Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Nuclear export protein

Gene

NS

Organism
Influenza C virus (strain C/Ann Arbor/1/1950)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Mediates the nuclear export of encapsidated genomic RNAs (ribonucleoproteins, RNPs). Acts as an adapter between viral RNPs complexes and the nuclear export machinery of the cell. Possesses no intrinsic RNA-binding activity, but includes a C-terminal M1-binding domain. This domain is believed to allow recognition of RNPs bound to the protein M1. Since protein M1 is not available in large quantities before late stages of infection, such an indirect recognition mechanism probably ensures that genomic RNPs are not exported from the host nucleus until sufficient quantities of viral mRNA and progeny genomic RNA have been synthesized. Furthermore, the RNPs enter the host cytoplasm only when associated with the M1 protein that is necessary to guide them to the plasma membrane. May down-regulate viral RNA synthesis when overproduced.UniRule annotation

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear export proteinUniRule annotation
Short name:
NEPUniRule annotation
Alternative name(s):
Non-structural protein 2UniRule annotation
Short name:
NS2UniRule annotation
Gene namesi
Name:NSUniRule annotation
OrganismiInfluenza C virus (strain C/Ann Arbor/1/1950)
Taxonomic identifieri11553 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesOrthomyxoviridaeInfluenzavirus C
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Sus scrofa (Pig) [TaxID: 9823]
Proteomesi
  • UP000008286 Componenti: Genome

Subcellular locationi

  • Virion UniRule annotation
  • Host nucleus UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Host nucleus, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000790171 – 182Nuclear export proteinAdd BLAST182

Interactioni

Subunit structurei

Interacts with protein M1. May interact with host nucleoporin RAB/HRB and exportin XPO1/CRM1.UniRule annotation

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi96 – 105Nuclear export signalUniRule annotation10
Motifi122 – 132Nuclear export signalUniRule annotationAdd BLAST11

Sequence similaritiesi

Belongs to the influenza viruses NEP family.UniRule annotation

Family and domain databases

HAMAPiMF_04067. INFV_NEP. 1 hit.
InterProiView protein in InterPro
IPR005188. Flu_C_NS2.
IPR000968. Flu_NS2.
PfamiView protein in Pfam
PF03555. Flu_C_NS2. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform NEP (identifier: Q01640-1) [UniParc]FASTAAdd to basket
Also known as: NS2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSDKTVKSTN LMAFVATKML ERQEDLDTCT EMQVEKMKTS TKARLKTESS
60 70 80 90 100
FAPRTWEDAI KDEILRRSVD TSSLDKWPEL KQELENVSDA LKADSLWLPM
110 120 130 140 150
KSLSLYSKVS NQEPSSIPIG EMKHQILTRL KLICSRLEKL DLNLSKAVLG
160 170 180
IQNSEDLILI IYNRDVCKNT ILMIKSLCNS LI
Length:182
Mass (Da):20,768
Last modified:April 5, 2011 - v3
Checksum:i2D44CC3CD1FB54E0
GO
Isoform NS1 (identifier: Q01639-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q01639.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:246
Mass (Da):27,752
GO

Sequence cautioni

The sequence BAA24045 differs from that shown. Reason: Frameshift at position 116.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti169N → T. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB283001 Viral cRNA. Translation: BAF74589.1.
D00029 Genomic RNA. Translation: BAA24045.1. Frameshift.
RefSeqiYP_002302328.1. NC_006306.2. [Q01640-1]

Genome annotation databases

GeneIDi7011833.
KEGGivg:7011833.

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiNEP_INCAA
AccessioniPrimary (citable) accession number: Q01640
Secondary accession number(s): A7BHX7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 5, 2011
Last modified: January 31, 2018
This is version 70 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome