##gff-version 3
Q01628	UniProtKB	Chain	1	133	.	.	.	ID=PRO_0000153729;Note=Interferon-induced transmembrane protein 3	
Q01628	UniProtKB	Topological domain	1	57	.	.	.	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255	
Q01628	UniProtKB	Intramembrane	58	78	.	.	.	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255	
Q01628	UniProtKB	Topological domain	79	107	.	.	.	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255	
Q01628	UniProtKB	Transmembrane	108	128	.	.	.	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255	
Q01628	UniProtKB	Topological domain	129	133	.	.	.	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255	
Q01628	UniProtKB	Region	60	93	.	.	.	Note=Interaction with SPP1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19901966;Dbxref=PMID:19901966	
Q01628	UniProtKB	Region	108	133	.	.	.	Note=Interaction with VAPA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23601107;Dbxref=PMID:23601107	
Q01628	UniProtKB	Modified residue	20	20	.	.	.	Note=Phosphotyrosine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26354436;Dbxref=PMID:26354436	
Q01628	UniProtKB	Lipidation	71	71	.	.	.	Note=S-palmitoyl cysteine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20601941;Dbxref=PMID:20601941	
Q01628	UniProtKB	Lipidation	72	72	.	.	.	Note=S-palmitoyl cysteine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20601941;Dbxref=PMID:20601941	
Q01628	UniProtKB	Lipidation	105	105	.	.	.	Note=S-palmitoyl cysteine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20601941;Dbxref=PMID:20601941	
Q01628	UniProtKB	Cross-link	24	24	.	.	.	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22511783;Dbxref=PMID:22511783	
Q01628	UniProtKB	Cross-link	83	83	.	.	.	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22511783;Dbxref=PMID:22511783	
Q01628	UniProtKB	Cross-link	88	88	.	.	.	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22511783;Dbxref=PMID:22511783	
Q01628	UniProtKB	Cross-link	104	104	.	.	.	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22511783;Dbxref=PMID:22511783	
Q01628	UniProtKB	Natural variant	3	3	.	.	.	ID=VAR_053810;Note=H->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs1136853,PMID:15489334	
Q01628	UniProtKB	Mutagenesis	20	20	.	.	.	Note=Loss of phosphorylation. Accumulates at the plasma membrane. Increases anti-HCV properties. Loss of anti-SARS-CoV-2 activity by enhancing Spike-mediated cell-to-cell fusion. Y->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:26354436,ECO:0000269|PubMed:33270927;Dbxref=PMID:26354436,PMID:33270927	
Q01628	UniProtKB	Mutagenesis	23	23	.	.	.	Note=Accumulates at the plasma membrane. Loss of anti-SARS-CoV-2 activity by enhancing Spike-mediated cell-to-cell fusion. L->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:33270927;Dbxref=PMID:33270927	
Q01628	UniProtKB	Mutagenesis	59	68	.	.	.	Note=Slightly enhances infection by SARS-CoV-2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:33270927;Dbxref=PMID:33270927	
Q01628	UniProtKB	Mutagenesis	61	65	.	.	.	Note=Decreases anti-SARS-CoV-2 activity. SLFNT->ALFAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:33270927;Dbxref=PMID:33270927	
Q01628	UniProtKB	Mutagenesis	71	72	.	.	.	Note=Loss of anti-HCV activity. Only localizes at the lysosome. No effect on SARS-CoV-2 infection%3B when associated with A-105. Loss of anti-influenza A virus activity%3B when associated with A-105. CC->AA;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:26354436,ECO:0000269|PubMed:33270927;Dbxref=PMID:26354436,PMID:33270927	
Q01628	UniProtKB	Mutagenesis	105	105	.	.	.	Note=Loss of anti-HCV activity. Only localizes at the lysosome. No effect on SARS-CoV-2 infection%3B when associated with 71-A-A-72. Loss of anti-influenza A virus activity%3B when associated with 71-A-A-72. C->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:26354436,ECO:0000269|PubMed:33270927;Dbxref=PMID:26354436,PMID:33270927	
Q01628	UniProtKB	Sequence conflict	2	2	.	.	.	Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305	
Q01628	UniProtKB	Sequence conflict	34	34	.	.	.	Note=A->G;Ontology_term=ECO:0000305;evidence=ECO:0000305