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Q01543

- FLI1_HUMAN

UniProt

Q01543 - FLI1_HUMAN

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Protein

Friend leukemia integration 1 transcription factor

Gene

FLI1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Sequence-specific transcriptional activator. Recognizes the DNA sequence 5'-C[CA]GGAAGT-3'.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi281 – 36181ETSPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. chromatin binding Source: Ensembl
  2. DNA binding Source: ProtInc
  3. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: Ensembl
  4. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: Ensembl
  5. RNA polymerase II distal enhancer sequence-specific DNA binding Source: Ensembl
  6. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: RefGenome
  7. sequence-specific DNA binding transcription factor activity Source: ProtInc

GO - Biological processi

  1. blood circulation Source: Ensembl
  2. cell differentiation Source: RefGenome
  3. hemostasis Source: ProtInc
  4. megakaryocyte development Source: Ensembl
  5. organ morphogenesis Source: ProtInc
  6. regulation of transcription from RNA polymerase II promoter Source: RefGenome
  7. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Friend leukemia integration 1 transcription factor
Alternative name(s):
Proto-oncogene Fli-1
Transcription factor ERGB
Gene namesi
Name:FLI1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:3749. FLI1.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Ewing sarcoma (ES) [MIM:612219]: A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors.
Note: The gene represented in this entry is involved in disease pathogenesis. A chromosomal aberration involving FLI1 is found in patients with Erwing sarcoma. Translocation t(11;22)(q24;q12) with EWSR1.

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

MIMi612219. phenotype.
Orphaneti319. Ewing sarcoma.
370334. Extraskeletal Ewing sarcoma.
248340. Isolated delta-storage pool disease.
851. Paris-Trousseau thrombocytopenia.
370348. Peripheral primitive neuroectodermal tumor.
PharmGKBiPA28170.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 452452Friend leukemia integration 1 transcription factorPRO_0000204124Add
BLAST

Proteomic databases

MaxQBiQ01543.
PaxDbiQ01543.
PRIDEiQ01543.

PTM databases

PhosphoSiteiQ01543.

Miscellaneous databases

PMAP-CutDBQ01543.

Expressioni

Gene expression databases

BgeeiQ01543.
CleanExiHS_FLI1.
ExpressionAtlasiQ01543. baseline and differential.
GenevestigatoriQ01543.

Interactioni

Subunit structurei

Can form homodimers or heterodimers with ETV6/TEL1.

Protein-protein interaction databases

BioGridi108602. 14 interactions.
IntActiQ01543. 4 interactions.
MINTiMINT-1189961.
STRINGi9606.ENSP00000339627.

Structurei

Secondary structure

1
452
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi112 – 1143Combined sources
Beta strandi120 – 1223Combined sources
Helixi130 – 1323Combined sources
Helixi137 – 14812Combined sources
Helixi156 – 1594Combined sources
Helixi164 – 1696Combined sources
Helixi172 – 1765Combined sources
Helixi181 – 19515Combined sources
Helixi284 – 2929Combined sources
Beta strandi298 – 3014Combined sources
Beta strandi305 – 3084Combined sources
Helixi314 – 32411Combined sources
Helixi333 – 34412Combined sources
Helixi352 – 3543Combined sources
Beta strandi355 – 3573Combined sources
Beta strandi366 – 3683Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1FLINMR-A276-373[»]
1X66NMR-A114-198[»]
2YTUNMR-A100-220[»]
ProteinModelPortaliQ01543.
SMRiQ01543. Positions 114-254, 276-373.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ01543.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini112 – 19887PNTPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ETS family.Curated
Contains 1 ETS DNA-binding domain.PROSITE-ProRule annotation
Contains 1 PNT (pointed) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG242679.
GeneTreeiENSGT00760000118907.
HOGENOMiHOG000290658.
HOVERGENiHBG001553.
InParanoidiQ01543.
KOiK09436.
OMAiKNGPPPN.
OrthoDBiEOG73V6K8.
PhylomeDBiQ01543.
TreeFamiTF350537.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.150.50. 1 hit.
InterProiIPR000418. Ets_dom.
IPR003118. Pointed_dom.
IPR013761. SAM/pointed.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00178. Ets. 1 hit.
PF02198. SAM_PNT. 1 hit.
[Graphical view]
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
SM00251. SAM_PNT. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
PS51433. PNT. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q01543-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDGTIKEALS VVSDDQSLFD SAYGAAAHLP KADMTASGSP DYGQPHKINP
60 70 80 90 100
LPPQQEWINQ PVRVNVKREY DHMNGSRESP VDCSVSKCSK LVGGGESNPM
110 120 130 140 150
NYNSYMDEKN GPPPPNMTTN ERRVIVPADP TLWTQEHVRQ WLEWAIKEYS
160 170 180 190 200
LMEIDTSFFQ NMDGKELCKM NKEDFLRATT LYNTEVLLSH LSYLRESSLL
210 220 230 240 250
AYNTTSHTDQ SSRLSVKEDP SYDSVRRGAW GNNMNSGLNK SPPLGGAQTI
260 270 280 290 300
SKNTEQRPQP DPYQILGPTS SRLANPGSGQ IQLWQFLLEL LSDSANASCI
310 320 330 340 350
TWEGTNGEFK MTDPDEVARR WGERKSKPNM NYDKLSRALR YYYDKNIMTK
360 370 380 390 400
VHGKRYAYKF DFHGIAQALQ PHPTESSMYK YPSDISYMPS YHAHQQKVNF
410 420 430 440 450
VPPHPSSMPV TSSSFFGAAS QYWTSPTGGI YPNPNVPRHP NTHVPSHLGS

YY
Length:452
Mass (Da):50,982
Last modified:July 1, 1993 - v1
Checksum:i9C2AAEEAF683F3FA
GO
Isoform 2 (identifier: Q01543-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-76: MDGTIKEALS...KREYDHMNGS → MEGGLAGERA

Show »
Length:386
Mass (Da):43,649
Checksum:iBEA132F4038A230C
GO
Isoform 3 (identifier: Q01543-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-33: Missing.

Note: No experimental confirmation available.

Show »
Length:419
Mass (Da):47,576
Checksum:i44928649B0BC6840
GO
Isoform 4 (identifier: Q01543-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-197: MDGTIKEALS...LSHLSYLRES → MDPG

Show »
Length:259
Mass (Da):29,084
Checksum:i4070E5F30894C473
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti69 – 691E → V in AAA58479. (PubMed:8439553)Curated
Sequence conflicti77 – 771Missing in AAA58479. (PubMed:8439553)Curated
Sequence conflicti130 – 1301P → A in AAA58479. (PubMed:8439553)Curated
Sequence conflicti130 – 1301P → A in AAA58480. (PubMed:8439553)Curated
Sequence conflicti133 – 1331W → V in AAA58479. (PubMed:8439553)Curated
Sequence conflicti133 – 1331W → V in AAA58480. (PubMed:8439553)Curated
Sequence conflicti294 – 2941S → N in BAG61938. (PubMed:14702039)Curated
Sequence conflicti323 – 3231E → Q in AAB23637. (PubMed:1394211)Curated
Sequence conflicti323 – 3231E → Q in AAA58479. (PubMed:8439553)Curated
Sequence conflicti323 – 3231E → Q in AAA58480. (PubMed:8439553)Curated
Sequence conflicti426 – 4261Missing in AAA58479. (PubMed:8439553)Curated
Sequence conflicti426 – 4261Missing in AAA58480. (PubMed:8439553)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 197197MDGTI…YLRES → MDPG in isoform 4. 1 PublicationVSP_046943Add
BLAST
Alternative sequencei1 – 7676MDGTI…HMNGS → MEGGLAGERA in isoform 2. 2 PublicationsVSP_001478Add
BLAST
Alternative sequencei1 – 3333Missing in isoform 3. 1 PublicationVSP_045276Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67001 mRNA. Translation: CAA47399.1.
M98833 mRNA. Translation: AAA35812.2.
S45205 mRNA. Translation: AAB23637.1.
M93255 mRNA. Translation: AAA58479.1.
M93255 mRNA. Translation: AAA58480.1.
AY029368 mRNA. Translation: AAK50443.1.
AK294279 mRNA. Translation: BAG57565.1.
AK300153 mRNA. Translation: BAG61938.1.
AK313370 mRNA. Translation: BAG36169.1.
AP001122 Genomic DNA. No translation available.
CH471065 Genomic DNA. Translation: EAW67715.1.
CH471065 Genomic DNA. Translation: EAW67718.1.
BC001670 mRNA. Translation: AAH01670.1.
BC010115 mRNA. Translation: AAH10115.1.
Y17293 Genomic DNA. Translation: CAA76731.1.
D38408 Genomic DNA. Translation: BAA07463.1. Different termination.
CCDSiCCDS44768.1. [Q01543-1]
CCDS53725.1. [Q01543-3]
CCDS59230.1. [Q01543-4]
CCDS59231.1. [Q01543-2]
PIRiI37565.
S29844.
RefSeqiNP_001161153.1. NM_001167681.2. [Q01543-3]
NP_001257939.1. NM_001271010.1. [Q01543-2]
NP_001257941.1. NM_001271012.1. [Q01543-4]
NP_002008.2. NM_002017.4. [Q01543-1]
UniGeneiHs.504281.

Genome annotation databases

EnsembliENST00000281428; ENSP00000281428; ENSG00000151702. [Q01543-2]
ENST00000344954; ENSP00000339627; ENSG00000151702. [Q01543-4]
ENST00000527786; ENSP00000433488; ENSG00000151702. [Q01543-1]
ENST00000534087; ENSP00000432950; ENSG00000151702. [Q01543-3]
GeneIDi2313.
KEGGihsa:2313.
UCSCiuc009zci.3. human. [Q01543-2]
uc010sbu.2. human. [Q01543-1]

Polymorphism databases

DMDMi399496.

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67001 mRNA. Translation: CAA47399.1 .
M98833 mRNA. Translation: AAA35812.2 .
S45205 mRNA. Translation: AAB23637.1 .
M93255 mRNA. Translation: AAA58479.1 .
M93255 mRNA. Translation: AAA58480.1 .
AY029368 mRNA. Translation: AAK50443.1 .
AK294279 mRNA. Translation: BAG57565.1 .
AK300153 mRNA. Translation: BAG61938.1 .
AK313370 mRNA. Translation: BAG36169.1 .
AP001122 Genomic DNA. No translation available.
CH471065 Genomic DNA. Translation: EAW67715.1 .
CH471065 Genomic DNA. Translation: EAW67718.1 .
BC001670 mRNA. Translation: AAH01670.1 .
BC010115 mRNA. Translation: AAH10115.1 .
Y17293 Genomic DNA. Translation: CAA76731.1 .
D38408 Genomic DNA. Translation: BAA07463.1 . Different termination.
CCDSi CCDS44768.1. [Q01543-1 ]
CCDS53725.1. [Q01543-3 ]
CCDS59230.1. [Q01543-4 ]
CCDS59231.1. [Q01543-2 ]
PIRi I37565.
S29844.
RefSeqi NP_001161153.1. NM_001167681.2. [Q01543-3 ]
NP_001257939.1. NM_001271010.1. [Q01543-2 ]
NP_001257941.1. NM_001271012.1. [Q01543-4 ]
NP_002008.2. NM_002017.4. [Q01543-1 ]
UniGenei Hs.504281.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1FLI NMR - A 276-373 [» ]
1X66 NMR - A 114-198 [» ]
2YTU NMR - A 100-220 [» ]
ProteinModelPortali Q01543.
SMRi Q01543. Positions 114-254, 276-373.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 108602. 14 interactions.
IntActi Q01543. 4 interactions.
MINTi MINT-1189961.
STRINGi 9606.ENSP00000339627.

PTM databases

PhosphoSitei Q01543.

Polymorphism databases

DMDMi 399496.

Proteomic databases

MaxQBi Q01543.
PaxDbi Q01543.
PRIDEi Q01543.

Protocols and materials databases

DNASUi 2313.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000281428 ; ENSP00000281428 ; ENSG00000151702 . [Q01543-2 ]
ENST00000344954 ; ENSP00000339627 ; ENSG00000151702 . [Q01543-4 ]
ENST00000527786 ; ENSP00000433488 ; ENSG00000151702 . [Q01543-1 ]
ENST00000534087 ; ENSP00000432950 ; ENSG00000151702 . [Q01543-3 ]
GeneIDi 2313.
KEGGi hsa:2313.
UCSCi uc009zci.3. human. [Q01543-2 ]
uc010sbu.2. human. [Q01543-1 ]

Organism-specific databases

CTDi 2313.
GeneCardsi GC11P128596.
HGNCi HGNC:3749. FLI1.
MIMi 193067. gene.
612219. phenotype.
neXtProti NX_Q01543.
Orphaneti 319. Ewing sarcoma.
370334. Extraskeletal Ewing sarcoma.
248340. Isolated delta-storage pool disease.
851. Paris-Trousseau thrombocytopenia.
370348. Peripheral primitive neuroectodermal tumor.
PharmGKBi PA28170.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG242679.
GeneTreei ENSGT00760000118907.
HOGENOMi HOG000290658.
HOVERGENi HBG001553.
InParanoidi Q01543.
KOi K09436.
OMAi KNGPPPN.
OrthoDBi EOG73V6K8.
PhylomeDBi Q01543.
TreeFami TF350537.

Miscellaneous databases

ChiTaRSi FLI1. human.
EvolutionaryTracei Q01543.
GeneWikii FLI1.
GenomeRNAii 2313.
NextBioi 35471593.
PMAP-CutDB Q01543.
PROi Q01543.
SOURCEi Search...

Gene expression databases

Bgeei Q01543.
CleanExi HS_FLI1.
ExpressionAtlasi Q01543. baseline and differential.
Genevestigatori Q01543.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
1.10.150.50. 1 hit.
InterProi IPR000418. Ets_dom.
IPR003118. Pointed_dom.
IPR013761. SAM/pointed.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00178. Ets. 1 hit.
PF02198. SAM_PNT. 1 hit.
[Graphical view ]
PRINTSi PR00454. ETSDOMAIN.
SMARTi SM00413. ETS. 1 hit.
SM00251. SAM_PNT. 1 hit.
[Graphical view ]
SUPFAMi SSF47769. SSF47769. 1 hit.
PROSITEi PS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
PS51433. PNT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours."
    Delattre O., Zucman J., Plougastel B., Desmaze C., Melot T., Peter M., Kovar H., Joubert I., de Jong P., Rouleau G., Aurias A., Thomas G.
    Nature 359:162-165(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Bone marrow.
  2. "The ERGB/Fli-1 gene: isolation and characterization of a new member of the family of human ETS transcription factors."
    Watson D.K., Smyth F.E., Thompson D.M., Cheng J.Q., Testa J.R., Papas T.S., Seth A.
    Cell Growth Differ. 3:705-713(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. Watson D.
    Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  4. "Structure and expression of human Fli-1 gene."
    Prasad D.D., Rao V.N., Reddy E.S.
    Cancer Res. 52:5833-5837(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  5. "Human FLI-1 localizes to chromosome 11q24 and has an aberrant transcript in neuroepithelioma."
    Hromas R., May W., Denny C., Raskind W., Moore J., Maki R.A., Beck E., Klemsz M.J.
    Biochim. Biophys. Acta 1172:155-158(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Tissue: Blood.
  6. "The human homolog of the mouse common viral integration region, FLI1, maps to 11q23-q24."
    Baud V., Lipinski M., Rassart E., Poliquin L., Bergeron D.
    Genomics 11:223-224(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), CHROMOSOMAL TRANSLOCATION.
  7. Ubhi B.T.S., Rainey D.R., Meredith D.M.
    Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  8. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4).
    Tissue: Amygdala, Placenta and Thymus.
  9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  11. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lymph.
  12. "Chromosome translocation based on illegitimate recombination in human tumors."
    Zucman-Rossi J., Legoix P., Victor J.M., Lopez B., Thomas G.
    Proc. Natl. Acad. Sci. U.S.A. 95:11786-11791(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 58-452.
  13. "Molecular analysis of a t(11;22) translocation junction in a case of Ewing's sarcoma."
    Bhagirath T., Abe S., Nojima T., Yoshida M.C.
    Genes Chromosomes Cancer 13:126-132(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 278-301.
    Tissue: Placenta.
  14. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  15. Cited for: STRUCTURE BY NMR OF 276-373.
  16. "Solution structure of the SAM_pnt-domain of the human Friend leukemia integration 1 transcription factor."
    RIKEN structural genomics initiative (RSGI)
    Submitted (NOV-2005) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 114-198.

Entry informationi

Entry nameiFLI1_HUMAN
AccessioniPrimary (citable) accession number: Q01543
Secondary accession number(s): B2R8H2
, B4DFV4, B4DTC6, G3V183, Q14319, Q92480, Q9UE07
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: November 26, 2014
This is version 166 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Located on a fragment of chromosome 11 flanked on the centromeric side by the acute lymphoblastic leukemia-associated t(4;11)(q21;q23) translocation breakpoint and on the telomeric side by the Ewing- and neuroepithelioma-associated t(11;22) (q24;q12) breakpoint.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3