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Protein

Glutathione S-transferase theta-1

Gene

Gstt1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Also binds steroids, bilirubin, carcinogens and numerous organic anions. Has dichloromethane dehalogenase activity.1 Publication

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei40 – 401GlutathioneBy similarity

GO - Molecular functioni

  • alkylhalidase activity Source: RGD
  • glutathione peroxidase activity Source: RGD
  • glutathione transferase activity Source: UniProtKB

GO - Biological processi

  • dichloromethane metabolic process Source: RGD
  • DNA modification Source: RGD
  • glutathione metabolic process Source: UniProtKB
  • response to drug Source: RGD
  • response to organic cyclic compound Source: RGD
  • response to salicylic acid Source: RGD
  • response to selenium ion Source: RGD
  • response to vitamin E Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Enzyme and pathway databases

SABIO-RKQ01579.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase theta-1 (EC:2.5.1.18)
Alternative name(s):
GST 5-5
GST class-theta-1
Glutathione S-transferase 5
Gene namesi
Name:Gstt1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi2765. Gstt1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL2423.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved
Chaini2 – 240239Glutathione S-transferase theta-1PRO_0000185942Add
BLAST

Proteomic databases

PaxDbiQ01579.
PRIDEiQ01579.

PTM databases

iPTMnetiQ01579.
PhosphoSiteiQ01579.

Expressioni

Tissue specificityi

In liver, highest expression found in central vein limiting plate hepatocytes. In lung, expressed mainly in Clara cells of the bronchiolar epithelium and, at low levels, in type II alveolar cells.1 Publication

Gene expression databases

BgeeiENSRNOG00000049771.
ExpressionAtlasiQ01579. baseline and differential.
GenevisibleiQ01579. RN.

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001669.

Chemistry

BindingDBiQ01579.

Structurei

3D structure databases

ProteinModelPortaliQ01579.
SMRiQ01579. Positions 3-240.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 8281GST N-terminalAdd
BLAST
Domaini88 – 223136GST C-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni53 – 542Glutathione bindingBy similarity
Regioni66 – 672Glutathione bindingBy similarity

Sequence similaritiesi

Belongs to the GST superfamily. Theta family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

eggNOGiKOG0867. Eukaryota.
COG0625. LUCA.
GeneTreeiENSGT00540000069741.
HOGENOMiHOG000125747.
HOVERGENiHBG051854.
InParanoidiQ01579.
KOiK00799.
OMAiTVKQKLM.
OrthoDBiEOG091G0PCG.
PhylomeDBiQ01579.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q01579-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLELYLDLL SQPCRAIYIF AKKNNIPFQM HTVELRKGEH LSDAFAQVNP
60 70 80 90 100
MKKVPAMKDG GFTLCESVAI LLYLAHKYKV PDHWYPQDLQ ARARVDEYLA
110 120 130 140 150
WQHTTLRRSC LRTLWHKVMF PVFLGEQIRP EMLAATLADL DVNVQVLEDQ
160 170 180 190 200
FLQDKDFLVG PHISLADVVA ITELMHPVGG GCPVFEGRPR LAAWYRRVEA
210 220 230 240
AVGKDLFLEA HEVILKVRDC PPADPVIKQK LMPRVLTMIQ
Length:240
Mass (Da):27,468
Last modified:January 23, 2007 - v2
Checksum:i09583ACF9C85DF8F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67654 mRNA. Translation: CAA47896.1.
BC086426 mRNA. Translation: AAH86426.1.
PIRiS27161.
RefSeqiNP_445745.1. NM_053293.2.
UniGeneiRn.11122.

Genome annotation databases

EnsembliENSRNOT00000001669; ENSRNOP00000001669; ENSRNOG00000049771.
GeneIDi25260.
KEGGirno:25260.
UCSCiRGD:2765. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67654 mRNA. Translation: CAA47896.1.
BC086426 mRNA. Translation: AAH86426.1.
PIRiS27161.
RefSeqiNP_445745.1. NM_053293.2.
UniGeneiRn.11122.

3D structure databases

ProteinModelPortaliQ01579.
SMRiQ01579. Positions 3-240.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001669.

Chemistry

BindingDBiQ01579.
ChEMBLiCHEMBL2423.

PTM databases

iPTMnetiQ01579.
PhosphoSiteiQ01579.

Proteomic databases

PaxDbiQ01579.
PRIDEiQ01579.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000001669; ENSRNOP00000001669; ENSRNOG00000049771.
GeneIDi25260.
KEGGirno:25260.
UCSCiRGD:2765. rat.

Organism-specific databases

CTDi2952.
RGDi2765. Gstt1.

Phylogenomic databases

eggNOGiKOG0867. Eukaryota.
COG0625. LUCA.
GeneTreeiENSGT00540000069741.
HOGENOMiHOG000125747.
HOVERGENiHBG051854.
InParanoidiQ01579.
KOiK00799.
OMAiTVKQKLM.
OrthoDBiEOG091G0PCG.
PhylomeDBiQ01579.

Enzyme and pathway databases

SABIO-RKQ01579.

Miscellaneous databases

PROiQ01579.

Gene expression databases

BgeeiENSRNOG00000049771.
ExpressionAtlasiQ01579. baseline and differential.
GenevisibleiQ01579. RN.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGSTT1_RAT
AccessioniPrimary (citable) accession number: Q01579
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.