Q01538 (MYT1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Myelin transcription factor 1
Short name=MyT1

Alternative name(s):
Myelin transcription factor I
Short name=MyTI
PLPB1
Proteolipid protein-binding protein

Gene names

Name:	MYT1
Synonyms:	KIAA0835, KIAA1050, MTF1, MYTI, PLPB1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1121 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds to the promoter regions of proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendrogalia in the CNS. May regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up-regulation of myelin gene transcription. Ref.8
Subunit structure	Interacts with STEAP3. Ref.7
Subcellular location	Nucleus.
Tissue specificity	Mostly in developing nervous system. Expressed in neural progenitors and oligodendrocyte lineage cells. More highly expressed in oligodendrocyte progenitors than in differentiated oligodendrocytes. Ref.6
Domain	Contains 7 zinc fingers of the C2HC class arranged in two widely separated clusters. These two domains of DNA binding can function independently and recognize the same DNA sequence.
Sequence similarities	Contains 7 C2HC-type zinc fingers.
Sequence caution	The sequence BAA74858.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Differentiation Neurogenesis Transcription Transcription regulation
Cellular component	Nucleus
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW nervous system development Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Non-traceable author statement Ref.5. Source: UniProtKB
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW sequence-specific DNA binding transcription factor activity Non-traceable author statement Ref.5. Source: UniProtKB zinc ion binding Non-traceable author statement Ref.5. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1121	1121	Myelin transcription factor 1		PRO_0000096676
Regions
	Zinc finger	28 – 54	27	C2HC-type 1
	Zinc finger	440 – 466	27	C2HC-type 2
	Zinc finger	484 – 510	27	C2HC-type 3
	Zinc finger	798 – 824	27	C2HC-type 4
	Zinc finger	842 – 868	27	C2HC-type 5
	Zinc finger	891 – 917	27	C2HC-type 6
	Zinc finger	944 – 970	27	C2HC-type 7
	Compositional bias	200 – 306	107	Glu-rich
	Compositional bias	685 – 723	39	Ser-rich
Experimental info
	Sequence conflict	567 – 574	8	ATPRANLA → RHTQGQLG in AAA59897. Ref.5
	Sequence conflict	616	1	C → SKPFPKASSPRHSPSSSYVR STSSSSAG Ref.5
	Sequence conflict	837	1	A → T in AAA59897. Ref.5
	Sequence conflict	943	1	G → D in AAA59897. Ref.5
	Sequence conflict	957 – 958	2	AN → TI in AAA59897. Ref.5
	Sequence conflict	1075	1	R → H in AAA59897. Ref.5
	Sequence conflict	1088 – 1089	2	DA → VP in AAA59897. Ref.5
	Sequence conflict	1102	1	D → A in AAA59897. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Q01538 [UniParc]. Last modified April 27, 2001. Version 2. Checksum: D4AF1F8C7D4EC01E	FASTA	1,121	122,329
	10 20 30 40 50 60 MSLENEDKRA RTRSKALRGP PETTAADLSC PTPGCTGSGH VRGKYSRHRS LQSCPLAKKR 70 80 90 100 110 120 KLEGAEAEHL VSKRKSHPLK LALDEGYGVD SDGSEDTEVK DASVSDESEG TLEGAEAETS 130 140 150 160 170 180 GQDEIHRPET AEGRSPVKSH FGSNPIGSAT ASSKGSYSSY QGIIATSLLN LGQIAEETLV 190 200 210 220 230 240 EEDLGQAAKP GPGIVHLLQE AAEGAASEEG EKGLFIQPED AEEVVEVTTE RSQDLCPQSL 250 260 270 280 290 300 EDAASEESSK QKGILSHEEE DEEEEEEEEE EEEDEEEEEE EEEEEEEEEE EEEEEEEEEE 310 320 330 340 350 360 EEEEEEAAPD VIFQEDTSHT SAQKAPELRG PESPSPKPEY SVIVEVRSDD DKDEDTHSRK 370 380 390 400 410 420 STVTDESEMQ DMMTRGNLGL LEQAIALKAE QVRTVCEPGC PPAEQSQLGL GEPGKAAKPL 430 440 450 460 470 480 DTVRKSYYSK DPSRAEKREI KCPTPGCDGT GHVTGLYPHH RSLSGCPHKD RIPPEILAMH 490 500 510 520 530 540 ENVLKCPTPG CTGQGHVNSN RNTHRSLSGC PIAAAEKLAK SHEKQQPQTG DPSKSSSNSD 550 560 570 580 590 600 RILRPMCFVK QLEVPPYGSY RPNVAPATPR ANLAKELEKF SKVTFDYASF DAQVFGKRML 610 620 630 640 650 660 APKIQTSETS PKAFQCFDYS QDAEAAHMAA TAILNLSTRC WEMPENLSTK PQDLPSKSVD 670 680 690 700 710 720 IEVDENGTLD LSMHKHRKRE NAFPSSSSCS SSPGVKSPDA SQRHSSTSAP SSSMTSPQSS 730 740 750 760 770 780 QASRQDEWDR PLDYTKPSRL REEEPEESEP AAHSFASSEA DDQEVSEENF EERKYPGEVT 790 800 810 820 830 840 LTNFKLKFLS KDIKKELLTC PTPGCDGSGH ITGNYASHRS LSGCPLADKS LRNLMAAHSA 850 860 870 880 890 900 DLKCPTPGCD GSGHITGNYA SHRSLSGCPR AKKSGVKVAP TKDDKEDPEL MKCPVPGCVG 910 920 930 940 950 960 LGHISGKYAS HRSASGCPLA ARRQKEGSLN GSSFSWKSLK NEGPTCPTPG CDGSGHANGS 970 980 990 1000 1010 1020 FLTHRSLSGC PRATFAGKKG KLSGDEVLSP KFKTSDVLEN DEEIKQLNQE IRDLNESNSE 1030 1040 1050 1060 1070 1080 MEAAMVQLQS QISSMEKNLK NIEEENKLIE EQNEALFLEL SGLSQALIQS LANIRLPHME 1090 1100 1110 1120 PICEQNFDAY VSTLTDMYSN QDPENKDLLE SIKQAVRGIQ V

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[2]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 293-1121. Tissue: Brain.
[5]	"Novel member of the zinc finger superfamily: a C2-HC finger that recognizes a glia-specific gene." Kim J.G., Hudson L.D. Mol. Cell. Biol. 12:5632-5639(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 424-1121. Tissue: Brain.
[6]	"Expression of myelin transcription factor I (MyTI), a 'zinc-finger' DNA-binding protein, in developing oligodendrocytes." Armstrong R.C., Kim J.G., Hudson L.D. Glia 14:303-321(1995) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[7]	"The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase." Passer B.J., Nancy-Portebois V., Amzallag N., Prieur S., Cans C., Roborel de Climens A., Fiucci G., Bouvard V., Tuynder M., Susini L., Morchoisne S., Crible V., Lespagnol A., Dausset J., Oren M., Amson R., Telerman A. Proc. Natl. Acad. Sci. U.S.A. 100:2284-2289(2003) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH STEAP3.
[8]	"Myelin transcription factor 1 (Myt1) modulates the proliferation and differentiation of oligodendrocyte lineage cells." Nielsen J.A., Berndt J.A., Hudson L.D., Armstrong R.C. Mol. Cell. Neurosci. 25:111-123(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB020642 mRNA. Translation: BAA74858.2. Different initiation. AL121581 Genomic DNA. Translation: CAC17005.1. CH471077 Genomic DNA. Translation: EAW75155.1. CH471077 Genomic DNA. Translation: EAW75157.1. CH471077 Genomic DNA. Translation: EAW75158.1. AB028973 mRNA. Translation: BAA83002.1. M96980 mRNA. Translation: AAA59897.1.
IPI	IPI00008332.
RefSeq	NP_004526.1. NM_004535.2.
UniGene	Hs.279562.
3D structure databases
ProteinModelPortal	Q01538.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q01538. 1 interaction.
MINT	MINT-4656467.
STRING	9606.ENSP00000327465.
PTM databases
PhosphoSite	Q01538.
Polymorphism databases
DMDM	13638422.
Proteomic databases
PaxDb	Q01538.
PRIDE	Q01538.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000328439; ENSP00000327465; ENSG00000196132.
GeneID	4661.
KEGG	hsa:4661.
UCSC	uc002yii.3. human.
Organism-specific databases
CTD	4661.
GeneCards	GC20P062795.
H-InvDB	HIX0080185.
HGNC	HGNC:7622. MYT1.
HPA	HPA006303.
MIM	600379. gene.
neXtProt	NX_Q01538.
PharmGKB	PA31426.
HUGE	Search... Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG329034.
HOGENOM	HOG000234099.
HOVERGEN	HBG006433.
InParanoid	Q01538.
OrthoDB	EOG4RBQJ2.
PhylomeDB	Q01538.
Gene expression databases
ArrayExpress	Q01538.
Bgee	Q01538.
CleanEx	HS_MTF1. HS_MYT1.
Genevestigator	Q01538.
GermOnline	ENSG00000196132. Homo sapiens.
Family and domain databases
InterPro	IPR013681. Myelin_TF. IPR002515. Znf_C2HC. [Graphical view]
Pfam	PF08474. MYT1. 2 hits. PF01530. zf-C2HC. 7 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	4661.
NextBio	17968.
SOURCE	Search...

Entry information

Entry name

MYT1_HUMAN

Accession

Primary (citable) accession number: Q01538
Secondary accession number(s): E1P5H0, O94922, Q9UPV2

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	April 27, 2001
Last modified:	May 29, 2013
This is version 124 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.