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Q01546

- K22O_HUMAN

UniProt

Q01546 - K22O_HUMAN

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Protein
Keratin, type II cytoskeletal 2 oral
Gene
KRT76, KRT2B, KRT2P
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Probably contributes to terminal cornification.1 Publication

GO - Molecular functioni

  1. structural molecule activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. cytoskeleton organization Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type II cytoskeletal 2 oral
Alternative name(s):
Cytokeratin-2P
Short name:
CK-2P
Short name:
K2P
Keratin-76
Short name:
K76
Type-II keratin Kb9
Gene namesi
Name:KRT76
Synonyms:KRT2B, KRT2P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:24430. KRT76.

Subcellular locationi

GO - Cellular componenti

  1. intermediate filament Source: UniProtKB
  2. keratin filament Source: InterPro
  3. nucleus Source: UniProt
Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA147357785.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 638638Keratin, type II cytoskeletal 2 oral
PRO_0000063714Add
BLAST

Proteomic databases

MaxQBiQ01546.
PaxDbiQ01546.
PRIDEiQ01546.

PTM databases

PhosphoSiteiQ01546.

Expressioni

Developmental stagei

Synthesized during maturation of epidermal keratinocytes.1 Publication

Gene expression databases

BgeeiQ01546.
CleanExiHS_KRT76.
GenevestigatoriQ01546.

Organism-specific databases

HPAiHPA019656.
HPA019696.

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins.

Protein-protein interaction databases

BioGridi119492. 10 interactions.
IntActiQ01546. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ01546.
SMRiQ01546. Positions 183-322, 349-491.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 182182Head
Add
BLAST
Regioni183 – 492310Rod
Add
BLAST
Regioni183 – 21836Coil 1A
Add
BLAST
Regioni219 – 23719Linker 1
Add
BLAST
Regioni238 – 32992Coil 1B
Add
BLAST
Regioni330 – 35324Linker 12
Add
BLAST
Regioni354 – 492139Coil 2
Add
BLAST
Regioni493 – 638146Tail
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG146968.
HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiQ01546.
KOiK07605.
OMAiPNNLEPF.
OrthoDBiEOG7FV3Q8.
PhylomeDBiQ01546.
TreeFamiTF317854.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR003054. Keratin_II.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q01546-1 [UniParc]FASTAAdd to Basket

« Hide

MNRQVCKKSF SGRSQGFSGR SAVVSGSSRM SCVARSGGAG GGACGFRSGA    50
GSFGSRSLYN LGSNKSISIS VAAGSSRAGG FGGGRSSCGF AGGYGGGFGG 100
SYGGGFGGGR GVGSGFGGAG GFGGAGGFGG PGVFGGPGSF GGPGGFGPGG 150
FPGGIQEVIV NQSLLQPLNV EIDPQIGQVK AQEREQIKTL NNKFASFIDK 200
VRFLEQQNKV LETKWELLQQ QTTGSGPSSL EPCFESYISF LCKQLDSLLG 250
ERGNLEGELK SMQDLVEDFK KKYEDEINKR TAAENEFVGL KKDVDAAFMN 300
KVELQAKVDS LTDEVSFLRT LYEMELSQMQ SHASDTSVVL SMDNNRCLDL 350
GSIIAEVRAQ YEEIAQRSKS EAEALYQTKL GELQTTAGRH GDDLRNTKSE 400
IMELNRMIQR LRAEIENVKK QNANLQTAIA EAEQRGEMAL KDANAKLQDL 450
QTALQKAKDD LARLLRDYQE LMNVKLALDV EIATYRKLLE GEECRMSGEC 500
QSAVCISVVS NVTSTSGSSG SSRGVFGGVS GSGSGGYKGG SSSSSSSGYG 550
VSGGSGSGYG GVSSGSTGGR GSSGSYQSSS SGSRLGGAGS ISVSHSGMGS 600
SSGSIQTSGG SGYKSGGGGS TSIRFSQTTS SSQHSSTK 638
Length:638
Mass (Da):65,841
Last modified:January 11, 2011 - v2
Checksum:i6A312B8260BE06A9
GO

Sequence cautioni

The sequence BAG61375.1 differs from that shown. Reason: Erroneous termination at position 267. Translated as Glu.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti168 – 1681L → V in a breast cancer sample; somatic mutation. 1 Publication
VAR_036368
Natural varianti283 – 2831A → T.
Corresponds to variant rs11170271 [ dbSNP | Ensembl ].
VAR_028425
Natural varianti359 – 3591A → T.2 Publications
Corresponds to variant rs6580904 [ dbSNP | Ensembl ].
VAR_028426
Natural varianti629 – 6291T → M.
Corresponds to variant rs2280480 [ dbSNP | Ensembl ].
VAR_028427

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti356 – 3561E → K in BAG61375. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M99063 mRNA. Translation: AAA35746.1.
AJ564103 Genomic DNA. Translation: CAD91891.1.
AK299390 mRNA. Translation: BAG61375.1. Sequence problems.
AC068988 Genomic DNA. No translation available.
AC139763 Genomic DNA. No translation available.
CCDSiCCDS8838.1.
PIRiI53169.
RefSeqiNP_056932.2. NM_015848.4.
UniGeneiHs.654392.

Genome annotation databases

EnsembliENST00000332411; ENSP00000330101; ENSG00000185069.
GeneIDi51350.
KEGGihsa:51350.
UCSCiuc001sax.3. human.

Polymorphism databases

DMDMi317373371.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Intermediate Filament Mutation Database

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M99063 mRNA. Translation: AAA35746.1 .
AJ564103 Genomic DNA. Translation: CAD91891.1 .
AK299390 mRNA. Translation: BAG61375.1 . Sequence problems.
AC068988 Genomic DNA. No translation available.
AC139763 Genomic DNA. No translation available.
CCDSi CCDS8838.1.
PIRi I53169.
RefSeqi NP_056932.2. NM_015848.4.
UniGenei Hs.654392.

3D structure databases

ProteinModelPortali Q01546.
SMRi Q01546. Positions 183-322, 349-491.
ModBasei Search...

Protein-protein interaction databases

BioGridi 119492. 10 interactions.
IntActi Q01546. 3 interactions.

PTM databases

PhosphoSitei Q01546.

Polymorphism databases

DMDMi 317373371.

Proteomic databases

MaxQBi Q01546.
PaxDbi Q01546.
PRIDEi Q01546.

Protocols and materials databases

DNASUi 51350.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000332411 ; ENSP00000330101 ; ENSG00000185069 .
GeneIDi 51350.
KEGGi hsa:51350.
UCSCi uc001sax.3. human.

Organism-specific databases

CTDi 51350.
GeneCardsi GC12M053161.
H-InvDB HIX0036895.
HGNCi HGNC:24430. KRT76.
HPAi HPA019656.
HPA019696.
neXtProti NX_Q01546.
PharmGKBi PA147357785.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG146968.
HOGENOMi HOG000230976.
HOVERGENi HBG013015.
InParanoidi Q01546.
KOi K07605.
OMAi PNNLEPF.
OrthoDBi EOG7FV3Q8.
PhylomeDBi Q01546.
TreeFami TF317854.

Miscellaneous databases

GenomeRNAii 51350.
NextBioi 54802.
PROi Q01546.

Gene expression databases

Bgeei Q01546.
CleanExi HS_KRT76.
Genevestigatori Q01546.

Family and domain databases

InterProi IPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR003054. Keratin_II.
[Graphical view ]
PANTHERi PTHR23239. PTHR23239. 1 hit.
Pfami PF00038. Filament. 1 hit.
[Graphical view ]
PRINTSi PR01276. TYPE2KERATIN.
PROSITEi PS00226. IF. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Suprabasal marker proteins distinguishing keratinizing squamous epithelia: cytokeratin 2 polypeptides of oral masticatory epithelium and epidermis are different."
    Collin C., Ouhayoun J.P., Grund C., Franke W.W.
    Differentiation 51:137-148(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE, VARIANT THR-359.
  2. "Characterization of new members of the human type II keratin gene family and a general evaluation of the keratin gene domain on chromosome 12q13.13."
    Rogers M.A., Edler L., Winter H., Langbein L., Beckmann I., Schweizer J.
    J. Invest. Dermatol. 124:536-544(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Tongue.
  4. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: VARIANT [LARGE SCALE ANALYSIS] VAL-168.
  6. Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-359, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiK22O_HUMAN
AccessioniPrimary (citable) accession number: Q01546
Secondary accession number(s): B4DRR3, Q7Z795
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: January 11, 2011
Last modified: July 9, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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