Q01631 (CYAA_NEUCR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adenylate cyclase
EC=4.6.1.1

Alternative name(s):
ATP pyrophosphate-lyase
Adenylyl cyclase

Gene names

Name:	cr-1
Synonyms:	nac
ORF Names:	NCU08377

Organism

Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)

Taxonomic identifier

367110 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Sordariomycetidae › Sordariales › Sordariaceae › Neurospora

Protein attributes

Sequence length	2300 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Plays essential roles in regulation of cellular metabolism by catalyzing the synthesis of a second messenger, cAMP.
Catalytic activity	ATP = 3',5'-cyclic AMP + diphosphate.
Cofactor	Binds 1 magnesium ion per subunit By similarity.
Sequence similarities	Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. Contains 1 guanylate cyclase domain. Contains 22 LRR (leucine-rich) repeats. Contains 1 PP2C-like domain. Contains 1 Ras-associating domain.

Ontologies

Keywords
Biological process	cAMP biosynthesis
Domain	Leucine-rich repeat Repeat
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	intracellular signal transduction Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW adenylate cyclase activity Inferred from electronic annotation. Source: EC magnesium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 2300	2300	Adenylate cyclase		PRO_0000195728
Regions
	Domain	749 – 841	93	Ras-associating
	Repeat	867 – 890	24	LRR 1
	Repeat	892 – 914	23	LRR 2
	Repeat	915 – 938	24	LRR 3
	Repeat	939 – 961	23	LRR 4
	Repeat	962 – 986	25	LRR 5
	Repeat	988 – 1008	21	LRR 6
	Repeat	1009 – 1031	23	LRR 7
	Repeat	1033 – 1055	23	LRR 8
	Repeat	1056 – 1079	24	LRR 9
	Repeat	1081 – 1097	17	LRR 10
	Repeat	1098 – 1119	22	LRR 11
	Repeat	1120 – 1142	23	LRR 12
	Repeat	1143 – 1165	23	LRR 13
	Repeat	1166 – 1188	23	LRR 14
	Repeat	1189 – 1211	23	LRR 15
	Repeat	1213 – 1234	22	LRR 16
	Repeat	1349 – 1369	21	LRR 17
	Repeat	1373 – 1396	24	LRR 18
	Repeat	1398 – 1420	23	LRR 19
	Repeat	1422 – 1445	24	LRR 20
	Repeat	1447 – 1469	23	LRR 21
	Repeat	1474 – 1497	24	LRR 22
	Domain	1564 – 1829	266	PP2C-like
	Domain	1892 – 2029	138	Guanylate cyclase
	Compositional bias	8 – 137	130	Ser-rich
	Compositional bias	204 – 221	18	Poly-Gln
Sites
	Metal binding	1897	1	Magnesium By similarity
	Metal binding	1940	1	Magnesium By similarity
Experimental info
	Sequence conflict	968	1	L → V in BAA00755. Ref.1
	Sequence conflict	1121 – 1123	3	TLK → IPQ in BAA00755. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q01631 [UniParc]. Last modified June 7, 2005. Version 2. Checksum: 902301C768AC9A64	FASTA	2,300	254,772
	10 20 30 40 50 60 MTRNDGGSRY SSIDSAQSSI TAKPFPLTPT SSLGSSMTRP LSPSLQAGSS SSNGGHNVSR 70 80 90 100 110 120 SASQGARRPA PTRLKTDDGT QFASRSSRDF ESSQSQSQPS HTQTRSHSLS QATLQSCSQP 130 140 150 160 170 180 QLSLNSQQSQ SPSQYHSQQT PTQQQPQQQV SPTGGSRLTQ SPTTPSNASI REHRMSELGG 190 200 210 220 230 240 YRREMAAMLD TTGGALSRTS SHSQQQPQQP QQQQQQQQQQ QGHAAGSVSG TFSNLSQYAP 250 260 270 280 290 300 YLGGNNGGGM SMGSFLNDST DNLSVISQLS PGIRPMTARP SQASAGSMEF PDSAYYDDER 310 320 330 340 350 360 RPSIASITTT ASSQGSRTSK TRGGLQKLQQ FFGDRDDWPG RDSSEISLPQ PSHSGPMSTG 370 380 390 400 410 420 KEHRSHSYSL PGSGRSHRDR NYSNATDHHP STFGSVSTVG GRDRDASPVP SRPRTPVPAP 430 440 450 460 470 480 EVVPFLYQEA DDIARYGEAP VRTSLTGPDR DRYIDSSQNP PKTSSSARSG HSIVHLPGHH 490 500 510 520 530 540 KHNKSNEDPR ALKPSLSRED SAASFARDFR NGSSSMMGTR SRAQSPAPSW TGTSRGLKAN 550 560 570 580 590 600 SISDGTSSPA PSHKKGILGR FRRHNKDKED GSSLRSGSNH TLVHRPSRQD LTRAAESTYP 610 620 630 640 650 660 ASVYVSDPSE QREVPVRPGY VRQTTAPGFT TKLFTSKKSS SAKQPQDDMD EDIGPTDMHM 670 680 690 700 710 720 GGGTVYHLDT NLNDMEGILT KPQPMTPLDN SISMRRESEK MIVPITTDPE GAWAAPDSWA 730 740 750 760 770 780 VRDNKKSLAP QVNEDLCSRQ PSEEKEKKSN YYIRVFRSDS TWTTLTLPLT ATAEDVIMGV 790 800 810 820 830 840 AKKTYLPPGA QDSYSLLIKK HDLFRVLNSA EQPLRIQKRL FQQIGYQEKD GIDEIGREDN 850 860 870 880 890 900 SYICRWVFLK EKEADMHLLS PDINFRNQKL NHVDLSGRNL ITIPVPLYRK AAEIVSLNLS 910 920 930 940 950 960 RNLSLDVPRD FIQACTALRD IKYNNNEAQA LPKSFATASK LTYLDVSNNR LQDLDHSELS 970 980 990 1000 1010 1020 KLTGLLKLNL ANNCLRSLPP TLGAYKSLRT LNISSNFLDV FPSFICELET IVDLDLSFNS 1030 1040 1050 1060 1070 1080 INNLPDNLMK LRNLEKFVIT NNRLSGPISE SVRDLVSLRE LDIRYNQIST IDVLSDLPRL 1090 1100 1110 1120 1130 1140 EILSADHNQI SKFSGSFERL RSLKLNSNPI VKFEVKAPVP TLKILNLSNA QLASIDESID 1150 1160 1170 1180 1190 1200 NLMNLERLIL DSNYFVSLPN QIGNLKKLDH LSMANNHLGE LPPEIGCLTE LRTLDVHGNN 1210 1220 1230 1240 1250 1260 MRKLPNEIWW ANKLEHLNAS SNILTEFPKP ASRAPQAPGE ASPSPGAYPF PNANKNGLLS 1270 1280 1290 1300 1310 1320 RTPSMDDLNG DASRRPSQAS STLLGVAVSP VPSGPDNRKS SMVSLYGKGG RKTSVVSRST 1330 1340 1350 1360 1370 1380 TQSSTGVITP SNGPRKDSSL SYRFTHTFSG SLKNLYLADN QLDDDVFEEL KHLPELRVLN 1390 1400 1410 1420 1430 1440 LSCNDLSDMP QGTIRSWPQL VELYLSGNEL TSLPAEDFLE EHCLLQTLHI NGNKFINLPA 1450 1460 1470 1480 1490 1500 EISRAKKLQV LDCSSNNLKY NVTNVPYDWN WNFNRDLRYL NLSGNKRLEI KNNYRQPQSY 1510 1520 1530 1540 1550 1560 RDDDFADTDF SKLTNLRVLG LMEVTHTLPN IPDQTEDRRV RTSEMKAGAY LPYGMADTLG 1570 1580 1590 1600 1610 1620 KNEHLSLFDL VVPRLGSVET DTLVALFDGK ELSTGGSKIA KFLYEEFSRL FILELEKVKG 1630 1640 1650 1660 1670 1680 KPNENPADAL RRTFLSVNKL LMSLSNSADE RGLDSHPSRN YAHTVLTKED LNSGCVATVA 1690 1700 1710 1720 1730 1740 YLSELKLYVA NVGDVQGMLI QANGSFKMLT KKHDPADPVE RSRIRNAGGW VSRNGRLNDV 1750 1760 1770 1780 1790 1800 LNVSRAFGYT ELLPAVQAAP DITEHTIDDK DETVLIASKE LWEHLRPELI VDVARECRSD 1810 1820 1830 1840 1850 1860 LMKASQKLRD LAIAYGSTNK LLIMMIGVAN LKQRQAQQFK GQLNATFSMP QDDPSHVPPS 1870 1880 1890 1900 1910 1920 GNKRRKVRAE GPLDSNLMRL NAEVPPPTGQ LSIVFTDIKN STQLWENYPE AMRLAIKLHN 1930 1940 1950 1960 1970 1980 EVMRRQLRMI GGFEVKTEGD AFMVSFPTAT SALLWCFAVQ MKLLTVDWPP EVLSNSSCQP 1990 2000 2010 2020 2030 2040 IYDRNNNLIT RGLSVRMGAH WGEPLAERDP VTRRMDYYGP MVNKASRISA VADGGQITAS 2050 2060 2070 2080 2090 2100 SDFITEIHRC LETYKESVDV DEDSLEDDAT AKAIRAELRA LSSQGFEVKD MGEKKLKGLE 2110 2120 2130 2140 2150 2160 NPELVYSVYP HALVGRTEQH HAHTESTQNQ AALQPYGALA TPKPATMDPD SEIQFEPETI 2170 2180 2190 2200 2210 2220 WALWRVALRL EMLCSTLEEP NARGLQAPET ELLERMKQRA GEVTDHFLLN FMEHQISRIE 2230 2240 2250 2260 2270 2280 TCITSLAVRH IAIGSGPITK LNDLRAPMND VLSTLKEQMD ELARYKAKYG SLDQAETDDA 2290 2300 TDNNSSGDVD TLDGSDTEQE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation and characterization of the adenylate cyclase structural gene of Neurospora crassa." Kore-Eda S., Murayama T., Uno I. Jpn. J. Genet. 66:317-334(1991) [PubMed: 1680356] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The genome sequence of the filamentous fungus Neurospora crassa." Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D. , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W. Nature 422:859-868(2003) [PubMed: 12712197] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D00909 Genomic DNA. Translation: BAA00755.1. AABX02000029 Genomic DNA. Translation: EAA36044.1.
RefSeq	XP_965280.1. XM_960187.1.
UniGene	Ncr.15552.
3D structure databases
ProteinModelPortal	Q01631.
ModBase	Search...
Protein-protein interaction databases
STRING	Q01631.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	EFNCRT00000006412; EFNCRP00000006404; EFNCRG00000006401.
GeneID	3881413.
KEGG	ncr:NCU08377.
NMPDR	fig|5141.1.peg.7356.
Phylogenomic databases
eggNOG	fuNOG06104.
GeneTree	EFGT00050000002537.
OMA	KYNVSNW.
OrthoDB	EOG41CB4C.
Family and domain databases
InterPro	IPR001054. A/G_cyclase. IPR013716. Adenylate_cyclase_G-a-bd. IPR001611. Leu-rich_rpt. IPR003591. Leu-rich_rpt_typical-subtyp. IPR001932. PP2C-like. IPR000159. Ras-assoc. [Graphical view]
Gene3D	G3DSA:3.30.70.1230. A/G_cyclase. 2 hits. G3DSA:3.60.40.10. PP2C-related. 1 hit.
KO	K01768.
Pfam	PF08509. Ad_cyc_g-alpha. 1 hit. PF00211. Guanylate_cyc. 1 hit. PF00560. LRR_1. 1 hit. PF00481. PP2C. 1 hit. PF00788. RA. 1 hit. [Graphical view]
SMART	SM00789. Ad_cyc_g-alpha. 1 hit. SM00044. CYCc. 1 hit. SM00369. LRR_TYP. 3 hits. SM00332. PP2Cc. 1 hit. SM00314. RA. 1 hit. [Graphical view]
SUPFAM	SSF55073. A/G_cyclase. 1 hit. SSF81606. PP2C-related. 1 hit.
PROSITE	PS00452. GUANYLATE_CYCLASE_1. False negative. PS50125. GUANYLATE_CYCLASE_2. 1 hit. PS51450. LRR. 17 hits. PS50200. RA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CYAA_NEUCR

Accession

Primary (citable) accession number: Q01631
Secondary accession number(s): Q7RVM0

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	June 7, 2005
Last modified:	December 14, 2011
This is version 99 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program