Q01629 (IFM2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Interferon-induced transmembrane protein 2

Alternative name(s):
Interferon-inducible protein 1-8D

Gene names

Name:

IFITM2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	132 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	IFN-induced antiviral protein that mediates cellular innate immunity to at least three major human pathogens, namely influenza A H1N1 virus, West Nile virus (WNV), and dengue virus (WNV), by inhibiting the early step(s) of replication. Induces cell cycle arrest and mediates apoptosis by caspase activation and in p53-independent manner. Ref.5 Ref.6 Ref.7
Subcellular location	Cell membrane; Multi-pass membrane protein Potential.
Induction	By IFN-alpha and IFNG/IFN-gamma. Down-regulated by p53/TP53. Ref.6
Post-translational modification	Palmitoylation on membrane-proximal cysteines controls clustering in membrane compartments and antiviral activity against influenza virus By similarity.
Sequence similarities	Belongs to the CD225 family.

Ontologies

Keywords
Biological process	Antiviral defense Immunity Innate immunity
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
PTM	Lipoprotein Palmitate
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	response to virus Inferred from electronic annotation. Source: UniProtKB-KW type I interferon-mediated signaling pathway Traceable author statement. Source: Reactome
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
UPF3A	Q9H1J1	1	EBI-373124,EBI-521530

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 132	132	Interferon-induced transmembrane protein 2		PRO_0000153728
Regions
	Topological domain	1 – 56	56	Extracellular Potential
	Transmembrane	57 – 77	21	Helical; Potential
	Topological domain	78 – 106	29	Cytoplasmic Potential
	Transmembrane	107 – 127	21	Helical; Potential
	Topological domain	128 – 132	5	Extracellular Potential
Amino acid modifications
	Lipidation	70	1	S-palmitoyl cysteine By similarity
	Lipidation	71	1	S-palmitoyl cysteine By similarity
	Lipidation	104	1	S-palmitoyl cysteine By similarity
Natural variations
	Natural variant	33	1	V → A. Ref.2 Ref.4 Corresponds to variant rs1058900 [ dbSNP | Ensembl ].		VAR_062677
	Natural variant	41	1	M → T. Ref.1 Ref.4 Corresponds to variant rs14408 [ dbSNP | Ensembl ].		VAR_014848
	Natural variant	121	1	I → V. Ref.1 Ref.4 Corresponds to variant rs1059091 [ dbSNP | Ensembl ].		VAR_060470
Experimental info
	Sequence conflict	33	1	V → G in CAA40625. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q01629 [UniParc]. Last modified March 2, 2010. Version 2. Checksum: 232A32D109EEBF5D	FASTA	132	14,632
	10 20 30 40 50 60 MNHIVQTFSP VNSGQPPNYE MLKEEQEVAM LGVPHNPAPP MSTVIHIRSE TSVPDHVVWS 70 80 90 100 110 120 LFNTLFMNTC CLGFIAFAYS VKSRDRKMVG DVTGAQAYAS TAKCLNIWAL ILGIFMTILL 130 IIIPVLVVQA QR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular analysis of a human interferon-inducible gene family." Lewin A.R., Reid L.E., McMahon M., Stark G.R., Kerr I.M. Eur. J. Biochem. 199:417-423(1991) [PubMed: 1906403] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS THR-41 AND VAL-121.
[2]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-33.
[3]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed: 16554811] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ALA-33; THR-41 AND VAL-121. Tissue: Lung.
[5]	"The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus." Brass A.L., Huang I.C., Benita Y., John S.P., Krishnan M.N., Feeley E.M., Ryan B.J., Weyer J.L., van der Weyden L., Fikrig E., Adams D.J., Xavier R.J., Farzan M., Elledge S.J. Cell 139:1243-1254(2009) [PubMed: 20064371] [Abstract] Cited for: FUNCTION IN VIRAL RESISTANCE.
[6]	"The human 1-8D gene (IFITM2) is a novel p53 independent pro-apoptotic gene." Daniel-Carmi V., Makovitzki-Avraham E., Reuven E.M., Goldstein I., Zilkha N., Rotter V., Tzehoval E., Eisenbach L. Int. J. Cancer 125:2810-2819(2009) [PubMed: 19544527] [Abstract] Cited for: FUNCTION, INDUCTION.
[7]	"Identification of five interferon-induced cellular proteins that inhibit west nile virus and dengue virus infections." Jiang D., Weidner J.M., Qing M., Pan X.B., Guo H., Xu C., Zhang X., Birk A., Chang J., Shi P.Y., Block T.M., Guo J.T. J. Virol. 84:8332-8341(2010) [PubMed: 20534863] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X57351 mRNA. Translation: CAA40625.1. CR541874 mRNA. Translation: CAG46672.1. AC136475 Genomic DNA. No translation available. BC009696 mRNA. Translation: AAH09696.1.
IPI	IPI00008922.
PIR	S17183.
RefSeq	NP_006426.2. NM_006435.2.
UniGene	Hs.709321.
3D structure databases
ProteinModelPortal	Q01629.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q01629. 6 interactions.
MINT	MINT-1432250.
STRING	Q01629.
PTM databases
PhosphoSite	Q01629.
Polymorphism databases
DMDM	290457648.
Proteomic databases
PRIDE	Q01629.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000399817; ENSP00000382714; ENSG00000185201.
GeneID	10581.
KEGG	hsa:10581.
Organism-specific databases
CTD	10581.
GeneCards	GC11P000300.
H-InvDB	HIX0009342.
HGNC	HGNC:5413. IFITM2.
HPA	HPA004337.
MIM	605578. gene.
neXtProt	NX_Q01629.
PharmGKB	PA29654.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	HBG001182.
OMA	LFMNTCC.
OrthoDB	EOG428234.
PhylomeDB	Q01629.
Enzyme and pathway databases
Reactome	REACT_6900. Immune System.
Gene expression databases
ArrayExpress	Q01629.
Bgee	Q01629.
CleanEx	HS_IFITM2.
Genevestigator	Q01629.
Family and domain databases
InterPro	IPR007593. Interferon-induced_TM_protein. [Graphical view]
KO	K06566.
Pfam	PF04505. CD225. 1 hit. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

IFM2_HUMAN

Accession

Primary (citable) accession number: Q01629
Secondary accession number(s): Q6FH82, Q96DA8

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	March 2, 2010
Last modified:	January 25, 2012
This is version 95 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.