Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q01524

- DEF6_HUMAN

UniProt

Q01524 - DEF6_HUMAN

Protein

Defensin-6

Gene

DEFA6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Has very low antimicrobial activity against Gram-negative and Gram-positive bacteria. May protect cells against infection with HIV-1.2 Publications

    GO - Biological processi

    1. antibacterial humoral response Source: UniProt
    2. defense response to fungus Source: UniProtKB-KW
    3. innate immune response Source: UniProt
    4. killing of cells of other organism Source: UniProtKB-KW

    Keywords - Molecular functioni

    Antibiotic, Antimicrobial, Defensin, Fungicide

    Enzyme and pathway databases

    ReactomeiREACT_115574. Alpha-defensins.
    REACT_115846. Defensins.

    Protein family/group databases

    TCDBi1.C.19.1.7. the defensin (defensin) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Defensin-6
    Alternative name(s):
    Defensin, alpha 6
    Gene namesi
    Name:DEFA6
    Synonyms:DEF6
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:2765. DEFA6.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: Reactome
    2. extracellular space Source: InterPro
    3. Golgi lumen Source: Reactome

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA27242.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Propeptidei20 – ?6849Sequence AnalysisPRO_0000006790Add
    BLAST
    Peptidei?69 – 10032Defensin-6PRO_0000006791Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi72 ↔ 991 Publication
    Disulfide bondi74 ↔ 881 Publication
    Disulfide bondi78 ↔ 981 Publication

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiQ01524.
    PeptideAtlasiQ01524.
    PRIDEiQ01524.

    PTM databases

    PhosphoSiteiQ01524.

    Expressioni

    Tissue specificityi

    Paneth cells of the small intestine.

    Gene expression databases

    ArrayExpressiQ01524.
    BgeeiQ01524.
    CleanExiHS_DEF6.
    HS_DEFA6.
    GenevestigatoriQ01524.

    Organism-specific databases

    HPAiHPA019462.

    Interactioni

    Subunit structurei

    Homodimer.1 Publication

    Protein-protein interaction databases

    BioGridi108035. 1 interaction.
    STRINGi9606.ENSP00000297436.

    Structurei

    Secondary structure

    1
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi70 – 778
    Beta strandi82 – 909
    Beta strandi93 – 1008

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1ZMQX-ray2.10A/B/C/D69-100[»]
    3QTEX-ray1.95A/B/C/D69-100[»]
    ProteinModelPortaliQ01524.
    SMRiQ01524. Positions 69-100.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ01524.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alpha-defensin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG286076.
    HOGENOMiHOG000233351.
    HOVERGENiHBG011703.
    InParanoidiQ01524.
    KOiK05230.
    OMAiYSTEYSY.
    OrthoDBiEOG75TMFQ.
    PhylomeDBiQ01524.
    TreeFamiTF338414.

    Family and domain databases

    InterProiIPR016327. Alpha-defensin.
    IPR006080. Defensin_beta/neutrophil.
    IPR002366. Defensin_propep.
    IPR006081. Mammalian_defensins.
    [Graphical view]
    PANTHERiPTHR11876. PTHR11876. 1 hit.
    PfamiPF00323. Defensin_1. 1 hit.
    PF00879. Defensin_propep. 2 hits.
    [Graphical view]
    PIRSFiPIRSF001875. Alpha-defensin. 1 hit.
    SMARTiSM00048. DEFSN. 1 hit.
    [Graphical view]
    PROSITEiPS00269. DEFENSIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q01524-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRTLTILTAV LLVALQAKAE PLQAEDDPLQ AKAYEADAQE QRGANDQDFA    50
    VSFAEDASSS LRALGSTRAF TCHCRRSCYS TEYSYGTCTV MGINHRFCCL 100
    Length:100
    Mass (Da):10,975
    Last modified:July 1, 1993 - v1
    Checksum:iEDF77E033DDCE2D5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M98331 mRNA. Translation: AAB59357.1.
    U33317 Genomic DNA. Translation: AAC50382.1. Sequence problems.
    AF200455 Genomic DNA. Translation: AAT68876.1.
    CH471153 Genomic DNA. Translation: EAW80484.1.
    BC069667 mRNA. Translation: AAH69667.1.
    BC069710 mRNA. Translation: AAH69710.1.
    BC069728 mRNA. Translation: AAH69728.1.
    BC069769 mRNA. Translation: AAH69769.1.
    BC093951 mRNA. Translation: AAH93951.1.
    BC093953 mRNA. Translation: AAH93953.1.
    CCDSiCCDS5960.1.
    PIRiS27016.
    RefSeqiNP_001917.1. NM_001926.3.
    UniGeneiHs.711.

    Genome annotation databases

    EnsembliENST00000297436; ENSP00000297436; ENSG00000164822.
    GeneIDi1671.
    KEGGihsa:1671.
    UCSCiuc003wqt.3. human.

    Polymorphism databases

    DMDMi399354.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M98331 mRNA. Translation: AAB59357.1 .
    U33317 Genomic DNA. Translation: AAC50382.1 . Sequence problems.
    AF200455 Genomic DNA. Translation: AAT68876.1 .
    CH471153 Genomic DNA. Translation: EAW80484.1 .
    BC069667 mRNA. Translation: AAH69667.1 .
    BC069710 mRNA. Translation: AAH69710.1 .
    BC069728 mRNA. Translation: AAH69728.1 .
    BC069769 mRNA. Translation: AAH69769.1 .
    BC093951 mRNA. Translation: AAH93951.1 .
    BC093953 mRNA. Translation: AAH93953.1 .
    CCDSi CCDS5960.1.
    PIRi S27016.
    RefSeqi NP_001917.1. NM_001926.3.
    UniGenei Hs.711.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1ZMQ X-ray 2.10 A/B/C/D 69-100 [» ]
    3QTE X-ray 1.95 A/B/C/D 69-100 [» ]
    ProteinModelPortali Q01524.
    SMRi Q01524. Positions 69-100.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108035. 1 interaction.
    STRINGi 9606.ENSP00000297436.

    Protein family/group databases

    TCDBi 1.C.19.1.7. the defensin (defensin) family.

    PTM databases

    PhosphoSitei Q01524.

    Polymorphism databases

    DMDMi 399354.

    Proteomic databases

    PaxDbi Q01524.
    PeptideAtlasi Q01524.
    PRIDEi Q01524.

    Protocols and materials databases

    DNASUi 1671.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000297436 ; ENSP00000297436 ; ENSG00000164822 .
    GeneIDi 1671.
    KEGGi hsa:1671.
    UCSCi uc003wqt.3. human.

    Organism-specific databases

    CTDi 1671.
    GeneCardsi GC08M006769.
    HGNCi HGNC:2765. DEFA6.
    HPAi HPA019462.
    MIMi 600471. gene.
    neXtProti NX_Q01524.
    PharmGKBi PA27242.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG286076.
    HOGENOMi HOG000233351.
    HOVERGENi HBG011703.
    InParanoidi Q01524.
    KOi K05230.
    OMAi YSTEYSY.
    OrthoDBi EOG75TMFQ.
    PhylomeDBi Q01524.
    TreeFami TF338414.

    Enzyme and pathway databases

    Reactomei REACT_115574. Alpha-defensins.
    REACT_115846. Defensins.

    Miscellaneous databases

    EvolutionaryTracei Q01524.
    GeneWikii DEFA6.
    GenomeRNAii 1671.
    NextBioi 6876.
    PROi Q01524.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q01524.
    Bgeei Q01524.
    CleanExi HS_DEF6.
    HS_DEFA6.
    Genevestigatori Q01524.

    Family and domain databases

    InterProi IPR016327. Alpha-defensin.
    IPR006080. Defensin_beta/neutrophil.
    IPR002366. Defensin_propep.
    IPR006081. Mammalian_defensins.
    [Graphical view ]
    PANTHERi PTHR11876. PTHR11876. 1 hit.
    Pfami PF00323. Defensin_1. 1 hit.
    PF00879. Defensin_propep. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF001875. Alpha-defensin. 1 hit.
    SMARTi SM00048. DEFSN. 1 hit.
    [Graphical view ]
    PROSITEi PS00269. DEFENSIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Defensin-6 mRNA in human Paneth cells: implications for antimicrobial peptides in host defense of the human bowel."
      Jones D.E., Bevins C.L.
      FEBS Lett. 315:187-192(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Intestine.
    2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "DNA sequence and analysis of human chromosome 8."
      Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
      , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
      Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    6. "Antibacterial activity and specificity of the six human alpha-defensins."
      Ericksen B., Wu Z., Lu W., Lehrer R.I.
      Antimicrob. Agents Chemother. 49:269-275(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    7. "Crystal structures of human alpha-defensins HNP4, HD5, and HD6."
      Szyk A., Wu Z., Tucker K., Yang D., Lu W., Lubkowski J.
      Protein Sci. 15:2749-2760(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 69-100, FUNCTION, SUBUNIT, DISULFIDE BONDS.

    Entry informationi

    Entry nameiDEF6_HUMAN
    AccessioniPrimary (citable) accession number: Q01524
    Secondary accession number(s): Q6EZF9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: July 1, 1993
    Last modified: October 1, 2014
    This is version 118 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3