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Q01538

- MYT1_HUMAN

UniProt

Q01538 - MYT1_HUMAN

Protein

Myelin transcription factor 1

Gene

MYT1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 137 (01 Oct 2014)
      Sequence version 2 (27 Apr 2001)
      Previous versions | rss
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    Functioni

    Binds to the promoter regions of proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendrogalia in the CNS. May regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up-regulation of myelin gene transcription.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri28 – 5427C2HC-type 1Add
    BLAST
    Zinc fingeri440 – 46627C2HC-type 2Add
    BLAST
    Zinc fingeri484 – 51027C2HC-type 3Add
    BLAST
    Zinc fingeri798 – 82427C2HC-type 4Add
    BLAST
    Zinc fingeri842 – 86827C2HC-type 5Add
    BLAST
    Zinc fingeri891 – 91727C2HC-type 6Add
    BLAST
    Zinc fingeri944 – 97027C2HC-type 7Add
    BLAST

    GO - Molecular functioni

    1. enhancer sequence-specific DNA binding Source: Ensembl
    2. sequence-specific DNA binding transcription factor activity Source: UniProtKB
    3. zinc ion binding Source: UniProtKB

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW
    2. nervous system development Source: UniProtKB-KW
    3. regulation of transcription, DNA-templated Source: UniProtKB
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Neurogenesis, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Myelin transcription factor 1
    Short name:
    MyT1
    Alternative name(s):
    Myelin transcription factor I
    Short name:
    MyTI
    PLPB1
    Proteolipid protein-binding protein
    Gene namesi
    Name:MYT1
    Synonyms:KIAA0835, KIAA1050, MTF1, MYTI, PLPB1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:7622. MYT1.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31426.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11211121Myelin transcription factor 1PRO_0000096676Add
    BLAST

    Proteomic databases

    MaxQBiQ01538.
    PaxDbiQ01538.
    PRIDEiQ01538.

    PTM databases

    PhosphoSiteiQ01538.

    Expressioni

    Tissue specificityi

    Mostly in developing nervous system. Expressed in neural progenitors and oligodendrocyte lineage cells. More highly expressed in oligodendrocyte progenitors than in differentiated oligodendrocytes.1 Publication

    Gene expression databases

    ArrayExpressiQ01538.
    BgeeiQ01538.
    CleanExiHS_MTF1.
    HS_MYT1.
    GenevestigatoriQ01538.

    Organism-specific databases

    HPAiHPA006303.

    Interactioni

    Subunit structurei

    Interacts with STEAP3.1 Publication

    Protein-protein interaction databases

    BioGridi110744. 4 interactions.
    IntActiQ01538. 1 interaction.
    MINTiMINT-4656467.
    STRINGi9606.ENSP00000327465.

    Structurei

    3D structure databases

    ProteinModelPortaliQ01538.
    SMRiQ01538. Positions 27-57, 438-513, 797-983.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi200 – 306107Glu-richAdd
    BLAST
    Compositional biasi685 – 72339Ser-richAdd
    BLAST

    Domaini

    Sequence similaritiesi

    Contains 7 C2HC-type zinc fingers.Curated

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri28 – 5427C2HC-type 1Add
    BLAST
    Zinc fingeri440 – 46627C2HC-type 2Add
    BLAST
    Zinc fingeri484 – 51027C2HC-type 3Add
    BLAST
    Zinc fingeri798 – 82427C2HC-type 4Add
    BLAST
    Zinc fingeri842 – 86827C2HC-type 5Add
    BLAST
    Zinc fingeri891 – 91727C2HC-type 6Add
    BLAST
    Zinc fingeri944 – 97027C2HC-type 7Add
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG329034.
    HOGENOMiHOG000234099.
    HOVERGENiHBG006433.
    InParanoidiQ01538.
    OMAiPSKANYS.
    OrthoDBiEOG7060Q4.
    PhylomeDBiQ01538.
    TreeFamiTF317299.

    Family and domain databases

    InterProiIPR013681. Myelin_TF.
    IPR002515. Znf_C2HC.
    [Graphical view]
    PfamiPF08474. MYT1. 2 hits.
    PF01530. zf-C2HC. 7 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q01538-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSLENEDKRA RTRSKALRGP PETTAADLSC PTPGCTGSGH VRGKYSRHRS     50
    LQSCPLAKKR KLEGAEAEHL VSKRKSHPLK LALDEGYGVD SDGSEDTEVK 100
    DASVSDESEG TLEGAEAETS GQDEIHRPET AEGRSPVKSH FGSNPIGSAT 150
    ASSKGSYSSY QGIIATSLLN LGQIAEETLV EEDLGQAAKP GPGIVHLLQE 200
    AAEGAASEEG EKGLFIQPED AEEVVEVTTE RSQDLCPQSL EDAASEESSK 250
    QKGILSHEEE DEEEEEEEEE EEEDEEEEEE EEEEEEEEEE EEEEEEEEEE 300
    EEEEEEAAPD VIFQEDTSHT SAQKAPELRG PESPSPKPEY SVIVEVRSDD 350
    DKDEDTHSRK STVTDESEMQ DMMTRGNLGL LEQAIALKAE QVRTVCEPGC 400
    PPAEQSQLGL GEPGKAAKPL DTVRKSYYSK DPSRAEKREI KCPTPGCDGT 450
    GHVTGLYPHH RSLSGCPHKD RIPPEILAMH ENVLKCPTPG CTGQGHVNSN 500
    RNTHRSLSGC PIAAAEKLAK SHEKQQPQTG DPSKSSSNSD RILRPMCFVK 550
    QLEVPPYGSY RPNVAPATPR ANLAKELEKF SKVTFDYASF DAQVFGKRML 600
    APKIQTSETS PKAFQCFDYS QDAEAAHMAA TAILNLSTRC WEMPENLSTK 650
    PQDLPSKSVD IEVDENGTLD LSMHKHRKRE NAFPSSSSCS SSPGVKSPDA 700
    SQRHSSTSAP SSSMTSPQSS QASRQDEWDR PLDYTKPSRL REEEPEESEP 750
    AAHSFASSEA DDQEVSEENF EERKYPGEVT LTNFKLKFLS KDIKKELLTC 800
    PTPGCDGSGH ITGNYASHRS LSGCPLADKS LRNLMAAHSA DLKCPTPGCD 850
    GSGHITGNYA SHRSLSGCPR AKKSGVKVAP TKDDKEDPEL MKCPVPGCVG 900
    LGHISGKYAS HRSASGCPLA ARRQKEGSLN GSSFSWKSLK NEGPTCPTPG 950
    CDGSGHANGS FLTHRSLSGC PRATFAGKKG KLSGDEVLSP KFKTSDVLEN 1000
    DEEIKQLNQE IRDLNESNSE MEAAMVQLQS QISSMEKNLK NIEEENKLIE 1050
    EQNEALFLEL SGLSQALIQS LANIRLPHME PICEQNFDAY VSTLTDMYSN 1100
    QDPENKDLLE SIKQAVRGIQ V 1121
    Length:1,121
    Mass (Da):122,329
    Last modified:April 27, 2001 - v2
    Checksum:iD4AF1F8C7D4EC01E
    GO
    Isoform 2 (identifier: Q01538-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         616-616: C → SKPFPKASSPRHSPSSSYVRSTSSSSAG

    Show »
    Length:1,148
    Mass (Da):125,075
    Checksum:i53CCE237F8356742
    GO

    Sequence cautioni

    The sequence BAA74858.2 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti567 – 5748ATPRANLA → RHTQGQLG in AAA59897. (PubMed:1280325)Curated
    Sequence conflicti837 – 8371A → T in AAA59897. (PubMed:1280325)Curated
    Sequence conflicti943 – 9431G → D in AAA59897. (PubMed:1280325)Curated
    Sequence conflicti957 – 9582AN → TI in AAA59897. (PubMed:1280325)Curated
    Sequence conflicti1075 – 10751R → H in AAA59897. (PubMed:1280325)Curated
    Sequence conflicti1088 – 10892DA → VP in AAA59897. (PubMed:1280325)Curated
    Sequence conflicti1102 – 11021D → A in AAA59897. (PubMed:1280325)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei616 – 6161C → SKPFPKASSPRHSPSSSYVR STSSSSAG in isoform 2. 2 PublicationsVSP_054313

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB020642 mRNA. Translation: BAA74858.2. Different initiation.
    AL121581 Genomic DNA. Translation: CAC17005.1.
    CH471077 Genomic DNA. Translation: EAW75155.1.
    CH471077 Genomic DNA. Translation: EAW75157.1.
    CH471077 Genomic DNA. Translation: EAW75158.1.
    AB028973 mRNA. Translation: BAA83002.1.
    BC053638 mRNA. Translation: AAH53638.1.
    M96980 mRNA. Translation: AAA59897.1.
    CCDSiCCDS13558.1. [Q01538-1]
    RefSeqiNP_004526.1. NM_004535.2. [Q01538-1]
    UniGeneiHs.279562.

    Genome annotation databases

    EnsembliENST00000328439; ENSP00000327465; ENSG00000196132. [Q01538-1]
    ENST00000536311; ENSP00000442412; ENSG00000196132. [Q01538-2]
    GeneIDi4661.
    KEGGihsa:4661.
    UCSCiuc002yii.3. human. [Q01538-1]

    Polymorphism databases

    DMDMi13638422.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB020642 mRNA. Translation: BAA74858.2 . Different initiation.
    AL121581 Genomic DNA. Translation: CAC17005.1 .
    CH471077 Genomic DNA. Translation: EAW75155.1 .
    CH471077 Genomic DNA. Translation: EAW75157.1 .
    CH471077 Genomic DNA. Translation: EAW75158.1 .
    AB028973 mRNA. Translation: BAA83002.1 .
    BC053638 mRNA. Translation: AAH53638.1 .
    M96980 mRNA. Translation: AAA59897.1 .
    CCDSi CCDS13558.1. [Q01538-1 ]
    RefSeqi NP_004526.1. NM_004535.2. [Q01538-1 ]
    UniGenei Hs.279562.

    3D structure databases

    ProteinModelPortali Q01538.
    SMRi Q01538. Positions 27-57, 438-513, 797-983.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110744. 4 interactions.
    IntActi Q01538. 1 interaction.
    MINTi MINT-4656467.
    STRINGi 9606.ENSP00000327465.

    Chemistry

    ChEMBLi CHEMBL2331044.

    PTM databases

    PhosphoSitei Q01538.

    Polymorphism databases

    DMDMi 13638422.

    Proteomic databases

    MaxQBi Q01538.
    PaxDbi Q01538.
    PRIDEi Q01538.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000328439 ; ENSP00000327465 ; ENSG00000196132 . [Q01538-1 ]
    ENST00000536311 ; ENSP00000442412 ; ENSG00000196132 . [Q01538-2 ]
    GeneIDi 4661.
    KEGGi hsa:4661.
    UCSCi uc002yii.3. human. [Q01538-1 ]

    Organism-specific databases

    CTDi 4661.
    GeneCardsi GC20P062795.
    H-InvDB HIX0080185.
    HGNCi HGNC:7622. MYT1.
    HPAi HPA006303.
    MIMi 600379. gene.
    neXtProti NX_Q01538.
    PharmGKBi PA31426.
    HUGEi Search...
    Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG329034.
    HOGENOMi HOG000234099.
    HOVERGENi HBG006433.
    InParanoidi Q01538.
    OMAi PSKANYS.
    OrthoDBi EOG7060Q4.
    PhylomeDBi Q01538.
    TreeFami TF317299.

    Miscellaneous databases

    GeneWikii MYT1.
    GenomeRNAii 4661.
    NextBioi 17968.
    PROi Q01538.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q01538.
    Bgeei Q01538.
    CleanExi HS_MTF1.
    HS_MYT1.
    Genevestigatori Q01538.

    Family and domain databases

    InterProi IPR013681. Myelin_TF.
    IPR002515. Znf_C2HC.
    [Graphical view ]
    Pfami PF08474. MYT1. 2 hits.
    PF01530. zf-C2HC. 7 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    2. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 293-1121 (ISOFORM 1).
      Tissue: Brain.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 303-1121 (ISOFORM 2).
      Tissue: Brain.
    6. "Novel member of the zinc finger superfamily: a C2-HC finger that recognizes a glia-specific gene."
      Kim J.G., Hudson L.D.
      Mol. Cell. Biol. 12:5632-5639(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 424-1121 (ISOFORM 2).
      Tissue: Brain.
    7. "Expression of myelin transcription factor I (MyTI), a 'zinc-finger' DNA-binding protein, in developing oligodendrocytes."
      Armstrong R.C., Kim J.G., Hudson L.D.
      Glia 14:303-321(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    8. Cited for: INTERACTION WITH STEAP3.
    9. "Myelin transcription factor 1 (Myt1) modulates the proliferation and differentiation of oligodendrocyte lineage cells."
      Nielsen J.A., Berndt J.A., Hudson L.D., Armstrong R.C.
      Mol. Cell. Neurosci. 25:111-123(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiMYT1_HUMAN
    AccessioniPrimary (citable) accession number: Q01538
    Secondary accession number(s): E1P5H0
    , F5H7M8, O94922, Q7Z5W2, Q9UPV2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: April 27, 2001
    Last modified: October 1, 2014
    This is version 137 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3