305.

Genome annotation databases

EnsembliENST00000204517; ENSP00000204517; ENSG00000090447.
GeneIDi7023.
KEGGihsa:7023.
UCSCiuc010uxg.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTFAP4_HUMAN
AccessioniPrimary (citable) accession number: Q01664
Secondary accession number(s): O60409
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1996
Last modified: September 27, 2017
This is version 168 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot