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Q01579

- GSTT1_RAT

UniProt

Q01579 - GSTT1_RAT

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Protein

Glutathione S-transferase theta-1

Gene

Gstt1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Also binds steroids, bilirubin, carcinogens and numerous organic anions. Has dichloromethane dehalogenase activity.1 Publication

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei40 – 401GlutathioneBy similarity

GO - Molecular functioni

  1. alkylhalidase activity Source: RGD
  2. glutathione peroxidase activity Source: RGD
  3. glutathione transferase activity Source: UniProtKB

GO - Biological processi

  1. dichloromethane metabolic process Source: RGD
  2. DNA modification Source: RGD
  3. glutathione metabolic process Source: UniProtKB
  4. oxidation-reduction process Source: GOC
  5. response to drug Source: RGD
  6. response to organic cyclic compound Source: RGD
  7. response to salicylic acid Source: RGD
  8. response to selenium ion Source: RGD
  9. response to vitamin E Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Enzyme and pathway databases

SABIO-RKQ01579.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase theta-1 (EC:2.5.1.18)
Alternative name(s):
GST 5-5
GST class-theta-1
Glutathione S-transferase 5
Gene namesi
Name:Gstt1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 20

Organism-specific databases

RGDi2765. Gstt1.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed
Chaini2 – 240239Glutathione S-transferase theta-1PRO_0000185942Add
BLAST

Proteomic databases

PaxDbiQ01579.
PRIDEiQ01579.

Expressioni

Tissue specificityi

In liver, highest expression found in central vein limiting plate hepatocytes. In lung, expressed mainly in Clara cells of the bronchiolar epithelium and, at low levels, in type II alveolar cells.1 Publication

Gene expression databases

ExpressionAtlasiQ01579. baseline.
GenevestigatoriQ01579.

Interactioni

Subunit structurei

Homodimer.

Structurei

3D structure databases

ProteinModelPortaliQ01579.
SMRiQ01579. Positions 3-240.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 8281GST N-terminalAdd
BLAST
Domaini88 – 223136GST C-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni53 – 542Glutathione bindingBy similarity
Regioni66 – 672Glutathione bindingBy similarity

Sequence similaritiesi

Belongs to the GST superfamily. Theta family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

eggNOGiCOG0625.
GeneTreeiENSGT00540000069741.
HOGENOMiHOG000125747.
HOVERGENiHBG051854.
InParanoidiQ01579.
KOiK00799.
OMAiTVKQKLM.
OrthoDBiEOG7GTT59.
PhylomeDBiQ01579.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q01579-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVLELYLDLL SQPCRAIYIF AKKNNIPFQM HTVELRKGEH LSDAFAQVNP
60 70 80 90 100
MKKVPAMKDG GFTLCESVAI LLYLAHKYKV PDHWYPQDLQ ARARVDEYLA
110 120 130 140 150
WQHTTLRRSC LRTLWHKVMF PVFLGEQIRP EMLAATLADL DVNVQVLEDQ
160 170 180 190 200
FLQDKDFLVG PHISLADVVA ITELMHPVGG GCPVFEGRPR LAAWYRRVEA
210 220 230 240
AVGKDLFLEA HEVILKVRDC PPADPVIKQK LMPRVLTMIQ
Length:240
Mass (Da):27,468
Last modified:January 23, 2007 - v2
Checksum:i09583ACF9C85DF8F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X67654 mRNA. Translation: CAA47896.1.
BC086426 mRNA. Translation: AAH86426.1.
PIRiS27161.
RefSeqiNP_445745.1. NM_053293.2.
UniGeneiRn.11122.

Genome annotation databases

EnsembliENSRNOT00000001669; ENSRNOP00000001669; ENSRNOG00000049771.
GeneIDi25260.
KEGGirno:25260.
UCSCiRGD:2765. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X67654 mRNA. Translation: CAA47896.1 .
BC086426 mRNA. Translation: AAH86426.1 .
PIRi S27161.
RefSeqi NP_445745.1. NM_053293.2.
UniGenei Rn.11122.

3D structure databases

ProteinModelPortali Q01579.
SMRi Q01579. Positions 3-240.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi Q01579.
ChEMBLi CHEMBL2423.

Proteomic databases

PaxDbi Q01579.
PRIDEi Q01579.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000001669 ; ENSRNOP00000001669 ; ENSRNOG00000049771 .
GeneIDi 25260.
KEGGi rno:25260.
UCSCi RGD:2765. rat.

Organism-specific databases

CTDi 2952.
RGDi 2765. Gstt1.

Phylogenomic databases

eggNOGi COG0625.
GeneTreei ENSGT00540000069741.
HOGENOMi HOG000125747.
HOVERGENi HBG051854.
InParanoidi Q01579.
KOi K00799.
OMAi TVKQKLM.
OrthoDBi EOG7GTT59.
PhylomeDBi Q01579.

Enzyme and pathway databases

SABIO-RK Q01579.

Miscellaneous databases

NextBioi 605907.
PROi Q01579.

Gene expression databases

ExpressionAtlasi Q01579. baseline.
Genevestigatori Q01579.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view ]
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "An evolutionary perspective on glutathione transferases inferred from class-theta glutathione transferase cDNA sequences."
    Pemble S.E., Taylor J.B.
    Biochem. J. 287:957-963(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
    Tissue: Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.
  3. "Theta, a new class of glutathione transferases purified from rat and man."
    Meyer D.J., Coles B., Pemble S.E., Gilmore K.S., Fraser G.M., Ketterer B.
    Biochem. J. 274:409-414(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: PRELIMINARY PROTEIN SEQUENCE OF 2-47; 58-95; 120-131 AND 176-193.
    Tissue: Liver.
  4. "The distribution of theta-class glutathione S-transferases in the liver and lung of mouse, rat and human."
    Mainwaring G.W., Williams S.M., Foster J.R., Tugwood J., Green T.
    Biochem. J. 318:297-303(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
    Tissue: Liver and Lung.
  5. "Residue 234 is a master switch of the alternative-substrate activity profile of human and rodent theta class glutathione transferase T1-1."
    Shokeer A., Mannervik B.
    Biochim. Biophys. Acta 1800:466-473(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, CATALYTIC ACTIVITY.

Entry informationi

Entry nameiGSTT1_RAT
AccessioniPrimary (citable) accession number: Q01579
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3