Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q01515

- AAC3_SERMA

UniProt

Q01515 - AAC3_SERMA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Aminoglycoside N(3')-acetyltransferase III

Gene

aac3-Vb

Organism
Serratia marcescens
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Resistance to antibiotics containing the 2-deoxy-streptamine ring including gentamicin, kanamycin, tobramycin, neomycin and apramycin.

Catalytic activityi

Acetyl-CoA + a 2-deoxystreptamine antibiotic = CoA + N(3')-acetyl-2-deoxystreptamine antibiotic.

GO - Molecular functioni

  1. aminoglycoside 3-N-acetyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Antibiotic resistance

Names & Taxonomyi

Protein namesi
Recommended name:
Aminoglycoside N(3')-acetyltransferase III (EC:2.3.1.81)
Alternative name(s):
ACC(3)-III
Aminocyclitol 3-N-acetyltransferase type III
Gentamicin-(3)-N-acetyl-transferase
Gene namesi
Name:aac3-Vb
OrganismiSerratia marcescens
Taxonomic identifieri615 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSerratia

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 269269Aminoglycoside N(3')-acetyltransferase IIIPRO_0000068547Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ01515.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR003679. Amioglycoside_AcTrfase.
[Graphical view]
PfamiPF02522. Antibiotic_NAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q01515-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNTIESITAD LHGLGVRPGD LIMVHASLKA VGPVEGGAAS VVSALRAAVG
60 70 80 90 100
SAGTLMGYAS WDRSPYEETL NGARMDEELR RRWPPFDLAT SGTYPGFGLL
110 120 130 140 150
NRFLLEAPDA RRSAHPDASM VAVGPLAATL TEPHRLGQAL GEGSPLERFV
160 170 180 190 200
GHGGKVLLLG APLDSVTVLH YAEAIAPIPN KRRVTYEMPM LGPDGRVRWE
210 220 230 240 250
LAEDFDSNGI LDCFAVDGKP DAVETIAKAY VELGRHREGI VGRAPSYLFE
260
AQDIVSFGVT YLEQHFGAP
Length:269
Mass (Da):28,801
Last modified:June 1, 1994 - v1
Checksum:i03C191289479400D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M97172 Genomic DNA. Translation: AAA26548.1.
PIRiA48906.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M97172 Genomic DNA. Translation: AAA26548.1 .
PIRi A48906.

3D structure databases

ProteinModelPortali Q01515.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR003679. Amioglycoside_AcTrfase.
[Graphical view ]
Pfami PF02522. Antibiotic_NAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and DNA sequence analysis of an aac(3)-Vb gene from Serratia marcescens."
    Rather P.N., Mierzwa R., Hare R.S., Miller G.H., Shaw K.J.
    Antimicrob. Agents Chemother. 36:2222-2227(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 82041944.

Entry informationi

Entry nameiAAC3_SERMA
AccessioniPrimary (citable) accession number: Q01515
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: October 1, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3