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Protein

Cytochrome c oxidase subunit 2

Gene

COX2

Organism
Trichophyton rubrum (Athlete's foot fungus) (Epidermophyton rubrum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Cu cationNote: Binds a copper A center.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi176Copper ACurated1
Metal bindingi211Copper ACurated1
Metal bindingi215Copper ACurated1
Metal bindingi219Copper ACurated1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandCopper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:COX2
Encoded oniMitochondrion
OrganismiTrichophyton rubrum (Athlete's foot fungus) (Epidermophyton rubrum)
Taxonomic identifieri5551 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaeTrichophyton

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 30Mitochondrial intermembraneSequence analysisAdd BLAST30
Transmembranei31 – 51HelicalSequence analysisAdd BLAST21
Topological domaini52 – 67Mitochondrial matrixSequence analysisAdd BLAST16
Transmembranei68 – 94HelicalSequence analysisAdd BLAST27
Topological domaini95 – 237Mitochondrial intermembraneSequence analysisAdd BLAST143

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001837061 – 237Cytochrome c oxidase subunit 2Add BLAST237

Structurei

3D structure databases

ProteinModelPortaliQ01556
SMRiQ01556
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

CDDicd13912 CcO_II_C, 1 hit
Gene3Di1.10.287.90, 1 hit
2.60.40.420, 1 hit
InterProiView protein in InterPro
IPR002429 CcO_II-like_C
IPR034210 CcO_II_C
IPR001505 Copper_CuA
IPR008972 Cupredoxin
IPR011759 Cyt_c_oxidase_su2_TM_dom
IPR036257 Cyt_c_oxidase_su2_TM_sf
PfamiView protein in Pfam
PF00116 COX2, 1 hit
PF02790 COX2_TM, 1 hit
SUPFAMiSSF49503 SSF49503, 1 hit
SSF81464 SSF81464, 1 hit
PROSITEiView protein in PROSITE
PS00078 COX2, 1 hit
PS50857 COX2_CUA, 1 hit
PS50999 COX2_TM, 1 hit

Sequencei

Sequence statusi: Complete.

Q01556-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLVAPTPWG LFFQDSATPQ MEGIEELHNN IMFYLTIILF SVTWMMITII
60 70 80 90 100
KSFVNTKSPI SHKYMNHGTL IELIWTITPA VILILIAFPS FKLLYLMDEV
110 120 130 140 150
MDPSLVIYGE GHQWYWSYQY PDFTNADGEF VEFDSYIVPE SDLEEGTLRM
160 170 180 190 200
LEVDNRVIIP ELTHTRFVIS AADVIHSFAC PSLGIKCDAY PGRLNQSSVY
210 220 230
LNRQGTYFGQ CSEICGILHS SMPIVIQSVS LKNFYYD
Length:237
Mass (Da):27,154
Last modified:June 1, 1994 - v1
Checksum:i56CBADE880426C2D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65223 Genomic DNA Translation: CAA46327.1
PIRiS26949

Similar proteinsi

Entry informationi

Entry nameiCOX2_TRIRU
AccessioniPrimary (citable) accession number: Q01556
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: March 28, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health