Q01515 (AAC3_SERMA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aminoglycoside N(3')-acetyltransferase III
EC=2.3.1.81

Alternative name(s):
ACC(3)-III
Aminocyclitol 3-N-acetyltransferase type III
Gentamicin-(3)-N-acetyl-transferase

Gene names

Name:

aac3-Vb

Organism

Serratia marcescens

Taxonomic identifier

615 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Serratia

Protein attributes

Sequence length	269 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Resistance to antibiotics containing the 2-deoxy-streptamine ring including gentamicin, kanamycin, tobramycin, neomycin and apramycin.
Catalytic activity	Acetyl-CoA + a 2-deoxystreptamine antibiotic = CoA + N(3')-acetyl-2-deoxystreptamine antibiotic.
Sequence similarities	Belongs to the antibiotic N-acetyltransferase family.

Ontologies

Keywords
Biological process	Antibiotic resistance
Molecular function	Acyltransferase Transferase
Gene Ontology (GO)
Biological_process	response to antibiotic Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	aminoglycoside 3-N-acetyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 269	269	Aminoglycoside N(3')-acetyltransferase III		PRO_0000068547

Sequences

	Sequence		Length	Mass (Da)
	Q01515 [UniParc]. Last modified June 1, 1994. Version 1. Checksum: 03C191289479400D	FASTA	269	28,801
	10 20 30 40 50 60 MNTIESITAD LHGLGVRPGD LIMVHASLKA VGPVEGGAAS VVSALRAAVG SAGTLMGYAS 70 80 90 100 110 120 WDRSPYEETL NGARMDEELR RRWPPFDLAT SGTYPGFGLL NRFLLEAPDA RRSAHPDASM 130 140 150 160 170 180 VAVGPLAATL TEPHRLGQAL GEGSPLERFV GHGGKVLLLG APLDSVTVLH YAEAIAPIPN 190 200 210 220 230 240 KRRVTYEMPM LGPDGRVRWE LAEDFDSNGI LDCFAVDGKP DAVETIAKAY VELGRHREGI 250 260 VGRAPSYLFE AQDIVSFGVT YLEQHFGAP

References

[1]	"Cloning and DNA sequence analysis of an aac(3)-Vb gene from Serratia marcescens." Rather P.N., Mierzwa R., Hare R.S., Miller G.H., Shaw K.J. Antimicrob. Agents Chemother. 36:2222-2227(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 82041944.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M97172 Genomic DNA. Translation: AAA26548.1.
PIR	A48906.
3D structure databases
ProteinModelPortal	Q01515.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR003679. Amioglycoside_AcTrfase. [Graphical view]
Pfam	PF02522. Antibiotic_NAT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AAC3_SERMA

Accession

Primary (citable) accession number: Q01515

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	April 3, 2013
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program