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Q01628

- IFM3_HUMAN

UniProt

Q01628 - IFM3_HUMAN

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Protein

Interferon-induced transmembrane protein 3

Gene
IFITM3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

IFN-induced antiviral protein which disrupts intracellular cholesterol homeostasis. Inhibits the entry of viruses to the host cell cytoplasm by preventing viral fusion with cholesterol depleted endosomes. May inactivate new enveloped viruses which buds out of the infected cell, by letting them go out with a cholesterol depleted membrane. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV) and Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and vesicular stomatitis virus (VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV S protein-mediated viral entry and VSV G protein-mediated viral entry. Plays a critical role in the structural stability and function of vacuolar ATPase (v-ATPase). Establishes physical contact with the v-ATPase of endosomes which is critical for proper clathrin localization and is also required for the function of the v-ATPase to lower the pH in phagocytic endosomes thus establishing an antiviral state.8 Publications

GO - Molecular functioni

  1. protein binding Source: IntAct

GO - Biological processi

  1. cytokine-mediated signaling pathway Source: Reactome
  2. defense response to virus Source: UniProtKB-KW
  3. immune response Source: ProtInc
  4. negative regulation of viral entry into host cell Source: UniProtKB
  5. negative regulation of viral genome replication Source: UniProtKB
  6. negative regulation of viral transcription Source: UniProtKB
  7. response to interferon-alpha Source: UniProtKB
  8. response to interferon-beta Source: UniProtKB
  9. response to interferon-gamma Source: UniProtKB
  10. response to virus Source: UniProtKB
  11. type I interferon signaling pathway Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Antiviral defense, Immunity, Innate immunity

Enzyme and pathway databases

ReactomeiREACT_25162. Interferon alpha/beta signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon-induced transmembrane protein 3
Alternative name(s):
Dispanin subfamily A member 2b
Short name:
DSPA2b
Interferon-inducible protein 1-8U
Gene namesi
Name:IFITM3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:5414. IFITM3.

Subcellular locationi

Cell membrane; Single-pass type II membrane protein. Late endosome membrane; Single-pass type II membrane protein. Lysosome membrane; Single-pass type II membrane protein 3 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5757Cytoplasmic Reviewed predictionAdd
BLAST
Intramembranei58 – 7821Helical; Reviewed predictionAdd
BLAST
Topological domaini79 – 10729Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei108 – 12821Helical; Reviewed predictionAdd
BLAST
Topological domaini129 – 1335Extracellular Reviewed prediction

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. integral component of membrane Source: UniProtKB-KW
  3. late endosome membrane Source: UniProtKB-SubCell
  4. lysosomal membrane Source: UniProtKB-SubCell
  5. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Lysosome, Membrane

Pathology & Biotechi

Organism-specific databases

MIMi614680. phenotype.
PharmGKBiPA29655.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 133133Interferon-induced transmembrane protein 3PRO_0000153729Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki24 – 24Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Lipidationi71 – 711S-palmitoyl cysteine2 Publications
Lipidationi72 – 721S-palmitoyl cysteine2 Publications
Cross-linki83 – 83Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki88 – 88Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki104 – 104Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Lipidationi105 – 1051S-palmitoyl cysteine2 Publications

Post-translational modificationi

Palmitoylation on membrane-proximal cysteines controls clustering in membrane compartments and antiviral activity against influenza virus.2 Publications
Not glycosylated.1 Publication
Polyubiquitinated with both 'Lys-48' and 'Lys-63' linkages. Ubiqutination negatively regulates antiviral activity. Lys-24 is the most prevalent ubiquitination site.

Keywords - PTMi

Isopeptide bond, Lipoprotein, Palmitate, Ubl conjugation

Proteomic databases

MaxQBiQ01628.
PaxDbiQ01628.
PRIDEiQ01628.

PTM databases

PhosphoSiteiQ01628.

Expressioni

Inductioni

By IFN-alpha and IFNG/IFN-gamma.

Gene expression databases

ArrayExpressiQ01628.
BgeeiQ01628.
CleanExiHS_IFITM3.
GenevestigatoriQ01628.

Organism-specific databases

HPAiHPA004337.

Interactioni

Subunit structurei

Interacts with ATP6V0B and CD81 By similarity. Interacts with SPP1; the interaction reduces OPN expression. Interacts with VAPA.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
NAMPTP434903EBI-7932862,EBI-2829310

Protein-protein interaction databases

BioGridi115681. 4 interactions.
IntActiQ01628. 1 interaction.
MINTiMINT-2805186.
STRINGi9606.ENSP00000382707.

Structurei

3D structure databases

ProteinModelPortaliQ01628.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni60 – 9334Interaction with SPP1Add
BLAST
Regioni108 – 13326Interaction with VAPAAdd
BLAST

Sequence similaritiesi

Belongs to the CD225/Dispanin family.

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG26698.
HOGENOMiHOG000115781.
HOVERGENiHBG001182.
KOiK06566.
OMAiVLIFQAY.
OrthoDBiEOG7288T5.
PhylomeDBiQ01628.
TreeFamiTF334894.

Family and domain databases

InterProiIPR007593. CD225/Dispanin_fam.
[Graphical view]
PfamiPF04505. Dispanin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q01628-1 [UniParc]FASTAAdd to Basket

« Hide

MNHTVQTFFS PVNSGQPPNY EMLKEEHEVA VLGAPHNPAP PTSTVIHIRS    50
ETSVPDHVVW SLFNTLFMNP CCLGFIAFAY SVKSRDRKMV GDVTGAQAYA 100
STAKCLNIWA LILGILMTIL LIVIPVLIFQ AYG 133
Length:133
Mass (Da):14,632
Last modified:April 16, 2002 - v2
Checksum:i9FFB2E4623F7A1DD
GO

Polymorphismi

Genetic variations in IFITM3 are responsible for susceptibility to severe influenza virus infection [MIMi:614680].

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti3 – 31H → Q.1 Publication
Corresponds to variant rs1136853 [ dbSNP | Ensembl ].
VAR_053810

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 21N → S in CAA40626. 1 Publication
Sequence conflicti34 – 341A → G in CAA40626. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X57352 mRNA. Translation: CAA40626.1.
JQ610571 Genomic DNA. Translation: AFF60305.1.
JQ610572 Genomic DNA. Translation: AFF60306.1.
JQ610573 Genomic DNA. Translation: AFF60307.1.
JQ610574 Genomic DNA. Translation: AFF60308.1.
JQ610575 Genomic DNA. Translation: AFF60309.1.
JQ610576 Genomic DNA. Translation: AFF60310.1.
JQ610577 Genomic DNA. Translation: AFF60311.1.
JQ610578 Genomic DNA. Translation: AFF60312.1.
JQ610579 Genomic DNA. Translation: AFF60313.1.
JQ610580 Genomic DNA. Translation: AFF60314.1.
JQ610581 Genomic DNA. Translation: AFF60315.1.
JQ610582 Genomic DNA. Translation: AFF60316.1.
JQ610583 Genomic DNA. Translation: AFF60317.1.
JQ610585 Genomic DNA. Translation: AFF60319.1.
JQ610586 Genomic DNA. Translation: AFF60320.1.
JQ610587 Genomic DNA. Translation: AFF60321.1.
JQ610588 Genomic DNA. Translation: AFF60322.1.
JQ610589 Genomic DNA. Translation: AFF60323.1.
JQ610590 Genomic DNA. Translation: AFF60324.1.
JQ610591 Genomic DNA. Translation: AFF60325.1.
JQ610592 Genomic DNA. Translation: AFF60326.1.
JQ610593 Genomic DNA. Translation: AFF60327.1.
JQ610594 Genomic DNA. Translation: AFF60328.1.
JQ610595 Genomic DNA. Translation: AFF60329.1.
JQ610596 Genomic DNA. Translation: AFF60330.1.
JQ610597 Genomic DNA. Translation: AFF60331.1.
JQ610598 Genomic DNA. Translation: AFF60332.1.
JQ610599 Genomic DNA. Translation: AFF60333.1.
JQ610600 Genomic DNA. Translation: AFF60334.1.
JQ610601 Genomic DNA. Translation: AFF60335.1.
JQ610602 Genomic DNA. Translation: AFF60336.1.
JQ610603 Genomic DNA. Translation: AFF60337.1.
JQ610604 Genomic DNA. Translation: AFF60338.1.
JQ610605 Genomic DNA. Translation: AFF60339.1.
JQ610606 Genomic DNA. Translation: AFF60340.1.
JQ610607 Genomic DNA. Translation: AFF60341.1.
JQ610608 Genomic DNA. Translation: AFF60342.1.
JQ610609 Genomic DNA. Translation: AFF60343.1.
JQ610610 Genomic DNA. Translation: AFF60344.1.
JQ610611 Genomic DNA. Translation: AFF60345.1.
JQ610613 Genomic DNA. Translation: AFF60347.1.
JQ610614 Genomic DNA. Translation: AFF60348.1.
JQ610615 Genomic DNA. Translation: AFF60349.1.
JQ610616 Genomic DNA. Translation: AFF60350.1.
JQ610617 Genomic DNA. Translation: AFF60351.1.
JQ610618 Genomic DNA. Translation: AFF60352.1.
JQ610620 Genomic DNA. Translation: AFF60354.1.
JQ610621 Genomic DNA. Translation: AFF60355.1.
BT006892 mRNA. Translation: AAP35538.1.
AK292173 mRNA. Translation: BAF84862.1.
AC136475 Genomic DNA. No translation available.
CH891444 Genomic DNA. Translation: EAW50866.1.
BC006794 mRNA. Translation: AAH06794.1.
BC008417 mRNA. Translation: AAH08417.1.
BC022439 mRNA. Translation: AAH22439.1.
BC070243 mRNA. Translation: AAH70243.1.
CCDSiCCDS41585.1.
PIRiS17182.
RefSeqiNP_066362.2. NM_021034.2.
UniGeneiHs.374650.

Genome annotation databases

EnsembliENST00000399808; ENSP00000382707; ENSG00000142089.
GeneIDi10410.
KEGGihsa:10410.
UCSCiuc001lpa.2. human.

Polymorphism databases

DMDMi20178301.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X57352 mRNA. Translation: CAA40626.1 .
JQ610571 Genomic DNA. Translation: AFF60305.1 .
JQ610572 Genomic DNA. Translation: AFF60306.1 .
JQ610573 Genomic DNA. Translation: AFF60307.1 .
JQ610574 Genomic DNA. Translation: AFF60308.1 .
JQ610575 Genomic DNA. Translation: AFF60309.1 .
JQ610576 Genomic DNA. Translation: AFF60310.1 .
JQ610577 Genomic DNA. Translation: AFF60311.1 .
JQ610578 Genomic DNA. Translation: AFF60312.1 .
JQ610579 Genomic DNA. Translation: AFF60313.1 .
JQ610580 Genomic DNA. Translation: AFF60314.1 .
JQ610581 Genomic DNA. Translation: AFF60315.1 .
JQ610582 Genomic DNA. Translation: AFF60316.1 .
JQ610583 Genomic DNA. Translation: AFF60317.1 .
JQ610585 Genomic DNA. Translation: AFF60319.1 .
JQ610586 Genomic DNA. Translation: AFF60320.1 .
JQ610587 Genomic DNA. Translation: AFF60321.1 .
JQ610588 Genomic DNA. Translation: AFF60322.1 .
JQ610589 Genomic DNA. Translation: AFF60323.1 .
JQ610590 Genomic DNA. Translation: AFF60324.1 .
JQ610591 Genomic DNA. Translation: AFF60325.1 .
JQ610592 Genomic DNA. Translation: AFF60326.1 .
JQ610593 Genomic DNA. Translation: AFF60327.1 .
JQ610594 Genomic DNA. Translation: AFF60328.1 .
JQ610595 Genomic DNA. Translation: AFF60329.1 .
JQ610596 Genomic DNA. Translation: AFF60330.1 .
JQ610597 Genomic DNA. Translation: AFF60331.1 .
JQ610598 Genomic DNA. Translation: AFF60332.1 .
JQ610599 Genomic DNA. Translation: AFF60333.1 .
JQ610600 Genomic DNA. Translation: AFF60334.1 .
JQ610601 Genomic DNA. Translation: AFF60335.1 .
JQ610602 Genomic DNA. Translation: AFF60336.1 .
JQ610603 Genomic DNA. Translation: AFF60337.1 .
JQ610604 Genomic DNA. Translation: AFF60338.1 .
JQ610605 Genomic DNA. Translation: AFF60339.1 .
JQ610606 Genomic DNA. Translation: AFF60340.1 .
JQ610607 Genomic DNA. Translation: AFF60341.1 .
JQ610608 Genomic DNA. Translation: AFF60342.1 .
JQ610609 Genomic DNA. Translation: AFF60343.1 .
JQ610610 Genomic DNA. Translation: AFF60344.1 .
JQ610611 Genomic DNA. Translation: AFF60345.1 .
JQ610613 Genomic DNA. Translation: AFF60347.1 .
JQ610614 Genomic DNA. Translation: AFF60348.1 .
JQ610615 Genomic DNA. Translation: AFF60349.1 .
JQ610616 Genomic DNA. Translation: AFF60350.1 .
JQ610617 Genomic DNA. Translation: AFF60351.1 .
JQ610618 Genomic DNA. Translation: AFF60352.1 .
JQ610620 Genomic DNA. Translation: AFF60354.1 .
JQ610621 Genomic DNA. Translation: AFF60355.1 .
BT006892 mRNA. Translation: AAP35538.1 .
AK292173 mRNA. Translation: BAF84862.1 .
AC136475 Genomic DNA. No translation available.
CH891444 Genomic DNA. Translation: EAW50866.1 .
BC006794 mRNA. Translation: AAH06794.1 .
BC008417 mRNA. Translation: AAH08417.1 .
BC022439 mRNA. Translation: AAH22439.1 .
BC070243 mRNA. Translation: AAH70243.1 .
CCDSi CCDS41585.1.
PIRi S17182.
RefSeqi NP_066362.2. NM_021034.2.
UniGenei Hs.374650.

3D structure databases

ProteinModelPortali Q01628.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115681. 4 interactions.
IntActi Q01628. 1 interaction.
MINTi MINT-2805186.
STRINGi 9606.ENSP00000382707.

PTM databases

PhosphoSitei Q01628.

Polymorphism databases

DMDMi 20178301.

Proteomic databases

MaxQBi Q01628.
PaxDbi Q01628.
PRIDEi Q01628.

Protocols and materials databases

DNASUi 10410.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000399808 ; ENSP00000382707 ; ENSG00000142089 .
GeneIDi 10410.
KEGGi hsa:10410.
UCSCi uc001lpa.2. human.

Organism-specific databases

CTDi 10410.
GeneCardsi GC11M000319.
HGNCi HGNC:5414. IFITM3.
HPAi HPA004337.
MIMi 605579. gene.
614680. phenotype.
neXtProti NX_Q01628.
PharmGKBi PA29655.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG26698.
HOGENOMi HOG000115781.
HOVERGENi HBG001182.
KOi K06566.
OMAi VLIFQAY.
OrthoDBi EOG7288T5.
PhylomeDBi Q01628.
TreeFami TF334894.

Enzyme and pathway databases

Reactomei REACT_25162. Interferon alpha/beta signaling.

Miscellaneous databases

GeneWikii IFITM3.
GenomeRNAii 10410.
NextBioi 39457.
PROi Q01628.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q01628.
Bgeei Q01628.
CleanExi HS_IFITM3.
Genevestigatori Q01628.

Family and domain databases

InterProi IPR007593. CD225/Dispanin_fam.
[Graphical view ]
Pfami PF04505. Dispanin. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular analysis of a human interferon-inducible gene family."
    Lewin A.R., Reid L.E., McMahon M., Stark G.R., Kerr I.M.
    Eur. J. Biochem. 199:417-423(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], INVOLVEMENT IN SUSCEPTIBILITY TO SEVERE INFLUENZA INFECTION.
  3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-3.
    Tissue: Brain, Cervix and Vascular endothelial cell.
  8. "The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus."
    Brass A.L., Huang I.C., Benita Y., John S.P., Krishnan M.N., Feeley E.M., Ryan B.J., Weyer J.L., van der Weyden L., Fikrig E., Adams D.J., Xavier R.J., Farzan M., Elledge S.J.
    Cell 139:1243-1254(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN VIRAL RESISTANCE.
  9. "Identification of five interferon-induced cellular proteins that inhibit west nile virus and dengue virus infections."
    Jiang D., Weidner J.M., Qing M., Pan X.B., Guo H., Xu C., Zhang X., Birk A., Chang J., Shi P.Y., Block T.M., Guo J.T.
    J. Virol. 84:8332-8341(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  10. "Interferon-induced cell membrane proteins, IFITM3 and tetherin, inhibit vesicular stomatitis virus infection via distinct mechanisms."
    Weidner J.M., Jiang D., Pan X.B., Chang J., Block T.M., Guo J.T.
    J. Virol. 84:12646-12657(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  11. "Interferon-induced transmembrane 3 binds osteopontin in vitro: expressed in vivo IFITM3 reduced OPN expression."
    El-Tanani M.K., Jin D., Campbell F.C., Johnston P.G.
    Oncogene 29:752-762(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SPP1.
  12. "Palmitoylome profiling reveals S-palmitoylation-dependent antiviral activity of IFITM3."
    Yount J.S., Moltedo B., Yang Y.Y., Charron G., Moran T.M., Lopez C.B., Hang H.C.
    Nat. Chem. Biol. 6:610-614(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PALMITOYLATION AT CYS-71; CYS-72 AND CYS-105.
  13. "The small interferon-induced transmembrane genes and proteins."
    Siegrist F., Ebeling M., Certa U.
    J. Interferon Cytokine Res. 31:183-197(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  14. "The IFITM proteins inhibit HIV-1 infection."
    Lu J., Pan Q., Rong L., He W., Liu S.L., Liang C.
    J. Virol. 85:2126-2137(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  15. Erratum
    Lu J., Pan Q., Rong L., He W., Liu S.L., Liang C.
    J. Virol. 85:4043-4043(2011)
  16. Cited for: FUNCTION, SUBCELLULAR LOCATION.
  17. Cited for: FUNCTION.
  18. "S-palmitoylation and ubiquitination differentially regulate interferon-induced transmembrane protein 3 (IFITM3)-mediated resistance to influenza virus."
    Yount J.S., Karssemeijer R.A., Hang H.C.
    J. Biol. Chem. 287:19631-19641(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION AT LYS-24; LYS-83; LYS-88 AND LYS-104, PALMITOYLATION, TOPOLOGY, ABSENCE OF GLYCOSYLATION, SUBCELLULAR LOCATION.
  19. "IFITM proteins restrict antibody-dependent enhancement of dengue virus infection."
    Chan Y.K., Huang I.C., Farzan M.
    PLoS ONE 7:E34508-E34508(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  20. "The dispanins: a novel gene family of ancient origin that contains 14 human members."
    Sallman Almen M., Bringeland N., Fredriksson R., Schioth H.B.
    PLoS ONE 7:E31961-E31961(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY.
  21. "The antiviral effector IFITM3 disrupts intracellular cholesterol homeostasis to block viral entry."
    Amini-Bavil-Olyaee S., Choi Y.J., Lee J.H., Shi M., Huang I.C., Farzan M., Jung J.U.
    Cell Host Microbe 13:452-464(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH VAPA.

Entry informationi

Entry nameiIFM3_HUMAN
AccessioniPrimary (citable) accession number: Q01628
Secondary accession number(s): Q53Y76, Q96HK8, Q96J15
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: April 16, 2002
Last modified: September 3, 2014
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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