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Protein

Keratin, type II cytoskeletal 2 oral

Gene

KRT76

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probably contributes to terminal cornification.1 Publication

GO - Molecular functioni

GO - Biological processi

  • cytoskeleton organization Source: UniProtKB
  • epidermis development Source: Ensembl
  • sebaceous gland development Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:G66-31357-MONOMER.
ReactomeiR-HSA-6805567. Keratinization.
R-HSA-6809371. Formation of the cornified envelope.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type II cytoskeletal 2 oral
Alternative name(s):
Cytokeratin-2P
Short name:
CK-2P
Short name:
K2P
Keratin-76
Short name:
K76
Type-II keratin Kb9
Gene namesi
Name:KRT76
Synonyms:KRT2B, KRT2P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:24430. KRT76.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • intermediate filament Source: UniProtKB
  • keratin filament Source: InterPro
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

Pathology & Biotechi

Organism-specific databases

DisGeNETi51350.
OpenTargetsiENSG00000185069.
PharmGKBiPA147357785.

Polymorphism and mutation databases

BioMutaiKRT76.
DMDMi317373371.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000637141 – 638Keratin, type II cytoskeletal 2 oralAdd BLAST638

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei18PhosphoserineBy similarity1
Modified residuei21PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ01546.
PaxDbiQ01546.
PeptideAtlasiQ01546.
PRIDEiQ01546.

PTM databases

iPTMnetiQ01546.
PhosphoSitePlusiQ01546.
SwissPalmiQ01546.

Expressioni

Developmental stagei

Synthesized during maturation of epidermal keratinocytes.1 Publication

Gene expression databases

BgeeiENSG00000185069.
CleanExiHS_KRT76.
GenevisibleiQ01546. HS.

Organism-specific databases

HPAiHPA019656.
HPA019696.

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins.

Protein-protein interaction databases

BioGridi119492. 9 interactors.
IntActiQ01546. 37 interactors.
STRINGi9606.ENSP00000330101.

Structurei

3D structure databases

ProteinModelPortaliQ01546.
SMRiQ01546.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 182HeadAdd BLAST182
Regioni183 – 492RodAdd BLAST310
Regioni183 – 218Coil 1AAdd BLAST36
Regioni219 – 237Linker 1Add BLAST19
Regioni238 – 329Coil 1BAdd BLAST92
Regioni330 – 353Linker 12Add BLAST24
Regioni354 – 492Coil 2Add BLAST139
Regioni493 – 638TailAdd BLAST146

Sequence similaritiesi

Belongs to the intermediate filament family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IKBD. Eukaryota.
ENOG4111UGN. LUCA.
GeneTreeiENSGT00760000118796.
HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiQ01546.
KOiK07605.
OMAiECQSAVC.
OrthoDBiEOG091G09KR.
PhylomeDBiQ01546.
TreeFamiTF317854.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR032444. Keratin_2_head.
IPR003054. Keratin_II.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 3 hits.
PfamiPF00038. Filament. 1 hit.
PF16208. Keratin_2_head. 1 hit.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q01546-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNRQVCKKSF SGRSQGFSGR SAVVSGSSRM SCVARSGGAG GGACGFRSGA
60 70 80 90 100
GSFGSRSLYN LGSNKSISIS VAAGSSRAGG FGGGRSSCGF AGGYGGGFGG
110 120 130 140 150
SYGGGFGGGR GVGSGFGGAG GFGGAGGFGG PGVFGGPGSF GGPGGFGPGG
160 170 180 190 200
FPGGIQEVIV NQSLLQPLNV EIDPQIGQVK AQEREQIKTL NNKFASFIDK
210 220 230 240 250
VRFLEQQNKV LETKWELLQQ QTTGSGPSSL EPCFESYISF LCKQLDSLLG
260 270 280 290 300
ERGNLEGELK SMQDLVEDFK KKYEDEINKR TAAENEFVGL KKDVDAAFMN
310 320 330 340 350
KVELQAKVDS LTDEVSFLRT LYEMELSQMQ SHASDTSVVL SMDNNRCLDL
360 370 380 390 400
GSIIAEVRAQ YEEIAQRSKS EAEALYQTKL GELQTTAGRH GDDLRNTKSE
410 420 430 440 450
IMELNRMIQR LRAEIENVKK QNANLQTAIA EAEQRGEMAL KDANAKLQDL
460 470 480 490 500
QTALQKAKDD LARLLRDYQE LMNVKLALDV EIATYRKLLE GEECRMSGEC
510 520 530 540 550
QSAVCISVVS NVTSTSGSSG SSRGVFGGVS GSGSGGYKGG SSSSSSSGYG
560 570 580 590 600
VSGGSGSGYG GVSSGSTGGR GSSGSYQSSS SGSRLGGAGS ISVSHSGMGS
610 620 630
SSGSIQTSGG SGYKSGGGGS TSIRFSQTTS SSQHSSTK
Length:638
Mass (Da):65,841
Last modified:January 11, 2011 - v2
Checksum:i6A312B8260BE06A9
GO

Sequence cautioni

The sequence BAG61375 differs from that shown. Reason: Erroneous termination at position 267. Translated as Glu.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti356E → K in BAG61375 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036368168L → V in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_028425283A → T.Corresponds to variant rs11170271dbSNPEnsembl.1
Natural variantiVAR_028426359A → T.Combined sources1 PublicationCorresponds to variant rs6580904dbSNPEnsembl.1
Natural variantiVAR_028427629T → M.Corresponds to variant rs2280480dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M99063 mRNA. Translation: AAA35746.1.
AJ564103 Genomic DNA. Translation: CAD91891.1.
AK299390 mRNA. Translation: BAG61375.1. Sequence problems.
AC068988 Genomic DNA. No translation available.
AC139763 Genomic DNA. No translation available.
CCDSiCCDS8838.1.
PIRiI53169.
RefSeqiNP_056932.2. NM_015848.4.
UniGeneiHs.654392.

Genome annotation databases

EnsembliENST00000332411; ENSP00000330101; ENSG00000185069.
GeneIDi51350.
KEGGihsa:51350.
UCSCiuc001sax.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Intermediate Filament Mutation Database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M99063 mRNA. Translation: AAA35746.1.
AJ564103 Genomic DNA. Translation: CAD91891.1.
AK299390 mRNA. Translation: BAG61375.1. Sequence problems.
AC068988 Genomic DNA. No translation available.
AC139763 Genomic DNA. No translation available.
CCDSiCCDS8838.1.
PIRiI53169.
RefSeqiNP_056932.2. NM_015848.4.
UniGeneiHs.654392.

3D structure databases

ProteinModelPortaliQ01546.
SMRiQ01546.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119492. 9 interactors.
IntActiQ01546. 37 interactors.
STRINGi9606.ENSP00000330101.

PTM databases

iPTMnetiQ01546.
PhosphoSitePlusiQ01546.
SwissPalmiQ01546.

Polymorphism and mutation databases

BioMutaiKRT76.
DMDMi317373371.

Proteomic databases

EPDiQ01546.
PaxDbiQ01546.
PeptideAtlasiQ01546.
PRIDEiQ01546.

Protocols and materials databases

DNASUi51350.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000332411; ENSP00000330101; ENSG00000185069.
GeneIDi51350.
KEGGihsa:51350.
UCSCiuc001sax.3. human.

Organism-specific databases

CTDi51350.
DisGeNETi51350.
GeneCardsiKRT76.
H-InvDBHIX0036895.
HGNCiHGNC:24430. KRT76.
HPAiHPA019656.
HPA019696.
MIMi616671. gene.
neXtProtiNX_Q01546.
OpenTargetsiENSG00000185069.
PharmGKBiPA147357785.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKBD. Eukaryota.
ENOG4111UGN. LUCA.
GeneTreeiENSGT00760000118796.
HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiQ01546.
KOiK07605.
OMAiECQSAVC.
OrthoDBiEOG091G09KR.
PhylomeDBiQ01546.
TreeFamiTF317854.

Enzyme and pathway databases

BioCyciZFISH:G66-31357-MONOMER.
ReactomeiR-HSA-6805567. Keratinization.
R-HSA-6809371. Formation of the cornified envelope.

Miscellaneous databases

GenomeRNAii51350.
PROiQ01546.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000185069.
CleanExiHS_KRT76.
GenevisibleiQ01546. HS.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR032444. Keratin_2_head.
IPR003054. Keratin_II.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 3 hits.
PfamiPF00038. Filament. 1 hit.
PF16208. Keratin_2_head. 1 hit.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiK22O_HUMAN
AccessioniPrimary (citable) accession number: Q01546
Secondary accession number(s): B4DRR3, Q7Z795
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: January 11, 2011
Last modified: November 30, 2016
This is version 140 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.