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Protein

AP-1-like transcription factor

Gene

pap1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for SPK1-confered staurosporine resistance. Can confer resistance alone in high levels. Transcriptional activator that recognizes the 5'-TGACTCA-3' sequence element common in GN4/AP-1 sites.

GO - Molecular functioni

GO - Biological processi

  • cellular response to caffeine Source: PomBase
  • cellular response to hydrogen peroxide Source: PomBase
  • cellular response to oxidative stress Source: PomBase
  • positive regulation of transcription from RNA polymerase II promoter Source: PomBase
  • positive regulation of transcription from RNA polymerase II promoter in response to heat stress Source: PomBase
  • positive regulation of transcription from RNA polymerase II promoter in response to increased salt Source: PomBase
  • positive regulation of transcription from RNA polymerase II promoter in response to menadione Source: PomBase
  • positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress Source: PomBase
  • regulation of transcription from RNA polymerase II promoter Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
AP-1-like transcription factor
Alternative name(s):
Caffeine resistance protein 3
Gene namesi
Name:pap1
Synonyms:caf3
ORF Names:SPAC1783.07c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC1783.07c.
PomBaseiSPAC1783.07c. pap1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • cytosol Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000765321 – 552AP-1-like transcription factorAdd BLAST552

Proteomic databases

MaxQBiQ01663.
PRIDEiQ01663.

Interactioni

Protein-protein interaction databases

BioGridi278616. 63 interactors.
IntActiQ01663. 1 interactor.
MINTiMINT-4693342.

Structurei

Secondary structure

1552
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi80 – 125Combined sources46
Helixi128 – 138Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GD2X-ray2.00E/F/G/H/I/J71-140[»]
ProteinModelPortaliQ01663.
SMRiQ01663.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ01663.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini76 – 139bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni81 – 102Basic motifPROSITE-ProRule annotationAdd BLAST22
Regioni104 – 111Leucine-zipperPROSITE-ProRule annotation8

Sequence similaritiesi

Belongs to the bZIP family.Curated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Phylogenomic databases

InParanoidiQ01663.
KOiK09043.
OMAiCSERGVV.
OrthoDBiEOG092C4KCZ.
PhylomeDBiQ01663.

Family and domain databases

Gene3Di1.10.238.100. 1 hit.
InterProiIPR004827. bZIP.
IPR013910. TF_PAP1.
IPR023167. Yap1_redox_dom.
[Graphical view]
PfamiPF00170. bZIP_1. 1 hit.
PF08601. PAP1. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q01663-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGQTETLSS TSNIPIAKAE PEQSADFSAS HKKRGPVSDR SSRRTSSEEV
60 70 80 90 100
DLMPNVDDEV DGDVKPKKIG RKNSDQEPSS KRKAQNRAAQ RAFRKRKEDH
110 120 130 140 150
LKALETQVVT LKELHSSTTL ENDQLRQKVR QLEEELRILK DGSFTFEMSL
160 170 180 190 200
PHRNPSLSSL PTTGFSSNFA HMKDGISPQS NLHLSPNSIE KPNMHQNVLH
210 220 230 240 250
NDRSADNLNH RYQVPPTLVD SNSAQGTLSP ETPSSSDSPS NLYLNYPKRK
260 270 280 290 300
SITHLHHDCS ALSNGENGED VADGKQFCQK LSTACGSIAC SMLTKTTPHR
310 320 330 340 350
ASVDILSNLH ESTVSPPMAD ESVQRSSEVS KSIPNVELSL NVNQQFVSPF
360 370 380 390 400
GGTDSFPLPT DTGLDSLFEP DSAIENSHLK NVVMEPELFQ AWREPAESLD
410 420 430 440 450
KEFFNDEGEI DDVFHNYFHN SNENGDLITN SLHGLDFLEN ANESFPEQMY
460 470 480 490 500
PFIKHNKDYI SNHPDEVPPD GLPQKGKHDT SSQMPSENEI VPAKERAYLS
510 520 530 540 550
CPKVWSKIIN HPRFESFDID DLCSKLKNKA KCSSSGVLLD ERDVEAALNQ

FN
Length:552
Mass (Da):61,532
Last modified:August 14, 2001 - v2
Checksum:iD9E7FEA0A286B4BE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti166S → P in CAA40363 (PubMed:1899230).Curated1
Sequence conflicti280 – 281KL → NV in CAA40363 (PubMed:1899230).Curated2
Sequence conflicti543 – 552DVEAALNQFN → RC in CAA40363 (PubMed:1899230).Curated10

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57078 Genomic DNA. Translation: CAA40363.1.
CU329670 Genomic DNA. Translation: CAB66170.1.
AB027778 Genomic DNA. Translation: BAA87082.1.
PIRiS15664.
T50109.
RefSeqiNP_593662.1. NM_001019094.2.

Genome annotation databases

EnsemblFungiiSPAC1783.07c.1; SPAC1783.07c.1:pep; SPAC1783.07c.
GeneIDi2542140.
KEGGispo:SPAC1783.07c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57078 Genomic DNA. Translation: CAA40363.1.
CU329670 Genomic DNA. Translation: CAB66170.1.
AB027778 Genomic DNA. Translation: BAA87082.1.
PIRiS15664.
T50109.
RefSeqiNP_593662.1. NM_001019094.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GD2X-ray2.00E/F/G/H/I/J71-140[»]
ProteinModelPortaliQ01663.
SMRiQ01663.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278616. 63 interactors.
IntActiQ01663. 1 interactor.
MINTiMINT-4693342.

Proteomic databases

MaxQBiQ01663.
PRIDEiQ01663.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC1783.07c.1; SPAC1783.07c.1:pep; SPAC1783.07c.
GeneIDi2542140.
KEGGispo:SPAC1783.07c.

Organism-specific databases

EuPathDBiFungiDB:SPAC1783.07c.
PomBaseiSPAC1783.07c. pap1.

Phylogenomic databases

InParanoidiQ01663.
KOiK09043.
OMAiCSERGVV.
OrthoDBiEOG092C4KCZ.
PhylomeDBiQ01663.

Miscellaneous databases

EvolutionaryTraceiQ01663.
PROiQ01663.

Family and domain databases

Gene3Di1.10.238.100. 1 hit.
InterProiIPR004827. bZIP.
IPR013910. TF_PAP1.
IPR023167. Yap1_redox_dom.
[Graphical view]
PfamiPF00170. bZIP_1. 1 hit.
PF08601. PAP1. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAP1_SCHPO
AccessioniPrimary (citable) accession number: Q01663
Secondary accession number(s): Q9US23, Q9UU69
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: August 14, 2001
Last modified: November 2, 2016
This is version 147 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.