Q01556 (COX2_TRIRU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 2
EC=1.9.3.1

Alternative name(s):
Cytochrome c oxidase polypeptide II

Gene names

Name:

COX2

Encoded on

Mitochondrion

Organism

Trichophyton rubrum (Athlete's foot fungus) (Epidermophyton rubrum)

Taxonomic identifier

5551 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › Eurotiomycetes › Eurotiomycetidae › Onygenales › Arthrodermataceae › mitosporic Arthrodermataceae › Trichophyton

Protein attributes

Sequence length	237 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.
Catalytic activity	4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
Cofactor	Copper A.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the cytochrome c oxidase subunit 2 family.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transmembrane Transmembrane helix
Ligand	Copper Metal-binding
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological_process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	copper ion binding Inferred from electronic annotation. Source: InterPro cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 237	237	Cytochrome c oxidase subunit 2		PRO_0000183706
Regions
	Topological domain	1 – 30	30	Mitochondrial intermembrane Potential
	Transmembrane	31 – 51	21	Helical; Potential
	Topological domain	52 – 67	16	Mitochondrial matrix Potential
	Transmembrane	68 – 94	27	Helical; Potential
	Topological domain	95 – 237	143	Mitochondrial intermembrane Potential
Sites
	Metal binding	176	1	Copper A Probable
	Metal binding	211	1	Copper A Probable
	Metal binding	215	1	Copper A Probable
	Metal binding	219	1	Copper A Probable

Sequences

	Sequence		Length	Mass (Da)
	Q01556 [UniParc]. Last modified June 1, 1994. Version 1. Checksum: 56CBADE880426C2D	FASTA	237	27,154
	10 20 30 40 50 60 MNLVAPTPWG LFFQDSATPQ MEGIEELHNN IMFYLTIILF SVTWMMITII KSFVNTKSPI 70 80 90 100 110 120 SHKYMNHGTL IELIWTITPA VILILIAFPS FKLLYLMDEV MDPSLVIYGE GHQWYWSYQY 130 140 150 160 170 180 PDFTNADGEF VEFDSYIVPE SDLEEGTLRM LEVDNRVIIP ELTHTRFVIS AADVIHSFAC 190 200 210 220 230 PSLGIKCDAY PGRLNQSSVY LNRQGTYFGQ CSEICGILHS SMPIVIQSVS LKNFYYD

References

[1]

"Mitochondrial DNA sequence analysis of the cytochrome oxidase subunit I and II genes, the ATPase9 gene, the NADH dehydrogenase ND4L and ND5 gene complex, and the glutaminyl, methionyl and arginyl tRNA genes from Trichophyton rubrum." de Bievre C., Dujon B. Curr. Genet. 22:229-234(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: IP 1817.89.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X65223 Genomic DNA. Translation: CAA46327.1.
PIR	S26949.
3D structure databases
ProteinModelPortal	Q01556.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	1.10.287.90. 1 hit. 2.60.40.420. 1 hit.
InterPro	IPR001505. Copper_CuA. IPR008972. Cupredoxin. IPR002429. Cyt_c_oxidase_su2_C. IPR011759. Cyt_c_oxidase_su2_TM_dom. [Graphical view]
Pfam	PF00116. COX2. 1 hit. PF02790. COX2_TM. 1 hit. [Graphical view]
SUPFAM	SSF49503. Cupredoxin. 1 hit. SSF81464. Cyt_c_oxidase_II-like_TM. 1 hit.
PROSITE	PS00078. COX2. 1 hit. PS50857. COX2_CUA. 1 hit. PS50999. COX2_TM. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COX2_TRIRU

Accession

Primary (citable) accession number: Q01556

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	May 1, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program