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Q01655

- PGK_CORGL

UniProt

Q01655 - PGK_CORGL

Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 2 (26 Jul 2002)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei40 – 401SubstrateBy similarity
    Binding sitei122 – 1221SubstrateBy similarity
    Binding sitei162 – 1621SubstrateBy similarity
    Binding sitei212 – 2121ATPBy similarity
    Binding sitei331 – 3311ATPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi361 – 3644ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoglycerate kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00109; UER00185.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoglycerate kinase (EC:2.7.2.3)
    Gene namesi
    Name:pgk
    Ordered Locus Names:Cgl1587, cg1790
    OrganismiCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
    Taxonomic identifieri196627 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
    ProteomesiUP000000582: Chromosome, UP000001009: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 405405Phosphoglycerate kinasePRO_0000145937Add
    BLAST

    2D gel databases

    World-2DPAGE0001:Q01655.

    Interactioni

    Subunit structurei

    Monomer.

    Protein-protein interaction databases

    STRINGi196627.cg1790.

    Structurei

    3D structure databases

    ProteinModelPortaliQ01655.
    SMRiQ01655. Positions 4-404.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni24 – 263Substrate bindingBy similarity
    Regioni63 – 664Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the phosphoglycerate kinase family.Curated

    Phylogenomic databases

    eggNOGiCOG0126.
    HOGENOMiHOG000227107.
    KOiK00927.
    OMAiHASVYDI.
    OrthoDBiEOG64N9Z0.

    Family and domain databases

    Gene3Di3.40.50.1260. 1 hit.
    3.40.50.1270. 1 hit.
    HAMAPiMF_00145. Phosphoglyc_kinase.
    InterProiIPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015911. Phosphoglycerate_kinase_CS.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view]
    PANTHERiPTHR11406. PTHR11406. 1 hit.
    PfamiPF00162. PGK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000724. Pgk. 1 hit.
    PRINTSiPR00477. PHGLYCKINASE.
    SUPFAMiSSF53748. SSF53748. 1 hit.
    PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q01655-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAVKTLKDLL DEGVDGRHVI VRSDFNVPLN DDREITDKGR IIASLPTLKA    50
    LSEGGAKVIV MAHLGRPKGE VNEKYSLAPV AEALSDELGQ YVALAADVVG 100
    EDAHERANGL TEGDILLLEN VRFDPRETSK DEAERTAFAQ ELAALAADNG 150
    AFVSDGFGVV HRAQTSVYDI AKLLPHYAGG LVETEISVLE KIAESPEAPY 200
    VVVLGGSKVS DKIGVIEALA AKADKIIVGG GMCYTFLAAQ GHNVQQSLLQ 250
    EEMKATCTDL LARFGDKIVL PVDLVAASEF NKDAEKQIVD LDSIPEGWMS 300
    LDIGPESVKN FGEVLSTAKT IFWNGPMGVF EFAAFSEGTR GIAQAIIDAT 350
    AGNDAFSVVG GGDSAASVRV LGLNEDGFSH ISTGGGASLE YLEGKELPGV 400
    AILAQ 405
    Length:405
    Mass (Da):42,697
    Last modified:July 26, 2002 - v2
    Checksum:iFDA8894290A9B7DE
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti67 – 682PK → Q in CAA42046. (PubMed:1400158)Curated
    Sequence conflicti136 – 1372TA → NR in CAA42046. (PubMed:1400158)Curated
    Sequence conflicti263 – 2653RFG → SV in CAA42046. (PubMed:1400158)Curated
    Sequence conflicti341 – 35010GIAQAIIDAT → ASPRPSSMQH in CAA42046. (PubMed:1400158)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X59403 Genomic DNA. Translation: CAA42046.1.
    BA000036 Genomic DNA. Translation: BAB98980.1.
    BX927152 Genomic DNA. Translation: CAF21595.1.
    PIRiB43260.
    RefSeqiNP_600801.1. NC_003450.3.
    YP_225871.1. NC_006958.1.

    Genome annotation databases

    EnsemblBacteriaiBAB98980; BAB98980; BAB98980.
    CAF21595; CAF21595; cg1790.
    GeneIDi1019555.
    KEGGicgb:cg1790.
    cgl:NCgl1525.
    PATRICi21495211. VBICorGlu203724_1549.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X59403 Genomic DNA. Translation: CAA42046.1 .
    BA000036 Genomic DNA. Translation: BAB98980.1 .
    BX927152 Genomic DNA. Translation: CAF21595.1 .
    PIRi B43260.
    RefSeqi NP_600801.1. NC_003450.3.
    YP_225871.1. NC_006958.1.

    3D structure databases

    ProteinModelPortali Q01655.
    SMRi Q01655. Positions 4-404.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 196627.cg1790.

    2D gel databases

    World-2DPAGE 0001:Q01655.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB98980 ; BAB98980 ; BAB98980 .
    CAF21595 ; CAF21595 ; cg1790 .
    GeneIDi 1019555.
    KEGGi cgb:cg1790.
    cgl:NCgl1525.
    PATRICi 21495211. VBICorGlu203724_1549.

    Phylogenomic databases

    eggNOGi COG0126.
    HOGENOMi HOG000227107.
    KOi K00927.
    OMAi HASVYDI.
    OrthoDBi EOG64N9Z0.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00185 .

    Family and domain databases

    Gene3Di 3.40.50.1260. 1 hit.
    3.40.50.1270. 1 hit.
    HAMAPi MF_00145. Phosphoglyc_kinase.
    InterProi IPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015911. Phosphoglycerate_kinase_CS.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view ]
    PANTHERi PTHR11406. PTHR11406. 1 hit.
    Pfami PF00162. PGK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000724. Pgk. 1 hit.
    PRINTSi PR00477. PHGLYCKINASE.
    SUPFAMi SSF53748. SSF53748. 1 hit.
    PROSITEi PS00111. PGLYCERATE_KINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification, sequence analysis, and expression of a Corynebacterium glutamicum gene cluster encoding the three glycolytic enzymes glyceraldehyde-3-phosphate dehydrogenase, 3-phosphoglycerate kinase, and triosephosphate isomerase."
      Eikmanns B.J.
      J. Bacteriol. 174:6076-6086(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 13059 / LMG 3658 / NCIB 10332 / AS019 / 613.
    2. "The Corynebacterium glutamicum genome: features and impacts on biotechnological processes."
      Ikeda M., Nakagawa S.
      Appl. Microbiol. Biotechnol. 62:99-109(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.

    Entry informationi

    Entry nameiPGK_CORGL
    AccessioniPrimary (citable) accession number: Q01655
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: July 26, 2002
    Last modified: October 1, 2014
    This is version 98 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3