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Protein

Aminoglycoside N(3)-acetyltransferase III

Gene

aac3-Vb

Organism
Serratia marcescens
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Resistance to antibiotics containing the 2-deoxy-streptamine ring including gentamicin, kanamycin, tobramycin, neomycin and apramycin.

Catalytic activityi

Acetyl-CoA + a 2-deoxystreptamine antibiotic = CoA + N(3)-acetyl-2-deoxystreptamine antibiotic.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Antibiotic resistance

Names & Taxonomyi

Protein namesi
Recommended name:
Aminoglycoside N(3)-acetyltransferase III (EC:2.3.1.81)
Alternative name(s):
ACC(3)-III
Aminocyclitol 3-N-acetyltransferase type III
Gentamicin-(3)-N-acetyl-transferase
Gene namesi
Name:aac3-Vb
OrganismiSerratia marcescens
Taxonomic identifieri615 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeSerratia

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000685471 – 269Aminoglycoside N(3)-acetyltransferase IIIAdd BLAST269

Proteomic databases

PRIDEiQ01515.

Structurei

3D structure databases

ProteinModelPortaliQ01515.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK19275.

Family and domain databases

InterProiIPR003679. Amioglycoside_AcTrfase.
[Graphical view]
PfamiPF02522. Antibiotic_NAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q01515-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTIESITAD LHGLGVRPGD LIMVHASLKA VGPVEGGAAS VVSALRAAVG
60 70 80 90 100
SAGTLMGYAS WDRSPYEETL NGARMDEELR RRWPPFDLAT SGTYPGFGLL
110 120 130 140 150
NRFLLEAPDA RRSAHPDASM VAVGPLAATL TEPHRLGQAL GEGSPLERFV
160 170 180 190 200
GHGGKVLLLG APLDSVTVLH YAEAIAPIPN KRRVTYEMPM LGPDGRVRWE
210 220 230 240 250
LAEDFDSNGI LDCFAVDGKP DAVETIAKAY VELGRHREGI VGRAPSYLFE
260
AQDIVSFGVT YLEQHFGAP
Length:269
Mass (Da):28,801
Last modified:June 1, 1994 - v1
Checksum:i03C191289479400D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M97172 Genomic DNA. Translation: AAA26548.1.
PIRiA48906.
RefSeqiWP_033147097.1. NG_047249.1.

Genome annotation databases

KEGGiag:AAA26548.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M97172 Genomic DNA. Translation: AAA26548.1.
PIRiA48906.
RefSeqiWP_033147097.1. NG_047249.1.

3D structure databases

ProteinModelPortaliQ01515.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ01515.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

KEGGiag:AAA26548.

Phylogenomic databases

KOiK19275.

Family and domain databases

InterProiIPR003679. Amioglycoside_AcTrfase.
[Graphical view]
PfamiPF02522. Antibiotic_NAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAAC3_SERMA
AccessioniPrimary (citable) accession number: Q01515
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: November 2, 2016
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.