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Protein

Cytochrome c oxidase subunit 6B

Gene

COX12

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. This protein may be one of the heme-binding subunits of the oxidase.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

GO - Molecular functioni

GO - Biological processi

  • mitochondrial respiratory chain complex IV assembly Source: SGD
  • oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciMetaCyc:YLR038C-MONOMER.
YEAST:YLR038C-MONOMER.
UniPathwayiUPA00705.

Protein family/group databases

TCDBi3.D.4.8.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 6B (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide VIb
Gene namesi
Name:COX12
Ordered Locus Names:YLR038C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR038C.
SGDiS000004028. COX12.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial intermembrane space Source: SGD
  • mitochondrial respiratory chain complex IV Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved2 Publications
Chaini2 – 8382Cytochrome c oxidase subunit 6BPRO_0000194925Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi27 ↔ 59By similarity
Disulfide bondi37 ↔ 48By similarity
Modified residuei82 – 821PhosphoserineCombined sources

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

MaxQBiQ01519.

2D gel databases

UCD-2DPAGEQ01519.

PTM databases

iPTMnetiQ01519.

Interactioni

Subunit structurei

Cytochrome c oxidase is composed of 11 subunits: one copy each of COX1, COX2, COX3, COX4, COX5A or COX5B, COX6, COX7, COX9, COX12, COX13 and two copies of COX8.

Protein-protein interaction databases

BioGridi31314. 114 interactions.
DIPiDIP-4520N.
IntActiQ01519. 11 interactions.
MINTiMINT-563973.

Structurei

3D structure databases

ProteinModelPortaliQ01519.
SMRiQ01519. Positions 10-80.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi27 – 3711Cx9C motifAdd
BLAST
Motifi48 – 5912Cx10C motifAdd
BLAST

Domaini

The Cx9C/Cx10C motifs are involved in the recognition by the mitochondrial MIA40-ERV1 disulfide relay system and the subsequent transfer of disulfide bonds by dithiol/disulfide exchange reactions to the newly imported protein.By similarity

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000001191.
HOGENOMiHOG000165128.
InParanoidiQ01519.
KOiK02267.
OMAiLDFHRCQ.
OrthoDBiEOG092C5PUX.

Family and domain databases

Gene3Di1.10.10.140. 1 hit.
InterProiIPR003213. Cyt_c_oxidase_su6B.
[Graphical view]
PfamiPF02297. COX6B. 1 hit.
[Graphical view]
PIRSFiPIRSF000278. Cyt_c_oxidase_6B. 1 hit.
SUPFAMiSSF47694. SSF47694. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q01519-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADQENSPLH TVGFDARFPQ QNQTKHCWQS YVDYHKCVNM KGEDFAPCKV
60 70 80
FWKTYNALCP LDWIEKWDDQ REKGIFAGDI NSD
Length:83
Mass (Da):9,788
Last modified:January 23, 2007 - v2
Checksum:i57A8FAD93756577E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M98332 Genomic DNA. Translation: AAA34510.1.
Z73210 Genomic DNA. Translation: CAA97566.1.
AY557925 Genomic DNA. Translation: AAS56251.1.
BK006945 Genomic DNA. Translation: DAA09357.1.
PIRiS31256.
RefSeqiNP_013139.1. NM_001181925.1.

Genome annotation databases

EnsemblFungiiYLR038C; YLR038C; YLR038C.
GeneIDi850727.
KEGGisce:YLR038C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M98332 Genomic DNA. Translation: AAA34510.1.
Z73210 Genomic DNA. Translation: CAA97566.1.
AY557925 Genomic DNA. Translation: AAS56251.1.
BK006945 Genomic DNA. Translation: DAA09357.1.
PIRiS31256.
RefSeqiNP_013139.1. NM_001181925.1.

3D structure databases

ProteinModelPortaliQ01519.
SMRiQ01519. Positions 10-80.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31314. 114 interactions.
DIPiDIP-4520N.
IntActiQ01519. 11 interactions.
MINTiMINT-563973.

Protein family/group databases

TCDBi3.D.4.8.1. the proton-translocating cytochrome oxidase (cox) superfamily.

PTM databases

iPTMnetiQ01519.

2D gel databases

UCD-2DPAGEQ01519.

Proteomic databases

MaxQBiQ01519.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYLR038C; YLR038C; YLR038C.
GeneIDi850727.
KEGGisce:YLR038C.

Organism-specific databases

EuPathDBiFungiDB:YLR038C.
SGDiS000004028. COX12.

Phylogenomic databases

GeneTreeiENSGT00390000001191.
HOGENOMiHOG000165128.
InParanoidiQ01519.
KOiK02267.
OMAiLDFHRCQ.
OrthoDBiEOG092C5PUX.

Enzyme and pathway databases

UniPathwayiUPA00705.
BioCyciMetaCyc:YLR038C-MONOMER.
YEAST:YLR038C-MONOMER.

Miscellaneous databases

PROiQ01519.

Family and domain databases

Gene3Di1.10.10.140. 1 hit.
InterProiIPR003213. Cyt_c_oxidase_su6B.
[Graphical view]
PfamiPF02297. COX6B. 1 hit.
[Graphical view]
PIRSFiPIRSF000278. Cyt_c_oxidase_6B. 1 hit.
SUPFAMiSSF47694. SSF47694. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCOX12_YEAST
AccessioniPrimary (citable) accession number: Q01519
Secondary accession number(s): D6VY41, Q9URA6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 143 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1390 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.