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Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Glyceraldehyde-3-phosphate dehydrogenase (gap)
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA)
  4. Enolase (eno)
  5. Pyruvate kinase (pyk)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei40SubstrateBy similarity1
Binding sitei122SubstrateBy similarity1
Binding sitei162SubstrateBy similarity1
Binding sitei212ATPBy similarity1
Binding sitei331ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi361 – 364ATPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processGlycolysis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCORYNE:G18NG-11172-MONOMER
UniPathwayiUPA00109; UER00185

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinase (EC:2.7.2.3)
Gene namesi
Name:pgk
Ordered Locus Names:Cgl1587, cg1790
OrganismiCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Taxonomic identifieri196627 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
Proteomesi
  • UP000000582 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001459371 – 405Phosphoglycerate kinaseAdd BLAST405

2D gel databases

World-2DPAGEi0001:Q01655

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

STRINGi196627.cg1790

Structurei

3D structure databases

ProteinModelPortaliQ01655
SMRiQ01655
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni24 – 26Substrate bindingBy similarity3
Regioni63 – 66Substrate bindingBy similarity4

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.Curated

Phylogenomic databases

eggNOGiENOG4105BZA Bacteria
COG0126 LUCA
HOGENOMiHOG000227107
KOiK00927
OMAiDMIFDIG

Family and domain databases

CDDicd00318 Phosphoglycerate_kinase, 1 hit
Gene3Di3.40.50.1260, 3 hits
HAMAPiMF_00145 Phosphoglyc_kinase, 1 hit
InterProiView protein in InterPro
IPR001576 Phosphoglycerate_kinase
IPR015911 Phosphoglycerate_kinase_CS
IPR015824 Phosphoglycerate_kinase_N
IPR036043 Phosphoglycerate_kinase_sf
PANTHERiPTHR11406 PTHR11406, 1 hit
PfamiView protein in Pfam
PF00162 PGK, 1 hit
PIRSFiPIRSF000724 Pgk, 1 hit
PRINTSiPR00477 PHGLYCKINASE
SUPFAMiSSF53748 SSF53748, 1 hit
PROSITEiView protein in PROSITE
PS00111 PGLYCERATE_KINASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q01655-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVKTLKDLL DEGVDGRHVI VRSDFNVPLN DDREITDKGR IIASLPTLKA
60 70 80 90 100
LSEGGAKVIV MAHLGRPKGE VNEKYSLAPV AEALSDELGQ YVALAADVVG
110 120 130 140 150
EDAHERANGL TEGDILLLEN VRFDPRETSK DEAERTAFAQ ELAALAADNG
160 170 180 190 200
AFVSDGFGVV HRAQTSVYDI AKLLPHYAGG LVETEISVLE KIAESPEAPY
210 220 230 240 250
VVVLGGSKVS DKIGVIEALA AKADKIIVGG GMCYTFLAAQ GHNVQQSLLQ
260 270 280 290 300
EEMKATCTDL LARFGDKIVL PVDLVAASEF NKDAEKQIVD LDSIPEGWMS
310 320 330 340 350
LDIGPESVKN FGEVLSTAKT IFWNGPMGVF EFAAFSEGTR GIAQAIIDAT
360 370 380 390 400
AGNDAFSVVG GGDSAASVRV LGLNEDGFSH ISTGGGASLE YLEGKELPGV

AILAQ
Length:405
Mass (Da):42,697
Last modified:July 26, 2002 - v2
Checksum:iFDA8894290A9B7DE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti67 – 68PK → Q in CAA42046 (PubMed:1400158).Curated2
Sequence conflicti136 – 137TA → NR in CAA42046 (PubMed:1400158).Curated2
Sequence conflicti263 – 265RFG → SV in CAA42046 (PubMed:1400158).Curated3
Sequence conflicti341 – 350GIAQAIIDAT → ASPRPSSMQH in CAA42046 (PubMed:1400158).Curated10

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59403 Genomic DNA Translation: CAA42046.1
BA000036 Genomic DNA Translation: BAB98980.1
BX927152 Genomic DNA Translation: CAF21595.1
PIRiB43260
RefSeqiNP_600801.1, NC_003450.3
WP_003862252.1, NC_006958.1

Genome annotation databases

EnsemblBacteriaiBAB98980; BAB98980; BAB98980
CAF21595; CAF21595; cg1790
GeneIDi1019555
KEGGicgb:cg1790
cgl:NCgl1525
PATRICifig|196627.13.peg.1549

Similar proteinsi

Entry informationi

Entry nameiPGK_CORGL
AccessioniPrimary (citable) accession number: Q01655
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: July 26, 2002
Last modified: May 23, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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