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Q01515 (AAC3_SERMA) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aminoglycoside N(3')-acetyltransferase III

EC=2.3.1.81
Alternative name(s):
ACC(3)-III
Aminocyclitol 3-N-acetyltransferase type III
Gentamicin-(3)-N-acetyl-transferase
Gene names
Name:aac3-Vb
OrganismSerratia marcescens
Taxonomic identifier615 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSerratia

Protein attributes

Sequence length269 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Resistance to antibiotics containing the 2-deoxy-streptamine ring including gentamicin, kanamycin, tobramycin, neomycin and apramycin.

Catalytic activity

Acetyl-CoA + a 2-deoxystreptamine antibiotic = CoA + N(3')-acetyl-2-deoxystreptamine antibiotic.

Sequence similarities

Belongs to the antibiotic N-acetyltransferase family.

Ontologies

Keywords
   Biological processAntibiotic resistance
   Molecular functionAcyltransferase
Transferase
Gene Ontology (GO)
   Biological_processresponse to antibiotic

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionaminoglycoside 3-N-acetyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 269269Aminoglycoside N(3')-acetyltransferase III
PRO_0000068547

Sequences

Sequence LengthMass (Da)Tools
Q01515 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: 03C191289479400D

FASTA26928,801
        10         20         30         40         50         60 
MNTIESITAD LHGLGVRPGD LIMVHASLKA VGPVEGGAAS VVSALRAAVG SAGTLMGYAS 

        70         80         90        100        110        120 
WDRSPYEETL NGARMDEELR RRWPPFDLAT SGTYPGFGLL NRFLLEAPDA RRSAHPDASM 

       130        140        150        160        170        180 
VAVGPLAATL TEPHRLGQAL GEGSPLERFV GHGGKVLLLG APLDSVTVLH YAEAIAPIPN 

       190        200        210        220        230        240 
KRRVTYEMPM LGPDGRVRWE LAEDFDSNGI LDCFAVDGKP DAVETIAKAY VELGRHREGI 

       250        260 
VGRAPSYLFE AQDIVSFGVT YLEQHFGAP 

« Hide

References

[1]"Cloning and DNA sequence analysis of an aac(3)-Vb gene from Serratia marcescens."
Rather P.N., Mierzwa R., Hare R.S., Miller G.H., Shaw K.J.
Antimicrob. Agents Chemother. 36:2222-2227(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 82041944.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M97172 Genomic DNA. Translation: AAA26548.1.
PIRA48906.

3D structure databases

ProteinModelPortalQ01515.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR003679. Amioglycoside_AcTrfase.
[Graphical view]
PfamPF02522. Antibiotic_NAT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAAC3_SERMA
AccessionPrimary (citable) accession number: Q01515
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: July 9, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families