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Protein

Protein Dr1

Gene

DR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.2 Publications

GO - Molecular functioni

  • DNA binding Source: ProtInc
  • TBP-class protein binding Source: BHF-UCL
  • transcription corepressor activity Source: ProtInc
  • transcription factor binding Source: ProtInc

GO - Biological processi

  • histone H3 acetylation Source: BHF-UCL
  • negative regulation of transcription from RNA polymerase II promoter Source: ProtInc
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000117505-MONOMER.
ReactomeiR-HSA-3214847. HATs acetylate histones.
SIGNORiQ01658.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Dr1
Alternative name(s):
Down-regulator of transcription 1
Negative cofactor 2-beta
Short name:
NC2-beta
TATA-binding protein-associated phosphoprotein
Gene namesi
Name:DR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:3017. DR1.

Subcellular locationi

GO - Cellular componenti

  • Ada2/Gcn5/Ada3 transcription activator complex Source: BHF-UCL
  • nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi1810.
OpenTargetsiENSG00000117505.
PharmGKBiPA27475.

Polymorphism and mutation databases

BioMutaiDR1.
DMDMi401162.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000724402 – 176Protein Dr1Add BLAST175

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei105PhosphoserineCombined sources1
Modified residuei106PhosphoserineCombined sources1
Modified residuei166PhosphoserineCombined sources1
Modified residuei167PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylation regulates its interaction with TBP. Not phosphorylated when bound to DRAP1.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ01658.
PaxDbiQ01658.
PeptideAtlasiQ01658.
PRIDEiQ01658.

PTM databases

iPTMnetiQ01658.
PhosphoSitePlusiQ01658.

Expressioni

Gene expression databases

BgeeiENSG00000117505.
CleanExiHS_DR1.
ExpressionAtlasiQ01658. baseline and differential.
GenevisibleiQ01658. HS.

Organism-specific databases

HPAiHPA050785.
HPA055308.

Interactioni

Subunit structurei

Heterodimer with DRAP1. DR1 exists in solution as a homotetramer that dissociates during interaction with TBP and then, after complexing with TBP, reassociates at a slow rate, to reconstitute the tetramer. Interacts with NFIL3. Component of the ADA2A-containing complex (ATAC), composed of KAT14, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1.4 Publications

GO - Molecular functioni

  • TBP-class protein binding Source: BHF-UCL
  • transcription factor binding Source: ProtInc

Protein-protein interaction databases

BioGridi108144. 38 interactors.
IntActiQ01658. 10 interactors.
MINTiMINT-204839.
STRINGi9606.ENSP00000359290.

Structurei

Secondary structure

1176
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi15 – 25Combined sources11
Helixi33 – 60Combined sources28
Beta strandi64 – 66Combined sources3
Helixi68 – 78Combined sources11
Helixi81 – 83Combined sources3
Helixi84 – 110Combined sources27
Beta strandi111 – 113Combined sources3
Helixi115 – 140Combined sources26

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JFIX-ray2.62B1-176[»]
ProteinModelPortaliQ01658.
SMRiQ01658.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ01658.

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi100 – 103Nuclear localization signalSequence analysis4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi121 – 168Ala/Gln-richAdd BLAST48

Sequence similaritiesi

Belongs to the NC2 beta/DR1 family.Curated
Contains 1 histone-fold domain.Curated

Phylogenomic databases

eggNOGiKOG0871. Eukaryota.
COG5150. LUCA.
GeneTreeiENSGT00550000075010.
HOGENOMiHOG000178641.
HOVERGENiHBG002051.
InParanoidiQ01658.
OMAiEICNKSD.
OrthoDBiEOG091G0ZDR.
PhylomeDBiQ01658.
TreeFamiTF317588.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR003958. CBFA_NFYB_domain.
IPR009072. Histone-fold.
[Graphical view]
PfamiPF00808. CBFD_NFYB_HMF. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q01658-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSSGNDDD LTIPRAAINK MIKETLPNVR VANDARELVV NCCTEFIHLI
60 70 80 90 100
SSEANEICNK SEKKTISPEH VIQALESLGF GSYISEVKEV LQECKTVALK
110 120 130 140 150
RRKASSRLEN LGIPEEELLR QQQELFAKAR QQQAELAQQE WLQMQQAAQQ
160 170
AQLAAASASA SNQAGSSQDE EDDDDI
Length:176
Mass (Da):19,444
Last modified:July 1, 1993 - v1
Checksum:i36E7E59F2FD6CAB5
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034506171E → D.Corresponds to variant rs3088371dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M97388 mRNA. Translation: AAA58442.1.
BT006972 mRNA. Translation: AAP35618.1.
AL137159 Genomic DNA. Translation: CAC17578.1.
BC002809 mRNA. Translation: AAH02809.1.
BC035507 mRNA. Translation: AAH35507.1.
BC068553 mRNA. Translation: AAH68553.1.
CCDSiCCDS744.1.
PIRiA43320.
RefSeqiNP_001929.1. NM_001938.2.
UniGeneiHs.348418.

Genome annotation databases

EnsembliENST00000370267; ENSP00000359290; ENSG00000117505.
ENST00000370272; ENSP00000359295; ENSG00000117505.
GeneIDi1810.
KEGGihsa:1810.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M97388 mRNA. Translation: AAA58442.1.
BT006972 mRNA. Translation: AAP35618.1.
AL137159 Genomic DNA. Translation: CAC17578.1.
BC002809 mRNA. Translation: AAH02809.1.
BC035507 mRNA. Translation: AAH35507.1.
BC068553 mRNA. Translation: AAH68553.1.
CCDSiCCDS744.1.
PIRiA43320.
RefSeqiNP_001929.1. NM_001938.2.
UniGeneiHs.348418.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JFIX-ray2.62B1-176[»]
ProteinModelPortaliQ01658.
SMRiQ01658.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108144. 38 interactors.
IntActiQ01658. 10 interactors.
MINTiMINT-204839.
STRINGi9606.ENSP00000359290.

PTM databases

iPTMnetiQ01658.
PhosphoSitePlusiQ01658.

Polymorphism and mutation databases

BioMutaiDR1.
DMDMi401162.

Proteomic databases

EPDiQ01658.
PaxDbiQ01658.
PeptideAtlasiQ01658.
PRIDEiQ01658.

Protocols and materials databases

DNASUi1810.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370267; ENSP00000359290; ENSG00000117505.
ENST00000370272; ENSP00000359295; ENSG00000117505.
GeneIDi1810.
KEGGihsa:1810.

Organism-specific databases

CTDi1810.
DisGeNETi1810.
GeneCardsiDR1.
HGNCiHGNC:3017. DR1.
HPAiHPA050785.
HPA055308.
MIMi601482. gene.
neXtProtiNX_Q01658.
OpenTargetsiENSG00000117505.
PharmGKBiPA27475.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0871. Eukaryota.
COG5150. LUCA.
GeneTreeiENSGT00550000075010.
HOGENOMiHOG000178641.
HOVERGENiHBG002051.
InParanoidiQ01658.
OMAiEICNKSD.
OrthoDBiEOG091G0ZDR.
PhylomeDBiQ01658.
TreeFamiTF317588.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000117505-MONOMER.
ReactomeiR-HSA-3214847. HATs acetylate histones.
SIGNORiQ01658.

Miscellaneous databases

EvolutionaryTraceiQ01658.
GeneWikiiDR1_(gene).
GenomeRNAii1810.
PROiQ01658.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000117505.
CleanExiHS_DR1.
ExpressionAtlasiQ01658. baseline and differential.
GenevisibleiQ01658. HS.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR003958. CBFA_NFYB_domain.
IPR009072. Histone-fold.
[Graphical view]
PfamiPF00808. CBFD_NFYB_HMF. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNC2B_HUMAN
AccessioniPrimary (citable) accession number: Q01658
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: November 30, 2016
This is version 159 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.