UniProtKB - Q01664 (TFAP4_HUMAN)
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Protein
Transcription factor AP-4
Gene
TFAP4
Organism
Homo sapiens (Human)
Status
Functioni
Transcription factor that activates both viral and cellular genes by binding to the symmetrical DNA sequence 5'-CAGCTG-3'.
GO - Molecular functioni
- DNA binding Source: UniProtKB
- E-box binding Source: UniProtKB
- histone deacetylase binding Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
- RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB
- sequence-specific DNA binding Source: UniProtKB
- transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding Source: Ensembl
- transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Source: UniProtKB
- transcription regulatory region DNA binding Source: UniProtKB
GO - Biological processi
- cellular response to dexamethasone stimulus Source: Ensembl
- DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator Source: UniProtKB
- negative regulation by host of viral transcription Source: UniProtKB
- negative regulation of cell cycle arrest Source: UniProtKB
- negative regulation of cell proliferation Source: UniProtKB
- negative regulation of cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB
- negative regulation of DNA binding Source: UniProtKB
- negative regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation by host of viral transcription Source: UniProtKB
- positive regulation of apoptotic process Source: UniProtKB
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway Source: Ensembl
- positive regulation of transcription, DNA-templated Source: UniProtKB
- protein complex assembly Source: UniProtKB
- regulation of mitotic cell cycle phase transition Source: UniProtKB
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
SIGNORi | Q01664. |
Names & Taxonomyi
Protein namesi | Recommended name: Transcription factor AP-4Alternative name(s): Activating enhancer-binding protein 4 Class C basic helix-loop-helix protein 41 Short name: bHLHc41 |
Gene namesi | Name:TFAP4 Synonyms:BHLHC41 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000090447.11. |
HGNCi | HGNC:11745. TFAP4. |
MIMi | 600743. gene. |
neXtProti | NX_Q01664. |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 7023. |
OpenTargetsi | ENSG00000090447. |
PharmGKBi | PA36462. |
Polymorphism and mutation databases
BioMutai | TFAP4. |
DMDMi | 1729833. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000127458 | 1 – 338 | Transcription factor AP-4Add BLAST | 338 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 123 | PhosphoserineCombined sources | 1 | |
Modified residuei | 124 | PhosphoserineCombined sources | 1 | |
Modified residuei | 139 | PhosphoserineCombined sources | 1 | |
Cross-linki | 147 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 187 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 189 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 285 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q01664. |
MaxQBi | Q01664. |
PaxDbi | Q01664. |
PeptideAtlasi | Q01664. |
PRIDEi | Q01664. |
PTM databases
iPTMneti | Q01664. |
PhosphoSitePlusi | Q01664. |
Expressioni
Gene expression databases
Bgeei | ENSG00000090447. |
CleanExi | HS_TFAP4. |
ExpressionAtlasi | Q01664. baseline and differential. |
Genevisiblei | Q01664. HS. |
Organism-specific databases
HPAi | HPA001912. |
Interactioni
Subunit structurei
Efficient DNA binding requires dimerization with another bHLH protein. Homodimer.
Binary interactionsi
GO - Molecular functioni
- histone deacetylase binding Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
Protein-protein interaction databases
BioGridi | 112881. 114 interactors. |
DIPi | DIP-53627N. |
IntActi | Q01664. 24 interactors. |
MINTi | Q01664. |
STRINGi | 9606.ENSP00000204517. |
Structurei
3D structure databases
ProteinModelPortali | Q01664. |
SMRi | Q01664. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 48 – 99 | bHLHPROSITE-ProRule annotationAdd BLAST | 52 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 100 – 120 | Leucine-zipper 1Add BLAST | 21 | |
Regioni | 151 – 179 | Leucine-zipper 2Add BLAST | 29 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 193 – 222 | Gln-richAdd BLAST | 30 | |
Compositional biasi | 225 – 244 | Pro-richAdd BLAST | 20 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0561. Eukaryota. ENOG4111JPE. LUCA. |
GeneTreei | ENSGT00390000015189. |
HOGENOMi | HOG000294087. |
HOVERGENi | HBG061473. |
InParanoidi | Q01664. |
KOi | K09108. |
OMAi | HHVNVVT. |
OrthoDBi | EOG091G194I. |
PhylomeDBi | Q01664. |
TreeFami | TF316489. |
Family and domain databases
CDDi | cd00083. HLH. 1 hit. |
Gene3Di | 4.10.280.10. 1 hit. |
InterProi | View protein in InterPro IPR011598. bHLH_dom. IPR036638. HLH_DNA-bd_sf. |
Pfami | View protein in Pfam PF00010. HLH. 1 hit. |
SMARTi | View protein in SMART SM00353. HLH. 1 hit. |
SUPFAMi | SSF47459. SSF47459. 1 hit. |
PROSITEi | View protein in PROSITE PS50888. BHLH. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q01664-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEYFMVPTQK VPSLQHFRKT EKEVIGGLCS LANIPLTPET QRDQERRIRR
60 70 80 90 100
EIANSNERRR MQSINAGFQS LKTLIPHTDG EKLSKAAILQ QTAEYIFSLE
110 120 130 140 150
QEKTRLLQQN TQLKRFIQEL SGSSPKRRRA EDKDEGIGSP DIWEDEKAED
160 170 180 190 200
LRREMIELRQ QLDKERSVRM MLEEQVRSLE AHMYPEKLKV IAQQVQLQQQ
210 220 230 240 250
QEQVRLLHQE KLEREQQQLR TQLLPPPAPT HHPTVIVPAP PPPPSHHINV
260 270 280 290 300
VTMGPSSVIN SVSTSRQNLD TIVQAIQHIE GTQEKQELEE EQRRAVIVKP
310 320 330
VRSCPEAPTS DTASDSEASD SDAMDQSREE PSGDGELP
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_059346 | 218 | Q → H1 PublicationCorresponds to variant dbSNP:rs251732Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | S73885 mRNA. Translation: AAB32235.1. AC004653 Genomic DNA. Translation: AAC17116.1. BC010576 mRNA. Translation: AAH10576.1. X57435 mRNA. Translation: CAA40683.1. |
CCDSi | CCDS10510.1. |
PIRi | I56893. |
RefSeqi | NP_003214.1. NM_003223.2. |
UniGenei | Hs.513305. |
Genome annotation databases
Ensembli | ENST00000204517; ENSP00000204517; ENSG00000090447. |
GeneIDi | 7023. |
KEGGi | hsa:7023. |
UCSCi | uc010uxg.3. human. |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Entry informationi
Entry namei | TFAP4_HUMAN | |
Accessioni | Q01664Primary (citable) accession number: Q01664 Secondary accession number(s): O60409 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1993 |
Last sequence update: | October 1, 1996 | |
Last modified: | March 28, 2018 | |
This is version 172 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |