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Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei40 – 401SubstrateBy similarity
Binding sitei122 – 1221SubstrateBy similarity
Binding sitei162 – 1621SubstrateBy similarity
Binding sitei212 – 2121ATPBy similarity
Binding sitei331 – 3311ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi361 – 3644ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoglycerate kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinase (EC:2.7.2.3)
Gene namesi
Name:pgk
Ordered Locus Names:Cgl1587, cg1790
OrganismiCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Taxonomic identifieri196627 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000001009 Componenti: Chromosome UP000000582 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 405405Phosphoglycerate kinasePRO_0000145937Add
BLAST

2D gel databases

World-2DPAGE0001:Q01655.

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

STRINGi196627.cg1790.

Structurei

3D structure databases

ProteinModelPortaliQ01655.
SMRiQ01655. Positions 4-404.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni24 – 263Substrate bindingBy similarity
Regioni63 – 664Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.Curated

Phylogenomic databases

eggNOGiCOG0126.
HOGENOMiHOG000227107.
KOiK00927.
OMAiDAFGTCH.
OrthoDBiEOG64N9Z0.

Family and domain databases

Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q01655-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVKTLKDLL DEGVDGRHVI VRSDFNVPLN DDREITDKGR IIASLPTLKA
60 70 80 90 100
LSEGGAKVIV MAHLGRPKGE VNEKYSLAPV AEALSDELGQ YVALAADVVG
110 120 130 140 150
EDAHERANGL TEGDILLLEN VRFDPRETSK DEAERTAFAQ ELAALAADNG
160 170 180 190 200
AFVSDGFGVV HRAQTSVYDI AKLLPHYAGG LVETEISVLE KIAESPEAPY
210 220 230 240 250
VVVLGGSKVS DKIGVIEALA AKADKIIVGG GMCYTFLAAQ GHNVQQSLLQ
260 270 280 290 300
EEMKATCTDL LARFGDKIVL PVDLVAASEF NKDAEKQIVD LDSIPEGWMS
310 320 330 340 350
LDIGPESVKN FGEVLSTAKT IFWNGPMGVF EFAAFSEGTR GIAQAIIDAT
360 370 380 390 400
AGNDAFSVVG GGDSAASVRV LGLNEDGFSH ISTGGGASLE YLEGKELPGV

AILAQ
Length:405
Mass (Da):42,697
Last modified:July 26, 2002 - v2
Checksum:iFDA8894290A9B7DE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti67 – 682PK → Q in CAA42046 (PubMed:1400158).Curated
Sequence conflicti136 – 1372TA → NR in CAA42046 (PubMed:1400158).Curated
Sequence conflicti263 – 2653RFG → SV in CAA42046 (PubMed:1400158).Curated
Sequence conflicti341 – 35010GIAQAIIDAT → ASPRPSSMQH in CAA42046 (PubMed:1400158).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59403 Genomic DNA. Translation: CAA42046.1.
BA000036 Genomic DNA. Translation: BAB98980.1.
BX927152 Genomic DNA. Translation: CAF21595.1.
PIRiB43260.
RefSeqiNP_600801.1. NC_003450.3.
YP_225871.1. NC_006958.1.

Genome annotation databases

EnsemblBacteriaiBAB98980; BAB98980; BAB98980.
GeneIDi1019555.
KEGGicgb:cg1790.
cgl:NCgl1525.
PATRICi21495211. VBICorGlu203724_1549.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59403 Genomic DNA. Translation: CAA42046.1.
BA000036 Genomic DNA. Translation: BAB98980.1.
BX927152 Genomic DNA. Translation: CAF21595.1.
PIRiB43260.
RefSeqiNP_600801.1. NC_003450.3.
YP_225871.1. NC_006958.1.

3D structure databases

ProteinModelPortaliQ01655.
SMRiQ01655. Positions 4-404.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi196627.cg1790.

2D gel databases

World-2DPAGE0001:Q01655.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB98980; BAB98980; BAB98980.
GeneIDi1019555.
KEGGicgb:cg1790.
cgl:NCgl1525.
PATRICi21495211. VBICorGlu203724_1549.

Phylogenomic databases

eggNOGiCOG0126.
HOGENOMiHOG000227107.
KOiK00927.
OMAiDAFGTCH.
OrthoDBiEOG64N9Z0.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185.

Family and domain databases

Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification, sequence analysis, and expression of a Corynebacterium glutamicum gene cluster encoding the three glycolytic enzymes glyceraldehyde-3-phosphate dehydrogenase, 3-phosphoglycerate kinase, and triosephosphate isomerase."
    Eikmanns B.J.
    J. Bacteriol. 174:6076-6086(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 13059 / LMG 3658 / NCIB 10332 / AS019 / 613.
  2. "The Corynebacterium glutamicum genome: features and impacts on biotechnological processes."
    Ikeda M., Nakagawa S.
    Appl. Microbiol. Biotechnol. 62:99-109(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.

Entry informationi

Entry nameiPGK_CORGL
AccessioniPrimary (citable) accession number: Q01655
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: July 26, 2002
Last modified: April 29, 2015
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.