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Protein

Defensin-6

Gene

DEFA6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Has very low antimicrobial activity against Gram-negative and Gram-positive bacteria. May protect cells against infection with HIV-1.2 Publications

GO - Biological processi

  1. antibacterial humoral response Source: UniProtKB
  2. defense response to fungus Source: UniProtKB-KW
  3. innate immune response Source: UniProtKB
  4. killing of cells of other organism Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Defensin, Fungicide

Enzyme and pathway databases

ReactomeiREACT_115574. Alpha-defensins.
REACT_115846. Defensins.

Protein family/group databases

TCDBi1.C.19.1.7. the defensin (defensin) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Defensin-6
Alternative name(s):
Defensin, alpha 6
Gene namesi
Name:DEFA6
Synonyms:DEF6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:2765. DEFA6.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: Reactome
  2. extracellular space Source: InterPro
  3. Golgi lumen Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27242.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Propeptidei20 – ?6849Sequence AnalysisPRO_0000006790Add
BLAST
Peptidei?69 – 10032Defensin-6PRO_0000006791Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi72 ↔ 991 Publication
Disulfide bondi74 ↔ 881 Publication
Disulfide bondi78 ↔ 981 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ01524.
PeptideAtlasiQ01524.
PRIDEiQ01524.

PTM databases

PhosphoSiteiQ01524.

Expressioni

Tissue specificityi

Paneth cells of the small intestine.

Gene expression databases

BgeeiQ01524.
CleanExiHS_DEF6.
HS_DEFA6.
GenevestigatoriQ01524.

Organism-specific databases

HPAiHPA019462.

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

BioGridi108035. 2 interactions.
STRINGi9606.ENSP00000297436.

Structurei

Secondary structure

1
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi70 – 778Combined sources
Beta strandi82 – 909Combined sources
Beta strandi93 – 1008Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ZMQX-ray2.10A/B/C/D69-100[»]
3QTEX-ray1.95A/B/C/D69-100[»]
ProteinModelPortaliQ01524.
SMRiQ01524. Positions 69-100.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ01524.

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG286076.
GeneTreeiENSGT00730000111183.
HOGENOMiHOG000233351.
HOVERGENiHBG011703.
InParanoidiQ01524.
KOiK05230.
OMAiYSTEYSY.
OrthoDBiEOG75TMFQ.
PhylomeDBiQ01524.
TreeFamiTF338414.

Family and domain databases

InterProiIPR016327. Alpha-defensin.
IPR006080. Defensin_beta/neutrophil.
IPR002366. Defensin_propep.
IPR006081. Mammalian_defensins.
[Graphical view]
PANTHERiPTHR11876. PTHR11876. 1 hit.
PfamiPF00323. Defensin_1. 1 hit.
PF00879. Defensin_propep. 2 hits.
[Graphical view]
PIRSFiPIRSF001875. Alpha-defensin. 1 hit.
SMARTiSM00048. DEFSN. 1 hit.
[Graphical view]
PROSITEiPS00269. DEFENSIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q01524-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTLTILTAV LLVALQAKAE PLQAEDDPLQ AKAYEADAQE QRGANDQDFA
60 70 80 90 100
VSFAEDASSS LRALGSTRAF TCHCRRSCYS TEYSYGTCTV MGINHRFCCL
Length:100
Mass (Da):10,975
Last modified:July 1, 1993 - v1
Checksum:iEDF77E033DDCE2D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M98331 mRNA. Translation: AAB59357.1.
U33317 Genomic DNA. Translation: AAC50382.1. Sequence problems.
AF200455 Genomic DNA. Translation: AAT68876.1.
CH471153 Genomic DNA. Translation: EAW80484.1.
BC069667 mRNA. Translation: AAH69667.1.
BC069710 mRNA. Translation: AAH69710.1.
BC069728 mRNA. Translation: AAH69728.1.
BC069769 mRNA. Translation: AAH69769.1.
BC093951 mRNA. Translation: AAH93951.1.
BC093953 mRNA. Translation: AAH93953.1.
CCDSiCCDS5960.1.
PIRiS27016.
RefSeqiNP_001917.1. NM_001926.3.
UniGeneiHs.711.

Genome annotation databases

EnsembliENST00000297436; ENSP00000297436; ENSG00000164822.
GeneIDi1671.
KEGGihsa:1671.
UCSCiuc003wqt.3. human.

Polymorphism databases

DMDMi399354.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M98331 mRNA. Translation: AAB59357.1.
U33317 Genomic DNA. Translation: AAC50382.1. Sequence problems.
AF200455 Genomic DNA. Translation: AAT68876.1.
CH471153 Genomic DNA. Translation: EAW80484.1.
BC069667 mRNA. Translation: AAH69667.1.
BC069710 mRNA. Translation: AAH69710.1.
BC069728 mRNA. Translation: AAH69728.1.
BC069769 mRNA. Translation: AAH69769.1.
BC093951 mRNA. Translation: AAH93951.1.
BC093953 mRNA. Translation: AAH93953.1.
CCDSiCCDS5960.1.
PIRiS27016.
RefSeqiNP_001917.1. NM_001926.3.
UniGeneiHs.711.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ZMQX-ray2.10A/B/C/D69-100[»]
3QTEX-ray1.95A/B/C/D69-100[»]
ProteinModelPortaliQ01524.
SMRiQ01524. Positions 69-100.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108035. 2 interactions.
STRINGi9606.ENSP00000297436.

Protein family/group databases

TCDBi1.C.19.1.7. the defensin (defensin) family.

PTM databases

PhosphoSiteiQ01524.

Polymorphism databases

DMDMi399354.

Proteomic databases

PaxDbiQ01524.
PeptideAtlasiQ01524.
PRIDEiQ01524.

Protocols and materials databases

DNASUi1671.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000297436; ENSP00000297436; ENSG00000164822.
GeneIDi1671.
KEGGihsa:1671.
UCSCiuc003wqt.3. human.

Organism-specific databases

CTDi1671.
GeneCardsiGC08M006769.
HGNCiHGNC:2765. DEFA6.
HPAiHPA019462.
MIMi600471. gene.
neXtProtiNX_Q01524.
PharmGKBiPA27242.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG286076.
GeneTreeiENSGT00730000111183.
HOGENOMiHOG000233351.
HOVERGENiHBG011703.
InParanoidiQ01524.
KOiK05230.
OMAiYSTEYSY.
OrthoDBiEOG75TMFQ.
PhylomeDBiQ01524.
TreeFamiTF338414.

Enzyme and pathway databases

ReactomeiREACT_115574. Alpha-defensins.
REACT_115846. Defensins.

Miscellaneous databases

ChiTaRSiDEFA6. human.
EvolutionaryTraceiQ01524.
GeneWikiiDEFA6.
GenomeRNAii1671.
NextBioi6876.
PROiQ01524.
SOURCEiSearch...

Gene expression databases

BgeeiQ01524.
CleanExiHS_DEF6.
HS_DEFA6.
GenevestigatoriQ01524.

Family and domain databases

InterProiIPR016327. Alpha-defensin.
IPR006080. Defensin_beta/neutrophil.
IPR002366. Defensin_propep.
IPR006081. Mammalian_defensins.
[Graphical view]
PANTHERiPTHR11876. PTHR11876. 1 hit.
PfamiPF00323. Defensin_1. 1 hit.
PF00879. Defensin_propep. 2 hits.
[Graphical view]
PIRSFiPIRSF001875. Alpha-defensin. 1 hit.
SMARTiSM00048. DEFSN. 1 hit.
[Graphical view]
PROSITEiPS00269. DEFENSIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Defensin-6 mRNA in human Paneth cells: implications for antimicrobial peptides in host defense of the human bowel."
    Jones D.E., Bevins C.L.
    FEBS Lett. 315:187-192(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Intestine.
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  6. "Antibacterial activity and specificity of the six human alpha-defensins."
    Ericksen B., Wu Z., Lu W., Lehrer R.I.
    Antimicrob. Agents Chemother. 49:269-275(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. "Crystal structures of human alpha-defensins HNP4, HD5, and HD6."
    Szyk A., Wu Z., Tucker K., Yang D., Lu W., Lubkowski J.
    Protein Sci. 15:2749-2760(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 69-100, FUNCTION, SUBUNIT, DISULFIDE BONDS.

Entry informationi

Entry nameiDEF6_HUMAN
AccessioniPrimary (citable) accession number: Q01524
Secondary accession number(s): Q6EZF9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: February 4, 2015
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.