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Q01538

- MYT1_HUMAN

UniProt

Q01538 - MYT1_HUMAN

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Protein

Myelin transcription factor 1

Gene

MYT1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Binds to the promoter regions of proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendrogalia in the CNS. May regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up-regulation of myelin gene transcription.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri28 – 5427C2HC-type 1Add
BLAST
Zinc fingeri440 – 46627C2HC-type 2Add
BLAST
Zinc fingeri484 – 51027C2HC-type 3Add
BLAST
Zinc fingeri798 – 82427C2HC-type 4Add
BLAST
Zinc fingeri842 – 86827C2HC-type 5Add
BLAST
Zinc fingeri891 – 91727C2HC-type 6Add
BLAST
Zinc fingeri944 – 97027C2HC-type 7Add
BLAST

GO - Molecular functioni

  1. enhancer sequence-specific DNA binding Source: Ensembl
  2. sequence-specific DNA binding transcription factor activity Source: UniProtKB
  3. zinc ion binding Source: UniProtKB

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. nervous system development Source: UniProtKB-KW
  3. regulation of transcription, DNA-templated Source: UniProtKB
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Myelin transcription factor 1
Short name:
MyT1
Alternative name(s):
Myelin transcription factor I
Short name:
MyTI
PLPB1
Proteolipid protein-binding protein
Gene namesi
Name:MYT1
Synonyms:KIAA0835, KIAA1050, MTF1, MYTI, PLPB1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:7622. MYT1.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31426.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11211121Myelin transcription factor 1PRO_0000096676Add
BLAST

Proteomic databases

MaxQBiQ01538.
PaxDbiQ01538.
PRIDEiQ01538.

PTM databases

PhosphoSiteiQ01538.

Expressioni

Tissue specificityi

Mostly in developing nervous system. Expressed in neural progenitors and oligodendrocyte lineage cells. More highly expressed in oligodendrocyte progenitors than in differentiated oligodendrocytes.1 Publication

Gene expression databases

BgeeiQ01538.
CleanExiHS_MTF1.
HS_MYT1.
ExpressionAtlasiQ01538. baseline and differential.
GenevestigatoriQ01538.

Organism-specific databases

HPAiHPA006303.

Interactioni

Subunit structurei

Interacts with STEAP3.1 Publication

Protein-protein interaction databases

BioGridi110744. 4 interactions.
IntActiQ01538. 1 interaction.
MINTiMINT-4656467.
STRINGi9606.ENSP00000327465.

Structurei

3D structure databases

ProteinModelPortaliQ01538.
SMRiQ01538. Positions 27-57, 438-513, 797-983.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi200 – 306107Glu-richAdd
BLAST
Compositional biasi685 – 72339Ser-richAdd
BLAST

Domaini

Sequence similaritiesi

Contains 7 C2HC-type zinc fingers.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri28 – 5427C2HC-type 1Add
BLAST
Zinc fingeri440 – 46627C2HC-type 2Add
BLAST
Zinc fingeri484 – 51027C2HC-type 3Add
BLAST
Zinc fingeri798 – 82427C2HC-type 4Add
BLAST
Zinc fingeri842 – 86827C2HC-type 5Add
BLAST
Zinc fingeri891 – 91727C2HC-type 6Add
BLAST
Zinc fingeri944 – 97027C2HC-type 7Add
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG329034.
GeneTreeiENSGT00440000038465.
HOGENOMiHOG000234099.
HOVERGENiHBG006433.
InParanoidiQ01538.
OMAiPSKANYS.
OrthoDBiEOG7060Q4.
PhylomeDBiQ01538.
TreeFamiTF317299.

Family and domain databases

InterProiIPR013681. Myelin_TF.
IPR002515. Znf_C2HC.
[Graphical view]
PfamiPF08474. MYT1. 2 hits.
PF01530. zf-C2HC. 7 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q01538-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLENEDKRA RTRSKALRGP PETTAADLSC PTPGCTGSGH VRGKYSRHRS
60 70 80 90 100
LQSCPLAKKR KLEGAEAEHL VSKRKSHPLK LALDEGYGVD SDGSEDTEVK
110 120 130 140 150
DASVSDESEG TLEGAEAETS GQDEIHRPET AEGRSPVKSH FGSNPIGSAT
160 170 180 190 200
ASSKGSYSSY QGIIATSLLN LGQIAEETLV EEDLGQAAKP GPGIVHLLQE
210 220 230 240 250
AAEGAASEEG EKGLFIQPED AEEVVEVTTE RSQDLCPQSL EDAASEESSK
260 270 280 290 300
QKGILSHEEE DEEEEEEEEE EEEDEEEEEE EEEEEEEEEE EEEEEEEEEE
310 320 330 340 350
EEEEEEAAPD VIFQEDTSHT SAQKAPELRG PESPSPKPEY SVIVEVRSDD
360 370 380 390 400
DKDEDTHSRK STVTDESEMQ DMMTRGNLGL LEQAIALKAE QVRTVCEPGC
410 420 430 440 450
PPAEQSQLGL GEPGKAAKPL DTVRKSYYSK DPSRAEKREI KCPTPGCDGT
460 470 480 490 500
GHVTGLYPHH RSLSGCPHKD RIPPEILAMH ENVLKCPTPG CTGQGHVNSN
510 520 530 540 550
RNTHRSLSGC PIAAAEKLAK SHEKQQPQTG DPSKSSSNSD RILRPMCFVK
560 570 580 590 600
QLEVPPYGSY RPNVAPATPR ANLAKELEKF SKVTFDYASF DAQVFGKRML
610 620 630 640 650
APKIQTSETS PKAFQCFDYS QDAEAAHMAA TAILNLSTRC WEMPENLSTK
660 670 680 690 700
PQDLPSKSVD IEVDENGTLD LSMHKHRKRE NAFPSSSSCS SSPGVKSPDA
710 720 730 740 750
SQRHSSTSAP SSSMTSPQSS QASRQDEWDR PLDYTKPSRL REEEPEESEP
760 770 780 790 800
AAHSFASSEA DDQEVSEENF EERKYPGEVT LTNFKLKFLS KDIKKELLTC
810 820 830 840 850
PTPGCDGSGH ITGNYASHRS LSGCPLADKS LRNLMAAHSA DLKCPTPGCD
860 870 880 890 900
GSGHITGNYA SHRSLSGCPR AKKSGVKVAP TKDDKEDPEL MKCPVPGCVG
910 920 930 940 950
LGHISGKYAS HRSASGCPLA ARRQKEGSLN GSSFSWKSLK NEGPTCPTPG
960 970 980 990 1000
CDGSGHANGS FLTHRSLSGC PRATFAGKKG KLSGDEVLSP KFKTSDVLEN
1010 1020 1030 1040 1050
DEEIKQLNQE IRDLNESNSE MEAAMVQLQS QISSMEKNLK NIEEENKLIE
1060 1070 1080 1090 1100
EQNEALFLEL SGLSQALIQS LANIRLPHME PICEQNFDAY VSTLTDMYSN
1110 1120
QDPENKDLLE SIKQAVRGIQ V
Length:1,121
Mass (Da):122,329
Last modified:April 27, 2001 - v2
Checksum:iD4AF1F8C7D4EC01E
GO
Isoform 2 (identifier: Q01538-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     616-616: C → SKPFPKASSPRHSPSSSYVRSTSSSSAG

Show »
Length:1,148
Mass (Da):125,075
Checksum:i53CCE237F8356742
GO

Sequence cautioni

The sequence BAA74858.2 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti567 – 5748ATPRANLA → RHTQGQLG in AAA59897. (PubMed:1280325)Curated
Sequence conflicti837 – 8371A → T in AAA59897. (PubMed:1280325)Curated
Sequence conflicti943 – 9431G → D in AAA59897. (PubMed:1280325)Curated
Sequence conflicti957 – 9582AN → TI in AAA59897. (PubMed:1280325)Curated
Sequence conflicti1075 – 10751R → H in AAA59897. (PubMed:1280325)Curated
Sequence conflicti1088 – 10892DA → VP in AAA59897. (PubMed:1280325)Curated
Sequence conflicti1102 – 11021D → A in AAA59897. (PubMed:1280325)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei616 – 6161C → SKPFPKASSPRHSPSSSYVR STSSSSAG in isoform 2. 2 PublicationsVSP_054313

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020642 mRNA. Translation: BAA74858.2. Different initiation.
AL121581 Genomic DNA. Translation: CAC17005.1.
CH471077 Genomic DNA. Translation: EAW75155.1.
CH471077 Genomic DNA. Translation: EAW75157.1.
CH471077 Genomic DNA. Translation: EAW75158.1.
AB028973 mRNA. Translation: BAA83002.1.
BC053638 mRNA. Translation: AAH53638.1.
M96980 mRNA. Translation: AAA59897.1.
CCDSiCCDS13558.1. [Q01538-1]
RefSeqiNP_004526.1. NM_004535.2. [Q01538-1]
UniGeneiHs.279562.

Genome annotation databases

EnsembliENST00000328439; ENSP00000327465; ENSG00000196132. [Q01538-1]
ENST00000536311; ENSP00000442412; ENSG00000196132. [Q01538-2]
GeneIDi4661.
KEGGihsa:4661.
UCSCiuc002yii.3. human. [Q01538-1]

Polymorphism databases

DMDMi13638422.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020642 mRNA. Translation: BAA74858.2 . Different initiation.
AL121581 Genomic DNA. Translation: CAC17005.1 .
CH471077 Genomic DNA. Translation: EAW75155.1 .
CH471077 Genomic DNA. Translation: EAW75157.1 .
CH471077 Genomic DNA. Translation: EAW75158.1 .
AB028973 mRNA. Translation: BAA83002.1 .
BC053638 mRNA. Translation: AAH53638.1 .
M96980 mRNA. Translation: AAA59897.1 .
CCDSi CCDS13558.1. [Q01538-1 ]
RefSeqi NP_004526.1. NM_004535.2. [Q01538-1 ]
UniGenei Hs.279562.

3D structure databases

ProteinModelPortali Q01538.
SMRi Q01538. Positions 27-57, 438-513, 797-983.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110744. 4 interactions.
IntActi Q01538. 1 interaction.
MINTi MINT-4656467.
STRINGi 9606.ENSP00000327465.

Chemistry

BindingDBi Q01538.
ChEMBLi CHEMBL2331044.

PTM databases

PhosphoSitei Q01538.

Polymorphism databases

DMDMi 13638422.

Proteomic databases

MaxQBi Q01538.
PaxDbi Q01538.
PRIDEi Q01538.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000328439 ; ENSP00000327465 ; ENSG00000196132 . [Q01538-1 ]
ENST00000536311 ; ENSP00000442412 ; ENSG00000196132 . [Q01538-2 ]
GeneIDi 4661.
KEGGi hsa:4661.
UCSCi uc002yii.3. human. [Q01538-1 ]

Organism-specific databases

CTDi 4661.
GeneCardsi GC20P062796.
H-InvDB HIX0080185.
HGNCi HGNC:7622. MYT1.
HPAi HPA006303.
MIMi 600379. gene.
neXtProti NX_Q01538.
PharmGKBi PA31426.
HUGEi Search...
Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG329034.
GeneTreei ENSGT00440000038465.
HOGENOMi HOG000234099.
HOVERGENi HBG006433.
InParanoidi Q01538.
OMAi PSKANYS.
OrthoDBi EOG7060Q4.
PhylomeDBi Q01538.
TreeFami TF317299.

Miscellaneous databases

GeneWikii MYT1.
GenomeRNAii 4661.
NextBioi 17968.
PROi Q01538.
SOURCEi Search...

Gene expression databases

Bgeei Q01538.
CleanExi HS_MTF1.
HS_MYT1.
ExpressionAtlasi Q01538. baseline and differential.
Genevestigatori Q01538.

Family and domain databases

InterProi IPR013681. Myelin_TF.
IPR002515. Znf_C2HC.
[Graphical view ]
Pfami PF08474. MYT1. 2 hits.
PF01530. zf-C2HC. 7 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 293-1121 (ISOFORM 1).
    Tissue: Brain.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 303-1121 (ISOFORM 2).
    Tissue: Brain.
  6. "Novel member of the zinc finger superfamily: a C2-HC finger that recognizes a glia-specific gene."
    Kim J.G., Hudson L.D.
    Mol. Cell. Biol. 12:5632-5639(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 424-1121 (ISOFORM 2).
    Tissue: Brain.
  7. "Expression of myelin transcription factor I (MyTI), a 'zinc-finger' DNA-binding protein, in developing oligodendrocytes."
    Armstrong R.C., Kim J.G., Hudson L.D.
    Glia 14:303-321(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  8. Cited for: INTERACTION WITH STEAP3.
  9. "Myelin transcription factor 1 (Myt1) modulates the proliferation and differentiation of oligodendrocyte lineage cells."
    Nielsen J.A., Berndt J.A., Hudson L.D., Armstrong R.C.
    Mol. Cell. Neurosci. 25:111-123(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiMYT1_HUMAN
AccessioniPrimary (citable) accession number: Q01538
Secondary accession number(s): E1P5H0
, F5H7M8, O94922, Q7Z5W2, Q9UPV2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: April 27, 2001
Last modified: November 26, 2014
This is version 139 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3