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Q01638

- ILRL1_HUMAN

UniProt

Q01638 - ILRL1_HUMAN

Protein

Interleukin-1 receptor-like 1

Gene

IL1RL1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 150 (01 Oct 2014)
      Sequence version 4 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    Receptor for interleukin-33 (IL-33), its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function.1 Publication

    GO - Molecular functioni

    1. cytokine receptor activity Source: UniProtKB
    2. interleukin-1 receptor activity Source: InterPro
    3. interleukin-33 receptor activity Source: Ensembl
    4. protein binding Source: IntAct
    5. receptor signaling protein activity Source: ProtInc

    GO - Biological processi

    1. immune response Source: UniProtKB
    2. intracellular signal transduction Source: GOC
    3. negative regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
    4. negative regulation of interferon-gamma production Source: Ensembl
    5. negative regulation of T-helper 1 type immune response Source: Ensembl
    6. positive regulation of chemokine secretion Source: Ensembl
    7. positive regulation of inflammatory response Source: Ensembl
    8. positive regulation of interleukin-5 production Source: Ensembl
    9. positive regulation of macrophage activation Source: Ensembl
    10. signal transduction Source: ProtInc

    Keywords - Molecular functioni

    Receptor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-1 receptor-like 1
    Alternative name(s):
    Protein ST2
    Gene namesi
    Name:IL1RL1
    Synonyms:DER4, ST2, T1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:5998. IL1RL1.

    Subcellular locationi

    Cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication

    GO - Cellular componenti

    1. external side of plasma membrane Source: Ensembl
    2. extracellular region Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell membrane, Membrane, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29814.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 18181 PublicationAdd
    BLAST
    Chaini19 – 556538Interleukin-1 receptor-like 1PRO_0000015442Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi36 ↔ 871 PublicationPROSITE-ProRule annotation
    Glycosylationi54 – 541N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi95 – 951N-linked (GlcNAc...)1 Publication
    Glycosylationi101 – 1011N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi111 ↔ 1511 PublicationPROSITE-ProRule annotation
    Disulfide bondi133 ↔ 1811 PublicationPROSITE-ProRule annotation
    Glycosylationi140 – 1401N-linked (GlcNAc...)1 Publication
    Glycosylationi191 – 1911N-linked (GlcNAc...)1 Publication
    Glycosylationi232 – 2321N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi235 ↔ 3031 PublicationPROSITE-ProRule annotation
    Disulfide bondi238 ↔ 2821 PublicationPROSITE-ProRule annotation
    Glycosylationi254 – 2541N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi273 – 2731N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ01638.
    PRIDEiQ01638.

    PTM databases

    PhosphoSiteiQ01638.

    Expressioni

    Tissue specificityi

    Highly expressed in kidney, lung, placenta, stomach, skeletal muscle, colon and small intestine. Isoform A is prevalently expressed in the lung, testis, placenta, stomach and colon. Isoform B is more abundant in the brain, kidney and the liver. Isoform C is not detected in brain, heart, liver, kidney and skeletal muscle.1 Publication

    Gene expression databases

    ArrayExpressiQ01638.
    BgeeiQ01638.
    CleanExiHS_IL1RL1.
    GenevestigatoriQ01638.

    Organism-specific databases

    HPAiHPA007406.
    HPA007917.

    Interactioni

    Subunit structurei

    Interacts with MYD88, IRAK1, IRAK4, and TRAF6.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    IL33O957602EBI-993762,EBI-724057

    Protein-protein interaction databases

    BioGridi114613. 6 interactions.
    DIPiDIP-37861N.
    IntActiQ01638. 4 interactions.
    STRINGi9606.ENSP00000233954.

    Structurei

    Secondary structure

    1
    556
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi24 – 274
    Beta strandi32 – 354
    Beta strandi44 – 496
    Beta strandi63 – 686
    Beta strandi71 – 766
    Helixi79 – 813
    Beta strandi83 – 908
    Beta strandi95 – 10511
    Beta strandi121 – 1233
    Beta strandi125 – 1273
    Beta strandi130 – 1323
    Helixi136 – 1383
    Beta strandi146 – 1494
    Turni156 – 1583
    Beta strandi159 – 1624
    Beta strandi165 – 1706
    Helixi173 – 1753
    Beta strandi177 – 18913
    Beta strandi191 – 20212
    Beta strandi209 – 2168
    Beta strandi219 – 2213
    Beta strandi234 – 2429
    Beta strandi248 – 2536
    Beta strandi265 – 2695
    Beta strandi281 – 2888
    Helixi295 – 2973
    Beta strandi301 – 3066
    Beta strandi311 – 3177

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4KC3X-ray3.27B19-321[»]
    ProteinModelPortaliQ01638.
    SMRiQ01638. Positions 21-317.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini19 – 328310ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini350 – 556207CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei329 – 34921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini19 – 10385Ig-like C2-type 1Add
    BLAST
    Domaini114 – 19784Ig-like C2-type 2Add
    BLAST
    Domaini212 – 319108Ig-like C2-type 3Add
    BLAST
    Domaini375 – 538164TIRPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni198 – 21114Flexible linkerAdd
    BLAST

    Sequence similaritiesi

    Belongs to the interleukin-1 receptor family.Curated
    Contains 1 TIR domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG124917.
    HOGENOMiHOG000113054.
    HOVERGENiHBG098401.
    InParanoidiQ01638.
    KOiK05171.
    OMAiVQGTIKW.
    OrthoDBiEOG7CVPXJ.
    PhylomeDBiQ01638.
    TreeFamiTF325519.

    Family and domain databases

    Gene3Di2.60.40.10. 3 hits.
    3.40.50.10140. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    IPR015621. IL-1_rcpt_fam.
    IPR004074. IL-1_rcpt_I/II-typ.
    IPR000157. TIR_dom.
    [Graphical view]
    PANTHERiPTHR11890. PTHR11890. 1 hit.
    PfamiPF07679. I-set. 1 hit.
    PF01582. TIR. 1 hit.
    [Graphical view]
    PRINTSiPR01536. INTRLKN1R12F.
    SMARTiSM00409. IG. 1 hit.
    SM00408. IGc2. 1 hit.
    SM00255. TIR. 1 hit.
    [Graphical view]
    SUPFAMiSSF52200. SSF52200. 1 hit.
    PROSITEiPS50835. IG_LIKE. 3 hits.
    PS50104. TIR. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform A (identifier: Q01638-1) [UniParc]FASTAAdd to Basket

    Also known as: ST2L

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGFWILAILT ILMYSTAAKF SKQSWGLENE ALIVRCPRQG KPSYTVDWYY    50
    SQTNKSIPTQ ERNRVFASGQ LLKFLPAAVA DSGIYTCIVR SPTFNRTGYA 100
    NVTIYKKQSD CNVPDYLMYS TVSGSEKNSK IYCPTIDLYN WTAPLEWFKN 150
    CQALQGSRYR AHKSFLVIDN VMTEDAGDYT CKFIHNENGA NYSVTATRSF 200
    TVKDEQGFSL FPVIGAPAQN EIKEVEIGKN ANLTCSACFG KGTQFLAAVL 250
    WQLNGTKITD FGEPRIQQEE GQNQSFSNGL ACLDMVLRIA DVKEEDLLLQ 300
    YDCLALNLHG LRRHTVRLSR KNPIDHHSIY CIIAVCSVFL MLINVLVIIL 350
    KMFWIEATLL WRDIAKPYKT RNDGKLYDAY VVYPRNYKSS TDGASRVEHF 400
    VHQILPDVLE NKCGYTLCIY GRDMLPGEDV VTAVETNIRK SRRHIFILTP 450
    QITHNKEFAY EQEVALHCAL IQNDAKVILI EMEALSELDM LQAEALQDSL 500
    QHLMKVQGTI KWREDHIANK RSLNSKFWKH VRYQMPVPSK IPRKASSLTP 550
    LAAQKQ 556
    Length:556
    Mass (Da):63,358
    Last modified:October 17, 2006 - v4
    Checksum:iCB3E444A2DD477B5
    GO
    Isoform B (identifier: Q01638-2) [UniParc]FASTAAdd to Basket

    Also known as: ST2S

    The sequence of this isoform differs from the canonical sequence as follows:
         324-328: IDHHS → SKECF
         329-556: Missing.

    Show »
    Length:328
    Mass (Da):36,993
    Checksum:iF91C46FE2D7FEAD1
    GO
    Isoform C (identifier: Q01638-3) [UniParc]FASTAAdd to Basket

    Also known as: ST2V

    The sequence of this isoform differs from the canonical sequence as follows:
         204-259: DEQGFSLFPV...LWQLNGTKIT → VWCQSFCKLK...LQYFQHHQWP
         260-556: Missing.

    Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Show »
    Length:259
    Mass (Da):29,951
    Checksum:iC349EC8B232EA231
    GO
    Isoform 4 (identifier: Q01638-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-117: Missing.
         324-328: IDHHS → SKECF
         329-556: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:211
    Mass (Da):23,723
    Checksum:i6AAFBE28B3FD0428
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti70 – 701Q → R in BAA85894. (PubMed:10527832)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti78 – 781A → E.3 Publications
    Corresponds to variant rs1041973 [ dbSNP | Ensembl ].
    VAR_023749
    Natural varianti433 – 4331A → T.1 Publication
    Corresponds to variant rs4988956 [ dbSNP | Ensembl ].
    VAR_053373
    Natural varianti501 – 5011Q → K.
    Corresponds to variant rs10192036 [ dbSNP | Ensembl ].
    VAR_053374
    Natural varianti501 – 5011Q → R.
    Corresponds to variant rs10204137 [ dbSNP | Ensembl ].
    VAR_053375
    Natural varianti549 – 5491T → I.
    Corresponds to variant rs10192157 [ dbSNP | Ensembl ].
    VAR_053376
    Natural varianti551 – 5511L → S.
    Corresponds to variant rs10206753 [ dbSNP | Ensembl ].
    VAR_053377

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 117117Missing in isoform 4. 1 PublicationVSP_054933Add
    BLAST
    Alternative sequencei204 – 25956DEQGF…GTKIT → VWCQSFCKLKKSLIFSNTHW IQSLMRGFVMVYYGVHKCCR VVFNLCLQYFQHHQWP in isoform C. 1 PublicationVSP_002664Add
    BLAST
    Alternative sequencei260 – 556297Missing in isoform C. 1 PublicationVSP_002665Add
    BLAST
    Alternative sequencei324 – 3285IDHHS → SKECF in isoform B and isoform 4. 3 PublicationsVSP_002666
    Alternative sequencei329 – 556228Missing in isoform B and isoform 4. 3 PublicationsVSP_002667Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D12763 mRNA. Translation: BAA02233.1.
    D12764 Genomic DNA. Translation: BAA20539.1.
    AB029084 mRNA. Translation: BAA85894.1.
    AB012701 mRNA. Translation: BAA82405.2.
    AK291578 mRNA. Translation: BAF84267.1.
    AK303389 mRNA. Translation: BAG64445.1.
    AC007248 Genomic DNA. Translation: AAY15047.1.
    CH471127 Genomic DNA. Translation: EAX01795.1.
    BC030975 mRNA. Translation: AAH30975.1.
    CCDSiCCDS2057.1. [Q01638-1]
    CCDS2058.1. [Q01638-2]
    PIRiJC7109.
    S30444.
    RefSeqiNP_001269337.1. NM_001282408.1. [Q01638-4]
    NP_003847.2. NM_003856.3. [Q01638-2]
    NP_057316.3. NM_016232.4. [Q01638-1]
    XP_006712902.1. XM_006712839.1. [Q01638-1]
    UniGeneiHs.66.
    Hs.731651.

    Genome annotation databases

    EnsembliENST00000233954; ENSP00000233954; ENSG00000115602. [Q01638-1]
    ENST00000311734; ENSP00000310371; ENSG00000115602. [Q01638-2]
    ENST00000404917; ENSP00000384822; ENSG00000115602. [Q01638-4]
    ENST00000427077; ENSP00000391120; ENSG00000115602. [Q01638-3]
    GeneIDi9173.
    KEGGihsa:9173.
    UCSCiuc002tbu.1. human. [Q01638-1]
    uc002tbv.3. human. [Q01638-2]

    Polymorphism databases

    DMDMi116242527.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D12763 mRNA. Translation: BAA02233.1 .
    D12764 Genomic DNA. Translation: BAA20539.1 .
    AB029084 mRNA. Translation: BAA85894.1 .
    AB012701 mRNA. Translation: BAA82405.2 .
    AK291578 mRNA. Translation: BAF84267.1 .
    AK303389 mRNA. Translation: BAG64445.1 .
    AC007248 Genomic DNA. Translation: AAY15047.1 .
    CH471127 Genomic DNA. Translation: EAX01795.1 .
    BC030975 mRNA. Translation: AAH30975.1 .
    CCDSi CCDS2057.1. [Q01638-1 ]
    CCDS2058.1. [Q01638-2 ]
    PIRi JC7109.
    S30444.
    RefSeqi NP_001269337.1. NM_001282408.1. [Q01638-4 ]
    NP_003847.2. NM_003856.3. [Q01638-2 ]
    NP_057316.3. NM_016232.4. [Q01638-1 ]
    XP_006712902.1. XM_006712839.1. [Q01638-1 ]
    UniGenei Hs.66.
    Hs.731651.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4KC3 X-ray 3.27 B 19-321 [» ]
    ProteinModelPortali Q01638.
    SMRi Q01638. Positions 21-317.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114613. 6 interactions.
    DIPi DIP-37861N.
    IntActi Q01638. 4 interactions.
    STRINGi 9606.ENSP00000233954.

    PTM databases

    PhosphoSitei Q01638.

    Polymorphism databases

    DMDMi 116242527.

    Proteomic databases

    PaxDbi Q01638.
    PRIDEi Q01638.

    Protocols and materials databases

    DNASUi 9173.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000233954 ; ENSP00000233954 ; ENSG00000115602 . [Q01638-1 ]
    ENST00000311734 ; ENSP00000310371 ; ENSG00000115602 . [Q01638-2 ]
    ENST00000404917 ; ENSP00000384822 ; ENSG00000115602 . [Q01638-4 ]
    ENST00000427077 ; ENSP00000391120 ; ENSG00000115602 . [Q01638-3 ]
    GeneIDi 9173.
    KEGGi hsa:9173.
    UCSCi uc002tbu.1. human. [Q01638-1 ]
    uc002tbv.3. human. [Q01638-2 ]

    Organism-specific databases

    CTDi 9173.
    GeneCardsi GC02P102927.
    HGNCi HGNC:5998. IL1RL1.
    HPAi HPA007406.
    HPA007917.
    MIMi 601203. gene.
    neXtProti NX_Q01638.
    PharmGKBi PA29814.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG124917.
    HOGENOMi HOG000113054.
    HOVERGENi HBG098401.
    InParanoidi Q01638.
    KOi K05171.
    OMAi VQGTIKW.
    OrthoDBi EOG7CVPXJ.
    PhylomeDBi Q01638.
    TreeFami TF325519.

    Miscellaneous databases

    GeneWikii IL1RL1.
    GenomeRNAii 9173.
    NextBioi 34399.
    PROi Q01638.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q01638.
    Bgeei Q01638.
    CleanExi HS_IL1RL1.
    Genevestigatori Q01638.

    Family and domain databases

    Gene3Di 2.60.40.10. 3 hits.
    3.40.50.10140. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    IPR015621. IL-1_rcpt_fam.
    IPR004074. IL-1_rcpt_I/II-typ.
    IPR000157. TIR_dom.
    [Graphical view ]
    PANTHERi PTHR11890. PTHR11890. 1 hit.
    Pfami PF07679. I-set. 1 hit.
    PF01582. TIR. 1 hit.
    [Graphical view ]
    PRINTSi PR01536. INTRLKN1R12F.
    SMARTi SM00409. IG. 1 hit.
    SM00408. IGc2. 1 hit.
    SM00255. TIR. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52200. SSF52200. 1 hit.
    PROSITEi PS50835. IG_LIKE. 3 hits.
    PS50104. TIR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM B), VARIANT GLU-78.
      Tissue: Lymphocyte.
    2. "Presence and expression of a novel variant form of ST2 gene product in human leukemic cell line UT-7/GM."
      Tominaga S., Kuroiwa K., Tago K., Iwahana H., Yanagisawa K., Komatsu N.
      Biochem. Biophys. Res. Commun. 264:14-18(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM C), VARIANT GLU-78.
    3. "The cloning and nucleotide sequence of human ST2L cDNA."
      Li H., Tago K., Io K., Kuroiwa K., Arai T., Iwahana H., Tominaga S., Yanagisawa K.
      Genomics 67:284-290(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), VARIANTS GLU-78 AND THR-433.
      Tissue: Megakaryoblast.
    4. Yanagisawa K.
      Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION TO 433.
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS B AND 4).
      Tissue: Placenta and Thymus.
    6. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).
      Tissue: Placenta.
    9. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z., Henzel W.J.
      Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 19-33.
    10. "Tissue distribution and subcellular localization of a variant form of the human ST2 gene product, ST2V."
      Tago K., Noda T., Hayakawa M., Iwahana H., Yanagisawa K., Yashiro T., Tominaga S.
      Biochem. Biophys. Res. Commun. 285:1377-1383(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    11. "IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST 2 and induces T helper type 2-associated cytokines."
      Schmitz J., Owyang A., Oldham E., Song Y., Murphy E., McClanahan T.K., Zurawski G., Moshrefi M., Qin J., Li X., Gorman D.M., Bazan J.F., Kastelein R.A.
      Immunity 23:479-490(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBUNIT.
    12. Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).
    13. "Structural insights into the interaction of IL-33 with its receptors."
      Liu X., Hammel M., He Y., Tainer J.A., Jeng U.S., Zhang L., Wang S., Wang X.
      Proc. Natl. Acad. Sci. U.S.A. 110:14918-14923(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.27 ANGSTROMS) OF 19-321 IN COMPLEX WITH IL33, GLYCOSYLATION AT ASN-95; ASN-140 AND ASN-191, DISULFIDE BONDS.

    Entry informationi

    Entry nameiILRL1_HUMAN
    AccessioniPrimary (citable) accession number: Q01638
    Secondary accession number(s): A8K6B3
    , B4E0I3, Q53TU7, Q8NEJ3, Q9ULV7, Q9UQ44
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 150 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3