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Protein

Interferon-induced transmembrane protein 2

Gene

IFITM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and vesicular stomatitis virus (VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV S protein-mediated viral entry and VSV G protein-mediated viral entry. Induces cell cycle arrest and mediates apoptosis by caspase activation and in p53-independent manner.7 Publications

GO - Biological processi

  • defense response to virus Source: UniProtKB-KW
  • immune response Source: ProtInc
  • negative regulation of viral entry into host cell Source: UniProtKB
  • negative regulation of viral genome replication Source: UniProtKB
  • response to interferon-alpha Source: UniProtKB
  • response to interferon-beta Source: UniProtKB
  • response to interferon-gamma Source: UniProtKB
  • response to virus Source: UniProtKB
  • type I interferon signaling pathway Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Antiviral defense, Immunity, Innate immunity

Enzyme and pathway databases

ReactomeiR-HSA-909733. Interferon alpha/beta signaling.

Protein family/group databases

TCDBi8.A.58.1.2. the dispanin (dispanin) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon-induced transmembrane protein 2
Alternative name(s):
Dispanin subfamily A member 2c
Short name:
DSPA2c
Interferon-inducible protein 1-8D
Gene namesi
Name:IFITM2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:5413. IFITM2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 56CytoplasmicSequence analysisAdd BLAST56
Intramembranei57 – 77HelicalBy similarityAdd BLAST21
Topological domaini78 – 106CytoplasmicSequence analysisAdd BLAST29
Transmembranei107 – 127HelicalSequence analysisAdd BLAST21
Topological domaini128 – 132ExtracellularSequence analysis5

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10581.
OpenTargetsiENSG00000185201.
PharmGKBiPA29654.

Polymorphism and mutation databases

BioMutaiIFITM2.
DMDMi290457648.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001537281 – 132Interferon-induced transmembrane protein 2Add BLAST132

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Lipidationi70S-palmitoyl cysteineBy similarity1
Lipidationi71S-palmitoyl cysteineBy similarity1
Lipidationi104S-palmitoyl cysteineBy similarity1

Post-translational modificationi

Palmitoylation on membrane-proximal cysteines controls clustering in membrane compartments and antiviral activity against influenza virus.By similarity

Keywords - PTMi

Acetylation, Lipoprotein, Palmitate

Proteomic databases

EPDiQ01629.
MaxQBiQ01629.
PaxDbiQ01629.
PeptideAtlasiQ01629.
PRIDEiQ01629.

PTM databases

iPTMnetiQ01629.
PhosphoSitePlusiQ01629.
SwissPalmiQ01629.

Expressioni

Inductioni

By IFN-alpha and IFNG/IFN-gamma. Down-regulated by p53/TP53.1 Publication

Gene expression databases

BgeeiENSG00000185201.
CleanExiHS_IFITM2.
ExpressionAtlasiQ01629. baseline and differential.
GenevisibleiQ01629. HS.

Organism-specific databases

HPAiHPA004337.

Interactioni

Subunit structurei

Interacts with CD81.By similarity

Protein-protein interaction databases

BioGridi115832. 2 interactors.
IntActiQ01629. 6 interactors.
MINTiMINT-1432250.
STRINGi9606.ENSP00000382714.

Structurei

3D structure databases

ProteinModelPortaliQ01629.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CD225/Dispanin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J2DU. Eukaryota.
ENOG4112C1U. LUCA.
GeneTreeiENSGT00390000003476.
HOGENOMiHOG000115781.
HOVERGENiHBG001182.
InParanoidiQ01629.
KOiK06566.
OMAiNIRSETI.
OrthoDBiEOG091G1143.
PhylomeDBiQ01629.
TreeFamiTF334894.

Family and domain databases

InterProiIPR007593. CD225/Dispanin_fam.
[Graphical view]
PfamiPF04505. CD225. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q01629-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNHIVQTFSP VNSGQPPNYE MLKEEQEVAM LGVPHNPAPP MSTVIHIRSE
60 70 80 90 100
TSVPDHVVWS LFNTLFMNTC CLGFIAFAYS VKSRDRKMVG DVTGAQAYAS
110 120 130
TAKCLNIWAL ILGIFMTILL IIIPVLVVQA QR
Length:132
Mass (Da):14,632
Last modified:March 2, 2010 - v2
Checksum:i232A32D109EEBF5D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti33V → G in CAA40625 (PubMed:1906403).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06267733V → A.2 PublicationsCorresponds to variant rs1058900dbSNPEnsembl.1
Natural variantiVAR_01484841M → T.2 PublicationsCorresponds to variant rs14408dbSNPEnsembl.1
Natural variantiVAR_060470121I → V.2 PublicationsCorresponds to variant rs1059091dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57351 mRNA. Translation: CAA40625.1.
CR541874 mRNA. Translation: CAG46672.1.
AC136475 Genomic DNA. No translation available.
BC009696 mRNA. Translation: AAH09696.1.
CCDSiCCDS41583.1.
PIRiS17183.
RefSeqiNP_006426.2. NM_006435.2.
UniGeneiHs.709321.

Genome annotation databases

EnsembliENST00000399817; ENSP00000382714; ENSG00000185201.
ENST00000616316; ENSP00000484689; ENSG00000185201.
GeneIDi10581.
KEGGihsa:10581.
UCSCiuc001lox.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57351 mRNA. Translation: CAA40625.1.
CR541874 mRNA. Translation: CAG46672.1.
AC136475 Genomic DNA. No translation available.
BC009696 mRNA. Translation: AAH09696.1.
CCDSiCCDS41583.1.
PIRiS17183.
RefSeqiNP_006426.2. NM_006435.2.
UniGeneiHs.709321.

3D structure databases

ProteinModelPortaliQ01629.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115832. 2 interactors.
IntActiQ01629. 6 interactors.
MINTiMINT-1432250.
STRINGi9606.ENSP00000382714.

Protein family/group databases

TCDBi8.A.58.1.2. the dispanin (dispanin) family.

PTM databases

iPTMnetiQ01629.
PhosphoSitePlusiQ01629.
SwissPalmiQ01629.

Polymorphism and mutation databases

BioMutaiIFITM2.
DMDMi290457648.

Proteomic databases

EPDiQ01629.
MaxQBiQ01629.
PaxDbiQ01629.
PeptideAtlasiQ01629.
PRIDEiQ01629.

Protocols and materials databases

DNASUi10581.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000399817; ENSP00000382714; ENSG00000185201.
ENST00000616316; ENSP00000484689; ENSG00000185201.
GeneIDi10581.
KEGGihsa:10581.
UCSCiuc001lox.5. human.

Organism-specific databases

CTDi10581.
DisGeNETi10581.
GeneCardsiIFITM2.
HGNCiHGNC:5413. IFITM2.
HPAiHPA004337.
MIMi605578. gene.
neXtProtiNX_Q01629.
OpenTargetsiENSG00000185201.
PharmGKBiPA29654.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J2DU. Eukaryota.
ENOG4112C1U. LUCA.
GeneTreeiENSGT00390000003476.
HOGENOMiHOG000115781.
HOVERGENiHBG001182.
InParanoidiQ01629.
KOiK06566.
OMAiNIRSETI.
OrthoDBiEOG091G1143.
PhylomeDBiQ01629.
TreeFamiTF334894.

Enzyme and pathway databases

ReactomeiR-HSA-909733. Interferon alpha/beta signaling.

Miscellaneous databases

ChiTaRSiIFITM2. human.
GenomeRNAii10581.
PROiQ01629.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000185201.
CleanExiHS_IFITM2.
ExpressionAtlasiQ01629. baseline and differential.
GenevisibleiQ01629. HS.

Family and domain databases

InterProiIPR007593. CD225/Dispanin_fam.
[Graphical view]
PfamiPF04505. CD225. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIFM2_HUMAN
AccessioniPrimary (citable) accession number: Q01629
Secondary accession number(s): Q6FH82, Q96DA8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: March 2, 2010
Last modified: November 2, 2016
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.