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Q01524 (DEF6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Defensin-6
Alternative name(s):
Defensin, alpha 6
Gene names
Name:DEFA6
Synonyms:DEF6
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length100 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Has very low antimicrobial activity against Gram-negative and Gram-positive bacteria. May protect cells against infection with HIV-1. Ref.6 Ref.7

Subunit structure

Homodimer. Ref.7

Subcellular location

Secreted.

Tissue specificity

Paneth cells of the small intestine.

Sequence similarities

Belongs to the alpha-defensin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Propeptide20 – ?6849 Potential
PRO_0000006790
Peptide?69 – 10032Defensin-6
PRO_0000006791

Amino acid modifications

Disulfide bond72 ↔ 99 Ref.7
Disulfide bond74 ↔ 88 Ref.7
Disulfide bond78 ↔ 98 Ref.7

Secondary structure

...... 100
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q01524 [UniParc].

Last modified July 1, 1993. Version 1.
Checksum: EDF77E033DDCE2D5

FASTA10010,975
        10         20         30         40         50         60 
MRTLTILTAV LLVALQAKAE PLQAEDDPLQ AKAYEADAQE QRGANDQDFA VSFAEDASSS 

        70         80         90        100 
LRALGSTRAF TCHCRRSCYS TEYSYGTCTV MGINHRFCCL 

« Hide

References

« Hide 'large scale' references
[1]"Defensin-6 mRNA in human Paneth cells: implications for antimicrobial peptides in host defense of the human bowel."
Jones D.E., Bevins C.L.
FEBS Lett. 315:187-192(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Intestine.
[2]"Human enteric defensins. Gene structure and developmental expression."
Mallow E.B., Harris A., Salzman N., Russell J.P., Deberardinis R.J., Ruchelli E., Bevins C.L.
J. Biol. Chem. 271:4038-4045(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"DNA sequence and analysis of human chromosome 8."
Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T. expand/collapse author list , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[6]"Antibacterial activity and specificity of the six human alpha-defensins."
Ericksen B., Wu Z., Lu W., Lehrer R.I.
Antimicrob. Agents Chemother. 49:269-275(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[7]"Crystal structures of human alpha-defensins HNP4, HD5, and HD6."
Szyk A., Wu Z., Tucker K., Yang D., Lu W., Lubkowski J.
Protein Sci. 15:2749-2760(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 69-100, FUNCTION, SUBUNIT, DISULFIDE BONDS.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M98331 mRNA. Translation: AAB59357.1.
U33317 Genomic DNA. Translation: AAC50382.1. Sequence problems.
AF200455 Genomic DNA. Translation: AAT68876.1.
CH471153 Genomic DNA. Translation: EAW80484.1.
BC069667 mRNA. Translation: AAH69667.1.
BC069710 mRNA. Translation: AAH69710.1.
BC069728 mRNA. Translation: AAH69728.1.
BC069769 mRNA. Translation: AAH69769.1.
BC093951 mRNA. Translation: AAH93951.1.
BC093953 mRNA. Translation: AAH93953.1.
PIRS27016.
RefSeqNP_001917.1. NM_001926.3.
UniGeneHs.711.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1ZMQX-ray2.10A/B/C/D69-100[»]
3QTEX-ray1.95A/B/C/D69-100[»]
ProteinModelPortalQ01524.
SMRQ01524. Positions 69-100.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid108035. 1 interaction.
STRING9606.ENSP00000297436.

PTM databases

PhosphoSiteQ01524.

Polymorphism databases

DMDM399354.

Proteomic databases

PaxDbQ01524.
PeptideAtlasQ01524.
PRIDEQ01524.

Protocols and materials databases

DNASU1671.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000297436; ENSP00000297436; ENSG00000164822.
GeneID1671.
KEGGhsa:1671.
UCSCuc003wqt.3. human.

Organism-specific databases

CTD1671.
GeneCardsGC08M006769.
HGNCHGNC:2765. DEFA6.
HPAHPA019462.
MIM600471. gene.
neXtProtNX_Q01524.
PharmGKBPA27242.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG286076.
HOGENOMHOG000233351.
HOVERGENHBG011703.
InParanoidQ01524.
KOK05230.
OMAYSTEYSY.
OrthoDBEOG75TMFQ.
PhylomeDBQ01524.
TreeFamTF338414.

Enzyme and pathway databases

ReactomeREACT_6900. Immune System.

Gene expression databases

ArrayExpressQ01524.
BgeeQ01524.
CleanExHS_DEF6.
HS_DEFA6.
GenevestigatorQ01524.

Family and domain databases

InterProIPR016327. Alpha-defensin.
IPR006080. Defensin_beta/neutrophil.
IPR002366. Defensin_propep.
IPR006081. Mammalian_defensins.
[Graphical view]
PANTHERPTHR11876. PTHR11876. 1 hit.
PfamPF00323. Defensin_1. 1 hit.
PF00879. Defensin_propep. 2 hits.
[Graphical view]
PIRSFPIRSF001875. Alpha-defensin. 1 hit.
SMARTSM00048. DEFSN. 1 hit.
[Graphical view]
PROSITEPS00269. DEFENSIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ01524.
GeneWikiDEFA6.
GenomeRNAi1671.
NextBio6876.
PROQ01524.
SOURCESearch...

Entry information

Entry nameDEF6_HUMAN
AccessionPrimary (citable) accession number: Q01524
Secondary accession number(s): Q6EZF9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: March 19, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM