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Q01556 (COX2_TRIRU) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 2

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene names
Name:COX2
Encoded onMitochondrion
OrganismTrichophyton rubrum (Athlete's foot fungus) (Epidermophyton rubrum)
Taxonomic identifier5551 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaemitosporic ArthrodermataceaeTrichophyton

Protein attributes

Sequence length237 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Copper A.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 237237Cytochrome c oxidase subunit 2
PRO_0000183706

Regions

Topological domain1 – 3030Mitochondrial intermembrane Potential
Transmembrane31 – 5121Helical; Potential
Topological domain52 – 6716Mitochondrial matrix Potential
Transmembrane68 – 9427Helical; Potential
Topological domain95 – 237143Mitochondrial intermembrane Potential

Sites

Metal binding1761Copper A Probable
Metal binding2111Copper A Probable
Metal binding2151Copper A Probable
Metal binding2191Copper A Probable

Sequences

Sequence LengthMass (Da)Tools
Q01556 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: 56CBADE880426C2D

FASTA23727,154
        10         20         30         40         50         60 
MNLVAPTPWG LFFQDSATPQ MEGIEELHNN IMFYLTIILF SVTWMMITII KSFVNTKSPI 

        70         80         90        100        110        120 
SHKYMNHGTL IELIWTITPA VILILIAFPS FKLLYLMDEV MDPSLVIYGE GHQWYWSYQY 

       130        140        150        160        170        180 
PDFTNADGEF VEFDSYIVPE SDLEEGTLRM LEVDNRVIIP ELTHTRFVIS AADVIHSFAC 

       190        200        210        220        230 
PSLGIKCDAY PGRLNQSSVY LNRQGTYFGQ CSEICGILHS SMPIVIQSVS LKNFYYD 

« Hide

References

[1]"Mitochondrial DNA sequence analysis of the cytochrome oxidase subunit I and II genes, the ATPase9 gene, the NADH dehydrogenase ND4L and ND5 gene complex, and the glutaminyl, methionyl and arginyl tRNA genes from Trichophyton rubrum."
de Bievre C., Dujon B.
Curr. Genet. 22:229-234(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: IP 1817.89.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X65223 Genomic DNA. Translation: CAA46327.1.
PIRS26949.

3D structure databases

ProteinModelPortalQ01556.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
PROSITEPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX2_TRIRU
AccessionPrimary (citable) accession number: Q01556
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: April 16, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families