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Protein

Non-structural protein 1

Gene

NS

Organism
Influenza C virus (strain C/Ann Arbor/1/1950)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Prevents the establishment of the cellular antiviral state initiated by host DDX58, which normally triggers the antiviral transduction signal that leads to the activation of type I IFN genes by transcription factors IRF3 and IRF7. Participates also in the upregulation of the splicing of viral mRNAs.UniRule annotation

Miscellaneous

The strain C/Ann Arbor/1/50-pi causes persistent infection.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
Biological processHost-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host interferon signaling pathway by virus, Inhibition of host RIG-I by virus, Inhibition of host RLR pathway by virus, Interferon antiviral system evasion, Viral immunoevasion

Names & Taxonomyi

Protein namesi
Recommended name:
Non-structural protein 1UniRule annotation
Short name:
NS1UniRule annotation
Alternative name(s):
NS1AUniRule annotation
Gene namesi
Name:NSUniRule annotation
OrganismiInfluenza C virus (strain C/Ann Arbor/1/1950)
Taxonomic identifieri11553 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesOrthomyxoviridaeInfluenzavirus C
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Sus scrofa (Pig) [TaxID: 9823]
Proteomesi
  • UP000008286 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm, Host nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000445881 – 246Non-structural protein 1Add BLAST246

Post-translational modificationi

The NS1 protein of strain C/Ann Arbor/1/50-pi is phosphorylated.

Interactioni

Protein-protein interaction databases

IntActiQ01639. 1 interactor.

Family & Domainsi

Sequence similaritiesi

Belongs to the influenza C viruses NS1 family.UniRule annotation

Family and domain databases

HAMAPiMF_04066. INFV_NS1. 1 hit.
InterProiView protein in InterPro
IPR004208. Flu_B_NS1.
IPR005187. Flu_C_NS1.
IPR005188. Flu_C_NS2.
PfamiView protein in Pfam
PF03506. Flu_C_NS1. 1 hit.
PF03555. Flu_C_NS2. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform NS1 (identifier: Q01639-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSDKTVKSTN LMAFVATKML ERQEDLDTCT EMQVEKMKTS TKARLRTESS
60 70 80 90 100
FAPRTWEDAI KDGELLFNGT ILQTESPTMT PASVEMKGKK FPIDFAPSNI
110 120 130 140 150
APIGQNPIYL SPCIPNFDGN VWEATMYHHR GATLTKTMNC NCFQRTIWCH
160 170 180 190 200
PNPSRMRLSY AFVLYCRNTK KICGYLIAKQ VAGIETGIRK CFRCIKSGFV
210 220 230 240
MATDEISLTI LQSIKSGAQL DPYWGNEKPD IDKTEAYMLS LREAGP
Length:246
Mass (Da):27,752
Last modified:February 21, 2006 - v2
Checksum:i3478E6665209C621
GO
Isoform NEP (identifier: Q01640-1) [UniParc]FASTAAdd to basket
Also known as: NS2
The sequence of this isoform can be found in the external entry Q01640.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:182
Mass (Da):20,768
GO

Sequence cautioni

The sequence BAA24044 differs from that shown. Reason: Frameshift at position 220.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti39T → K in strain: C/Ann Arbor/1/50-pi. 1
Natural varianti46R → K. 1
Natural varianti74T → A. 1
Natural varianti84V → I in strain: C/Ann Arbor/1/50-pi. 1
Natural varianti96A → T in strain: C/Ann Arbor/1/50-pi. 1
Natural varianti98S → R. 1
Natural varianti179K → R. 1
Natural varianti189R → K in strain: C/Ann Arbor/1/50-pi. 1
Natural varianti228K → T. 1
Natural varianti232D → N in strain: C/Ann Arbor/1/50-pi. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF102026 mRNA. Translation: AAC98304.1.
AF102027 mRNA. Translation: AAC98305.1.
AB283001 Viral cRNA. Translation: BAF74590.1.
D00029 Genomic RNA. Translation: BAA24044.1. Frameshift.
RefSeqiYP_002302329.1. NC_006306.2.

Genome annotation databases

GeneIDi3077236.
KEGGivg:3077236.

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiNS1_INCAA
AccessioniPrimary (citable) accession number: Q01639
Secondary accession number(s): A7BHX8, Q9YMF4, Q9YMF5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: February 21, 2006
Last modified: December 20, 2017
This is version 64 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families