Q01628 (IFM3_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 99.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Interferon-induced transmembrane protein 3 Alternative name(s): Interferon-inducible protein 1-8U | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 133 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | IFN-induced antiviral protein that mediates cellular innate immunity to at least three major human pathogens, namely influenza A H1N1 virus, West Nile virus (WNV), and dengue virus (WNV), by inhibiting the early step(s) of replication. Ref.3 Ref.4 |
| Subunit structure | Interacts with SPP1; the interaction reduces OPN expression. Ref.5 |
| Subcellular location | Cell membrane; Multi-pass membrane protein By similarity. |
| Induction | By IFN-alpha and IFNG/IFN-gamma. |
| Post-translational modification | Palmitoylation on membrane-proximal cysteines controls clustering in membrane compartments and antiviral activity against influenza virus. |
| Sequence similarities | Belongs to the CD225 family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Antiviral defense Immunity Innate immunity |
| Cellular component | Cell membrane Membrane |
| Coding sequence diversity | Polymorphism |
| Domain | Transmembrane Transmembrane helix |
| PTM | Lipoprotein Palmitate |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | response to virus Inferred from electronic annotation. Source: UniProtKB-KW type I interferon-mediated signaling pathwayTraceable author statement. Source: Reactome |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membraneInferred from direct assay. Source: LIFEdb |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 133 | 133 | Interferon-induced transmembrane protein 3 | PRO_0000153729 | |||||
Regions | |||||||||
| Topological domain | 1 – 57 | 57 | Extracellular Potential | ||||||
| Transmembrane | 58 – 78 | 21 | Helical; Potential | ||||||
| Topological domain | 79 – 107 | 29 | Cytoplasmic Potential | ||||||
| Transmembrane | 108 – 128 | 21 | Helical; Potential | ||||||
| Topological domain | 129 – 133 | 5 | Extracellular Potential | ||||||
| Region | 60 – 93 | 34 | Interaction with SPP1 | ||||||
Amino acid modifications | |||||||||
| Lipidation | 71 | 1 | S-palmitoyl cysteine Ref.6 | ||||||
| Lipidation | 72 | 1 | S-palmitoyl cysteine Ref.6 | ||||||
| Lipidation | 105 | 1 | S-palmitoyl cysteine Ref.6 | ||||||
Natural variations | |||||||||
| Natural variant | 3 | 1 | H → Q. Ref.2 Corresponds to variant rs1136853 [ dbSNP | Ensembl ]. | VAR_053810 | |||||
Experimental info | |||||||||
| Sequence conflict | 2 | 1 | N → S in CAA40626. Ref.1 | ||||||
| Sequence conflict | 34 | 1 | A → G in CAA40626. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Molecular analysis of a human interferon-inducible gene family." Lewin A.R., Reid L.E., McMahon M., Stark G.R., Kerr I.M. Eur. J. Biochem. 199:417-423(1991) [PubMed: 1906403] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-3. Tissue: Brain, Cervix and Vascular endothelial cell. |
| [3] | "The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus." Brass A.L., Huang I.C., Benita Y., John S.P., Krishnan M.N., Feeley E.M., Ryan B.J., Weyer J.L., van der Weyden L., Fikrig E., Adams D.J., Xavier R.J., Farzan M., Elledge S.J. Cell 139:1243-1254(2009) [PubMed: 20064371] [Abstract] Cited for: FUNCTION IN VIRAL RESISTANCE. |
| [4] | "Identification of five interferon-induced cellular proteins that inhibit west nile virus and dengue virus infections." Jiang D., Weidner J.M., Qing M., Pan X.B., Guo H., Xu C., Zhang X., Birk A., Chang J., Shi P.Y., Block T.M., Guo J.T. J. Virol. 84:8332-8341(2010) [PubMed: 20534863] [Abstract] Cited for: FUNCTION. |
| [5] | "Interferon-induced transmembrane 3 binds osteopontin in vitro: expressed in vivo IFITM3 reduced OPN expression." El-Tanani M.K., Jin D., Campbell F.C., Johnston P.G. Oncogene 29:752-762(2010) [PubMed: 19901966] [Abstract] Cited for: INTERACTION WITH SPP1. |
| [6] | "Palmitoylome profiling reveals S-palmitoylation-dependent antiviral activity of IFITM3." Yount J.S., Moltedo B., Yang Y.Y., Charron G., Moran T.M., Lopez C.B., Hang H.C. Nat. Chem. Biol. 6:610-614(2010) [PubMed: 20601941] [Abstract] Cited for: PALMITOYLATION AT CYS-71; CYS-72 AND CYS-105. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | X57352 mRNA. Translation: CAA40626.1. BC006794 mRNA. Translation: AAH06794.1. BC008417 mRNA. Translation: AAH08417.1. BC022439 mRNA. Translation: AAH22439.1. BC070243 mRNA. Translation: AAH70243.1. |
| IPI | IPI00303726. |
| PIR | S17182. |
| RefSeq | NP_066362.2. NM_021034.2. |
| UniGene | Hs.374650. |
3D structure databases | |
| ProteinModelPortal | Q01628. |
| ModBase | Search... |
Protein-protein interaction databases | |
| MINT | MINT-2805186. |
| STRING | Q01628. |
PTM databases | |
| PhosphoSite | Q01628. |
Polymorphism databases | |
| DMDM | 20178301. |
Proteomic databases | |
| PRIDE | Q01628. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENST00000399808; ENSP00000382707; ENSG00000142089. |
| GeneID | 10410. |
| KEGG | hsa:10410. |
| UCSC | uc001lpa.2. human. |
Organism-specific databases | |
| CTD | 10410. |
| GeneCards | GC11M000319. |
| H-InvDB | HIX0021368. |
| HGNC | HGNC:5414. IFITM3. |
| HPA | HPA004337. |
| MIM | 605579. gene. |
| neXtProt | NX_Q01628. |
| PharmGKB | PA29655. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOVERGEN | HBG001182. |
| OMA | MVIICII. |
| PhylomeDB | Q01628. |
Enzyme and pathway databases | |
| Reactome | REACT_6900. Immune System. |
Gene expression databases | |
| ArrayExpress | Q01628. |
| Bgee | Q01628. |
| CleanEx | HS_IFITM3. |
| Genevestigator | Q01628. |
Family and domain databases | |
| InterPro | IPR007593. Interferon-induced_TM_protein. [Graphical view] |
| KO | K06566. |
| Pfam | PF04505. CD225. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 39457. |
| SOURCE | Search... |
Entry information
| Entry name | IFM3_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q01628 Secondary accession number(s): Q96HK8, Q96J15 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 11 Human chromosome 11: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

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