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Protein

Peroxidase

Gene

Pxd

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in the chorion hardening process, through protein cross-linking mediated by the formation of di- and tri-tyrosine bonds.1 Publication

Catalytic activityi

2 phenolic donor + H2O2 = 2 phenoxyl radical of the donor + 2 H2O.

Cofactori

heme bBy similarityNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei185Proton acceptorPROSITE-ProRule annotation1
Sitei331Transition state stabilizerPROSITE-ProRule annotation1
Metal bindingi437Iron (heme axial ligand)PROSITE-ProRule annotation1

GO - Molecular functioni

  • heme binding Source: InterPro
  • metal ion binding Source: UniProtKB-KW
  • peroxidase activity Source: FlyBase

GO - Biological processi

  • eggshell chorion assembly Source: FlyBase
  • hydrogen peroxide catabolic process Source: UniProtKB-KW
  • response to ethanol Source: FlyBase
  • response to oxidative stress Source: InterPro

Keywordsi

Molecular functionOxidoreductase, Peroxidase
Biological processHydrogen peroxide
LigandHeme, Iron, Metal-binding

Protein family/group databases

PeroxiBasei4118 DmPxt02-A

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxidase (EC:1.11.1.7)
Short name:
DmPO
Alternative name(s):
Chorion peroxidase
Gene namesi
Name:Pxd
Synonyms:HDC14047, PO
ORF Names:CG3477
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0004577 Pxd

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000002363821 – 690PeroxidaseAdd BLAST670

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi100 ↔ 112PROSITE-ProRule annotation
Glycosylationi310N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi315 ↔ 324PROSITE-ProRule annotation
Disulfide bondi536 ↔ 592PROSITE-ProRule annotation
Disulfide bondi636 ↔ 662PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ01603
PRIDEiQ01603

Expressioni

Gene expression databases

BgeeiFBgn0004577
ExpressionAtlasiQ01603 baseline and differential
GenevisibleiQ01603 DM

Interactioni

Protein-protein interaction databases

IntActiQ01603, 1 interactor
STRINGi7227.FBpp0088343

Structurei

3D structure databases

ProteinModelPortaliQ01603
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. XPO subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2408 Eukaryota
ENOG410XPZ3 LUCA
GeneTreeiENSGT00550000074325
InParanoidiQ01603
OMAiWIDQKPY
OrthoDBiEOG091G00D8
PhylomeDBiQ01603

Family and domain databases

Gene3Di1.10.640.10, 1 hit
InterProiView protein in InterPro
IPR010255 Haem_peroxidase
IPR019791 Haem_peroxidase_animal
IPR037120 Haem_peroxidase_sf
IPR029585 Pxd-like
PANTHERiPTHR11475:SF86 PTHR11475:SF86, 1 hit
PfamiView protein in Pfam
PF03098 An_peroxidase, 1 hit
PRINTSiPR00457 ANPEROXIDASE
SUPFAMiSSF48113 SSF48113, 1 hit
PROSITEiView protein in PROSITE
PS50292 PEROXIDASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q01603-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIRARDLLLL ALLGFISSAL GLKVSSGYHI VHNQPQSSFP NYHGFSYLQG
60 70 80 90 100
SAPYVIGNSL PTSPAPQNPF SSPASPPVSA YGYSFPTAGR VSCAAPPAVC
110 120 130 140 150
EKTAYRTLDG SCNHLEQPGL GVANSKYGRL LTPKYADGIS APTRSVTGDE
160 170 180 190 200
LPSARLVSLV AFGEQDVPDP EFTLHNMQWG QIMTHDMSMQ AGGTQSKKHP
210 220 230 240 250
TRCCTDDGRL IGLDTAHKTC FAIIVPPHDP AYSQVGTECL NFVRTLTDRD
260 270 280 290 300
SNCQYQGGPA EQLTVVTSYL DLSLVYGNSI QQNSDIREFQ GGRMIVEERN
310 320 330 340 350
GAKWLPLSRN VTGDCDAVDA SEVCYRSGDV RVNQNPGLAI LQTILLREHN
360 370 380 390 400
RIADALSALN PHYDDRTLFQ EARKINIAQY QQISYYEWLP IFLGGENMLK
410 420 430 440 450
NRLIYKAPSG SYINDFDPNI DPSVLNEHAT AAFRYFHSQI EGRLDLLSEL
460 470 480 490 500
RQVLGSLTLS DWFNRPGIIE VGDNFDSLTR GHATQPEELT DINFDRQIKH
510 520 530 540 550
FLFRRNMPFG SDLRSLDIQR NRDHGLASYN DMREFCGLRR AHSWEGYGDL
560 570 580 590 600
ISPPILEKLK SLYPSHEDVD LTVGASLEAH VAGALAGPTF LCILTEQFYR
610 620 630 640 650
TRVGDRFFFE NGDKLTGFTP DQLEELRKAS MARLLCDNGN HISSMQPEAF
660 670 680 690
RTVSHSNPII PCSNIPQVDL TKWIDQKLYA TVDPSHYGKK
Length:690
Mass (Da):76,719
Last modified:March 2, 2010 - v2
Checksum:i51BC6F450A8773C0
GO

Sequence cautioni

The sequence DAA04104 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti584A → T in CAA48238 (PubMed:1482687).Curated1
Sequence conflicti584A → T in AAS48542 (PubMed:15979004).Curated1
Sequence conflicti678L → P in CAA48238 (PubMed:1482687).Curated1
Sequence conflicti678L → P in AAS48542 (PubMed:15979004).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68131 Genomic DNA Translation: CAA48238.1
AY541497 mRNA Translation: AAS48542.1
AE014297 Genomic DNA Translation: AAS65161.1
BK002598 Genomic DNA Translation: DAA04104.1 Different initiation.
PIRiS28222
RefSeqiNP_001163633.1, NM_001170162.2
NP_996223.1, NM_206501.3
UniGeneiDm.31257

Genome annotation databases

EnsemblMetazoaiFBtr0089287; FBpp0088343; FBgn0004577
FBtr0301526; FBpp0290741; FBgn0004577
GeneIDi2768671
KEGGidme:Dmel_CG3477
UCSCiCG3477-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiPERO_DROME
AccessioniPrimary (citable) accession number: Q01603
Secondary accession number(s): Q6IJW8, Q7KSF9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: March 2, 2010
Last modified: May 23, 2018
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

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