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Reviewed, UniProtKB/Swiss-Prot Q01638 (ILRL1_HUMAN)

Last modified March 2, 2010. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
Interleukin-1 receptor-like 1
Alternative name(s):
Protein ST2
Gene names
Name:IL1RL1
Synonyms:DER4, ST2, T1
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length556 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Receptor for interleukin-33 (IL-33), its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function. Ref.11

Subunit structure

Interacts with MYD88, IRAK1, IRAK4, and TRAF6. Ref.11

Subcellular location

Isoform C: Cell membrane Ref.10.

Isoform B: Secreted Ref.10.

Cell membrane; Single-pass type I membrane protein Ref.10.

Tissue specificity

Highly expressed in kidney, lung, placenta, stomach, skeletal muscle, colon and small intestine. Isoform A is prevalently expressed in the lung, testis, placenta, stomach and colon. Isoform B is more abundant in the brain, kidney and the liver. Isoform C is not detected in brain, heart, liver, kidney and skeletal muscle. Ref.10

Sequence similarities

Belongs to the interleukin-1 receptor family.

Contains 3 Ig-like C2-type (immunoglobulin-like) domains.

Contains 1 TIR domain.

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Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform A (identifier: Q01638-1)

Also known as: ST2L;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform B (identifier: Q01638-2)

Also known as: ST2S;

The sequence of this isoform differs from the canonical sequence as follows:
     324-328: IDHHS → SKECF
     329-556: Missing.
Isoform C (identifier: Q01638-3)

Also known as: ST2V;

The sequence of this isoform differs from the canonical sequence as follows:
     204-259: DEQGFSLFPV...LWQLNGTKIT → VWCQSFCKLK...LQYFQHHQWP
     260-556: Missing.
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Ref.9
Chain19 – 556538Interleukin-1 receptor-like 1
PRO_0000015442

Regions

Topological domain19 – 328310Extracellular Potential
Transmembrane329 – 34921 Potential
Topological domain350 – 556207Cytoplasmic Potential
Domain19 – 10385Ig-like C2-type 1
Domain114 – 19784Ig-like C2-type 2
Domain212 – 319108Ig-like C2-type 3
Domain375 – 538164TIR

Amino acid modifications

Glycosylation541N-linked (GlcNAc...) Potential
Glycosylation951N-linked (GlcNAc...) Potential
Glycosylation1011N-linked (GlcNAc...) Potential
Glycosylation1401N-linked (GlcNAc...) Potential
Glycosylation1911N-linked (GlcNAc...) Potential
Glycosylation2321N-linked (GlcNAc...) Potential
Glycosylation2541N-linked (GlcNAc...) Potential
Glycosylation2731N-linked (GlcNAc...) Potential
Disulfide bond36 ↔ 87 By similarity
Disulfide bond133 ↔ 181 By similarity
Disulfide bond235 ↔ 303 By similarity

Natural variations

Alternative sequence204 – 25956DEQGF…GTKIT → VWCQSFCKLKKSLIFSNTHW IQSLMRGFVMVYYGVHKCCR VVFNLCLQYFQHHQWP in isoform C.
VSP_002664
Alternative sequence260 – 556297Missing in isoform C.
VSP_002665
Alternative sequence324 – 3285IDHHS → SKECF in isoform B.
VSP_002666
Alternative sequence329 – 556228Missing in isoform B.
VSP_002667
Natural variant781A → E: dbSNP rs1041973. Ref.1 Ref.2 Ref.3
VAR_023749
Natural variant4331A → T: dbSNP rs4988956. Ref.3
VAR_053373
Natural variant5011Q → K: dbSNP rs10192036.
VAR_053374
Natural variant5011Q → R: dbSNP rs10204137.
VAR_053375
Natural variant5491T → I: dbSNP rs10192157.
VAR_053376
Natural variant5511L → S: dbSNP rs10206753.
VAR_053377

Experimental info

Sequence conflict701Q → R in BAA85894. Ref.2

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Sequences

Sequence LengthMass (Da)Tools
Isoform A (ST2L) [UniParc].

Last modified October 17, 2006. Version 4.
Checksum: CB3E444A2DD477B5

FASTA55663,358
        10         20         30         40         50         60 
MGFWILAILT ILMYSTAAKF SKQSWGLENE ALIVRCPRQG KPSYTVDWYY SQTNKSIPTQ 

        70         80         90        100        110        120 
ERNRVFASGQ LLKFLPAAVA DSGIYTCIVR SPTFNRTGYA NVTIYKKQSD CNVPDYLMYS 

       130        140        150        160        170        180 
TVSGSEKNSK IYCPTIDLYN WTAPLEWFKN CQALQGSRYR AHKSFLVIDN VMTEDAGDYT 

       190        200        210        220        230        240 
CKFIHNENGA NYSVTATRSF TVKDEQGFSL FPVIGAPAQN EIKEVEIGKN ANLTCSACFG 

       250        260        270        280        290        300 
KGTQFLAAVL WQLNGTKITD FGEPRIQQEE GQNQSFSNGL ACLDMVLRIA DVKEEDLLLQ 

       310        320        330        340        350        360 
YDCLALNLHG LRRHTVRLSR KNPIDHHSIY CIIAVCSVFL MLINVLVIIL KMFWIEATLL 

       370        380        390        400        410        420 
WRDIAKPYKT RNDGKLYDAY VVYPRNYKSS TDGASRVEHF VHQILPDVLE NKCGYTLCIY 

       430        440        450        460        470        480 
GRDMLPGEDV VTAVETNIRK SRRHIFILTP QITHNKEFAY EQEVALHCAL IQNDAKVILI 

       490        500        510        520        530        540 
EMEALSELDM LQAEALQDSL QHLMKVQGTI KWREDHIANK RSLNSKFWKH VRYQMPVPSK 

       550 
IPRKASSLTP LAAQKQ

« Hide

Isoform B (ST2S).

Checksum: F91C46FE2D7FEAD1
Show »

FASTA32836,993
Isoform C (ST2V).

Checksum: C349EC8B232EA231
Show »

FASTA25929,951

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References

« Hide 'large scale' references
[1]"Nucleotide sequence of a complementary DNA for human ST2."
Tominaga S., Yokota T., Yanagisawa K., Tsukamoto T., Takagi T., Tetsuka T.
Biochim. Biophys. Acta 1171:215-218(1992) [PubMed: 1482686] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM B), VARIANT GLU-78.
Tissue: Lymphocyte.
[2]"Presence and expression of a novel variant form of ST2 gene product in human leukemic cell line UT-7/GM."
Tominaga S., Kuroiwa K., Tago K., Iwahana H., Yanagisawa K., Komatsu N.
Biochem. Biophys. Res. Commun. 264:14-18(1999) [PubMed: 10527832] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM C), VARIANT GLU-78.
[3]"The cloning and nucleotide sequence of human ST2L cDNA."
Li H., Tago K., Io K., Kuroiwa K., Arai T., Iwahana H., Tominaga S., Yanagisawa K.
Genomics 67:284-290(2000) [PubMed: 10936050] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), VARIANTS GLU-78 AND THR-433.
Tissue: Megakaryoblast.
[4]Yanagisawa K.
Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION TO 433.
[5]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).
Tissue: Placenta.
[6]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed: 15815621] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).
Tissue: Placenta.
[9]"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z., Henzel W.J.
Protein Sci. 13:2819-2824(2004) [PubMed: 15340161] [Abstract]
Cited for: PROTEIN SEQUENCE OF 19-33.
[10]"Tissue distribution and subcellular localization of a variant form of the human ST2 gene product, ST2V."
Tago K., Noda T., Hayakawa M., Iwahana H., Yanagisawa K., Yashiro T., Tominaga S.
Biochem. Biophys. Res. Commun. 285:1377-1383(2001) [PubMed: 11478810] [Abstract]
Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[11]"IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST 2 and induces T helper type 2-associated cytokines."
Schmitz J., Owyang A., Oldham E., Song Y., Murphy E., McClanahan T.K., Zurawski G., Moshrefi M., Qin J., Li X., Gorman D.M., Bazan J.F., Kastelein R.A.
Immunity 23:479-490(2005) [PubMed: 16286016] [Abstract]
Cited for: FUNCTION, SUBUNIT.
[12]"An unappreciated role for RNA surveillance."
Hillman R.T., Green R.E., Brenner S.E.
Genome Biol. 5:R8.1-R8.16(2004) [PubMed: 14759258] [Abstract]
Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		D12763 mRNA. Translation: BAA02233.1.
D12764 Genomic DNA. Translation: BAA20539.1.
AB029084 mRNA. Translation: BAA85894.1.
AB012701 mRNA. Translation: BAA82405.2.
AC007248 Genomic DNA. Translation: AAY15047.1.
AK291578 mRNA. Translation: BAF84267.1.
CH471127 Genomic DNA. Translation: EAX01795.1.
BC030975 mRNA. Translation: AAH30975.1.
IPIIPI00218676.
IPI00296161.
IPI00296164.
PIRJC7109.
S30444.
RefSeqNP_003847.2.
NP_057316.3.
UniGeneHs.66

3D structure databases

SMRQ01638. Positions 375-537.
ModBaseSearch...

Protein-protein interaction databases

IntActQ01638. 4 interactions.
STRINGQ01638.

PTM databases

PhosphoSiteQ01638.

Proteomic databases

PRIDEQ01638.

Genome annotation databases

EnsemblENST00000233954; ENSP00000233954; ENSG00000115602; Homo sapiens. [Genome view]
ENST00000404917; ENSP00000384822; ENSG00000115602; Homo sapiens. [Genome view]
GeneID9173.
KEGGhsa:9173.
UCSCuc002tbu.1. human.
uc002tbv.1. human.

Organism-specific databases

CTD9173.
GeneCardsGC02P102294.
HGNCHGNC:5998. IL1RL1.
HPAHPA007406.
HPA007917.
MIM601203. gene.
PharmGKBPA29814.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG17040.
HOGENOMHBG282748.
HOVERGENHBG098401.
InParanoidQ01638.
OMAEQEIALH.
OrthoDBEOG92RGSG.
PhylomeDBQ01638.

Gene expression databases

ArrayExpressQ01638.
BgeeQ01638.
CleanExHS_IL1RL1.
GenevestigatorQ01638.
GermOnlineENSG00000115602. Homo sapiens.

Family and domain databases

InterProIPR007110. Ig-like.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR015621. IL1-receptor.
IPR004075. IL1_rcpt_1.
IPR004074. IL1_rcpt_I/II.
IPR000157. Toll-Interleukin_rcpt.
[Graphical view]
Gene3DG3DSA:2.60.40.10. Ig-like_fold. 3 hits.
PANTHERPTHR11890. IL1-receptor. 1 hit.
PfamPF01582. TIR. 1 hit.
[Graphical view]
PRINTSPR01536. INTRLKN1R12F.
PR01537. INTRLKN1R1F.
SMARTSM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMSSF52200. TIR. 1 hit.
PROSITEPS50835. IG_LIKE. 3 hits.
PS50104. TIR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio34399.
SOURCESearch...

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Entry information

Entry nameILRL1_HUMAN
AccessionPrimary (citable) accession number: Q01638
Secondary accession number(s): A8K6B3 expand/collapse secondary AC list , Q53TU7, Q8NEJ3, Q9ULV7, Q9UQ44
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: October 17, 2006
Last modified: March 2, 2010
This is version 109 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Relevant documents

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents