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Q01629 (IFM2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interferon-induced transmembrane protein 2
Alternative name(s):
Dispanin subfamily A member 2c
Short name=DSPA2c
Interferon-inducible protein 1-8D
Gene names
Name:IFITM2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length132 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and vesicular stomatitis virus (VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV S protein-mediated viral entry and VSV G protein-mediated viral entry. Induces cell cycle arrest and mediates apoptosis by caspase activation and in p53-independent manner. Ref.5 Ref.6 Ref.7 Ref.8 Ref.11 Ref.13 Ref.14

Subunit structure

Interacts with CD81 By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein Potential.

Induction

By IFN-alpha and IFNG/IFN-gamma. Down-regulated by p53/TP53. Ref.6

Post-translational modification

Palmitoylation on membrane-proximal cysteines controls clustering in membrane compartments and antiviral activity against influenza virus By similarity.

Sequence similarities

Belongs to the CD225/Dispanin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 132132Interferon-induced transmembrane protein 2
PRO_0000153728

Regions

Topological domain1 – 5656Extracellular Potential
Transmembrane57 – 7721Helical; Potential
Topological domain78 – 10629Cytoplasmic Potential
Transmembrane107 – 12721Helical; Potential
Topological domain128 – 1325Extracellular Potential

Amino acid modifications

Modified residue11N-acetylmethionine Ref.9
Lipidation701S-palmitoyl cysteine By similarity
Lipidation711S-palmitoyl cysteine By similarity
Lipidation1041S-palmitoyl cysteine By similarity

Natural variations

Natural variant331V → A. Ref.2 Ref.4
Corresponds to variant rs1058900 [ dbSNP | Ensembl ].
VAR_062677
Natural variant411M → T. Ref.1 Ref.4
Corresponds to variant rs14408 [ dbSNP | Ensembl ].
VAR_014848
Natural variant1211I → V. Ref.1 Ref.4
Corresponds to variant rs1059091 [ dbSNP | Ensembl ].
VAR_060470

Experimental info

Sequence conflict331V → G in CAA40625. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q01629 [UniParc].

Last modified March 2, 2010. Version 2.
Checksum: 232A32D109EEBF5D

FASTA13214,632
        10         20         30         40         50         60 
MNHIVQTFSP VNSGQPPNYE MLKEEQEVAM LGVPHNPAPP MSTVIHIRSE TSVPDHVVWS 

        70         80         90        100        110        120 
LFNTLFMNTC CLGFIAFAYS VKSRDRKMVG DVTGAQAYAS TAKCLNIWAL ILGIFMTILL 

       130 
IIIPVLVVQA QR 

« Hide

References

« Hide 'large scale' references
[1]"Molecular analysis of a human interferon-inducible gene family."
Lewin A.R., Reid L.E., McMahon M., Stark G.R., Kerr I.M.
Eur. J. Biochem. 199:417-423(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS THR-41 AND VAL-121.
[2]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-33.
[3]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ALA-33; THR-41 AND VAL-121.
Tissue: Lung.
[5]"The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus."
Brass A.L., Huang I.C., Benita Y., John S.P., Krishnan M.N., Feeley E.M., Ryan B.J., Weyer J.L., van der Weyden L., Fikrig E., Adams D.J., Xavier R.J., Farzan M., Elledge S.J.
Cell 139:1243-1254(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION IN VIRAL RESISTANCE.
[6]"The human 1-8D gene (IFITM2) is a novel p53 independent pro-apoptotic gene."
Daniel-Carmi V., Makovitzki-Avraham E., Reuven E.M., Goldstein I., Zilkha N., Rotter V., Tzehoval E., Eisenbach L.
Int. J. Cancer 125:2810-2819(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INDUCTION.
[7]"Identification of five interferon-induced cellular proteins that inhibit west nile virus and dengue virus infections."
Jiang D., Weidner J.M., Qing M., Pan X.B., Guo H., Xu C., Zhang X., Birk A., Chang J., Shi P.Y., Block T.M., Guo J.T.
J. Virol. 84:8332-8341(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[8]"Interferon-induced cell membrane proteins, IFITM3 and tetherin, inhibit vesicular stomatitis virus infection via distinct mechanisms."
Weidner J.M., Jiang D., Pan X.B., Chang J., Block T.M., Guo J.T.
J. Virol. 84:12646-12657(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[9]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[10]"The small interferon-induced transmembrane genes and proteins."
Siegrist F., Ebeling M., Certa U.
J. Interferon Cytokine Res. 31:183-197(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[11]"The IFITM proteins inhibit HIV-1 infection."
Lu J., Pan Q., Rong L., He W., Liu S.L., Liang C.
J. Virol. 85:2126-2137(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[12]Erratum
Lu J., Pan Q., Rong L., He W., Liu S.L., Liang C.
J. Virol. 85:4043-4043(2011)
[13]"Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus."
Huang I.C., Bailey C.C., Weyer J.L., Radoshitzky S.R., Becker M.M., Chiang J.J., Brass A.L., Ahmed A.A., Chi X., Dong L., Longobardi L.E., Boltz D., Kuhn J.H., Elledge S.J., Bavari S., Denison M.R., Choe H., Farzan M.
PLoS Pathog. 7:E1001258-E1001258(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[14]"IFITM proteins restrict antibody-dependent enhancement of dengue virus infection."
Chan Y.K., Huang I.C., Farzan M.
PLoS ONE 7:E34508-E34508(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[15]"The dispanins: a novel gene family of ancient origin that contains 14 human members."
Sallman Almen M., Bringeland N., Fredriksson R., Schioth H.B.
PLoS ONE 7:E31961-E31961(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: GENE FAMILY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X57351 mRNA. Translation: CAA40625.1.
CR541874 mRNA. Translation: CAG46672.1.
AC136475 Genomic DNA. No translation available.
BC009696 mRNA. Translation: AAH09696.1.
PIRS17183.
RefSeqNP_006426.2. NM_006435.2.
UniGeneHs.709321.

3D structure databases

ProteinModelPortalQ01629.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid115832. 3 interactions.
IntActQ01629. 6 interactions.
MINTMINT-1432250.
STRING9606.ENSP00000382714.

PTM databases

PhosphoSiteQ01629.

Polymorphism databases

DMDM290457648.

Proteomic databases

PaxDbQ01629.
PRIDEQ01629.

Protocols and materials databases

DNASU10581.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000399817; ENSP00000382714; ENSG00000185201.
GeneID10581.
KEGGhsa:10581.
UCSCuc001lox.4. human.

Organism-specific databases

CTD10581.
GeneCardsGC11P000300.
HGNCHGNC:5413. IFITM2.
HPAHPA004337.
MIM605578. gene.
neXtProtNX_Q01629.
PharmGKBPA29654.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG26698.
HOGENOMHOG000115781.
HOVERGENHBG001182.
KOK06566.
OMARTPHSGF.
PhylomeDBQ01629.
TreeFamTF334894.

Enzyme and pathway databases

ReactomeREACT_6900. Immune System.

Gene expression databases

ArrayExpressQ01629.
BgeeQ01629.
CleanExHS_IFITM2.
GenevestigatorQ01629.

Family and domain databases

InterProIPR007593. CD225/Dispanin_fam.
[Graphical view]
PfamPF04505. Dispanin. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSIFITM2. human.
GenomeRNAi10581.
NextBio40181.
PROQ01629.
SOURCESearch...

Entry information

Entry nameIFM2_HUMAN
AccessionPrimary (citable) accession number: Q01629
Secondary accession number(s): Q6FH82, Q96DA8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: March 2, 2010
Last modified: April 16, 2014
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM