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Protein

Adenylyl cyclase-associated protein 1

Gene

CAP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity.

GO - Molecular functioni

GO - Biological processi

  • actin polymerization or depolymerization Source: GO_Central
  • activation of adenylate cyclase activity Source: ProtInc
  • ameboidal-type cell migration Source: Ensembl
  • cell morphogenesis Source: GO_Central
  • establishment or maintenance of cell polarity Source: ProtInc
  • neutrophil degranulation Source: Reactome
  • receptor-mediated endocytosis Source: Ensembl
  • signal transduction Source: ProtInc

Keywordsi

Molecular functionActin-binding

Enzyme and pathway databases

ReactomeiR-HSA-114608. Platelet degranulation.
R-HSA-428890. Role of Abl in Robo-Slit signaling.
R-HSA-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylyl cyclase-associated protein 1
Short name:
CAP 1
Gene namesi
Name:CAP1
Synonyms:CAP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:20040. CAP1.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10487.
MalaCardsiCAP1.
OpenTargetsiENSG00000131236.
PharmGKBiPA399.

Polymorphism and mutation databases

BioMutaiCAP1.
DMDMi308153681.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00002056962 – 475Adenylyl cyclase-associated protein 1Add BLAST474

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei31PhosphotyrosineBy similarity1
Modified residuei34PhosphoserineCombined sources1
Modified residuei81N6-acetyllysineCombined sources1
Modified residuei287N6-methyllysineCombined sources1
Modified residuei290PhosphoserineCombined sources1
Modified residuei295PhosphoserineCombined sources1
Modified residuei301PhosphoserineCombined sources1
Modified residuei307PhosphothreonineCombined sources1
Modified residuei308PhosphoserineCombined sources1
Modified residuei310PhosphoserineCombined sources1
Cross-linki348Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ01518.
MaxQBiQ01518.
PaxDbiQ01518.
PeptideAtlasiQ01518.
PRIDEiQ01518.

2D gel databases

OGPiQ01518.
REPRODUCTION-2DPAGEiIPI00639931.

PTM databases

iPTMnetiQ01518.
PhosphoSitePlusiQ01518.
SwissPalmiQ01518.

Expressioni

Gene expression databases

BgeeiENSG00000131236.
CleanExiHS_CAP1.
ExpressionAtlasiQ01518. baseline and differential.
GenevisibleiQ01518. HS.

Organism-specific databases

HPAiHPA030124.

Interactioni

Subunit structurei

Homodimer. Binds actin monomers.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115750. 52 interactors.
DIPiDIP-62063N.
IntActiQ01518. 7 interactors.
MINTiMINT-3024327.
STRINGi9606.ENSP00000361878.

Structurei

Secondary structure

1475
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi321 – 325Combined sources5
Beta strandi328 – 333Combined sources6
Beta strandi340 – 342Combined sources3
Beta strandi350 – 355Combined sources6
Beta strandi360 – 374Combined sources15
Beta strandi376 – 393Combined sources18
Beta strandi395 – 403Combined sources9
Beta strandi406 – 412Combined sources7
Beta strandi414 – 419Combined sources6
Beta strandi428 – 433Combined sources6
Beta strandi435 – 443Combined sources9
Turni444 – 446Combined sources3
Beta strandi447 – 452Combined sources6
Beta strandi456 – 461Combined sources6
Beta strandi463 – 471Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1K8FX-ray2.80A/B/C/D319-475[»]
ProteinModelPortaliQ01518.
SMRiQ01518.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ01518.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini319 – 453C-CAP/cofactor C-likePROSITE-ProRule annotationAdd BLAST135

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi218 – 256Ala/Pro/Ser-richAdd BLAST39
Compositional biasi230 – 241Poly-ProAdd BLAST12

Sequence similaritiesi

Belongs to the CAP family.Curated

Phylogenomic databases

eggNOGiKOG2675. Eukaryota.
ENOG410XPXJ. LUCA.
GeneTreeiENSGT00390000017955.
HOGENOMiHOG000206192.
HOVERGENiHBG003080.
InParanoidiQ01518.
KOiK17261.
OMAiHCGYGDS.
OrthoDBiEOG091G0DLX.
PhylomeDBiQ01518.
TreeFamiTF313791.

Family and domain databases

InterProiView protein in InterPro
IPR001837. Adenylate_cyclase-assoc_CAP.
IPR013912. Adenylate_cyclase-assoc_CAP_C.
IPR013992. Adenylate_cyclase-assoc_CAP_N.
IPR017901. C-CAP_CF_C-like.
IPR028415. CAP1.
IPR028417. CAP_CS_C.
IPR018106. CAP_CS_N.
IPR006599. CARP_motif.
PANTHERiPTHR10652. PTHR10652. 1 hit.
PTHR10652:SF16. PTHR10652:SF16. 1 hit.
PfamiView protein in Pfam
PF08603. CAP_C. 1 hit.
PF01213. CAP_N. 1 hit.
SMARTiView protein in SMART
SM00673. CARP. 2 hits.
SUPFAMiSSF101278. SSF101278. 1 hit.
SSF69340. SSF69340. 1 hit.
PROSITEiView protein in PROSITE
PS51329. C_CAP_COFACTOR_C. 1 hit.
PS01088. CAP_1. 1 hit.
PS01089. CAP_2. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q01518-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADMQNLVER LERAVGRLEA VSHTSDMHRG YADSPSKAGA APYVQAFDSL
60 70 80 90 100
LAGPVAEYLK ISKEIGGDVQ KHAEMVHTGL KLERALLVTA SQCQQPAENK
110 120 130 140 150
LSDLLAPISE QIKEVITFRE KNRGSKLFNH LSAVSESIQA LGWVAMAPKP
160 170 180 190 200
GPYVKEMNDA AMFYTNRVLK EYKDVDKKHV DWVKAYLSIW TELQAYIKEF
210 220 230 240 250
HTTGLAWSKT GPVAKELSGL PSGPSAGSCP PPPPPCPPPP PVSTISCSYE
260 270 280 290 300
SASRSSLFAQ INQGESITHA LKHVSDDMKT HKNPALKAQS GPVRSGPKPF
310 320 330 340 350
SAPKPQTSPS PKRATKKEPA VLELEGKKWR VENQENVSNL VIEDTELKQV
360 370 380 390 400
AYIYKCVNTT LQIKGKINSI TVDNCKKLGL VFDDVVGIVE IINSKDVKVQ
410 420 430 440 450
VMGKVPTISI NKTDGCHAYL SKNSLDCEIV SAKSSEMNVL IPTEGGDFNE
460 470
FPVPEQFKTL WNGQKLVTTV TEIAG
Length:475
Mass (Da):51,901
Last modified:October 5, 2010 - v5
Checksum:i7789D1FAC0D1AB7B
GO
Isoform 2 (identifier: Q01518-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     38-38: Missing.

Show »
Length:474
Mass (Da):51,830
Checksum:iE0CD26F4975A39A0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti374N → S in BAD96233 (Ref. 5) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_028419229C → G6 PublicationsCorresponds to variant dbSNP:rs11207440Ensembl.1
Natural variantiVAR_028420236C → G6 PublicationsCorresponds to variant dbSNP:rs6665926Ensembl.1
Natural variantiVAR_028421245I → S6 PublicationsCorresponds to variant dbSNP:rs6665933Ensembl.1
Natural variantiVAR_028422247C → G6 PublicationsCorresponds to variant dbSNP:rs6665936Ensembl.1
Natural variantiVAR_028423249Y → D6 PublicationsCorresponds to variant dbSNP:rs6665937Ensembl.1
Natural variantiVAR_028424256S → A6 PublicationsCorresponds to variant dbSNP:rs6665944Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03603838Missing in isoform 2. Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M98474 mRNA. Translation: AAA35648.1.
L12168 mRNA. Translation: AAA35507.1.
BT007152 mRNA. Translation: AAP35816.1.
CR457409 mRNA. Translation: CAG33690.1.
AK222513 mRNA. Translation: BAD96233.1.
AL512599 Genomic DNA. Translation: CAI11021.1.
AL512599 Genomic DNA. Translation: CAI11022.1.
BC013963 mRNA. Translation: AAH13963.1.
BC095440 mRNA. Translation: AAH95440.1.
CCDSiCCDS41309.1. [Q01518-1]
CCDS81304.1. [Q01518-2]
PIRiA48120.
RefSeqiNP_001099000.1. NM_001105530.1.
NP_006358.1. NM_006367.3.
XP_005270425.1. XM_005270368.1. [Q01518-1]
XP_011538811.1. XM_011540509.1. [Q01518-1]
XP_011538812.1. XM_011540510.1. [Q01518-1]
XP_011538813.1. XM_011540511.1. [Q01518-2]
XP_011538814.1. XM_011540512.1. [Q01518-2]
XP_011538815.1. XM_011540513.2. [Q01518-2]
XP_011538816.1. XM_011540514.1. [Q01518-2]
XP_011538817.1. XM_011540515.1. [Q01518-2]
XP_016855556.1. XM_017000067.1. [Q01518-1]
XP_016855557.1. XM_017000068.1. [Q01518-1]
XP_016855558.1. XM_017000069.1. [Q01518-1]
XP_016855559.1. XM_017000070.1. [Q01518-1]
XP_016855560.1. XM_017000071.1. [Q01518-1]
XP_016855561.1. XM_017000072.1. [Q01518-1]
UniGeneiHs.370581.

Genome annotation databases

EnsembliENST00000340450; ENSP00000344832; ENSG00000131236. [Q01518-2]
ENST00000372792; ENSP00000361878; ENSG00000131236. [Q01518-1]
ENST00000372797; ENSP00000361883; ENSG00000131236. [Q01518-1]
ENST00000372798; ENSP00000361884; ENSG00000131236. [Q01518-2]
ENST00000372802; ENSP00000361888; ENSG00000131236. [Q01518-2]
ENST00000372805; ENSP00000361891; ENSG00000131236. [Q01518-1]
GeneIDi10487.
KEGGihsa:10487.
UCSCiuc001cey.5. human. [Q01518-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCAP1_HUMAN
AccessioniPrimary (citable) accession number: Q01518
Secondary accession number(s): Q53HR7
, Q5T0S1, Q5T0S2, Q6I9U6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: October 5, 2010
Last modified: June 7, 2017
This is version 172 of the entry and version 5 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families