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Q01546

- K22O_HUMAN

UniProt

Q01546 - K22O_HUMAN

Protein

Keratin, type II cytoskeletal 2 oral

Gene

KRT76

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 2 (11 Jan 2011)
      Previous versions | rss
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    Functioni

    Probably contributes to terminal cornification.1 Publication

    GO - Molecular functioni

    1. structural molecule activity Source: InterPro

    GO - Biological processi

    1. cytoskeleton organization Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Keratin, type II cytoskeletal 2 oral
    Alternative name(s):
    Cytokeratin-2P
    Short name:
    CK-2P
    Short name:
    K2P
    Keratin-76
    Short name:
    K76
    Type-II keratin Kb9
    Gene namesi
    Name:KRT76
    Synonyms:KRT2B, KRT2P
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:24430. KRT76.

    Subcellular locationi

    GO - Cellular componenti

    1. intermediate filament Source: UniProtKB
    2. keratin filament Source: InterPro
    3. nucleus Source: UniProt

    Keywords - Cellular componenti

    Intermediate filament, Keratin

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA147357785.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 638638Keratin, type II cytoskeletal 2 oralPRO_0000063714Add
    BLAST

    Proteomic databases

    MaxQBiQ01546.
    PaxDbiQ01546.
    PRIDEiQ01546.

    PTM databases

    PhosphoSiteiQ01546.

    Expressioni

    Developmental stagei

    Synthesized during maturation of epidermal keratinocytes.1 Publication

    Gene expression databases

    BgeeiQ01546.
    CleanExiHS_KRT76.
    GenevestigatoriQ01546.

    Organism-specific databases

    HPAiHPA019656.
    HPA019696.

    Interactioni

    Subunit structurei

    Heterotetramer of two type I and two type II keratins.

    Protein-protein interaction databases

    BioGridi119492. 10 interactions.
    IntActiQ01546. 3 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ01546.
    SMRiQ01546. Positions 183-322, 349-491.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 182182HeadAdd
    BLAST
    Regioni183 – 492310RodAdd
    BLAST
    Regioni183 – 21836Coil 1AAdd
    BLAST
    Regioni219 – 23719Linker 1Add
    BLAST
    Regioni238 – 32992Coil 1BAdd
    BLAST
    Regioni330 – 35324Linker 12Add
    BLAST
    Regioni354 – 492139Coil 2Add
    BLAST
    Regioni493 – 638146TailAdd
    BLAST

    Sequence similaritiesi

    Belongs to the intermediate filament family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG146968.
    HOGENOMiHOG000230976.
    HOVERGENiHBG013015.
    InParanoidiQ01546.
    KOiK07605.
    OMAiPNNLEPF.
    OrthoDBiEOG7FV3Q8.
    PhylomeDBiQ01546.
    TreeFamiTF317854.

    Family and domain databases

    InterProiIPR001664. IF.
    IPR018039. Intermediate_filament_CS.
    IPR003054. Keratin_II.
    [Graphical view]
    PANTHERiPTHR23239. PTHR23239. 1 hit.
    PfamiPF00038. Filament. 1 hit.
    [Graphical view]
    PRINTSiPR01276. TYPE2KERATIN.
    PROSITEiPS00226. IF. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q01546-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNRQVCKKSF SGRSQGFSGR SAVVSGSSRM SCVARSGGAG GGACGFRSGA    50
    GSFGSRSLYN LGSNKSISIS VAAGSSRAGG FGGGRSSCGF AGGYGGGFGG 100
    SYGGGFGGGR GVGSGFGGAG GFGGAGGFGG PGVFGGPGSF GGPGGFGPGG 150
    FPGGIQEVIV NQSLLQPLNV EIDPQIGQVK AQEREQIKTL NNKFASFIDK 200
    VRFLEQQNKV LETKWELLQQ QTTGSGPSSL EPCFESYISF LCKQLDSLLG 250
    ERGNLEGELK SMQDLVEDFK KKYEDEINKR TAAENEFVGL KKDVDAAFMN 300
    KVELQAKVDS LTDEVSFLRT LYEMELSQMQ SHASDTSVVL SMDNNRCLDL 350
    GSIIAEVRAQ YEEIAQRSKS EAEALYQTKL GELQTTAGRH GDDLRNTKSE 400
    IMELNRMIQR LRAEIENVKK QNANLQTAIA EAEQRGEMAL KDANAKLQDL 450
    QTALQKAKDD LARLLRDYQE LMNVKLALDV EIATYRKLLE GEECRMSGEC 500
    QSAVCISVVS NVTSTSGSSG SSRGVFGGVS GSGSGGYKGG SSSSSSSGYG 550
    VSGGSGSGYG GVSSGSTGGR GSSGSYQSSS SGSRLGGAGS ISVSHSGMGS 600
    SSGSIQTSGG SGYKSGGGGS TSIRFSQTTS SSQHSSTK 638
    Length:638
    Mass (Da):65,841
    Last modified:January 11, 2011 - v2
    Checksum:i6A312B8260BE06A9
    GO

    Sequence cautioni

    The sequence BAG61375.1 differs from that shown. Reason: Erroneous termination at position 267. Translated as Glu.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti356 – 3561E → K in BAG61375. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti168 – 1681L → V in a breast cancer sample; somatic mutation. 1 Publication
    VAR_036368
    Natural varianti283 – 2831A → T.
    Corresponds to variant rs11170271 [ dbSNP | Ensembl ].
    VAR_028425
    Natural varianti359 – 3591A → T.2 Publications
    Corresponds to variant rs6580904 [ dbSNP | Ensembl ].
    VAR_028426
    Natural varianti629 – 6291T → M.
    Corresponds to variant rs2280480 [ dbSNP | Ensembl ].
    VAR_028427

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M99063 mRNA. Translation: AAA35746.1.
    AJ564103 Genomic DNA. Translation: CAD91891.1.
    AK299390 mRNA. Translation: BAG61375.1. Sequence problems.
    AC068988 Genomic DNA. No translation available.
    AC139763 Genomic DNA. No translation available.
    CCDSiCCDS8838.1.
    PIRiI53169.
    RefSeqiNP_056932.2. NM_015848.4.
    UniGeneiHs.654392.

    Genome annotation databases

    EnsembliENST00000332411; ENSP00000330101; ENSG00000185069.
    GeneIDi51350.
    KEGGihsa:51350.
    UCSCiuc001sax.3. human.

    Polymorphism databases

    DMDMi317373371.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Intermediate Filament Mutation Database

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M99063 mRNA. Translation: AAA35746.1 .
    AJ564103 Genomic DNA. Translation: CAD91891.1 .
    AK299390 mRNA. Translation: BAG61375.1 . Sequence problems.
    AC068988 Genomic DNA. No translation available.
    AC139763 Genomic DNA. No translation available.
    CCDSi CCDS8838.1.
    PIRi I53169.
    RefSeqi NP_056932.2. NM_015848.4.
    UniGenei Hs.654392.

    3D structure databases

    ProteinModelPortali Q01546.
    SMRi Q01546. Positions 183-322, 349-491.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119492. 10 interactions.
    IntActi Q01546. 3 interactions.

    PTM databases

    PhosphoSitei Q01546.

    Polymorphism databases

    DMDMi 317373371.

    Proteomic databases

    MaxQBi Q01546.
    PaxDbi Q01546.
    PRIDEi Q01546.

    Protocols and materials databases

    DNASUi 51350.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000332411 ; ENSP00000330101 ; ENSG00000185069 .
    GeneIDi 51350.
    KEGGi hsa:51350.
    UCSCi uc001sax.3. human.

    Organism-specific databases

    CTDi 51350.
    GeneCardsi GC12M053161.
    H-InvDB HIX0036895.
    HGNCi HGNC:24430. KRT76.
    HPAi HPA019656.
    HPA019696.
    neXtProti NX_Q01546.
    PharmGKBi PA147357785.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG146968.
    HOGENOMi HOG000230976.
    HOVERGENi HBG013015.
    InParanoidi Q01546.
    KOi K07605.
    OMAi PNNLEPF.
    OrthoDBi EOG7FV3Q8.
    PhylomeDBi Q01546.
    TreeFami TF317854.

    Miscellaneous databases

    GenomeRNAii 51350.
    NextBioi 54802.
    PROi Q01546.

    Gene expression databases

    Bgeei Q01546.
    CleanExi HS_KRT76.
    Genevestigatori Q01546.

    Family and domain databases

    InterProi IPR001664. IF.
    IPR018039. Intermediate_filament_CS.
    IPR003054. Keratin_II.
    [Graphical view ]
    PANTHERi PTHR23239. PTHR23239. 1 hit.
    Pfami PF00038. Filament. 1 hit.
    [Graphical view ]
    PRINTSi PR01276. TYPE2KERATIN.
    PROSITEi PS00226. IF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Suprabasal marker proteins distinguishing keratinizing squamous epithelia: cytokeratin 2 polypeptides of oral masticatory epithelium and epidermis are different."
      Collin C., Ouhayoun J.P., Grund C., Franke W.W.
      Differentiation 51:137-148(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE, VARIANT THR-359.
    2. "Characterization of new members of the human type II keratin gene family and a general evaluation of the keratin gene domain on chromosome 12q13.13."
      Rogers M.A., Edler L., Winter H., Langbein L., Beckmann I., Schweizer J.
      J. Invest. Dermatol. 124:536-544(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Tongue.
    4. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: VARIANT [LARGE SCALE ANALYSIS] VAL-168.
    6. Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-359, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiK22O_HUMAN
    AccessioniPrimary (citable) accession number: Q01546
    Secondary accession number(s): B4DRR3, Q7Z795
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: January 11, 2011
    Last modified: October 1, 2014
    This is version 120 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3