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Q01655 (PGK_CORGL) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoglycerate kinase

EC=2.7.2.3
Gene names
Name:pgk
Ordered Locus Names:Cgl1587, cg1790
OrganismCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025) [Reference proteome] [HAMAP]
Taxonomic identifier196627 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium

Protein attributes

Sequence length405 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. HAMAP-Rule MF_00145

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. HAMAP-Rule MF_00145

Subunit structure

Monomer.

Subcellular location

Cytoplasm HAMAP-Rule MF_00145.

Sequence similarities

Belongs to the phosphoglycerate kinase family.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processglycolysis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoglycerate kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 405405Phosphoglycerate kinase HAMAP-Rule MF_00145
PRO_0000145937

Regions

Nucleotide binding361 – 3644ATP By similarity
Region24 – 263Substrate binding By similarity
Region63 – 664Substrate binding By similarity

Sites

Binding site401Substrate By similarity
Binding site1221Substrate By similarity
Binding site1621Substrate By similarity
Binding site2121ATP By similarity
Binding site3311ATP By similarity

Experimental info

Sequence conflict67 – 682PK → Q in CAA42046. Ref.1
Sequence conflict136 – 1372TA → NR in CAA42046. Ref.1
Sequence conflict263 – 2653RFG → SV in CAA42046. Ref.1
Sequence conflict341 – 35010GIAQAIIDAT → ASPRPSSMQH in CAA42046. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q01655 [UniParc].

Last modified July 26, 2002. Version 2.
Checksum: FDA8894290A9B7DE

FASTA40542,697
        10         20         30         40         50         60 
MAVKTLKDLL DEGVDGRHVI VRSDFNVPLN DDREITDKGR IIASLPTLKA LSEGGAKVIV 

        70         80         90        100        110        120 
MAHLGRPKGE VNEKYSLAPV AEALSDELGQ YVALAADVVG EDAHERANGL TEGDILLLEN 

       130        140        150        160        170        180 
VRFDPRETSK DEAERTAFAQ ELAALAADNG AFVSDGFGVV HRAQTSVYDI AKLLPHYAGG 

       190        200        210        220        230        240 
LVETEISVLE KIAESPEAPY VVVLGGSKVS DKIGVIEALA AKADKIIVGG GMCYTFLAAQ 

       250        260        270        280        290        300 
GHNVQQSLLQ EEMKATCTDL LARFGDKIVL PVDLVAASEF NKDAEKQIVD LDSIPEGWMS 

       310        320        330        340        350        360 
LDIGPESVKN FGEVLSTAKT IFWNGPMGVF EFAAFSEGTR GIAQAIIDAT AGNDAFSVVG 

       370        380        390        400 
GGDSAASVRV LGLNEDGFSH ISTGGGASLE YLEGKELPGV AILAQ 

« Hide

References

« Hide 'large scale' references
[1]"Identification, sequence analysis, and expression of a Corynebacterium glutamicum gene cluster encoding the three glycolytic enzymes glyceraldehyde-3-phosphate dehydrogenase, 3-phosphoglycerate kinase, and triosephosphate isomerase."
Eikmanns B.J.
J. Bacteriol. 174:6076-6086(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 13059 / LMG 3658 / NCIB 10332 / AS019 / 613.
[2]"The Corynebacterium glutamicum genome: features and impacts on biotechnological processes."
Ikeda M., Nakagawa S.
Appl. Microbiol. Biotechnol. 62:99-109(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
[3]"The complete Corynebacterium glutamicum ATCC 13032 genome sequence and its impact on the production of L-aspartate-derived amino acids and vitamins."
Kalinowski J., Bathe B., Bartels D., Bischoff N., Bott M., Burkovski A., Dusch N., Eggeling L., Eikmanns B.J., Gaigalat L., Goesmann A., Hartmann M., Huthmacher K., Kraemer R., Linke B., McHardy A.C., Meyer F., Moeckel B. expand/collapse author list , Pfefferle W., Puehler A., Rey D.A., Rueckert C., Rupp O., Sahm H., Wendisch V.F., Wiegraebe I., Tauch A.
J. Biotechnol. 104:5-25(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X59403 Genomic DNA. Translation: CAA42046.1.
BA000036 Genomic DNA. Translation: BAB98980.1.
BX927152 Genomic DNA. Translation: CAF21595.1.
PIRB43260.
RefSeqNP_600801.1. NC_003450.3.
YP_225871.1. NC_006958.1.

3D structure databases

ProteinModelPortalQ01655.
SMRQ01655. Positions 4-404.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING196627.cg1790.

2D gel databases

World-2DPAGE0001:Q01655.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAB98980; BAB98980; BAB98980.
CAF21595; CAF21595; cg1790.
GeneID1019555.
3343494.
KEGGcgb:cg1790.
cgl:NCgl1525.
PATRIC21495211. VBICorGlu203724_1549.

Phylogenomic databases

eggNOGCOG0126.
HOGENOMHOG000227107.
KOK00927.
OMADMIFDIG.
OrthoDBEOG64N9Z0.
ProtClustDBPRK00073.

Enzyme and pathway databases

UniPathwayUPA00109; UER00185.

Family and domain databases

Gene3D3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPMF_00145. Phosphoglyc_kinase.
InterProIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERPTHR11406. PTHR11406. 1 hit.
PfamPF00162. PGK. 1 hit.
[Graphical view]
PIRSFPIRSF000724. Pgk. 1 hit.
PRINTSPR00477. PHGLYCKINASE.
SUPFAMSSF53748. SSF53748. 1 hit.
PROSITEPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePGK_CORGL
AccessionPrimary (citable) accession number: Q01655
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: July 26, 2002
Last modified: February 19, 2014
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways