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Q01579

- GSTT1_RAT

UniProt

Q01579 - GSTT1_RAT

Protein

Glutathione S-transferase theta-1

Gene

Gstt1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Also binds steroids, bilirubin, carcinogens and numerous organic anions. Has dichloromethane dehalogenase activity.1 Publication

    Catalytic activityi

    RX + glutathione = HX + R-S-glutathione.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei40 – 401GlutathioneBy similarity

    GO - Molecular functioni

    1. alkylhalidase activity Source: RGD
    2. glutathione peroxidase activity Source: RGD
    3. glutathione transferase activity Source: UniProtKB

    GO - Biological processi

    1. dichloromethane metabolic process Source: RGD
    2. DNA modification Source: RGD
    3. glutathione metabolic process Source: UniProtKB
    4. oxidation-reduction process Source: GOC
    5. response to drug Source: RGD
    6. response to organic cyclic compound Source: RGD
    7. response to salicylic acid Source: RGD
    8. response to selenium ion Source: RGD
    9. response to vitamin E Source: RGD

    Keywords - Molecular functioni

    Transferase

    Enzyme and pathway databases

    SABIO-RKQ01579.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutathione S-transferase theta-1 (EC:2.5.1.18)
    Alternative name(s):
    GST 5-5
    GST class-theta-1
    Glutathione S-transferase 5
    Gene namesi
    Name:Gstt1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 20

    Organism-specific databases

    RGDi2765. Gstt1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: RGD

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed
    Chaini2 – 240239Glutathione S-transferase theta-1PRO_0000185942Add
    BLAST

    Proteomic databases

    PaxDbiQ01579.
    PRIDEiQ01579.

    Expressioni

    Tissue specificityi

    In liver, highest expression found in central vein limiting plate hepatocytes. In lung, expressed mainly in Clara cells of the bronchiolar epithelium and, at low levels, in type II alveolar cells.1 Publication

    Gene expression databases

    GenevestigatoriQ01579.

    Interactioni

    Subunit structurei

    Homodimer.

    Structurei

    3D structure databases

    ProteinModelPortaliQ01579.
    SMRiQ01579. Positions 3-240.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 8281GST N-terminalAdd
    BLAST
    Domaini88 – 223136GST C-terminalAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni53 – 542Glutathione bindingBy similarity
    Regioni66 – 672Glutathione bindingBy similarity

    Sequence similaritiesi

    Belongs to the GST superfamily. Theta family.Curated
    Contains 1 GST C-terminal domain.Curated
    Contains 1 GST N-terminal domain.Curated

    Phylogenomic databases

    eggNOGiCOG0625.
    GeneTreeiENSGT00540000069741.
    HOGENOMiHOG000125747.
    HOVERGENiHBG051854.
    KOiK00799.
    OMAiTVKQKLM.
    OrthoDBiEOG7GTT59.
    PhylomeDBiQ01579.

    Family and domain databases

    Gene3Di1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProiIPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PfamiPF00043. GST_C. 1 hit.
    PF02798. GST_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEiPS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q01579-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVLELYLDLL SQPCRAIYIF AKKNNIPFQM HTVELRKGEH LSDAFAQVNP    50
    MKKVPAMKDG GFTLCESVAI LLYLAHKYKV PDHWYPQDLQ ARARVDEYLA 100
    WQHTTLRRSC LRTLWHKVMF PVFLGEQIRP EMLAATLADL DVNVQVLEDQ 150
    FLQDKDFLVG PHISLADVVA ITELMHPVGG GCPVFEGRPR LAAWYRRVEA 200
    AVGKDLFLEA HEVILKVRDC PPADPVIKQK LMPRVLTMIQ 240
    Length:240
    Mass (Da):27,468
    Last modified:January 23, 2007 - v2
    Checksum:i09583ACF9C85DF8F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X67654 mRNA. Translation: CAA47896.1.
    BC086426 mRNA. Translation: AAH86426.1.
    PIRiS27161.
    RefSeqiNP_445745.1. NM_053293.2.
    UniGeneiRn.11122.

    Genome annotation databases

    EnsembliENSRNOT00000001669; ENSRNOP00000001669; ENSRNOG00000049771.
    GeneIDi25260.
    KEGGirno:25260.
    UCSCiRGD:2765. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X67654 mRNA. Translation: CAA47896.1 .
    BC086426 mRNA. Translation: AAH86426.1 .
    PIRi S27161.
    RefSeqi NP_445745.1. NM_053293.2.
    UniGenei Rn.11122.

    3D structure databases

    ProteinModelPortali Q01579.
    SMRi Q01579. Positions 3-240.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi Q01579.
    ChEMBLi CHEMBL2423.

    Proteomic databases

    PaxDbi Q01579.
    PRIDEi Q01579.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000001669 ; ENSRNOP00000001669 ; ENSRNOG00000049771 .
    GeneIDi 25260.
    KEGGi rno:25260.
    UCSCi RGD:2765. rat.

    Organism-specific databases

    CTDi 2952.
    RGDi 2765. Gstt1.

    Phylogenomic databases

    eggNOGi COG0625.
    GeneTreei ENSGT00540000069741.
    HOGENOMi HOG000125747.
    HOVERGENi HBG051854.
    KOi K00799.
    OMAi TVKQKLM.
    OrthoDBi EOG7GTT59.
    PhylomeDBi Q01579.

    Enzyme and pathway databases

    SABIO-RK Q01579.

    Miscellaneous databases

    NextBioi 605907.
    PROi Q01579.

    Gene expression databases

    Genevestigatori Q01579.

    Family and domain databases

    Gene3Di 1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProi IPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    Pfami PF00043. GST_C. 1 hit.
    PF02798. GST_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEi PS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "An evolutionary perspective on glutathione transferases inferred from class-theta glutathione transferase cDNA sequences."
      Pemble S.E., Taylor J.B.
      Biochem. J. 287:957-963(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Wistar.
      Tissue: Liver.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Ovary.
    3. "Theta, a new class of glutathione transferases purified from rat and man."
      Meyer D.J., Coles B., Pemble S.E., Gilmore K.S., Fraser G.M., Ketterer B.
      Biochem. J. 274:409-414(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: PRELIMINARY PROTEIN SEQUENCE OF 2-47; 58-95; 120-131 AND 176-193.
      Tissue: Liver.
    4. "The distribution of theta-class glutathione S-transferases in the liver and lung of mouse, rat and human."
      Mainwaring G.W., Williams S.M., Foster J.R., Tugwood J., Green T.
      Biochem. J. 318:297-303(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
      Tissue: Liver and Lung.
    5. "Residue 234 is a master switch of the alternative-substrate activity profile of human and rodent theta class glutathione transferase T1-1."
      Shokeer A., Mannervik B.
      Biochim. Biophys. Acta 1800:466-473(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, CATALYTIC ACTIVITY.

    Entry informationi

    Entry nameiGSTT1_RAT
    AccessioniPrimary (citable) accession number: Q01579
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 105 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3