Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q01538 (MYT1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 132. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Myelin transcription factor 1

Short name=MyT1
Alternative name(s):
Myelin transcription factor I
Short name=MyTI
PLPB1
Proteolipid protein-binding protein
Gene names
Name:MYT1
Synonyms:KIAA0835, KIAA1050, MTF1, MYTI, PLPB1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1121 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds to the promoter regions of proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendrogalia in the CNS. May regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up-regulation of myelin gene transcription. Ref.9

Subunit structure

Interacts with STEAP3. Ref.8

Subcellular location

Nucleus.

Tissue specificity

Mostly in developing nervous system. Expressed in neural progenitors and oligodendrocyte lineage cells. More highly expressed in oligodendrocyte progenitors than in differentiated oligodendrocytes. Ref.7

Domain

Contains 7 zinc fingers of the C2HC class arranged in two widely separated clusters. These two domains of DNA binding can function independently and recognize the same DNA sequence.

Sequence similarities

Contains 7 C2HC-type zinc fingers.

Sequence caution

The sequence BAA74858.2 differs from that shown. Reason: Erroneous initiation.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q01538-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q01538-2)

The sequence of this isoform differs from the canonical sequence as follows:
     616-616: C → SKPFPKASSPRHSPSSSYVRSTSSSSAG

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11211121Myelin transcription factor 1
PRO_0000096676

Regions

Zinc finger28 – 5427C2HC-type 1
Zinc finger440 – 46627C2HC-type 2
Zinc finger484 – 51027C2HC-type 3
Zinc finger798 – 82427C2HC-type 4
Zinc finger842 – 86827C2HC-type 5
Zinc finger891 – 91727C2HC-type 6
Zinc finger944 – 97027C2HC-type 7
Compositional bias200 – 306107Glu-rich
Compositional bias685 – 72339Ser-rich

Natural variations

Alternative sequence6161C → SKPFPKASSPRHSPSSSYVR STSSSSAG in isoform 2.
VSP_054313

Experimental info

Sequence conflict567 – 5748ATPRANLA → RHTQGQLG in AAA59897. Ref.6
Sequence conflict8371A → T in AAA59897. Ref.6
Sequence conflict9431G → D in AAA59897. Ref.6
Sequence conflict957 – 9582AN → TI in AAA59897. Ref.6
Sequence conflict10751R → H in AAA59897. Ref.6
Sequence conflict1088 – 10892DA → VP in AAA59897. Ref.6
Sequence conflict11021D → A in AAA59897. Ref.6

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified April 27, 2001. Version 2.
Checksum: D4AF1F8C7D4EC01E

FASTA1,121122,329
        10         20         30         40         50         60 
MSLENEDKRA RTRSKALRGP PETTAADLSC PTPGCTGSGH VRGKYSRHRS LQSCPLAKKR 

        70         80         90        100        110        120 
KLEGAEAEHL VSKRKSHPLK LALDEGYGVD SDGSEDTEVK DASVSDESEG TLEGAEAETS 

       130        140        150        160        170        180 
GQDEIHRPET AEGRSPVKSH FGSNPIGSAT ASSKGSYSSY QGIIATSLLN LGQIAEETLV 

       190        200        210        220        230        240 
EEDLGQAAKP GPGIVHLLQE AAEGAASEEG EKGLFIQPED AEEVVEVTTE RSQDLCPQSL 

       250        260        270        280        290        300 
EDAASEESSK QKGILSHEEE DEEEEEEEEE EEEDEEEEEE EEEEEEEEEE EEEEEEEEEE 

       310        320        330        340        350        360 
EEEEEEAAPD VIFQEDTSHT SAQKAPELRG PESPSPKPEY SVIVEVRSDD DKDEDTHSRK 

       370        380        390        400        410        420 
STVTDESEMQ DMMTRGNLGL LEQAIALKAE QVRTVCEPGC PPAEQSQLGL GEPGKAAKPL 

       430        440        450        460        470        480 
DTVRKSYYSK DPSRAEKREI KCPTPGCDGT GHVTGLYPHH RSLSGCPHKD RIPPEILAMH 

       490        500        510        520        530        540 
ENVLKCPTPG CTGQGHVNSN RNTHRSLSGC PIAAAEKLAK SHEKQQPQTG DPSKSSSNSD 

       550        560        570        580        590        600 
RILRPMCFVK QLEVPPYGSY RPNVAPATPR ANLAKELEKF SKVTFDYASF DAQVFGKRML 

       610        620        630        640        650        660 
APKIQTSETS PKAFQCFDYS QDAEAAHMAA TAILNLSTRC WEMPENLSTK PQDLPSKSVD 

       670        680        690        700        710        720 
IEVDENGTLD LSMHKHRKRE NAFPSSSSCS SSPGVKSPDA SQRHSSTSAP SSSMTSPQSS 

       730        740        750        760        770        780 
QASRQDEWDR PLDYTKPSRL REEEPEESEP AAHSFASSEA DDQEVSEENF EERKYPGEVT 

       790        800        810        820        830        840 
LTNFKLKFLS KDIKKELLTC PTPGCDGSGH ITGNYASHRS LSGCPLADKS LRNLMAAHSA 

       850        860        870        880        890        900 
DLKCPTPGCD GSGHITGNYA SHRSLSGCPR AKKSGVKVAP TKDDKEDPEL MKCPVPGCVG 

       910        920        930        940        950        960 
LGHISGKYAS HRSASGCPLA ARRQKEGSLN GSSFSWKSLK NEGPTCPTPG CDGSGHANGS 

       970        980        990       1000       1010       1020 
FLTHRSLSGC PRATFAGKKG KLSGDEVLSP KFKTSDVLEN DEEIKQLNQE IRDLNESNSE 

      1030       1040       1050       1060       1070       1080 
MEAAMVQLQS QISSMEKNLK NIEEENKLIE EQNEALFLEL SGLSQALIQS LANIRLPHME 

      1090       1100       1110       1120 
PICEQNFDAY VSTLTDMYSN QDPENKDLLE SIKQAVRGIQ V 

« Hide

Isoform 2 [UniParc].

Checksum: 53CCE237F8356742
Show »

FASTA1,148125,075

References

« Hide 'large scale' references
[1]"Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
[2]"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. expand/collapse author list , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 293-1121 (ISOFORM 1).
Tissue: Brain.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 303-1121 (ISOFORM 2).
Tissue: Brain.
[6]"Novel member of the zinc finger superfamily: a C2-HC finger that recognizes a glia-specific gene."
Kim J.G., Hudson L.D.
Mol. Cell. Biol. 12:5632-5639(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 424-1121 (ISOFORM 2).
Tissue: Brain.
[7]"Expression of myelin transcription factor I (MyTI), a 'zinc-finger' DNA-binding protein, in developing oligodendrocytes."
Armstrong R.C., Kim J.G., Hudson L.D.
Glia 14:303-321(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[8]"The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase."
Passer B.J., Nancy-Portebois V., Amzallag N., Prieur S., Cans C., Roborel de Climens A., Fiucci G., Bouvard V., Tuynder M., Susini L., Morchoisne S., Crible V., Lespagnol A., Dausset J., Oren M., Amson R., Telerman A.
Proc. Natl. Acad. Sci. U.S.A. 100:2284-2289(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH STEAP3.
[9]"Myelin transcription factor 1 (Myt1) modulates the proliferation and differentiation of oligodendrocyte lineage cells."
Nielsen J.A., Berndt J.A., Hudson L.D., Armstrong R.C.
Mol. Cell. Neurosci. 25:111-123(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB020642 mRNA. Translation: BAA74858.2. Different initiation.
AL121581 Genomic DNA. Translation: CAC17005.1.
CH471077 Genomic DNA. Translation: EAW75155.1.
CH471077 Genomic DNA. Translation: EAW75157.1.
CH471077 Genomic DNA. Translation: EAW75158.1.
AB028973 mRNA. Translation: BAA83002.1.
BC053638 mRNA. Translation: AAH53638.1.
M96980 mRNA. Translation: AAA59897.1.
RefSeqNP_004526.1. NM_004535.2.
UniGeneHs.279562.

3D structure databases

ProteinModelPortalQ01538.
SMRQ01538. Positions 27-57, 438-513, 797-983.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110744. 4 interactions.
IntActQ01538. 1 interaction.
MINTMINT-4656467.
STRING9606.ENSP00000327465.

Chemistry

ChEMBLCHEMBL2331044.

PTM databases

PhosphoSiteQ01538.

Polymorphism databases

DMDM13638422.

Proteomic databases

PaxDbQ01538.
PRIDEQ01538.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000328439; ENSP00000327465; ENSG00000196132.
ENST00000536311; ENSP00000442412; ENSG00000196132.
GeneID4661.
KEGGhsa:4661.
UCSCuc002yii.3. human.

Organism-specific databases

CTD4661.
GeneCardsGC20P062795.
H-InvDBHIX0080185.
HGNCHGNC:7622. MYT1.
HPAHPA006303.
MIM600379. gene.
neXtProtNX_Q01538.
PharmGKBPA31426.
HUGESearch...
Search...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG329034.
HOGENOMHOG000234099.
HOVERGENHBG006433.
InParanoidQ01538.
OrthoDBEOG7060Q4.
PhylomeDBQ01538.
TreeFamTF317299.

Gene expression databases

ArrayExpressQ01538.
BgeeQ01538.
CleanExHS_MTF1.
HS_MYT1.
GenevestigatorQ01538.

Family and domain databases

InterProIPR013681. Myelin_TF.
IPR002515. Znf_C2HC.
[Graphical view]
PfamPF08474. MYT1. 2 hits.
PF01530. zf-C2HC. 7 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiMYT1.
GenomeRNAi4661.
NextBio17968.
PROQ01538.
SOURCESearch...

Entry information

Entry nameMYT1_HUMAN
AccessionPrimary (citable) accession number: Q01538
Secondary accession number(s): E1P5H0 expand/collapse secondary AC list , F5H7M8, O94922, Q7Z5W2, Q9UPV2
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: April 27, 2001
Last modified: April 16, 2014
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 20

Human chromosome 20: entries, gene names and cross-references to MIM