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Q01543

- FLI1_HUMAN

UniProt

Q01543 - FLI1_HUMAN

Protein

Friend leukemia integration 1 transcription factor

Gene

FLI1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 164 (01 Oct 2014)
      Sequence version 1 (01 Jul 1993)
      Previous versions | rss
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    Functioni

    Sequence-specific transcriptional activator. Recognizes the DNA sequence 5'-C[CA]GGAAGT-3'.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi281 – 36181ETSPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: ProtInc
    2. sequence-specific DNA binding Source: InterPro
    3. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: RefGenome
    4. sequence-specific DNA binding transcription factor activity Source: ProtInc

    GO - Biological processi

    1. cell differentiation Source: RefGenome
    2. hemostasis Source: ProtInc
    3. organ morphogenesis Source: ProtInc
    4. regulation of transcription from RNA polymerase II promoter Source: RefGenome
    5. transcription from RNA polymerase II promoter Source: GOC

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Friend leukemia integration 1 transcription factor
    Alternative name(s):
    Proto-oncogene Fli-1
    Transcription factor ERGB
    Gene namesi
    Name:FLI1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:3749. FLI1.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: RefGenome

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    Ewing sarcoma (ES) [MIM:612219]: A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors.
    Note: The gene represented in this entry is involved in disease pathogenesis. A chromosomal aberration involving FLI1 is found in patients with Erwing sarcoma. Translocation t(11;22)(q24;q12) with EWSR1.

    Keywords - Diseasei

    Proto-oncogene

    Organism-specific databases

    MIMi612219. phenotype.
    Orphaneti319. Ewing sarcoma.
    370334. Extraskeletal Ewing sarcoma.
    248340. Isolated delta-storage pool disease.
    851. Paris-Trousseau thrombocytopenia.
    370348. Peripheral primitive neuroectodermal tumor.
    PharmGKBiPA28170.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 452452Friend leukemia integration 1 transcription factorPRO_0000204124Add
    BLAST

    Proteomic databases

    MaxQBiQ01543.
    PaxDbiQ01543.
    PRIDEiQ01543.

    PTM databases

    PhosphoSiteiQ01543.

    Miscellaneous databases

    PMAP-CutDBQ01543.

    Expressioni

    Gene expression databases

    ArrayExpressiQ01543.
    BgeeiQ01543.
    CleanExiHS_FLI1.
    GenevestigatoriQ01543.

    Interactioni

    Subunit structurei

    Can form homodimers or heterodimers with ETV6/TEL1.

    Protein-protein interaction databases

    BioGridi108602. 14 interactions.
    IntActiQ01543. 4 interactions.
    MINTiMINT-1189961.
    STRINGi9606.ENSP00000339627.

    Structurei

    Secondary structure

    1
    452
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi112 – 1143
    Beta strandi120 – 1223
    Helixi130 – 1323
    Helixi137 – 14812
    Helixi156 – 1594
    Helixi164 – 1696
    Helixi172 – 1765
    Helixi181 – 19515
    Helixi284 – 2929
    Beta strandi298 – 3014
    Beta strandi305 – 3084
    Helixi314 – 32411
    Helixi333 – 34412
    Helixi352 – 3543
    Beta strandi355 – 3573
    Beta strandi366 – 3683

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1FLINMR-A276-373[»]
    1X66NMR-A114-198[»]
    2YTUNMR-A100-220[»]
    ProteinModelPortaliQ01543.
    SMRiQ01543. Positions 114-254, 276-373.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ01543.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini112 – 19887PNTPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ETS family.Curated
    Contains 1 ETS DNA-binding domain.PROSITE-ProRule annotation
    Contains 1 PNT (pointed) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG242679.
    HOGENOMiHOG000290658.
    HOVERGENiHBG001553.
    InParanoidiQ01543.
    KOiK09436.
    OMAiKNGPPPN.
    OrthoDBiEOG73V6K8.
    PhylomeDBiQ01543.
    TreeFamiTF350537.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    1.10.150.50. 1 hit.
    InterProiIPR000418. Ets_dom.
    IPR003118. Pointed_dom.
    IPR013761. SAM/pointed.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00178. Ets. 1 hit.
    PF02198. SAM_PNT. 1 hit.
    [Graphical view]
    PRINTSiPR00454. ETSDOMAIN.
    SMARTiSM00413. ETS. 1 hit.
    SM00251. SAM_PNT. 1 hit.
    [Graphical view]
    SUPFAMiSSF47769. SSF47769. 1 hit.
    PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
    PS00346. ETS_DOMAIN_2. 1 hit.
    PS50061. ETS_DOMAIN_3. 1 hit.
    PS51433. PNT. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q01543-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDGTIKEALS VVSDDQSLFD SAYGAAAHLP KADMTASGSP DYGQPHKINP    50
    LPPQQEWINQ PVRVNVKREY DHMNGSRESP VDCSVSKCSK LVGGGESNPM 100
    NYNSYMDEKN GPPPPNMTTN ERRVIVPADP TLWTQEHVRQ WLEWAIKEYS 150
    LMEIDTSFFQ NMDGKELCKM NKEDFLRATT LYNTEVLLSH LSYLRESSLL 200
    AYNTTSHTDQ SSRLSVKEDP SYDSVRRGAW GNNMNSGLNK SPPLGGAQTI 250
    SKNTEQRPQP DPYQILGPTS SRLANPGSGQ IQLWQFLLEL LSDSANASCI 300
    TWEGTNGEFK MTDPDEVARR WGERKSKPNM NYDKLSRALR YYYDKNIMTK 350
    VHGKRYAYKF DFHGIAQALQ PHPTESSMYK YPSDISYMPS YHAHQQKVNF 400
    VPPHPSSMPV TSSSFFGAAS QYWTSPTGGI YPNPNVPRHP NTHVPSHLGS 450
    YY 452
    Length:452
    Mass (Da):50,982
    Last modified:July 1, 1993 - v1
    Checksum:i9C2AAEEAF683F3FA
    GO
    Isoform 2 (identifier: Q01543-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-76: MDGTIKEALS...KREYDHMNGS → MEGGLAGERA

    Show »
    Length:386
    Mass (Da):43,649
    Checksum:iBEA132F4038A230C
    GO
    Isoform 3 (identifier: Q01543-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-33: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:419
    Mass (Da):47,576
    Checksum:i44928649B0BC6840
    GO
    Isoform 4 (identifier: Q01543-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-197: MDGTIKEALS...LSHLSYLRES → MDPG

    Show »
    Length:259
    Mass (Da):29,084
    Checksum:i4070E5F30894C473
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti69 – 691E → V in AAA58479. (PubMed:8439553)Curated
    Sequence conflicti77 – 771Missing in AAA58479. (PubMed:8439553)Curated
    Sequence conflicti130 – 1301P → A in AAA58479. (PubMed:8439553)Curated
    Sequence conflicti130 – 1301P → A in AAA58480. (PubMed:8439553)Curated
    Sequence conflicti133 – 1331W → V in AAA58479. (PubMed:8439553)Curated
    Sequence conflicti133 – 1331W → V in AAA58480. (PubMed:8439553)Curated
    Sequence conflicti294 – 2941S → N in BAG61938. (PubMed:14702039)Curated
    Sequence conflicti323 – 3231E → Q in AAB23637. (PubMed:1394211)Curated
    Sequence conflicti323 – 3231E → Q in AAA58479. (PubMed:8439553)Curated
    Sequence conflicti323 – 3231E → Q in AAA58480. (PubMed:8439553)Curated
    Sequence conflicti426 – 4261Missing in AAA58479. (PubMed:8439553)Curated
    Sequence conflicti426 – 4261Missing in AAA58480. (PubMed:8439553)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 197197MDGTI…YLRES → MDPG in isoform 4. 1 PublicationVSP_046943Add
    BLAST
    Alternative sequencei1 – 7676MDGTI…HMNGS → MEGGLAGERA in isoform 2. 2 PublicationsVSP_001478Add
    BLAST
    Alternative sequencei1 – 3333Missing in isoform 3. 1 PublicationVSP_045276Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X67001 mRNA. Translation: CAA47399.1.
    M98833 mRNA. Translation: AAA35812.2.
    S45205 mRNA. Translation: AAB23637.1.
    M93255 mRNA. Translation: AAA58479.1.
    M93255 mRNA. Translation: AAA58480.1.
    AY029368 mRNA. Translation: AAK50443.1.
    AK294279 mRNA. Translation: BAG57565.1.
    AK300153 mRNA. Translation: BAG61938.1.
    AK313370 mRNA. Translation: BAG36169.1.
    AP001122 Genomic DNA. No translation available.
    CH471065 Genomic DNA. Translation: EAW67715.1.
    CH471065 Genomic DNA. Translation: EAW67718.1.
    BC001670 mRNA. Translation: AAH01670.1.
    BC010115 mRNA. Translation: AAH10115.1.
    Y17293 Genomic DNA. Translation: CAA76731.1.
    D38408 Genomic DNA. Translation: BAA07463.1. Different termination.
    CCDSiCCDS44768.1. [Q01543-1]
    CCDS53725.1. [Q01543-3]
    CCDS59230.1. [Q01543-4]
    CCDS59231.1. [Q01543-2]
    PIRiI37565.
    S29844.
    RefSeqiNP_001161153.1. NM_001167681.2. [Q01543-3]
    NP_001257939.1. NM_001271010.1. [Q01543-2]
    NP_001257941.1. NM_001271012.1. [Q01543-4]
    NP_002008.2. NM_002017.4. [Q01543-1]
    UniGeneiHs.504281.

    Genome annotation databases

    EnsembliENST00000281428; ENSP00000281428; ENSG00000151702. [Q01543-2]
    ENST00000344954; ENSP00000339627; ENSG00000151702. [Q01543-3]
    ENST00000527786; ENSP00000433488; ENSG00000151702. [Q01543-1]
    ENST00000534087; ENSP00000432950; ENSG00000151702. [Q01543-3]
    GeneIDi2313.
    KEGGihsa:2313.
    UCSCiuc009zci.3. human. [Q01543-2]
    uc010sbu.2. human. [Q01543-1]

    Polymorphism databases

    DMDMi399496.

    Keywords - Coding sequence diversityi

    Alternative splicing, Chromosomal rearrangement

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X67001 mRNA. Translation: CAA47399.1 .
    M98833 mRNA. Translation: AAA35812.2 .
    S45205 mRNA. Translation: AAB23637.1 .
    M93255 mRNA. Translation: AAA58479.1 .
    M93255 mRNA. Translation: AAA58480.1 .
    AY029368 mRNA. Translation: AAK50443.1 .
    AK294279 mRNA. Translation: BAG57565.1 .
    AK300153 mRNA. Translation: BAG61938.1 .
    AK313370 mRNA. Translation: BAG36169.1 .
    AP001122 Genomic DNA. No translation available.
    CH471065 Genomic DNA. Translation: EAW67715.1 .
    CH471065 Genomic DNA. Translation: EAW67718.1 .
    BC001670 mRNA. Translation: AAH01670.1 .
    BC010115 mRNA. Translation: AAH10115.1 .
    Y17293 Genomic DNA. Translation: CAA76731.1 .
    D38408 Genomic DNA. Translation: BAA07463.1 . Different termination.
    CCDSi CCDS44768.1. [Q01543-1 ]
    CCDS53725.1. [Q01543-3 ]
    CCDS59230.1. [Q01543-4 ]
    CCDS59231.1. [Q01543-2 ]
    PIRi I37565.
    S29844.
    RefSeqi NP_001161153.1. NM_001167681.2. [Q01543-3 ]
    NP_001257939.1. NM_001271010.1. [Q01543-2 ]
    NP_001257941.1. NM_001271012.1. [Q01543-4 ]
    NP_002008.2. NM_002017.4. [Q01543-1 ]
    UniGenei Hs.504281.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1FLI NMR - A 276-373 [» ]
    1X66 NMR - A 114-198 [» ]
    2YTU NMR - A 100-220 [» ]
    ProteinModelPortali Q01543.
    SMRi Q01543. Positions 114-254, 276-373.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108602. 14 interactions.
    IntActi Q01543. 4 interactions.
    MINTi MINT-1189961.
    STRINGi 9606.ENSP00000339627.

    PTM databases

    PhosphoSitei Q01543.

    Polymorphism databases

    DMDMi 399496.

    Proteomic databases

    MaxQBi Q01543.
    PaxDbi Q01543.
    PRIDEi Q01543.

    Protocols and materials databases

    DNASUi 2313.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000281428 ; ENSP00000281428 ; ENSG00000151702 . [Q01543-2 ]
    ENST00000344954 ; ENSP00000339627 ; ENSG00000151702 . [Q01543-3 ]
    ENST00000527786 ; ENSP00000433488 ; ENSG00000151702 . [Q01543-1 ]
    ENST00000534087 ; ENSP00000432950 ; ENSG00000151702 . [Q01543-3 ]
    GeneIDi 2313.
    KEGGi hsa:2313.
    UCSCi uc009zci.3. human. [Q01543-2 ]
    uc010sbu.2. human. [Q01543-1 ]

    Organism-specific databases

    CTDi 2313.
    GeneCardsi GC11P128596.
    HGNCi HGNC:3749. FLI1.
    MIMi 193067. gene.
    612219. phenotype.
    neXtProti NX_Q01543.
    Orphaneti 319. Ewing sarcoma.
    370334. Extraskeletal Ewing sarcoma.
    248340. Isolated delta-storage pool disease.
    851. Paris-Trousseau thrombocytopenia.
    370348. Peripheral primitive neuroectodermal tumor.
    PharmGKBi PA28170.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG242679.
    HOGENOMi HOG000290658.
    HOVERGENi HBG001553.
    InParanoidi Q01543.
    KOi K09436.
    OMAi KNGPPPN.
    OrthoDBi EOG73V6K8.
    PhylomeDBi Q01543.
    TreeFami TF350537.

    Miscellaneous databases

    ChiTaRSi FLI1. human.
    EvolutionaryTracei Q01543.
    GeneWikii FLI1.
    GenomeRNAii 2313.
    NextBioi 35471593.
    PMAP-CutDB Q01543.
    PROi Q01543.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q01543.
    Bgeei Q01543.
    CleanExi HS_FLI1.
    Genevestigatori Q01543.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    1.10.150.50. 1 hit.
    InterProi IPR000418. Ets_dom.
    IPR003118. Pointed_dom.
    IPR013761. SAM/pointed.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00178. Ets. 1 hit.
    PF02198. SAM_PNT. 1 hit.
    [Graphical view ]
    PRINTSi PR00454. ETSDOMAIN.
    SMARTi SM00413. ETS. 1 hit.
    SM00251. SAM_PNT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47769. SSF47769. 1 hit.
    PROSITEi PS00345. ETS_DOMAIN_1. 1 hit.
    PS00346. ETS_DOMAIN_2. 1 hit.
    PS50061. ETS_DOMAIN_3. 1 hit.
    PS51433. PNT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours."
      Delattre O., Zucman J., Plougastel B., Desmaze C., Melot T., Peter M., Kovar H., Joubert I., de Jong P., Rouleau G., Aurias A., Thomas G.
      Nature 359:162-165(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Bone marrow.
    2. "The ERGB/Fli-1 gene: isolation and characterization of a new member of the family of human ETS transcription factors."
      Watson D.K., Smyth F.E., Thompson D.M., Cheng J.Q., Testa J.R., Papas T.S., Seth A.
      Cell Growth Differ. 3:705-713(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. Watson D.
      Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    4. "Structure and expression of human Fli-1 gene."
      Prasad D.D., Rao V.N., Reddy E.S.
      Cancer Res. 52:5833-5837(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    5. "Human FLI-1 localizes to chromosome 11q24 and has an aberrant transcript in neuroepithelioma."
      Hromas R., May W., Denny C., Raskind W., Moore J., Maki R.A., Beck E., Klemsz M.J.
      Biochim. Biophys. Acta 1172:155-158(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
      Tissue: Blood.
    6. "The human homolog of the mouse common viral integration region, FLI1, maps to 11q23-q24."
      Baud V., Lipinski M., Rassart E., Poliquin L., Bergeron D.
      Genomics 11:223-224(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), CHROMOSOMAL TRANSLOCATION.
    7. Ubhi B.T.S., Rainey D.R., Meredith D.M.
      Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    8. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4).
      Tissue: Amygdala, Placenta and Thymus.
    9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    11. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Lymph.
    12. "Chromosome translocation based on illegitimate recombination in human tumors."
      Zucman-Rossi J., Legoix P., Victor J.M., Lopez B., Thomas G.
      Proc. Natl. Acad. Sci. U.S.A. 95:11786-11791(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 58-452.
    13. "Molecular analysis of a t(11;22) translocation junction in a case of Ewing's sarcoma."
      Bhagirath T., Abe S., Nojima T., Yoshida M.C.
      Genes Chromosomes Cancer 13:126-132(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 278-301.
      Tissue: Placenta.
    14. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    15. Cited for: STRUCTURE BY NMR OF 276-373.
    16. "Solution structure of the SAM_pnt-domain of the human Friend leukemia integration 1 transcription factor."
      RIKEN structural genomics initiative (RSGI)
      Submitted (NOV-2005) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 114-198.

    Entry informationi

    Entry nameiFLI1_HUMAN
    AccessioniPrimary (citable) accession number: Q01543
    Secondary accession number(s): B2R8H2
    , B4DFV4, B4DTC6, G3V183, Q14319, Q92480, Q9UE07
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: July 1, 1993
    Last modified: October 1, 2014
    This is version 164 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Located on a fragment of chromosome 11 flanked on the centromeric side by the acute lymphoblastic leukemia-associated t(4;11)(q21;q23) translocation breakpoint and on the telomeric side by the Ewing- and neuroepithelioma-associated t(11;22) (q24;q12) breakpoint.

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3