Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Interferon-induced transmembrane protein 2

Gene

IFITM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and vesicular stomatitis virus (VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV S protein-mediated viral entry and VSV G protein-mediated viral entry. Induces cell cycle arrest and mediates apoptosis by caspase activation and in p53-independent manner.7 Publications

GO - Biological processi

  • cytokine-mediated signaling pathway Source: Reactome
  • defense response to virus Source: UniProtKB-KW
  • immune response Source: ProtInc
  • negative regulation of viral entry into host cell Source: UniProtKB
  • negative regulation of viral genome replication Source: UniProtKB
  • response to interferon-alpha Source: UniProtKB
  • response to interferon-beta Source: UniProtKB
  • response to interferon-gamma Source: UniProtKB
  • response to virus Source: UniProtKB
  • type I interferon signaling pathway Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Antiviral defense, Immunity, Innate immunity

Enzyme and pathway databases

ReactomeiR-HSA-909733. Interferon alpha/beta signaling.

Protein family/group databases

TCDBi8.A.58.1.2. the interferon-induced transmembrane protein (ifitm) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon-induced transmembrane protein 2
Alternative name(s):
Dispanin subfamily A member 2c
Short name:
DSPA2c
Interferon-inducible protein 1-8D
Gene namesi
Name:IFITM2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:5413. IFITM2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5656CytoplasmicSequence analysisAdd
BLAST
Intramembranei57 – 7721HelicalBy similarityAdd
BLAST
Topological domaini78 – 10629CytoplasmicSequence analysisAdd
BLAST
Transmembranei107 – 12721HelicalSequence analysisAdd
BLAST
Topological domaini128 – 1325ExtracellularSequence analysis

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29654.

Polymorphism and mutation databases

BioMutaiIFITM2.
DMDMi290457648.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 132132Interferon-induced transmembrane protein 2PRO_0000153728Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources
Lipidationi70 – 701S-palmitoyl cysteineBy similarity
Lipidationi71 – 711S-palmitoyl cysteineBy similarity
Lipidationi104 – 1041S-palmitoyl cysteineBy similarity

Post-translational modificationi

Palmitoylation on membrane-proximal cysteines controls clustering in membrane compartments and antiviral activity against influenza virus.By similarity

Keywords - PTMi

Acetylation, Lipoprotein, Palmitate

Proteomic databases

EPDiQ01629.
MaxQBiQ01629.
PaxDbiQ01629.
PRIDEiQ01629.

PTM databases

iPTMnetiQ01629.
PhosphoSiteiQ01629.
SwissPalmiQ01629.

Expressioni

Inductioni

By IFN-alpha and IFNG/IFN-gamma. Down-regulated by p53/TP53.1 Publication

Gene expression databases

BgeeiQ01629.
CleanExiHS_IFITM2.
ExpressionAtlasiQ01629. baseline and differential.
GenevisibleiQ01629. HS.

Organism-specific databases

HPAiHPA004337.

Interactioni

Subunit structurei

Interacts with CD81.By similarity

Protein-protein interaction databases

BioGridi115832. 2 interactions.
IntActiQ01629. 6 interactions.
MINTiMINT-1432250.
STRINGi9606.ENSP00000382714.

Structurei

3D structure databases

ProteinModelPortaliQ01629.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CD225/Dispanin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J2DU. Eukaryota.
ENOG4112C1U. LUCA.
GeneTreeiENSGT00390000003476.
HOGENOMiHOG000115781.
HOVERGENiHBG001182.
InParanoidiQ01629.
KOiK06566.
OMAiEEHEVAT.
PhylomeDBiQ01629.
TreeFamiTF334894.

Family and domain databases

InterProiIPR007593. CD225/Dispanin_fam.
[Graphical view]
PfamiPF04505. CD225. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q01629-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNHIVQTFSP VNSGQPPNYE MLKEEQEVAM LGVPHNPAPP MSTVIHIRSE
60 70 80 90 100
TSVPDHVVWS LFNTLFMNTC CLGFIAFAYS VKSRDRKMVG DVTGAQAYAS
110 120 130
TAKCLNIWAL ILGIFMTILL IIIPVLVVQA QR
Length:132
Mass (Da):14,632
Last modified:March 2, 2010 - v2
Checksum:i232A32D109EEBF5D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti33 – 331V → G in CAA40625 (PubMed:1906403).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti33 – 331V → A.2 Publications
Corresponds to variant rs1058900 [ dbSNP | Ensembl ].
VAR_062677
Natural varianti41 – 411M → T.2 Publications
Corresponds to variant rs14408 [ dbSNP | Ensembl ].
VAR_014848
Natural varianti121 – 1211I → V.2 Publications
Corresponds to variant rs1059091 [ dbSNP | Ensembl ].
VAR_060470

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57351 mRNA. Translation: CAA40625.1.
CR541874 mRNA. Translation: CAG46672.1.
AC136475 Genomic DNA. No translation available.
BC009696 mRNA. Translation: AAH09696.1.
CCDSiCCDS41583.1.
PIRiS17183.
RefSeqiNP_006426.2. NM_006435.2.
UniGeneiHs.709321.

Genome annotation databases

EnsembliENST00000399817; ENSP00000382714; ENSG00000185201.
ENST00000616316; ENSP00000484689; ENSG00000185201.
GeneIDi10581.
KEGGihsa:10581.
UCSCiuc001lox.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57351 mRNA. Translation: CAA40625.1.
CR541874 mRNA. Translation: CAG46672.1.
AC136475 Genomic DNA. No translation available.
BC009696 mRNA. Translation: AAH09696.1.
CCDSiCCDS41583.1.
PIRiS17183.
RefSeqiNP_006426.2. NM_006435.2.
UniGeneiHs.709321.

3D structure databases

ProteinModelPortaliQ01629.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115832. 2 interactions.
IntActiQ01629. 6 interactions.
MINTiMINT-1432250.
STRINGi9606.ENSP00000382714.

Protein family/group databases

TCDBi8.A.58.1.2. the interferon-induced transmembrane protein (ifitm) family.

PTM databases

iPTMnetiQ01629.
PhosphoSiteiQ01629.
SwissPalmiQ01629.

Polymorphism and mutation databases

BioMutaiIFITM2.
DMDMi290457648.

Proteomic databases

EPDiQ01629.
MaxQBiQ01629.
PaxDbiQ01629.
PRIDEiQ01629.

Protocols and materials databases

DNASUi10581.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000399817; ENSP00000382714; ENSG00000185201.
ENST00000616316; ENSP00000484689; ENSG00000185201.
GeneIDi10581.
KEGGihsa:10581.
UCSCiuc001lox.5. human.

Organism-specific databases

CTDi10581.
GeneCardsiIFITM2.
HGNCiHGNC:5413. IFITM2.
HPAiHPA004337.
MIMi605578. gene.
neXtProtiNX_Q01629.
PharmGKBiPA29654.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J2DU. Eukaryota.
ENOG4112C1U. LUCA.
GeneTreeiENSGT00390000003476.
HOGENOMiHOG000115781.
HOVERGENiHBG001182.
InParanoidiQ01629.
KOiK06566.
OMAiEEHEVAT.
PhylomeDBiQ01629.
TreeFamiTF334894.

Enzyme and pathway databases

ReactomeiR-HSA-909733. Interferon alpha/beta signaling.

Miscellaneous databases

ChiTaRSiIFITM2. human.
GenomeRNAii10581.
NextBioi40181.
PROiQ01629.
SOURCEiSearch...

Gene expression databases

BgeeiQ01629.
CleanExiHS_IFITM2.
ExpressionAtlasiQ01629. baseline and differential.
GenevisibleiQ01629. HS.

Family and domain databases

InterProiIPR007593. CD225/Dispanin_fam.
[Graphical view]
PfamiPF04505. CD225. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular analysis of a human interferon-inducible gene family."
    Lewin A.R., Reid L.E., McMahon M., Stark G.R., Kerr I.M.
    Eur. J. Biochem. 199:417-423(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS THR-41 AND VAL-121.
  2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-33.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ALA-33; THR-41 AND VAL-121.
    Tissue: Lung.
  5. "The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus."
    Brass A.L., Huang I.C., Benita Y., John S.P., Krishnan M.N., Feeley E.M., Ryan B.J., Weyer J.L., van der Weyden L., Fikrig E., Adams D.J., Xavier R.J., Farzan M., Elledge S.J.
    Cell 139:1243-1254(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN VIRAL RESISTANCE.
  6. Cited for: FUNCTION, INDUCTION.
  7. "Identification of five interferon-induced cellular proteins that inhibit west nile virus and dengue virus infections."
    Jiang D., Weidner J.M., Qing M., Pan X.B., Guo H., Xu C., Zhang X., Birk A., Chang J., Shi P.Y., Block T.M., Guo J.T.
    J. Virol. 84:8332-8341(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  8. "Interferon-induced cell membrane proteins, IFITM3 and tetherin, inhibit vesicular stomatitis virus infection via distinct mechanisms."
    Weidner J.M., Jiang D., Pan X.B., Chang J., Block T.M., Guo J.T.
    J. Virol. 84:12646-12657(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "The small interferon-induced transmembrane genes and proteins."
    Siegrist F., Ebeling M., Certa U.
    J. Interferon Cytokine Res. 31:183-197(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  11. "The IFITM proteins inhibit HIV-1 infection."
    Lu J., Pan Q., Rong L., He W., Liu S.L., Liang C.
    J. Virol. 85:2126-2137(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  12. Erratum
    Lu J., Pan Q., Rong L., He W., Liu S.L., Liang C.
    J. Virol. 85:4043-4043(2011)
  13. Cited for: FUNCTION.
  14. "IFITM proteins restrict antibody-dependent enhancement of dengue virus infection."
    Chan Y.K., Huang I.C., Farzan M.
    PLoS ONE 7:E34508-E34508(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  15. "The dispanins: a novel gene family of ancient origin that contains 14 human members."
    Sallman Almen M., Bringeland N., Fredriksson R., Schioth H.B.
    PLoS ONE 7:E31961-E31961(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY.

Entry informationi

Entry nameiIFM2_HUMAN
AccessioniPrimary (citable) accession number: Q01629
Secondary accession number(s): Q6FH82, Q96DA8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: March 2, 2010
Last modified: March 16, 2016
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.