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Protein

Keratin, type II cytoskeletal 2 oral

Gene

KRT76

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probably contributes to terminal cornification.1 Publication

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

GO - Molecular functioni

GO - Biological processi

  • cornification Source: Reactome
  • cytoskeleton organization Source: UniProtKB
  • keratinization Source: Reactome
  • pigmentation Source: Ensembl
  • sebaceous gland development Source: Ensembl

Enzyme and pathway databases

ReactomeiR-HSA-6805567 Keratinization
R-HSA-6809371 Formation of the cornified envelope

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type II cytoskeletal 2 oral
Alternative name(s):
Cytokeratin-2P
Short name:
CK-2P
Short name:
K2P
Keratin-76
Short name:
K76
Type-II keratin Kb9
Gene namesi
Name:KRT76
Synonyms:KRT2B, KRT2P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000185069.2
HGNCiHGNC:24430 KRT76
MIMi616671 gene
neXtProtiNX_Q01546

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filament, Keratin

Pathology & Biotechi

Organism-specific databases

DisGeNETi51350
OpenTargetsiENSG00000185069
PharmGKBiPA147357785

Polymorphism and mutation databases

BioMutaiKRT76
DMDMi317373371

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000637141 – 638Keratin, type II cytoskeletal 2 oralAdd BLAST638

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei21PhosphoserineBy similarity1
Modified residuei57PhosphoserineBy similarity1
Modified residuei279N6,N6-dimethyllysineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ01546
PaxDbiQ01546
PeptideAtlasiQ01546
PRIDEiQ01546

PTM databases

iPTMnetiQ01546
PhosphoSitePlusiQ01546
SwissPalmiQ01546

Expressioni

Developmental stagei

Synthesized during maturation of epidermal keratinocytes.1 Publication

Gene expression databases

BgeeiENSG00000185069
CleanExiHS_KRT76
GenevisibleiQ01546 HS

Organism-specific databases

HPAiHPA019656
HPA019696

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins.

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi119492, 9 interactors
IntActiQ01546, 43 interactors

Structurei

3D structure databases

ProteinModelPortaliQ01546
SMRiQ01546
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini183 – 496IF rodPROSITE-ProRule annotationAdd BLAST314

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 182HeadAdd BLAST182
Regioni183 – 218Coil 1AAdd BLAST36
Regioni219 – 237Linker 1Add BLAST19
Regioni238 – 329Coil 1BAdd BLAST92
Regioni330 – 353Linker 12Add BLAST24
Regioni354 – 492Coil 2Add BLAST139
Regioni493 – 638TailAdd BLAST146

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IKBD Eukaryota
ENOG4111UGN LUCA
GeneTreeiENSGT00760000118796
HOGENOMiHOG000230976
HOVERGENiHBG013015
InParanoidiQ01546
KOiK07605
OMAiECQSAVC
OrthoDBiEOG091G09KR
PhylomeDBiQ01546
TreeFamiTF317854

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR032444 Keratin_2_head
IPR003054 Keratin_II
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PF16208 Keratin_2_head, 1 hit
PRINTSiPR01276 TYPE2KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q01546-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNRQVCKKSF SGRSQGFSGR SAVVSGSSRM SCVARSGGAG GGACGFRSGA
60 70 80 90 100
GSFGSRSLYN LGSNKSISIS VAAGSSRAGG FGGGRSSCGF AGGYGGGFGG
110 120 130 140 150
SYGGGFGGGR GVGSGFGGAG GFGGAGGFGG PGVFGGPGSF GGPGGFGPGG
160 170 180 190 200
FPGGIQEVIV NQSLLQPLNV EIDPQIGQVK AQEREQIKTL NNKFASFIDK
210 220 230 240 250
VRFLEQQNKV LETKWELLQQ QTTGSGPSSL EPCFESYISF LCKQLDSLLG
260 270 280 290 300
ERGNLEGELK SMQDLVEDFK KKYEDEINKR TAAENEFVGL KKDVDAAFMN
310 320 330 340 350
KVELQAKVDS LTDEVSFLRT LYEMELSQMQ SHASDTSVVL SMDNNRCLDL
360 370 380 390 400
GSIIAEVRAQ YEEIAQRSKS EAEALYQTKL GELQTTAGRH GDDLRNTKSE
410 420 430 440 450
IMELNRMIQR LRAEIENVKK QNANLQTAIA EAEQRGEMAL KDANAKLQDL
460 470 480 490 500
QTALQKAKDD LARLLRDYQE LMNVKLALDV EIATYRKLLE GEECRMSGEC
510 520 530 540 550
QSAVCISVVS NVTSTSGSSG SSRGVFGGVS GSGSGGYKGG SSSSSSSGYG
560 570 580 590 600
VSGGSGSGYG GVSSGSTGGR GSSGSYQSSS SGSRLGGAGS ISVSHSGMGS
610 620 630
SSGSIQTSGG SGYKSGGGGS TSIRFSQTTS SSQHSSTK
Length:638
Mass (Da):65,841
Last modified:January 11, 2011 - v2
Checksum:i6A312B8260BE06A9
GO

Sequence cautioni

The sequence BAG61375 differs from that shown. Reason: Erroneous termination at position 267. Translated as Glu.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti356E → K in BAG61375 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036368168L → V in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_028425283A → T. Corresponds to variant dbSNP:rs11170271Ensembl.1
Natural variantiVAR_028426359A → TCombined sources1 PublicationCorresponds to variant dbSNP:rs6580904Ensembl.1
Natural variantiVAR_028427629T → M. Corresponds to variant dbSNP:rs2280480Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M99063 mRNA Translation: AAA35746.1
AJ564103 Genomic DNA Translation: CAD91891.1
AK299390 mRNA Translation: BAG61375.1 Sequence problems.
AC068988 Genomic DNA No translation available.
AC139763 Genomic DNA No translation available.
CCDSiCCDS8838.1
PIRiI53169
RefSeqiNP_056932.2, NM_015848.4
UniGeneiHs.654392

Genome annotation databases

EnsembliENST00000332411; ENSP00000330101; ENSG00000185069
GeneIDi51350
KEGGihsa:51350
UCSCiuc001sax.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiK22O_HUMAN
AccessioniPrimary (citable) accession number: Q01546
Secondary accession number(s): B4DRR3, Q7Z795
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: January 11, 2011
Last modified: May 23, 2018
This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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