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Q01628

- IFM3_HUMAN

UniProt

Q01628 - IFM3_HUMAN

Protein

Interferon-induced transmembrane protein 3

Gene

IFITM3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    IFN-induced antiviral protein which disrupts intracellular cholesterol homeostasis. Inhibits the entry of viruses to the host cell cytoplasm by preventing viral fusion with cholesterol depleted endosomes. May inactivate new enveloped viruses which buds out of the infected cell, by letting them go out with a cholesterol depleted membrane. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV) and Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and vesicular stomatitis virus (VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV S protein-mediated viral entry and VSV G protein-mediated viral entry. Plays a critical role in the structural stability and function of vacuolar ATPase (v-ATPase). Establishes physical contact with the v-ATPase of endosomes which is critical for proper clathrin localization and is also required for the function of the v-ATPase to lower the pH in phagocytic endosomes thus establishing an antiviral state.8 Publications

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. cytokine-mediated signaling pathway Source: Reactome
    2. defense response to virus Source: UniProtKB-KW
    3. immune response Source: ProtInc
    4. negative regulation of viral entry into host cell Source: UniProtKB
    5. negative regulation of viral genome replication Source: UniProtKB
    6. negative regulation of viral transcription Source: UniProtKB
    7. response to interferon-alpha Source: UniProtKB
    8. response to interferon-beta Source: UniProtKB
    9. response to interferon-gamma Source: UniProtKB
    10. response to virus Source: UniProtKB
    11. type I interferon signaling pathway Source: Reactome

    Keywords - Biological processi

    Antiviral defense, Immunity, Innate immunity

    Enzyme and pathway databases

    ReactomeiREACT_25162. Interferon alpha/beta signaling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interferon-induced transmembrane protein 3
    Alternative name(s):
    Dispanin subfamily A member 2b
    Short name:
    DSPA2b
    Interferon-inducible protein 1-8U
    Gene namesi
    Name:IFITM3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:5414. IFITM3.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. integral component of membrane Source: UniProtKB-KW
    3. late endosome membrane Source: UniProtKB-SubCell
    4. lysosomal membrane Source: UniProtKB-SubCell
    5. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Endosome, Lysosome, Membrane

    Pathology & Biotechi

    Organism-specific databases

    MIMi614680. phenotype.
    PharmGKBiPA29655.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 133133Interferon-induced transmembrane protein 3PRO_0000153729Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki24 – 24Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
    Lipidationi71 – 711S-palmitoyl cysteine2 Publications
    Lipidationi72 – 721S-palmitoyl cysteine2 Publications
    Cross-linki83 – 83Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
    Cross-linki88 – 88Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
    Cross-linki104 – 104Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
    Lipidationi105 – 1051S-palmitoyl cysteine2 Publications

    Post-translational modificationi

    Palmitoylation on membrane-proximal cysteines controls clustering in membrane compartments and antiviral activity against influenza virus.2 Publications
    Not glycosylated.
    Polyubiquitinated with both 'Lys-48' and 'Lys-63' linkages. Ubiqutination negatively regulates antiviral activity. Lys-24 is the most prevalent ubiquitination site.1 Publication

    Keywords - PTMi

    Isopeptide bond, Lipoprotein, Palmitate, Ubl conjugation

    Proteomic databases

    MaxQBiQ01628.
    PaxDbiQ01628.
    PRIDEiQ01628.

    PTM databases

    PhosphoSiteiQ01628.

    Expressioni

    Inductioni

    By IFN-alpha and IFNG/IFN-gamma.

    Gene expression databases

    ArrayExpressiQ01628.
    BgeeiQ01628.
    CleanExiHS_IFITM3.
    GenevestigatoriQ01628.

    Organism-specific databases

    HPAiHPA004337.

    Interactioni

    Subunit structurei

    Interacts with ATP6V0B and CD81 By similarity. Interacts with SPP1; the interaction reduces OPN expression. Interacts with VAPA.By similarity2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    NAMPTP434903EBI-7932862,EBI-2829310

    Protein-protein interaction databases

    BioGridi115681. 4 interactions.
    IntActiQ01628. 1 interaction.
    MINTiMINT-2805186.
    STRINGi9606.ENSP00000382707.

    Structurei

    3D structure databases

    ProteinModelPortaliQ01628.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 5757CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini79 – 10729CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini129 – 1335ExtracellularSequence Analysis

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei58 – 7821HelicalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei108 – 12821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni60 – 9334Interaction with SPP1Add
    BLAST
    Regioni108 – 13326Interaction with VAPAAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CD225/Dispanin family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG26698.
    HOGENOMiHOG000115781.
    HOVERGENiHBG001182.
    KOiK06566.
    OMAiVLIFQAY.
    OrthoDBiEOG7288T5.
    PhylomeDBiQ01628.
    TreeFamiTF334894.

    Family and domain databases

    InterProiIPR007593. CD225/Dispanin_fam.
    [Graphical view]
    PfamiPF04505. Dispanin. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q01628-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNHTVQTFFS PVNSGQPPNY EMLKEEHEVA VLGAPHNPAP PTSTVIHIRS    50
    ETSVPDHVVW SLFNTLFMNP CCLGFIAFAY SVKSRDRKMV GDVTGAQAYA 100
    STAKCLNIWA LILGILMTIL LIVIPVLIFQ AYG 133
    Length:133
    Mass (Da):14,632
    Last modified:April 16, 2002 - v2
    Checksum:i9FFB2E4623F7A1DD
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti2 – 21N → S in CAA40626. (PubMed:1906403)Curated
    Sequence conflicti34 – 341A → G in CAA40626. (PubMed:1906403)Curated

    Polymorphismi

    Genetic variations in IFITM3 are responsible for susceptibility to severe influenza virus infection [MIMi:614680].

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti3 – 31H → Q.1 Publication
    Corresponds to variant rs1136853 [ dbSNP | Ensembl ].
    VAR_053810

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X57352 mRNA. Translation: CAA40626.1.
    JQ610571 Genomic DNA. Translation: AFF60305.1.
    JQ610572 Genomic DNA. Translation: AFF60306.1.
    JQ610573 Genomic DNA. Translation: AFF60307.1.
    JQ610574 Genomic DNA. Translation: AFF60308.1.
    JQ610575 Genomic DNA. Translation: AFF60309.1.
    JQ610576 Genomic DNA. Translation: AFF60310.1.
    JQ610577 Genomic DNA. Translation: AFF60311.1.
    JQ610578 Genomic DNA. Translation: AFF60312.1.
    JQ610579 Genomic DNA. Translation: AFF60313.1.
    JQ610580 Genomic DNA. Translation: AFF60314.1.
    JQ610581 Genomic DNA. Translation: AFF60315.1.
    JQ610582 Genomic DNA. Translation: AFF60316.1.
    JQ610583 Genomic DNA. Translation: AFF60317.1.
    JQ610585 Genomic DNA. Translation: AFF60319.1.
    JQ610586 Genomic DNA. Translation: AFF60320.1.
    JQ610587 Genomic DNA. Translation: AFF60321.1.
    JQ610588 Genomic DNA. Translation: AFF60322.1.
    JQ610589 Genomic DNA. Translation: AFF60323.1.
    JQ610590 Genomic DNA. Translation: AFF60324.1.
    JQ610591 Genomic DNA. Translation: AFF60325.1.
    JQ610592 Genomic DNA. Translation: AFF60326.1.
    JQ610593 Genomic DNA. Translation: AFF60327.1.
    JQ610594 Genomic DNA. Translation: AFF60328.1.
    JQ610595 Genomic DNA. Translation: AFF60329.1.
    JQ610596 Genomic DNA. Translation: AFF60330.1.
    JQ610597 Genomic DNA. Translation: AFF60331.1.
    JQ610598 Genomic DNA. Translation: AFF60332.1.
    JQ610599 Genomic DNA. Translation: AFF60333.1.
    JQ610600 Genomic DNA. Translation: AFF60334.1.
    JQ610601 Genomic DNA. Translation: AFF60335.1.
    JQ610602 Genomic DNA. Translation: AFF60336.1.
    JQ610603 Genomic DNA. Translation: AFF60337.1.
    JQ610604 Genomic DNA. Translation: AFF60338.1.
    JQ610605 Genomic DNA. Translation: AFF60339.1.
    JQ610606 Genomic DNA. Translation: AFF60340.1.
    JQ610607 Genomic DNA. Translation: AFF60341.1.
    JQ610608 Genomic DNA. Translation: AFF60342.1.
    JQ610609 Genomic DNA. Translation: AFF60343.1.
    JQ610610 Genomic DNA. Translation: AFF60344.1.
    JQ610611 Genomic DNA. Translation: AFF60345.1.
    JQ610613 Genomic DNA. Translation: AFF60347.1.
    JQ610614 Genomic DNA. Translation: AFF60348.1.
    JQ610615 Genomic DNA. Translation: AFF60349.1.
    JQ610616 Genomic DNA. Translation: AFF60350.1.
    JQ610617 Genomic DNA. Translation: AFF60351.1.
    JQ610618 Genomic DNA. Translation: AFF60352.1.
    JQ610620 Genomic DNA. Translation: AFF60354.1.
    JQ610621 Genomic DNA. Translation: AFF60355.1.
    BT006892 mRNA. Translation: AAP35538.1.
    AK292173 mRNA. Translation: BAF84862.1.
    AC136475 Genomic DNA. No translation available.
    CH891444 Genomic DNA. Translation: EAW50866.1.
    BC006794 mRNA. Translation: AAH06794.1.
    BC008417 mRNA. Translation: AAH08417.1.
    BC022439 mRNA. Translation: AAH22439.1.
    BC070243 mRNA. Translation: AAH70243.1.
    CCDSiCCDS41585.1.
    PIRiS17182.
    RefSeqiNP_066362.2. NM_021034.2.
    UniGeneiHs.374650.

    Genome annotation databases

    EnsembliENST00000399808; ENSP00000382707; ENSG00000142089.
    GeneIDi10410.
    KEGGihsa:10410.
    UCSCiuc001lpa.2. human.

    Polymorphism databases

    DMDMi20178301.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X57352 mRNA. Translation: CAA40626.1 .
    JQ610571 Genomic DNA. Translation: AFF60305.1 .
    JQ610572 Genomic DNA. Translation: AFF60306.1 .
    JQ610573 Genomic DNA. Translation: AFF60307.1 .
    JQ610574 Genomic DNA. Translation: AFF60308.1 .
    JQ610575 Genomic DNA. Translation: AFF60309.1 .
    JQ610576 Genomic DNA. Translation: AFF60310.1 .
    JQ610577 Genomic DNA. Translation: AFF60311.1 .
    JQ610578 Genomic DNA. Translation: AFF60312.1 .
    JQ610579 Genomic DNA. Translation: AFF60313.1 .
    JQ610580 Genomic DNA. Translation: AFF60314.1 .
    JQ610581 Genomic DNA. Translation: AFF60315.1 .
    JQ610582 Genomic DNA. Translation: AFF60316.1 .
    JQ610583 Genomic DNA. Translation: AFF60317.1 .
    JQ610585 Genomic DNA. Translation: AFF60319.1 .
    JQ610586 Genomic DNA. Translation: AFF60320.1 .
    JQ610587 Genomic DNA. Translation: AFF60321.1 .
    JQ610588 Genomic DNA. Translation: AFF60322.1 .
    JQ610589 Genomic DNA. Translation: AFF60323.1 .
    JQ610590 Genomic DNA. Translation: AFF60324.1 .
    JQ610591 Genomic DNA. Translation: AFF60325.1 .
    JQ610592 Genomic DNA. Translation: AFF60326.1 .
    JQ610593 Genomic DNA. Translation: AFF60327.1 .
    JQ610594 Genomic DNA. Translation: AFF60328.1 .
    JQ610595 Genomic DNA. Translation: AFF60329.1 .
    JQ610596 Genomic DNA. Translation: AFF60330.1 .
    JQ610597 Genomic DNA. Translation: AFF60331.1 .
    JQ610598 Genomic DNA. Translation: AFF60332.1 .
    JQ610599 Genomic DNA. Translation: AFF60333.1 .
    JQ610600 Genomic DNA. Translation: AFF60334.1 .
    JQ610601 Genomic DNA. Translation: AFF60335.1 .
    JQ610602 Genomic DNA. Translation: AFF60336.1 .
    JQ610603 Genomic DNA. Translation: AFF60337.1 .
    JQ610604 Genomic DNA. Translation: AFF60338.1 .
    JQ610605 Genomic DNA. Translation: AFF60339.1 .
    JQ610606 Genomic DNA. Translation: AFF60340.1 .
    JQ610607 Genomic DNA. Translation: AFF60341.1 .
    JQ610608 Genomic DNA. Translation: AFF60342.1 .
    JQ610609 Genomic DNA. Translation: AFF60343.1 .
    JQ610610 Genomic DNA. Translation: AFF60344.1 .
    JQ610611 Genomic DNA. Translation: AFF60345.1 .
    JQ610613 Genomic DNA. Translation: AFF60347.1 .
    JQ610614 Genomic DNA. Translation: AFF60348.1 .
    JQ610615 Genomic DNA. Translation: AFF60349.1 .
    JQ610616 Genomic DNA. Translation: AFF60350.1 .
    JQ610617 Genomic DNA. Translation: AFF60351.1 .
    JQ610618 Genomic DNA. Translation: AFF60352.1 .
    JQ610620 Genomic DNA. Translation: AFF60354.1 .
    JQ610621 Genomic DNA. Translation: AFF60355.1 .
    BT006892 mRNA. Translation: AAP35538.1 .
    AK292173 mRNA. Translation: BAF84862.1 .
    AC136475 Genomic DNA. No translation available.
    CH891444 Genomic DNA. Translation: EAW50866.1 .
    BC006794 mRNA. Translation: AAH06794.1 .
    BC008417 mRNA. Translation: AAH08417.1 .
    BC022439 mRNA. Translation: AAH22439.1 .
    BC070243 mRNA. Translation: AAH70243.1 .
    CCDSi CCDS41585.1.
    PIRi S17182.
    RefSeqi NP_066362.2. NM_021034.2.
    UniGenei Hs.374650.

    3D structure databases

    ProteinModelPortali Q01628.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115681. 4 interactions.
    IntActi Q01628. 1 interaction.
    MINTi MINT-2805186.
    STRINGi 9606.ENSP00000382707.

    PTM databases

    PhosphoSitei Q01628.

    Polymorphism databases

    DMDMi 20178301.

    Proteomic databases

    MaxQBi Q01628.
    PaxDbi Q01628.
    PRIDEi Q01628.

    Protocols and materials databases

    DNASUi 10410.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000399808 ; ENSP00000382707 ; ENSG00000142089 .
    GeneIDi 10410.
    KEGGi hsa:10410.
    UCSCi uc001lpa.2. human.

    Organism-specific databases

    CTDi 10410.
    GeneCardsi GC11M000319.
    HGNCi HGNC:5414. IFITM3.
    HPAi HPA004337.
    MIMi 605579. gene.
    614680. phenotype.
    neXtProti NX_Q01628.
    PharmGKBi PA29655.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG26698.
    HOGENOMi HOG000115781.
    HOVERGENi HBG001182.
    KOi K06566.
    OMAi VLIFQAY.
    OrthoDBi EOG7288T5.
    PhylomeDBi Q01628.
    TreeFami TF334894.

    Enzyme and pathway databases

    Reactomei REACT_25162. Interferon alpha/beta signaling.

    Miscellaneous databases

    GeneWikii IFITM3.
    GenomeRNAii 10410.
    NextBioi 39457.
    PROi Q01628.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q01628.
    Bgeei Q01628.
    CleanExi HS_IFITM3.
    Genevestigatori Q01628.

    Family and domain databases

    InterProi IPR007593. CD225/Dispanin_fam.
    [Graphical view ]
    Pfami PF04505. Dispanin. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular analysis of a human interferon-inducible gene family."
      Lewin A.R., Reid L.E., McMahon M., Stark G.R., Kerr I.M.
      Eur. J. Biochem. 199:417-423(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], INVOLVEMENT IN SUSCEPTIBILITY TO SEVERE INFLUENZA INFECTION.
    3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-3.
      Tissue: Brain, Cervix and Vascular endothelial cell.
    8. "The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus."
      Brass A.L., Huang I.C., Benita Y., John S.P., Krishnan M.N., Feeley E.M., Ryan B.J., Weyer J.L., van der Weyden L., Fikrig E., Adams D.J., Xavier R.J., Farzan M., Elledge S.J.
      Cell 139:1243-1254(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN VIRAL RESISTANCE.
    9. "Identification of five interferon-induced cellular proteins that inhibit west nile virus and dengue virus infections."
      Jiang D., Weidner J.M., Qing M., Pan X.B., Guo H., Xu C., Zhang X., Birk A., Chang J., Shi P.Y., Block T.M., Guo J.T.
      J. Virol. 84:8332-8341(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    10. "Interferon-induced cell membrane proteins, IFITM3 and tetherin, inhibit vesicular stomatitis virus infection via distinct mechanisms."
      Weidner J.M., Jiang D., Pan X.B., Chang J., Block T.M., Guo J.T.
      J. Virol. 84:12646-12657(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    11. "Interferon-induced transmembrane 3 binds osteopontin in vitro: expressed in vivo IFITM3 reduced OPN expression."
      El-Tanani M.K., Jin D., Campbell F.C., Johnston P.G.
      Oncogene 29:752-762(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SPP1.
    12. "Palmitoylome profiling reveals S-palmitoylation-dependent antiviral activity of IFITM3."
      Yount J.S., Moltedo B., Yang Y.Y., Charron G., Moran T.M., Lopez C.B., Hang H.C.
      Nat. Chem. Biol. 6:610-614(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PALMITOYLATION AT CYS-71; CYS-72 AND CYS-105.
    13. "The small interferon-induced transmembrane genes and proteins."
      Siegrist F., Ebeling M., Certa U.
      J. Interferon Cytokine Res. 31:183-197(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    14. "The IFITM proteins inhibit HIV-1 infection."
      Lu J., Pan Q., Rong L., He W., Liu S.L., Liang C.
      J. Virol. 85:2126-2137(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    15. Erratum
      Lu J., Pan Q., Rong L., He W., Liu S.L., Liang C.
      J. Virol. 85:4043-4043(2011)
    16. Cited for: FUNCTION, SUBCELLULAR LOCATION.
    17. Cited for: FUNCTION.
    18. "S-palmitoylation and ubiquitination differentially regulate interferon-induced transmembrane protein 3 (IFITM3)-mediated resistance to influenza virus."
      Yount J.S., Karssemeijer R.A., Hang H.C.
      J. Biol. Chem. 287:19631-19641(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: UBIQUITINATION AT LYS-24; LYS-83; LYS-88 AND LYS-104, PALMITOYLATION, TOPOLOGY, ABSENCE OF GLYCOSYLATION, SUBCELLULAR LOCATION.
    19. "IFITM proteins restrict antibody-dependent enhancement of dengue virus infection."
      Chan Y.K., Huang I.C., Farzan M.
      PLoS ONE 7:E34508-E34508(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    20. "The dispanins: a novel gene family of ancient origin that contains 14 human members."
      Sallman Almen M., Bringeland N., Fredriksson R., Schioth H.B.
      PLoS ONE 7:E31961-E31961(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY.
    21. "The antiviral effector IFITM3 disrupts intracellular cholesterol homeostasis to block viral entry."
      Amini-Bavil-Olyaee S., Choi Y.J., Lee J.H., Shi M., Huang I.C., Farzan M., Jung J.U.
      Cell Host Microbe 13:452-464(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH VAPA.

    Entry informationi

    Entry nameiIFM3_HUMAN
    AccessioniPrimary (citable) accession number: Q01628
    Secondary accession number(s): Q53Y76, Q96HK8, Q96J15
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: April 16, 2002
    Last modified: October 1, 2014
    This is version 122 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3