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Q01638

- ILRL1_HUMAN

UniProt

Q01638 - ILRL1_HUMAN

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Protein

Interleukin-1 receptor-like 1

Gene

IL1RL1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Receptor for interleukin-33 (IL-33), its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function.1 Publication

GO - Molecular functioni

  1. cytokine receptor activity Source: UniProtKB
  2. interleukin-1 receptor activity Source: InterPro
  3. interleukin-33 receptor activity Source: Ensembl
  4. receptor signaling protein activity Source: ProtInc

GO - Biological processi

  1. immune response Source: UniProtKB
  2. intracellular signal transduction Source: GOC
  3. negative regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
  4. negative regulation of interferon-gamma production Source: Ensembl
  5. negative regulation of T-helper 1 type immune response Source: Ensembl
  6. positive regulation of chemokine secretion Source: Ensembl
  7. positive regulation of inflammatory response Source: Ensembl
  8. positive regulation of interleukin-5 production Source: Ensembl
  9. positive regulation of macrophage activation Source: Ensembl
  10. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-1 receptor-like 1
Alternative name(s):
Protein ST2
Gene namesi
Name:IL1RL1
Synonyms:DER4, ST2, T1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:5998. IL1RL1.

Subcellular locationi

Cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 328310ExtracellularSequence AnalysisAdd
BLAST
Transmembranei329 – 34921HelicalSequence AnalysisAdd
BLAST
Topological domaini350 – 556207CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. external side of plasma membrane Source: Ensembl
  2. extracellular matrix Source: Ensembl
  3. extracellular region Source: UniProtKB-KW
  4. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29814.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 18181 PublicationAdd
BLAST
Chaini19 – 556538Interleukin-1 receptor-like 1PRO_0000015442Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi36 ↔ 871 PublicationPROSITE-ProRule annotation
Glycosylationi54 – 541N-linked (GlcNAc...)Sequence Analysis
Glycosylationi95 – 951N-linked (GlcNAc...)1 Publication
Glycosylationi101 – 1011N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi111 ↔ 1511 PublicationPROSITE-ProRule annotation
Disulfide bondi133 ↔ 1811 PublicationPROSITE-ProRule annotation
Glycosylationi140 – 1401N-linked (GlcNAc...)1 Publication
Glycosylationi191 – 1911N-linked (GlcNAc...)1 Publication
Glycosylationi232 – 2321N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi235 ↔ 3031 PublicationPROSITE-ProRule annotation
Disulfide bondi238 ↔ 2821 PublicationPROSITE-ProRule annotation
Glycosylationi254 – 2541N-linked (GlcNAc...)Sequence Analysis
Glycosylationi273 – 2731N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ01638.
PRIDEiQ01638.

PTM databases

PhosphoSiteiQ01638.

Expressioni

Tissue specificityi

Highly expressed in kidney, lung, placenta, stomach, skeletal muscle, colon and small intestine. Isoform A is prevalently expressed in the lung, testis, placenta, stomach and colon. Isoform B is more abundant in the brain, kidney and the liver. Isoform C is not detected in brain, heart, liver, kidney and skeletal muscle.1 Publication

Gene expression databases

BgeeiQ01638.
CleanExiHS_IL1RL1.
ExpressionAtlasiQ01638. baseline and differential.
GenevestigatoriQ01638.

Organism-specific databases

HPAiHPA007406.
HPA007917.

Interactioni

Subunit structurei

Interacts with MYD88, IRAK1, IRAK4, and TRAF6.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
IL33O957602EBI-993762,EBI-724057

Protein-protein interaction databases

BioGridi114613. 6 interactions.
DIPiDIP-37861N.
IntActiQ01638. 4 interactions.
STRINGi9606.ENSP00000233954.

Structurei

Secondary structure

1
556
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi24 – 274Combined sources
Beta strandi32 – 354Combined sources
Beta strandi44 – 496Combined sources
Beta strandi63 – 686Combined sources
Beta strandi71 – 766Combined sources
Helixi79 – 813Combined sources
Beta strandi83 – 908Combined sources
Beta strandi95 – 10511Combined sources
Beta strandi121 – 1233Combined sources
Beta strandi125 – 1273Combined sources
Beta strandi130 – 1323Combined sources
Helixi136 – 1383Combined sources
Beta strandi146 – 1494Combined sources
Turni156 – 1583Combined sources
Beta strandi159 – 1624Combined sources
Beta strandi165 – 1706Combined sources
Helixi173 – 1753Combined sources
Beta strandi177 – 18913Combined sources
Beta strandi191 – 20212Combined sources
Beta strandi209 – 2168Combined sources
Beta strandi219 – 2213Combined sources
Beta strandi234 – 2429Combined sources
Beta strandi248 – 2536Combined sources
Beta strandi265 – 2695Combined sources
Beta strandi281 – 2888Combined sources
Helixi295 – 2973Combined sources
Beta strandi301 – 3066Combined sources
Beta strandi311 – 3177Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4KC3X-ray3.27B19-321[»]
ProteinModelPortaliQ01638.
SMRiQ01638. Positions 21-317, 402-532.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 10385Ig-like C2-type 1Add
BLAST
Domaini114 – 19784Ig-like C2-type 2Add
BLAST
Domaini212 – 319108Ig-like C2-type 3Add
BLAST
Domaini375 – 538164TIRPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni198 – 21114Flexible linkerAdd
BLAST

Sequence similaritiesi

Belongs to the interleukin-1 receptor family.Curated
Contains 1 TIR domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG124917.
GeneTreeiENSGT00760000119071.
HOGENOMiHOG000113054.
HOVERGENiHBG098401.
InParanoidiQ01638.
KOiK05171.
OMAiVQGTIKW.
OrthoDBiEOG7CVPXJ.
PhylomeDBiQ01638.
TreeFamiTF325519.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.40.50.10140. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR015621. IL-1_rcpt_fam.
IPR004074. IL-1_rcpt_I/II-typ.
IPR000157. TIR_dom.
[Graphical view]
PANTHERiPTHR11890. PTHR11890. 1 hit.
PfamiPF07679. I-set. 1 hit.
PF01582. TIR. 1 hit.
[Graphical view]
PRINTSiPR01536. INTRLKN1R12F.
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF52200. SSF52200. 1 hit.
PROSITEiPS50835. IG_LIKE. 3 hits.
PS50104. TIR. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform A (identifier: Q01638-1) [UniParc]FASTAAdd to Basket

Also known as: ST2L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGFWILAILT ILMYSTAAKF SKQSWGLENE ALIVRCPRQG KPSYTVDWYY
60 70 80 90 100
SQTNKSIPTQ ERNRVFASGQ LLKFLPAAVA DSGIYTCIVR SPTFNRTGYA
110 120 130 140 150
NVTIYKKQSD CNVPDYLMYS TVSGSEKNSK IYCPTIDLYN WTAPLEWFKN
160 170 180 190 200
CQALQGSRYR AHKSFLVIDN VMTEDAGDYT CKFIHNENGA NYSVTATRSF
210 220 230 240 250
TVKDEQGFSL FPVIGAPAQN EIKEVEIGKN ANLTCSACFG KGTQFLAAVL
260 270 280 290 300
WQLNGTKITD FGEPRIQQEE GQNQSFSNGL ACLDMVLRIA DVKEEDLLLQ
310 320 330 340 350
YDCLALNLHG LRRHTVRLSR KNPIDHHSIY CIIAVCSVFL MLINVLVIIL
360 370 380 390 400
KMFWIEATLL WRDIAKPYKT RNDGKLYDAY VVYPRNYKSS TDGASRVEHF
410 420 430 440 450
VHQILPDVLE NKCGYTLCIY GRDMLPGEDV VTAVETNIRK SRRHIFILTP
460 470 480 490 500
QITHNKEFAY EQEVALHCAL IQNDAKVILI EMEALSELDM LQAEALQDSL
510 520 530 540 550
QHLMKVQGTI KWREDHIANK RSLNSKFWKH VRYQMPVPSK IPRKASSLTP

LAAQKQ
Length:556
Mass (Da):63,358
Last modified:October 17, 2006 - v4
Checksum:iCB3E444A2DD477B5
GO
Isoform B (identifier: Q01638-2) [UniParc]FASTAAdd to Basket

Also known as: ST2S

The sequence of this isoform differs from the canonical sequence as follows:
     324-328: IDHHS → SKECF
     329-556: Missing.

Show »
Length:328
Mass (Da):36,993
Checksum:iF91C46FE2D7FEAD1
GO
Isoform C (identifier: Q01638-3) [UniParc]FASTAAdd to Basket

Also known as: ST2V

The sequence of this isoform differs from the canonical sequence as follows:
     204-259: DEQGFSLFPV...LWQLNGTKIT → VWCQSFCKLK...LQYFQHHQWP
     260-556: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »
Length:259
Mass (Da):29,951
Checksum:iC349EC8B232EA231
GO
Isoform 4 (identifier: Q01638-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-117: Missing.
     324-328: IDHHS → SKECF
     329-556: Missing.

Note: No experimental confirmation available.

Show »
Length:211
Mass (Da):23,723
Checksum:i6AAFBE28B3FD0428
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti70 – 701Q → R in BAA85894. (PubMed:10527832)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti78 – 781A → E.3 Publications
Corresponds to variant rs1041973 [ dbSNP | Ensembl ].
VAR_023749
Natural varianti433 – 4331A → T.1 Publication
Corresponds to variant rs4988956 [ dbSNP | Ensembl ].
VAR_053373
Natural varianti501 – 5011Q → K.
Corresponds to variant rs10192036 [ dbSNP | Ensembl ].
VAR_053374
Natural varianti501 – 5011Q → R.
Corresponds to variant rs10204137 [ dbSNP | Ensembl ].
VAR_053375
Natural varianti549 – 5491T → I.
Corresponds to variant rs10192157 [ dbSNP | Ensembl ].
VAR_053376
Natural varianti551 – 5511L → S.
Corresponds to variant rs10206753 [ dbSNP | Ensembl ].
VAR_053377

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 117117Missing in isoform 4. 1 PublicationVSP_054933Add
BLAST
Alternative sequencei204 – 25956DEQGF…GTKIT → VWCQSFCKLKKSLIFSNTHW IQSLMRGFVMVYYGVHKCCR VVFNLCLQYFQHHQWP in isoform C. 1 PublicationVSP_002664Add
BLAST
Alternative sequencei260 – 556297Missing in isoform C. 1 PublicationVSP_002665Add
BLAST
Alternative sequencei324 – 3285IDHHS → SKECF in isoform B and isoform 4. 3 PublicationsVSP_002666
Alternative sequencei329 – 556228Missing in isoform B and isoform 4. 3 PublicationsVSP_002667Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D12763 mRNA. Translation: BAA02233.1.
D12764 Genomic DNA. Translation: BAA20539.1.
AB029084 mRNA. Translation: BAA85894.1.
AB012701 mRNA. Translation: BAA82405.2.
AK291578 mRNA. Translation: BAF84267.1.
AK303389 mRNA. Translation: BAG64445.1.
AC007248 Genomic DNA. Translation: AAY15047.1.
CH471127 Genomic DNA. Translation: EAX01795.1.
BC030975 mRNA. Translation: AAH30975.1.
CCDSiCCDS2057.1. [Q01638-1]
CCDS2058.1. [Q01638-2]
CCDS74548.1. [Q01638-4]
PIRiJC7109.
S30444.
RefSeqiNP_001269337.1. NM_001282408.1. [Q01638-4]
NP_003847.2. NM_003856.3. [Q01638-2]
NP_057316.3. NM_016232.4. [Q01638-1]
XP_006712902.1. XM_006712839.1. [Q01638-1]
UniGeneiHs.66.
Hs.731651.

Genome annotation databases

EnsembliENST00000233954; ENSP00000233954; ENSG00000115602. [Q01638-1]
ENST00000311734; ENSP00000310371; ENSG00000115602. [Q01638-2]
ENST00000404917; ENSP00000384822; ENSG00000115602. [Q01638-4]
ENST00000427077; ENSP00000391120; ENSG00000115602. [Q01638-3]
GeneIDi9173.
KEGGihsa:9173.
UCSCiuc002tbu.1. human. [Q01638-1]
uc002tbv.3. human. [Q01638-2]

Polymorphism databases

DMDMi116242527.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D12763 mRNA. Translation: BAA02233.1 .
D12764 Genomic DNA. Translation: BAA20539.1 .
AB029084 mRNA. Translation: BAA85894.1 .
AB012701 mRNA. Translation: BAA82405.2 .
AK291578 mRNA. Translation: BAF84267.1 .
AK303389 mRNA. Translation: BAG64445.1 .
AC007248 Genomic DNA. Translation: AAY15047.1 .
CH471127 Genomic DNA. Translation: EAX01795.1 .
BC030975 mRNA. Translation: AAH30975.1 .
CCDSi CCDS2057.1. [Q01638-1 ]
CCDS2058.1. [Q01638-2 ]
CCDS74548.1. [Q01638-4 ]
PIRi JC7109.
S30444.
RefSeqi NP_001269337.1. NM_001282408.1. [Q01638-4 ]
NP_003847.2. NM_003856.3. [Q01638-2 ]
NP_057316.3. NM_016232.4. [Q01638-1 ]
XP_006712902.1. XM_006712839.1. [Q01638-1 ]
UniGenei Hs.66.
Hs.731651.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4KC3 X-ray 3.27 B 19-321 [» ]
ProteinModelPortali Q01638.
SMRi Q01638. Positions 21-317, 402-532.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114613. 6 interactions.
DIPi DIP-37861N.
IntActi Q01638. 4 interactions.
STRINGi 9606.ENSP00000233954.

PTM databases

PhosphoSitei Q01638.

Polymorphism databases

DMDMi 116242527.

Proteomic databases

PaxDbi Q01638.
PRIDEi Q01638.

Protocols and materials databases

DNASUi 9173.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000233954 ; ENSP00000233954 ; ENSG00000115602 . [Q01638-1 ]
ENST00000311734 ; ENSP00000310371 ; ENSG00000115602 . [Q01638-2 ]
ENST00000404917 ; ENSP00000384822 ; ENSG00000115602 . [Q01638-4 ]
ENST00000427077 ; ENSP00000391120 ; ENSG00000115602 . [Q01638-3 ]
GeneIDi 9173.
KEGGi hsa:9173.
UCSCi uc002tbu.1. human. [Q01638-1 ]
uc002tbv.3. human. [Q01638-2 ]

Organism-specific databases

CTDi 9173.
GeneCardsi GC02P102927.
HGNCi HGNC:5998. IL1RL1.
HPAi HPA007406.
HPA007917.
MIMi 601203. gene.
neXtProti NX_Q01638.
PharmGKBi PA29814.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG124917.
GeneTreei ENSGT00760000119071.
HOGENOMi HOG000113054.
HOVERGENi HBG098401.
InParanoidi Q01638.
KOi K05171.
OMAi VQGTIKW.
OrthoDBi EOG7CVPXJ.
PhylomeDBi Q01638.
TreeFami TF325519.

Miscellaneous databases

GeneWikii IL1RL1.
GenomeRNAii 9173.
NextBioi 34399.
PROi Q01638.
SOURCEi Search...

Gene expression databases

Bgeei Q01638.
CleanExi HS_IL1RL1.
ExpressionAtlasi Q01638. baseline and differential.
Genevestigatori Q01638.

Family and domain databases

Gene3Di 2.60.40.10. 3 hits.
3.40.50.10140. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR015621. IL-1_rcpt_fam.
IPR004074. IL-1_rcpt_I/II-typ.
IPR000157. TIR_dom.
[Graphical view ]
PANTHERi PTHR11890. PTHR11890. 1 hit.
Pfami PF07679. I-set. 1 hit.
PF01582. TIR. 1 hit.
[Graphical view ]
PRINTSi PR01536. INTRLKN1R12F.
SMARTi SM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
SM00255. TIR. 1 hit.
[Graphical view ]
SUPFAMi SSF52200. SSF52200. 1 hit.
PROSITEi PS50835. IG_LIKE. 3 hits.
PS50104. TIR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM B), VARIANT GLU-78.
    Tissue: Lymphocyte.
  2. "Presence and expression of a novel variant form of ST2 gene product in human leukemic cell line UT-7/GM."
    Tominaga S., Kuroiwa K., Tago K., Iwahana H., Yanagisawa K., Komatsu N.
    Biochem. Biophys. Res. Commun. 264:14-18(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM C), VARIANT GLU-78.
  3. "The cloning and nucleotide sequence of human ST2L cDNA."
    Li H., Tago K., Io K., Kuroiwa K., Arai T., Iwahana H., Tominaga S., Yanagisawa K.
    Genomics 67:284-290(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), VARIANTS GLU-78 AND THR-433.
    Tissue: Megakaryoblast.
  4. Yanagisawa K.
    Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 433.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS B AND 4).
    Tissue: Placenta and Thymus.
  6. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).
    Tissue: Placenta.
  9. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 19-33.
  10. "Tissue distribution and subcellular localization of a variant form of the human ST2 gene product, ST2V."
    Tago K., Noda T., Hayakawa M., Iwahana H., Yanagisawa K., Yashiro T., Tominaga S.
    Biochem. Biophys. Res. Commun. 285:1377-1383(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  11. "IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST 2 and induces T helper type 2-associated cytokines."
    Schmitz J., Owyang A., Oldham E., Song Y., Murphy E., McClanahan T.K., Zurawski G., Moshrefi M., Qin J., Li X., Gorman D.M., Bazan J.F., Kastelein R.A.
    Immunity 23:479-490(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT.
  12. Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).
  13. "Structural insights into the interaction of IL-33 with its receptors."
    Liu X., Hammel M., He Y., Tainer J.A., Jeng U.S., Zhang L., Wang S., Wang X.
    Proc. Natl. Acad. Sci. U.S.A. 110:14918-14923(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.27 ANGSTROMS) OF 19-321 IN COMPLEX WITH IL33, GLYCOSYLATION AT ASN-95; ASN-140 AND ASN-191, DISULFIDE BONDS.

Entry informationi

Entry nameiILRL1_HUMAN
AccessioniPrimary (citable) accession number: Q01638
Secondary accession number(s): A8K6B3
, B4E0I3, Q53TU7, Q8NEJ3, Q9ULV7, Q9UQ44
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: October 17, 2006
Last modified: November 26, 2014
This is version 152 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3