TFAP4

Functionⁱ

Transcription factor that activates both viral and cellular genes by binding to the symmetrical DNA sequence 5'-CAGCTG-3'.

GO - Molecular functionⁱ

DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 9931457
E-box binding
Source: UniProtKB
Inferred from direct assayⁱ
histone deacetylase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 16540471
- 16924111
protein homodimerization activity
Source: UniProtKB
Inferred from physical interactionⁱ
- 2123466
RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: Ensembl
sequence-specific DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 2123466
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding Source: Ensembl
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
Source: UniProtKB
Inferred from direct assayⁱ
- 2833704
transcription regulatory region DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 14645924
- 16540471

Complete GO annotation...

GO - Biological processⁱ

Complete GO annotation...

Keywordsⁱ

Molecular function	Activator, DNA-binding
Biological process	Transcription, Transcription regulation

Enzyme and pathway databases

SIGNORⁱ	Q01664.

SIGNORⁱ

Q01664.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transcription factor AP-4 Alternative name(s): Activating enhancer-binding protein 4 Class C basic helix-loop-helix protein 41 Short name: bHLHc41
Gene namesⁱ	Name:TFAP4 Synonyms:BHLHC41
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11745. TFAP4.

HGNCⁱ

HGNC:11745. TFAP4.

Subcellular locationⁱ

Nucleus

GO - Cellular componentⁱ

Complete GO annotation...

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	7023.
Open Targets More...OpenTargetsⁱ	ENSG00000090447.
PharmGKBⁱ	PA36462.

Polymorphism and mutation databases

BioMutaⁱ	TFAP4.
DMDMⁱ	1729833.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000127458	1 – 338	Transcription factor AP-4Add BLAST		338

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	123	PhosphoserineCombined sources	1
Modified residueⁱ	124	PhosphoserineCombined sources	1
Modified residueⁱ	139	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q01664.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q01664.
PaxDbⁱ	Q01664.
PeptideAtlas More...PeptideAtlasⁱ	Q01664.
PRIDEⁱ	Q01664.

PTM databases

iPTMnetⁱ	Q01664.
PhosphoSitePlusⁱ	Q01664.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000090447.
CleanExⁱ	HS_TFAP4.
ExpressionAtlasⁱ	Q01664. baseline and differential.
Genevisibleⁱ	Q01664. HS.

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA001912.

HPAⁱ

HPA001912.

Interactionⁱ

Subunit structureⁱ

Efficient DNA binding requires dimerization with another bHLH protein. Homodimer.

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
EXOSC8	Q96B26	5	EBI-2514218,EBI-371922
GOLGA2	Q08379	3	EBI-2514218,EBI-618309
TRAF1	Q13077	3	EBI-2514218,EBI-359224

Show more details

GO - Molecular functionⁱ

Complete GO annotation...

Protein-protein interaction databases

BioGridⁱ	112881. 111 interactors.
Database of interacting proteins More...DIPⁱ	DIP-53627N.
IntActⁱ	Q01664. 23 interactors.
STRINGⁱ	9606.ENSP00000204517.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q01664.
SMRⁱ	Q01664.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	48 – 99	bHLHPROSITE-ProRule annotationAdd BLAST		52

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	100 – 120	Leucine-zipper 1Add BLAST		21
Regionⁱ	151 – 179	Leucine-zipper 2Add BLAST		29

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	193 – 222	Gln-richAdd BLAST		30
Compositional biasⁱ	225 – 244	Pro-richAdd BLAST		20

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	KOG0561. Eukaryota. ENOG4111JPE. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000015189.
HOGENOMⁱ	HOG000294087.
HOVERGENⁱ	HBG061473.
InParanoidⁱ	Q01664.
KEGG Orthology (KO) More...KOⁱ	K09108.
OMAⁱ	HHVNVVT.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G194I.
PhylomeDBⁱ	Q01664.
TreeFamⁱ	TF316489.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00083. HLH. 1 hit.
Gene3Dⁱ	4.10.280.10. 1 hit.
InterProⁱ	View protein in InterPro IPR011598. bHLH_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00010. HLH. 1 hit.
SMARTⁱ	View protein in SMART SM00353. HLH. 1 hit.
SUPFAMⁱ	SSF47459. SSF47459. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50888. BHLH. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q01664-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEYFMVPTQK VPSLQHFRKT EKEVIGGLCS LANIPLTPET QRDQERRIRR 
        60         70         80         90        100
EIANSNERRR MQSINAGFQS LKTLIPHTDG EKLSKAAILQ QTAEYIFSLE 
       110        120        130        140        150
QEKTRLLQQN TQLKRFIQEL SGSSPKRRRA EDKDEGIGSP DIWEDEKAED 
       160        170        180        190        200
LRREMIELRQ QLDKERSVRM MLEEQVRSLE AHMYPEKLKV IAQQVQLQQQ 
       210        220        230        240        250
QEQVRLLHQE KLEREQQQLR TQLLPPPAPT HHPTVIVPAP PPPPSHHINV 
       260        270        280        290        300
VTMGPSSVIN SVSTSRQNLD TIVQAIQHIE GTQEKQELEE EQRRAVIVKP 
       310        320        330 
VRSCPEAPTS DTASDSEASD SDAMDQSREE PSGDGELP

Length:338

Mass (Da):38,726

Last modified:October 1, 1996 - v2

Checksum:ⁱ540C008658596B83

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_059346	218	Q → H1 PublicationCorresponds to variant dbSNP:rs251732Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	S73885 mRNA. Translation: AAB32235.1. AC004653 Genomic DNA. Translation: AAC17116.1. BC010576 mRNA. Translation: AAH10576.1. X57435 mRNA. Translation: CAA40683.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10510.1.
PIRⁱ	I56893.
NCBI Reference Sequences More...RefSeqⁱ	NP_003214.1. NM_003223.2.
UniGeneⁱ	Hs.513305.

Genome annotation databases

Ensemblⁱ	ENST00000204517; ENSP00000204517; ENSG00000090447.
GeneIDⁱ	7023.
KEGGⁱ	hsa:7023.
UCSC genome browser More...UCSCⁱ	uc010uxg.3. human.

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	S73885 mRNA. Translation: AAB32235.1. AC004653 Genomic DNA. Translation: AAC17116.1. BC010576 mRNA. Translation: AAH10576.1. X57435 mRNA. Translation: CAA40683.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10510.1.
PIRⁱ	I56893.
NCBI Reference Sequences More...RefSeqⁱ	NP_003214.1. NM_003223.2.
UniGeneⁱ	Hs.513305.

3D structure databases

ProteinModelPortalⁱ	Q01664.
SMRⁱ	Q01664.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112881. 111 interactors.
Database of interacting proteins More...DIPⁱ	DIP-53627N.
IntActⁱ	Q01664. 23 interactors.
STRINGⁱ	9606.ENSP00000204517.

PTM databases

iPTMnetⁱ	Q01664.
PhosphoSitePlusⁱ	Q01664.

Polymorphism and mutation databases

BioMutaⁱ	TFAP4.
DMDMⁱ	1729833.

Proteomic databases

EPDⁱ	Q01664.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q01664.
PaxDbⁱ	Q01664.
PeptideAtlas More...PeptideAtlasⁱ	Q01664.
PRIDEⁱ	Q01664.

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	7023.
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000204517; ENSP00000204517; ENSG00000090447.
GeneIDⁱ	7023.
KEGGⁱ	hsa:7023.
UCSC genome browser More...UCSCⁱ	uc010uxg.3. human.

Organism-specific databases

CTDⁱ	7023.
DisGeNET More...DisGeNETⁱ	7023.
GeneCardsⁱ	TFAP4.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11745. TFAP4.
Human Protein Atlas More...HPAⁱ	HPA001912.
MIMⁱ	600743. gene.
neXtProtⁱ	NX_Q01664.
Open Targets More...OpenTargetsⁱ	ENSG00000090447.
PharmGKBⁱ	PA36462.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0561. Eukaryota. ENOG4111JPE. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000015189.
HOGENOMⁱ	HOG000294087.
HOVERGENⁱ	HBG061473.
InParanoidⁱ	Q01664.
KEGG Orthology (KO) More...KOⁱ	K09108.
OMAⁱ	HHVNVVT.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G194I.
PhylomeDBⁱ	Q01664.
TreeFamⁱ	TF316489.

Enzyme and pathway databases

SIGNORⁱ	Q01664.

SIGNORⁱ

Q01664.

Miscellaneous databases

GeneWikiⁱ	TFAP4.
GenomeRNAiⁱ	7023.
Protein Ontology More...PROⁱ	PR:Q01664.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000090447.
CleanExⁱ	HS_TFAP4.
ExpressionAtlasⁱ	Q01664. baseline and differential.
Genevisibleⁱ	Q01664. HS.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00083. HLH. 1 hit.
Gene3Dⁱ	4.10.280.10. 1 hit.
InterProⁱ	View protein in InterPro IPR011598. bHLH_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00010. HLH. 1 hit.
SMARTⁱ	View protein in SMART SM00353. HLH. 1 hit.
SUPFAMⁱ	SSF47459. SSF47459. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50888. BHLH. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TFAP4_HUMAN
Accessionⁱ	Q01664Primary (citable) accession number: Q01664 Secondary accession number(s): O60409
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1993
	Last sequence update:	October 1, 1996
	Last modified:	May 10, 2017
	This is version 166 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q01664 (TFAP4_HUMAN)

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Transcription factor AP-4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Compositional bias

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ