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Protein

Interleukin-1 receptor-like 1

Gene

IL1RL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for interleukin-33 (IL-33); signaling requires association of the coreceptor IL1RAP. Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function.1 Publication1 Publication
Isoform B: Inhibits IL-33 signaling.By similarity

GO - Molecular functioni

  • cytokine receptor activity Source: UniProtKB
  • interleukin-1 receptor activity Source: InterPro
  • interleukin-33 receptor activity Source: Ensembl
  • signal transducer activity, downstream of receptor Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

BioCyciZFISH:ENSG00000115602-MONOMER.
ReactomeiR-HSA-449147. Signaling by Interleukins.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-1 receptor-like 1
Alternative name(s):
Protein ST2
Gene namesi
Name:IL1RL1
Synonyms:DER4, ST2, T1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:5998. IL1RL1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 328ExtracellularSequence analysisAdd BLAST310
Transmembranei329 – 349HelicalSequence analysisAdd BLAST21
Topological domaini350 – 556CytoplasmicSequence analysisAdd BLAST207

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi9173.
OpenTargetsiENSG00000115602.
PharmGKBiPA29814.

Polymorphism and mutation databases

BioMutaiIL1RL1.
DMDMi116242527.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 181 PublicationAdd BLAST18
ChainiPRO_000001544219 – 556Interleukin-1 receptor-like 1Add BLAST538

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi36 ↔ 87PROSITE-ProRule annotation1 Publication
Glycosylationi54N-linked (GlcNAc...)Sequence analysis1
Glycosylationi95N-linked (GlcNAc...)1 Publication1
Glycosylationi101N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi111 ↔ 151PROSITE-ProRule annotation1 Publication
Disulfide bondi133 ↔ 181PROSITE-ProRule annotation1 Publication
Glycosylationi140N-linked (GlcNAc...)1 Publication1
Glycosylationi191N-linked (GlcNAc...)1 Publication1
Glycosylationi232N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi235 ↔ 303PROSITE-ProRule annotation1 Publication
Disulfide bondi238 ↔ 282PROSITE-ProRule annotation1 Publication
Glycosylationi254N-linked (GlcNAc...)Sequence analysis1
Glycosylationi273N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ01638.
PeptideAtlasiQ01638.
PRIDEiQ01638.
TopDownProteomicsiQ01638-2. [Q01638-2]

PTM databases

iPTMnetiQ01638.
PhosphoSitePlusiQ01638.

Expressioni

Tissue specificityi

Highly expressed in kidney, lung, placenta, stomach, skeletal muscle, colon and small intestine. Isoform A is prevalently expressed in the lung, testis, placenta, stomach and colon. Isoform B is more abundant in the brain, kidney and the liver. Isoform C is not detected in brain, heart, liver, kidney and skeletal muscle. Expressed on T-cells in fibrotic liver; at protein level. Overexpressed in fibrotic and cirrhotic liver.2 Publications

Gene expression databases

BgeeiENSG00000115602.
CleanExiHS_IL1RL1.
ExpressionAtlasiQ01638. baseline and differential.
GenevisibleiQ01638. HS.

Organism-specific databases

HPAiHPA007406.
HPA007917.

Interactioni

Subunit structurei

Interacts with MYD88, IRAK1, IRAK4, and TRAF6. Bound to its ligand IL-33, interacts with IL1RAP to form the minimal interleukin-33 signaling complex with a 1:1:1 stoechiometry. Interacts with KIT (bound to KITLG/SCF). A mast cell-specific KITLG/SCF-induced interleukin-33 signaling complex contains IL1RL1, IL1RAP, KIT and MYD88.By similarity1 Publication2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CLEC7AQ9BXN23EBI-993762,EBI-3939278
IL33O957602EBI-993762,EBI-724057

Protein-protein interaction databases

BioGridi114613. 7 interactors.
DIPiDIP-37861N.
IntActiQ01638. 5 interactors.
STRINGi9606.ENSP00000233954.

Structurei

Secondary structure

1556
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi24 – 27Combined sources4
Beta strandi32 – 35Combined sources4
Beta strandi44 – 49Combined sources6
Beta strandi63 – 68Combined sources6
Beta strandi71 – 76Combined sources6
Helixi79 – 81Combined sources3
Beta strandi83 – 90Combined sources8
Beta strandi95 – 105Combined sources11
Beta strandi121 – 123Combined sources3
Beta strandi125 – 127Combined sources3
Beta strandi130 – 132Combined sources3
Helixi136 – 138Combined sources3
Beta strandi146 – 149Combined sources4
Turni156 – 158Combined sources3
Beta strandi159 – 162Combined sources4
Beta strandi165 – 170Combined sources6
Helixi173 – 175Combined sources3
Beta strandi177 – 189Combined sources13
Beta strandi191 – 202Combined sources12
Beta strandi209 – 216Combined sources8
Beta strandi219 – 221Combined sources3
Beta strandi234 – 242Combined sources9
Beta strandi248 – 253Combined sources6
Beta strandi265 – 269Combined sources5
Beta strandi281 – 288Combined sources8
Helixi295 – 297Combined sources3
Beta strandi301 – 306Combined sources6
Beta strandi311 – 317Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4KC3X-ray3.27B19-321[»]
ProteinModelPortaliQ01638.
SMRiQ01638.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 103Ig-like C2-type 1Add BLAST85
Domaini114 – 197Ig-like C2-type 2Add BLAST84
Domaini212 – 319Ig-like C2-type 3Add BLAST108
Domaini375 – 538TIRPROSITE-ProRule annotationAdd BLAST164

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni198 – 211Flexible linkerAdd BLAST14

Sequence similaritiesi

Belongs to the interleukin-1 receptor family.Curated
Contains 1 TIR domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IPTT. Eukaryota.
ENOG4110Z8K. LUCA.
GeneTreeiENSGT00760000119071.
HOGENOMiHOG000113054.
HOVERGENiHBG098401.
InParanoidiQ01638.
KOiK05171.
OMAiKVQGTIK.
OrthoDBiEOG091G0GXW.
PhylomeDBiQ01638.
TreeFamiTF325519.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.40.50.10140. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR015621. IL-1_rcpt_fam.
IPR004074. IL-1_rcpt_I/II-typ.
IPR000157. TIR_dom.
[Graphical view]
PANTHERiPTHR11890. PTHR11890. 1 hit.
PfamiPF07679. I-set. 1 hit.
PF01582. TIR. 1 hit.
[Graphical view]
PRINTSiPR01536. INTRLKN1R12F.
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 2 hits.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
SSF52200. SSF52200. 1 hit.
PROSITEiPS50835. IG_LIKE. 3 hits.
PS50104. TIR. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform A (identifier: Q01638-1) [UniParc]FASTAAdd to basket
Also known as: ST2L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGFWILAILT ILMYSTAAKF SKQSWGLENE ALIVRCPRQG KPSYTVDWYY
60 70 80 90 100
SQTNKSIPTQ ERNRVFASGQ LLKFLPAAVA DSGIYTCIVR SPTFNRTGYA
110 120 130 140 150
NVTIYKKQSD CNVPDYLMYS TVSGSEKNSK IYCPTIDLYN WTAPLEWFKN
160 170 180 190 200
CQALQGSRYR AHKSFLVIDN VMTEDAGDYT CKFIHNENGA NYSVTATRSF
210 220 230 240 250
TVKDEQGFSL FPVIGAPAQN EIKEVEIGKN ANLTCSACFG KGTQFLAAVL
260 270 280 290 300
WQLNGTKITD FGEPRIQQEE GQNQSFSNGL ACLDMVLRIA DVKEEDLLLQ
310 320 330 340 350
YDCLALNLHG LRRHTVRLSR KNPIDHHSIY CIIAVCSVFL MLINVLVIIL
360 370 380 390 400
KMFWIEATLL WRDIAKPYKT RNDGKLYDAY VVYPRNYKSS TDGASRVEHF
410 420 430 440 450
VHQILPDVLE NKCGYTLCIY GRDMLPGEDV VTAVETNIRK SRRHIFILTP
460 470 480 490 500
QITHNKEFAY EQEVALHCAL IQNDAKVILI EMEALSELDM LQAEALQDSL
510 520 530 540 550
QHLMKVQGTI KWREDHIANK RSLNSKFWKH VRYQMPVPSK IPRKASSLTP

LAAQKQ
Length:556
Mass (Da):63,358
Last modified:October 17, 2006 - v4
Checksum:iCB3E444A2DD477B5
GO
Isoform B (identifier: Q01638-2) [UniParc]FASTAAdd to basket
Also known as: ST2S

The sequence of this isoform differs from the canonical sequence as follows:
     324-328: IDHHS → SKECF
     329-556: Missing.

Show »
Length:328
Mass (Da):36,993
Checksum:iF91C46FE2D7FEAD1
GO
Isoform C (identifier: Q01638-3) [UniParc]FASTAAdd to basket
Also known as: ST2V

The sequence of this isoform differs from the canonical sequence as follows:
     204-259: DEQGFSLFPV...LWQLNGTKIT → VWCQSFCKLK...LQYFQHHQWP
     260-556: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:259
Mass (Da):29,951
Checksum:iC349EC8B232EA231
GO
Isoform 4 (identifier: Q01638-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-117: Missing.
     324-328: IDHHS → SKECF
     329-556: Missing.

Note: No experimental confirmation available.
Show »
Length:211
Mass (Da):23,723
Checksum:i6AAFBE28B3FD0428
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti70Q → R in BAA85894 (PubMed:10527832).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02374978A → E.3 PublicationsCorresponds to variant rs1041973dbSNPEnsembl.1
Natural variantiVAR_053373433A → T.1 PublicationCorresponds to variant rs4988956dbSNPEnsembl.1
Natural variantiVAR_053374501Q → K.Corresponds to variant rs10192036dbSNPEnsembl.1
Natural variantiVAR_053375501Q → R.Corresponds to variant rs10204137dbSNPEnsembl.1
Natural variantiVAR_053376549T → I.Corresponds to variant rs10192157dbSNPEnsembl.1
Natural variantiVAR_053377551L → S.Corresponds to variant rs10206753dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0549331 – 117Missing in isoform 4. 1 PublicationAdd BLAST117
Alternative sequenceiVSP_002664204 – 259DEQGF…GTKIT → VWCQSFCKLKKSLIFSNTHW IQSLMRGFVMVYYGVHKCCR VVFNLCLQYFQHHQWP in isoform C. 1 PublicationAdd BLAST56
Alternative sequenceiVSP_002665260 – 556Missing in isoform C. 1 PublicationAdd BLAST297
Alternative sequenceiVSP_002666324 – 328IDHHS → SKECF in isoform B and isoform 4. 3 Publications5
Alternative sequenceiVSP_002667329 – 556Missing in isoform B and isoform 4. 3 PublicationsAdd BLAST228

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D12763 mRNA. Translation: BAA02233.1.
D12764 Genomic DNA. Translation: BAA20539.1.
AB029084 mRNA. Translation: BAA85894.1.
AB012701 mRNA. Translation: BAA82405.2.
AK291578 mRNA. Translation: BAF84267.1.
AK303389 mRNA. Translation: BAG64445.1.
AC007248 Genomic DNA. Translation: AAY15047.1.
CH471127 Genomic DNA. Translation: EAX01795.1.
BC030975 mRNA. Translation: AAH30975.1.
CCDSiCCDS2057.1. [Q01638-1]
CCDS2058.1. [Q01638-2]
CCDS74548.1. [Q01638-4]
PIRiJC7109.
S30444.
RefSeqiNP_001269337.1. NM_001282408.1. [Q01638-4]
NP_003847.2. NM_003856.3. [Q01638-2]
NP_057316.3. NM_016232.4. [Q01638-1]
XP_006712902.1. XM_006712839.3. [Q01638-1]
XP_011510453.1. XM_011512151.1. [Q01638-2]
UniGeneiHs.66.
Hs.731651.

Genome annotation databases

EnsembliENST00000233954; ENSP00000233954; ENSG00000115602. [Q01638-1]
ENST00000311734; ENSP00000310371; ENSG00000115602. [Q01638-2]
ENST00000404917; ENSP00000384822; ENSG00000115602. [Q01638-4]
ENST00000427077; ENSP00000391120; ENSG00000115602. [Q01638-3]
GeneIDi9173.
KEGGihsa:9173.
UCSCiuc002tbu.1. human. [Q01638-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D12763 mRNA. Translation: BAA02233.1.
D12764 Genomic DNA. Translation: BAA20539.1.
AB029084 mRNA. Translation: BAA85894.1.
AB012701 mRNA. Translation: BAA82405.2.
AK291578 mRNA. Translation: BAF84267.1.
AK303389 mRNA. Translation: BAG64445.1.
AC007248 Genomic DNA. Translation: AAY15047.1.
CH471127 Genomic DNA. Translation: EAX01795.1.
BC030975 mRNA. Translation: AAH30975.1.
CCDSiCCDS2057.1. [Q01638-1]
CCDS2058.1. [Q01638-2]
CCDS74548.1. [Q01638-4]
PIRiJC7109.
S30444.
RefSeqiNP_001269337.1. NM_001282408.1. [Q01638-4]
NP_003847.2. NM_003856.3. [Q01638-2]
NP_057316.3. NM_016232.4. [Q01638-1]
XP_006712902.1. XM_006712839.3. [Q01638-1]
XP_011510453.1. XM_011512151.1. [Q01638-2]
UniGeneiHs.66.
Hs.731651.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4KC3X-ray3.27B19-321[»]
ProteinModelPortaliQ01638.
SMRiQ01638.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114613. 7 interactors.
DIPiDIP-37861N.
IntActiQ01638. 5 interactors.
STRINGi9606.ENSP00000233954.

PTM databases

iPTMnetiQ01638.
PhosphoSitePlusiQ01638.

Polymorphism and mutation databases

BioMutaiIL1RL1.
DMDMi116242527.

Proteomic databases

PaxDbiQ01638.
PeptideAtlasiQ01638.
PRIDEiQ01638.
TopDownProteomicsiQ01638-2. [Q01638-2]

Protocols and materials databases

DNASUi9173.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000233954; ENSP00000233954; ENSG00000115602. [Q01638-1]
ENST00000311734; ENSP00000310371; ENSG00000115602. [Q01638-2]
ENST00000404917; ENSP00000384822; ENSG00000115602. [Q01638-4]
ENST00000427077; ENSP00000391120; ENSG00000115602. [Q01638-3]
GeneIDi9173.
KEGGihsa:9173.
UCSCiuc002tbu.1. human. [Q01638-1]

Organism-specific databases

CTDi9173.
DisGeNETi9173.
GeneCardsiIL1RL1.
HGNCiHGNC:5998. IL1RL1.
HPAiHPA007406.
HPA007917.
MIMi601203. gene.
neXtProtiNX_Q01638.
OpenTargetsiENSG00000115602.
PharmGKBiPA29814.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IPTT. Eukaryota.
ENOG4110Z8K. LUCA.
GeneTreeiENSGT00760000119071.
HOGENOMiHOG000113054.
HOVERGENiHBG098401.
InParanoidiQ01638.
KOiK05171.
OMAiKVQGTIK.
OrthoDBiEOG091G0GXW.
PhylomeDBiQ01638.
TreeFamiTF325519.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000115602-MONOMER.
ReactomeiR-HSA-449147. Signaling by Interleukins.

Miscellaneous databases

GeneWikiiIL1RL1.
GenomeRNAii9173.
PROiQ01638.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000115602.
CleanExiHS_IL1RL1.
ExpressionAtlasiQ01638. baseline and differential.
GenevisibleiQ01638. HS.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.40.50.10140. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR015621. IL-1_rcpt_fam.
IPR004074. IL-1_rcpt_I/II-typ.
IPR000157. TIR_dom.
[Graphical view]
PANTHERiPTHR11890. PTHR11890. 1 hit.
PfamiPF07679. I-set. 1 hit.
PF01582. TIR. 1 hit.
[Graphical view]
PRINTSiPR01536. INTRLKN1R12F.
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 2 hits.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
SSF52200. SSF52200. 1 hit.
PROSITEiPS50835. IG_LIKE. 3 hits.
PS50104. TIR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiILRL1_HUMAN
AccessioniPrimary (citable) accession number: Q01638
Secondary accession number(s): A8K6B3
, B4E0I3, Q53TU7, Q8NEJ3, Q9ULV7, Q9UQ44
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: October 17, 2006
Last modified: November 30, 2016
This is version 169 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.