Reviewed, UniProtKB/Swiss-Prot Q01628 (IFM3_HUMAN)

Names and origin

Protein names

Recommended name:
    Interferon-induced transmembrane protein 3
Alternative name(s):
    Interferon-inducible protein 1-8U

Gene names

Name:

IFITM3

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	133 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Induction	By alpha and gamma interferons.
Sequence similarities	Belongs to the CD225 family.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane
Gene Ontology (GO)
Biological process	immune response Ref.1 Traceable author statement. Source: ProtInc response to biotic stimulus Inferred from electronic annotation. Source: InterPro
Cellular component	Golgi apparatus Inferred from direct assay. Source: HPA integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from direct assay. Source: LIFEdb
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 133	133	Interferon-induced transmembrane protein 3		PRO_0000153729
Regions
	Transmembrane	58 – 78	21	Potential
	Transmembrane	108 – 128	21	Potential
Natural variations
	Natural variant	3	1	H → Q: dbSNP rs1136853. Ref.2		VAR_053810
Experimental info
	Sequence conflict	2	1	N → S in CAA40626. Ref.1
	Sequence conflict	34	1	A → G in CAA40626. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q01628-1 [UniParc]. Last modified April 16, 2002. Version 2. Checksum: 9FFB2E4623F7A1DD	FASTA	133	14,632
	10 20 30 40 50 60 MNHTVQTFFS PVNSGQPPNY EMLKEEHEVA VLGAPHNPAP PTSTVIHIRS ETSVPDHVVW 70 80 90 100 110 120 SLFNTLFMNP CCLGFIAFAY SVKSRDRKMV GDVTGAQAYA STAKCLNIWA LILGILMTIL 130 LIVIPVLIFQ AYG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular analysis of a human interferon-inducible gene family." Lewin A.R., Reid L.E., McMahon M., Stark G.R., Kerr I.M. Eur. J. Biochem. 199:417-423(1991) [PubMed: 1906403] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-3. Tissue: Brain, Cervix and Vascular endothelial cell.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X57352 mRNA. Translation: CAA40626.1. BC006794 mRNA. Translation: AAH06794.1. BC008417 mRNA. Translation: AAH08417.1. BC022439 mRNA. Translation: AAH22439.1. BC070243 mRNA. Translation: AAH70243.1.
IPI	IPI00303726.
PIR	S17182.
RefSeq	NP_066362.2.
UniGene	Hs.374650
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q01628.
Proteomic databases
PRIDE	Q01628.
Genome annotation databases
Ensembl	ENSG00000142089. Homo sapiens. [Contig view]
GeneID	10410.
KEGG	hsa:10410.
Organism-specific databases
GeneCards	GC11M000309.
H-InvDB	HIX0021368. HIX0033464. HIX0034662. HIX0037244.
HGNC	HGNC:5414. IFITM3.
HPA	HPA004337.
MIM	605579. gene.
PharmGKB	PA29655.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q01628.
OMA	Q01628. PHGSASV.
Gene expression databases
Bgee	Q01628.
CleanEx	HS_IFITM3.
Family and domain databases
InterPro	IPR007593. Interferon-induced_TM_protein. [Graphical view]
Pfam	PF04505. CD225. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	39457.
SOURCE	Search...

Entry information

Entry name

IFM3_HUMAN

Accession

Primary (citable) accession number: Q01628
Secondary accession number(s): Q96HK8, Q96J15

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	April 16, 2002
Last modified:	June 16, 2009
This is version 75 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)