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Q01604

- PGK_DROME

UniProt

Q01604 - PGK_DROME

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Protein
Phosphoglycerate kinase
Gene
Pgk, CG3127
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei38 – 381Substrate By similarity
Binding sitei121 – 1211Substrate By similarity
Binding sitei169 – 1691Substrate By similarity
Binding sitei218 – 2181ATP By similarity
Binding sitei311 – 3111ATP; via carbonyl oxygen By similarity
Binding sitei342 – 3421ATP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi371 – 3744ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB
  2. phosphoglycerate kinase activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. glycolytic process Source: UniProtKB-UniPathway
  2. muscle cell cellular homeostasis Source: FlyBase
  3. phosphorylation Source: UniProtKB
  4. synaptic transmission Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_206319. Glycolysis.
REACT_220315. Gluconeogenesis.
UniPathwayiUPA00109; UER00185.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinase (EC:2.7.2.3)
Gene namesi
Name:Pgk
ORF Names:CG3127
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0250906. Pgk.

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. M band Source: FlyBase
  2. Z disc Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 415415Phosphoglycerate kinaseUniRule annotation
PRO_0000145843Add
BLAST

Proteomic databases

PaxDbiQ01604.
PRIDEiQ01604.

Expressioni

Gene expression databases

BgeeiQ01604.

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

BioGridi59686. 35 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ01604.
SMRiQ01604. Positions 4-414.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni23 – 253Substrate binding By similarity
Regioni62 – 654Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0126.
GeneTreeiENSGT00390000008820.
HOGENOMiHOG000242304.
InParanoidiQ01604.
KOiK00927.
OMAiASCCAKW.
OrthoDBiEOG74R1QN.
PhylomeDBiQ01604.

Family and domain databases

Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q01604-1 [UniParc]FASTAAdd to Basket

« Hide

MAFNKLSIEN LDLAGKRVLM RVDFNVPIKE GKITSNQRIV AALDSIKLAL    50
SKKAKSVVLM SHLGRPDGNK NIKYTLAPVA AELKTLLGQD VIFLSDCVGS 100
EVEAACKDPA PGSVILLENV RFYVEEEGKG LDASGGKVKA DPAKVKEFRA 150
SLAKLGDVYV NDAFGTAHRA HSSMMGDGFE QRAAGLLLNK ELKYFSQALD 200
KPPNPFLAIL GGAKVADKIQ LIENLLDKVN EMIIGGGMAF TFLKVLNNMK 250
IGGSLFDEEG SKIVEKLVEK AKKNNVQLHL PVDFVCGDKF AENAAVSEAT 300
VEAGIPDGHM GLDVGPKTRE LFAAPIARAK LIVWNGPPGV FEFPNFANGT 350
KSIMDGVVAA TKNGTVSIIG GGDTASCCAK WNTEALVSHV STGGGASLEL 400
LEGKTLPGVA ALTSA 415
Length:415
Mass (Da):43,862
Last modified:June 1, 2001 - v2
Checksum:i7D1225FCC81F8B42
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti388 – 3881S → A in strain: HFL97_3e2. 1 Publication

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti410 – 4101A → R in CAA78404. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z14029 Genomic DNA. Translation: CAA78404.1.
DQ863952 Genomic DNA. Translation: ABH06587.1.
DQ863953 Genomic DNA. Translation: ABH06588.1.
DQ863954 Genomic DNA. Translation: ABH06589.1.
DQ863955 Genomic DNA. Translation: ABH06590.1.
DQ863956 Genomic DNA. Translation: ABH06591.1.
DQ863957 Genomic DNA. Translation: ABH06592.1.
DQ863958 Genomic DNA. Translation: ABH06593.1.
DQ863959 Genomic DNA. Translation: ABH06594.1.
DQ863960 Genomic DNA. Translation: ABH06595.1.
DQ863961 Genomic DNA. Translation: ABH06596.1.
DQ863962 Genomic DNA. Translation: ABH06597.1.
DQ863963 Genomic DNA. Translation: ABH06598.1.
DQ863964 Genomic DNA. Translation: ABH06599.1.
DQ863965 Genomic DNA. Translation: ABH06600.1.
DQ863966 Genomic DNA. Translation: ABH06601.1.
DQ863967 Genomic DNA. Translation: ABH06602.1.
DQ863968 Genomic DNA. Translation: ABH06603.1.
DQ863969 Genomic DNA. Translation: ABH06604.1.
DQ863970 Genomic DNA. Translation: ABH06605.1.
DQ863971 Genomic DNA. Translation: ABH06606.1.
DQ863972 Genomic DNA. Translation: ABH06607.1.
DQ863973 Genomic DNA. Translation: ABH06608.1.
DQ863974 Genomic DNA. Translation: ABH06609.1.
DQ863975 Genomic DNA. Translation: ABH06610.1.
DQ863976 Genomic DNA. Translation: ABH06611.1.
AE014134 Genomic DNA. Translation: AAF51218.1.
BT023910 mRNA. Translation: ABA81844.1.
PIRiS30111. KIFFPG.
RefSeqiNP_001259956.1. NM_001273027.1.
NP_001259957.1. NM_001273028.1.
NP_001259958.1. NM_001273029.1.
NP_001259959.1. NM_001273030.1.
NP_476676.1. NM_057328.4.
UniGeneiDm.6415.

Genome annotation databases

EnsemblMetazoaiFBtr0077739; FBpp0077419; FBgn0250906.
FBtr0330716; FBpp0303560; FBgn0250906.
FBtr0330717; FBpp0303561; FBgn0250906.
FBtr0330718; FBpp0303562; FBgn0250906.
GeneIDi33461.
KEGGidme:Dmel_CG3127.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z14029 Genomic DNA. Translation: CAA78404.1 .
DQ863952 Genomic DNA. Translation: ABH06587.1 .
DQ863953 Genomic DNA. Translation: ABH06588.1 .
DQ863954 Genomic DNA. Translation: ABH06589.1 .
DQ863955 Genomic DNA. Translation: ABH06590.1 .
DQ863956 Genomic DNA. Translation: ABH06591.1 .
DQ863957 Genomic DNA. Translation: ABH06592.1 .
DQ863958 Genomic DNA. Translation: ABH06593.1 .
DQ863959 Genomic DNA. Translation: ABH06594.1 .
DQ863960 Genomic DNA. Translation: ABH06595.1 .
DQ863961 Genomic DNA. Translation: ABH06596.1 .
DQ863962 Genomic DNA. Translation: ABH06597.1 .
DQ863963 Genomic DNA. Translation: ABH06598.1 .
DQ863964 Genomic DNA. Translation: ABH06599.1 .
DQ863965 Genomic DNA. Translation: ABH06600.1 .
DQ863966 Genomic DNA. Translation: ABH06601.1 .
DQ863967 Genomic DNA. Translation: ABH06602.1 .
DQ863968 Genomic DNA. Translation: ABH06603.1 .
DQ863969 Genomic DNA. Translation: ABH06604.1 .
DQ863970 Genomic DNA. Translation: ABH06605.1 .
DQ863971 Genomic DNA. Translation: ABH06606.1 .
DQ863972 Genomic DNA. Translation: ABH06607.1 .
DQ863973 Genomic DNA. Translation: ABH06608.1 .
DQ863974 Genomic DNA. Translation: ABH06609.1 .
DQ863975 Genomic DNA. Translation: ABH06610.1 .
DQ863976 Genomic DNA. Translation: ABH06611.1 .
AE014134 Genomic DNA. Translation: AAF51218.1 .
BT023910 mRNA. Translation: ABA81844.1 .
PIRi S30111. KIFFPG.
RefSeqi NP_001259956.1. NM_001273027.1.
NP_001259957.1. NM_001273028.1.
NP_001259958.1. NM_001273029.1.
NP_001259959.1. NM_001273030.1.
NP_476676.1. NM_057328.4.
UniGenei Dm.6415.

3D structure databases

ProteinModelPortali Q01604.
SMRi Q01604. Positions 4-414.
ModBasei Search...

Protein-protein interaction databases

BioGridi 59686. 35 interactions.

Proteomic databases

PaxDbi Q01604.
PRIDEi Q01604.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0077739 ; FBpp0077419 ; FBgn0250906 .
FBtr0330716 ; FBpp0303560 ; FBgn0250906 .
FBtr0330717 ; FBpp0303561 ; FBgn0250906 .
FBtr0330718 ; FBpp0303562 ; FBgn0250906 .
GeneIDi 33461.
KEGGi dme:Dmel_CG3127.

Organism-specific databases

CTDi 33461.
FlyBasei FBgn0250906. Pgk.

Phylogenomic databases

eggNOGi COG0126.
GeneTreei ENSGT00390000008820.
HOGENOMi HOG000242304.
InParanoidi Q01604.
KOi K00927.
OMAi ASCCAKW.
OrthoDBi EOG74R1QN.
PhylomeDBi Q01604.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00185 .
Reactomei REACT_206319. Glycolysis.
REACT_220315. Gluconeogenesis.

Miscellaneous databases

ChiTaRSi PRKG1. drosophila.
GenomeRNAii 33461.
NextBioi 783688.

Gene expression databases

Bgeei Q01604.

Family and domain databases

Gene3Di 3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPi MF_00145. Phosphoglyc_kinase.
InterProi IPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view ]
PANTHERi PTHR11406. PTHR11406. 1 hit.
Pfami PF00162. PGK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000724. Pgk. 1 hit.
PRINTSi PR00477. PHGLYCKINASE.
SUPFAMi SSF53748. SSF53748. 1 hit.
PROSITEi PS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structure and expression of the phosphoglycerate kinase (Pgk) gene of Drosophila melanogaster."
    Roselli-Rehfuss L., Ye F., Lissemore J.L., Sullivan D.T.
    Mol. Gen. Genet. 235:213-220(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Oregon-R.
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ALA-388.
    Strain: DPF96_10, DPF96_26, DPF96_5.1, DPF96_8.3, HFL97_15e, HFL97_23e, HFL97_3e2, HFL97_61e, HFL97_68e, MA96_24.2, MA96_26.4, MA96_3.5, MA96_4.4, MA96_40.1, MA96_42.4, MA96_49.2, MA96_9.3, Z(H)_26e2, Z(H)_28e2, Z(H)_36e2, Z(H)_38e2, Z(H)_44e2, Z(S)_11e2, Z(S)_28e2 and Z(S)_49e2.
  3. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  4. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  5. Stapleton M., Carlson J.W., Frise E., Kapadia B., Park S., Wan K.H., Yu C., Celniker S.E.
    Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
    Tissue: Head.

Entry informationi

Entry nameiPGK_DROME
AccessioniPrimary (citable) accession number: Q01604
Secondary accession number(s): A5XCG6, Q3KN29, Q9VQF6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: June 1, 2001
Last modified: September 3, 2014
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi