Q01524 (DEF6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Defensin-6

Alternative name(s):
Defensin, alpha 6

Gene names

Name:	DEFA6
Synonyms:	DEF6

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	100 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Has very low antimicrobial activity against Gram-negative and Gram-positive bacteria. May protect cells against infection with HIV-1. Ref.4 Ref.5
Subunit structure	Homodimer. Ref.5
Subcellular location	Secreted.
Tissue specificity	Paneth cells of the small intestine.
Sequence similarities	Belongs to the alpha-defensin family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Antibiotic Antimicrobial Defensin Fungicide
PTM	Disulfide bond
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	defense response to bacterium Inferred from electronic annotation. Source: UniProtKB-KW defense response to fungus Inferred from electronic annotation. Source: UniProtKB-KW killing of cells of other organism Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular space Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 19

19

Potential

Propeptide

20 – ?65

46

Potential

PRO_0000006790

Peptide

?66 – 100

35

Defensin-6

PRO_0000006791

Amino acid modifications

Disulfide bond

72 ↔ 99

Ref.5

Disulfide bond

74 ↔ 88

Ref.5

Disulfide bond

78 ↔ 98

Ref.5

Secondary structure

1

.

.

.

.

.

100

Helix Strand Turn

Details...

Beta strand

71 – 77

7

Beta strand

82 – 90

9

Sequences

	Sequence		Length	Mass (Da)
	Q01524 [UniParc]. Last modified July 1, 1993. Version 1. Checksum: EDF77E033DDCE2D5	FASTA	100	10,975
	10 20 30 40 50 60 MRTLTILTAV LLVALQAKAE PLQAEDDPLQ AKAYEADAQE QRGANDQDFA VSFAEDASSS 70 80 90 100 LRALGSTRAF TCHCRRSCYS TEYSYGTCTV MGINHRFCCL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Defensin-6 mRNA in human Paneth cells: implications for antimicrobial peptides in host defense of the human bowel." Jones D.E., Bevins C.L. FEBS Lett. 315:187-192(1993) [PubMed: 8417977] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Intestine.
[2]	"Human enteric defensins. Gene structure and developmental expression." Mallow E.B., Harris A., Salzman N., Russell J.P., Deberardinis R.J., Ruchelli E., Bevins C.L. J. Biol. Chem. 271:4038-4045(1996) [PubMed: 8626737] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"Antibacterial activity and specificity of the six human alpha-defensins." Ericksen B., Wu Z., Lu W., Lehrer R.I. Antimicrob. Agents Chemother. 49:269-275(2005) [PubMed: 15616305] [Abstract] Cited for: FUNCTION.
[5]	"Crystal structures of human alpha-defensins HNP4, HD5, and HD6." Szyk A., Wu Z., Tucker K., Yang D., Lu W., Lubkowski J. Protein Sci. 15:2749-2760(2006) [PubMed: 17088326] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 69-100, FUNCTION, SUBUNIT, DISULFIDE BONDS.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

M98331 mRNA. Translation: AAB59357.1.
U33317 Genomic DNA. Translation: AAC50382.1. Sequence problems.
BC069667 mRNA. Translation: AAH69667.1.
BC069710 mRNA. Translation: AAH69710.1.
BC069728 mRNA. Translation: AAH69728.1.
BC069769 mRNA. Translation: AAH69769.1.

IPI

IPI00008301.

PIR

S27016.

RefSeq

NP_001917.1. NM_001926.3.

UniGene

Hs.711.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1ZMQ	X-ray	2.10	A/B/C/D	69-100	[»]

ProteinModelPortal

Q01524.

SMR

Q01524. Positions 69-100.

ModBase

Search...

Protein-protein interaction databases

STRING

Q01524.

Polymorphism databases

DMDM

399354.

Proteomic databases

PeptideAtlas

Q01524.

PRIDE

Q01524.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000297436; ENSP00000297436; ENSG00000164822.

GeneID

1671.

KEGG

hsa:1671.

UCSC

uc003wqt.1. human.

Organism-specific databases

CTD

1671.

GeneCards

GC08M006769.

H-InvDB

HIX0034354.

HGNC

HGNC:2765. DEFA6.

HPA

HPA019462.

MIM

600471. gene.

neXtProt

NX_Q01524.

PharmGKB

PA27242.

GenAtlas

Search...

Phylogenomic databases

eggNOG

prNOG21338.

HOGENOM

HBG283450.

HOVERGEN

HBG011703.

InParanoid

Q01524.

OMA

SCYSTEY.

OrthoDB

EOG4GF3GT.

PhylomeDB

Q01524.

Gene expression databases

ArrayExpress

Q01524.

Bgee

Q01524.

CleanEx

HS_DEF6.
HS_DEFA6.

Genevestigator

Q01524.

GermOnline

ENSG00000164822. Homo sapiens.

Family and domain databases

InterPro

IPR016327. Alpha-defensin.
IPR006080. Defensin_beta/neutrophil.
IPR002366. Defensin_propep.
IPR006081. Mammalian_defensins.
[Graphical view]

KO

K05230.

PANTHER

PTHR11876. PTHR11876. 1 hit.

Pfam

PF00323. Defensin_1. 1 hit.
PF00879. Defensin_propep. 2 hits.
[Graphical view]

PIRSF

PIRSF001875. Alpha-defensin. 1 hit.

SMART

SM00048. DEFSN. 1 hit.
[Graphical view]

PROSITE

PS00269. DEFENSIN. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

NextBio

6876.

SOURCE

Search...

Entry information

Entry name

DEF6_HUMAN

Accession

Primary (citable) accession number: Q01524

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	July 1, 1993
Last modified:	January 25, 2012
This is version 94 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.