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Q01515

- AAC3_SERMA

UniProt

Q01515 - AAC3_SERMA

Protein

Aminoglycoside N(3')-acetyltransferase III

Gene

aac3-Vb

Organism
Serratia marcescens
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (01 Jun 1994)
      Previous versions | rss
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    Functioni

    Resistance to antibiotics containing the 2-deoxy-streptamine ring including gentamicin, kanamycin, tobramycin, neomycin and apramycin.

    Catalytic activityi

    Acetyl-CoA + a 2-deoxystreptamine antibiotic = CoA + N(3')-acetyl-2-deoxystreptamine antibiotic.

    GO - Molecular functioni

    1. aminoglycoside 3-N-acetyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. response to antibiotic Source: UniProtKB-KW

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Antibiotic resistance

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aminoglycoside N(3')-acetyltransferase III (EC:2.3.1.81)
    Alternative name(s):
    ACC(3)-III
    Aminocyclitol 3-N-acetyltransferase type III
    Gentamicin-(3)-N-acetyl-transferase
    Gene namesi
    Name:aac3-Vb
    OrganismiSerratia marcescens
    Taxonomic identifieri615 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSerratia

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 269269Aminoglycoside N(3')-acetyltransferase IIIPRO_0000068547Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ01515.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    InterProiIPR003679. Amioglycoside_AcTrfase.
    [Graphical view]
    PfamiPF02522. Antibiotic_NAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q01515-1 [UniParc]FASTAAdd to Basket

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    MNTIESITAD LHGLGVRPGD LIMVHASLKA VGPVEGGAAS VVSALRAAVG    50
    SAGTLMGYAS WDRSPYEETL NGARMDEELR RRWPPFDLAT SGTYPGFGLL 100
    NRFLLEAPDA RRSAHPDASM VAVGPLAATL TEPHRLGQAL GEGSPLERFV 150
    GHGGKVLLLG APLDSVTVLH YAEAIAPIPN KRRVTYEMPM LGPDGRVRWE 200
    LAEDFDSNGI LDCFAVDGKP DAVETIAKAY VELGRHREGI VGRAPSYLFE 250
    AQDIVSFGVT YLEQHFGAP 269
    Length:269
    Mass (Da):28,801
    Last modified:June 1, 1994 - v1
    Checksum:i03C191289479400D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M97172 Genomic DNA. Translation: AAA26548.1.
    PIRiA48906.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M97172 Genomic DNA. Translation: AAA26548.1 .
    PIRi A48906.

    3D structure databases

    ProteinModelPortali Q01515.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR003679. Amioglycoside_AcTrfase.
    [Graphical view ]
    Pfami PF02522. Antibiotic_NAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and DNA sequence analysis of an aac(3)-Vb gene from Serratia marcescens."
      Rather P.N., Mierzwa R., Hare R.S., Miller G.H., Shaw K.J.
      Antimicrob. Agents Chemother. 36:2222-2227(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 82041944.

    Entry informationi

    Entry nameiAAC3_SERMA
    AccessioniPrimary (citable) accession number: Q01515
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3