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Protein

Peroxisomal targeting signal receptor

Gene

PEX5

Organism
Pichia angusta (Yeast) (Hansenula polymorpha)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import.

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal targeting signal receptor
Short name:
PTS1 receptor
Short name:
PTS1R
Alternative name(s):
Peroxin-5
Peroxisomal protein PAH2
Gene namesi
Name:PEX5
Synonyms:PAH2, PER3
OrganismiPichia angusta (Yeast) (Hansenula polymorpha)
Taxonomic identifieri870730 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesPichiaceaeOgataea

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001063121 – 569Peroxisomal targeting signal receptorAdd BLAST569

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki9Glycyl cysteine thioester (Cys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki21Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Post-translational modificationi

Ubiquitination at Cys-9 is UBC4-independent but requires the presence of PEX4. Ubiquitination at Lys-21 is UBC4-dependent (By similarity).By similarity

Keywords - PTMi

Isopeptide bond, Thioester bond, Ubl conjugation

Proteomic databases

PRIDEiQ01495.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PEX20Q3ZJZ23EBI-7372203,EBI-7372223

Protein-protein interaction databases

ELMiQ01495.
IntActiQ01495. 1 interactor.
MINTiMINT-4653472.

Structurei

3D structure databases

ProteinModelPortaliQ01495.
SMRiQ01495.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati272 – 305TPR 1Add BLAST34
Repeati306 – 339TPR 2Add BLAST34
Repeati340 – 377TPR 3Add BLAST38
Repeati378 – 415TPR 4Add BLAST38
Repeati416 – 449TPR 5Add BLAST34
Repeati450 – 483TPR 6Add BLAST34
Repeati484 – 517TPR 7Add BLAST34

Sequence similaritiesi

Keywords - Domaini

Repeat, TPR repeat

Family and domain databases

Gene3Di1.25.40.10. 3 hits.
InterProiView protein in InterPro
IPR024111. PTS1R_family.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
PANTHERiPTHR10130. PTHR10130. 1 hit.
PfamiView protein in Pfam
PF00515. TPR_1. 1 hit.
SMARTiView protein in SMART
SM00028. TPR. 4 hits.
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiView protein in PROSITE
PS50005. TPR. 4 hits.
PS50293. TPR_REGION. 1 hit.

Sequencei

Sequence statusi: Complete.

Q01495-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFLGGSECA ANANPLAQFF KQSQHDTSLE QSLRNSAHDT HQNAQIRAPV
60 70 80 90 100
AMNEAERAHM EQFMNQSTPF NFQPMANELR MIQPDLQTQT TPALRGPRAQ
110 120 130 140 150
NPVPLQIPGQ AQPQVSGWSS EFQNTATSQV THSPSPVSQV RMRSMGMAPR
160 170 180 190 200
LHLRPFSSAN GPIQASSMTN SVMQEDTSQQ VDWEQQFKEM EEMEEMEEAT
210 220 230 240 250
AAMQQPAEET VSAQESAFDQ VWDNIQETYA DNMLSNDEFQ AQWEKDFEKY
260 270 280 290 300
AQTRLNYGEY TFEENNQFRN NLDAYEIGIK LMESGAKLSE AALAFEAAVE
310 320 330 340 350
QNPGHVDAWL RLGQVQTQNE KELAGIAALE KCLELSPQNL VALMTLAISY
360 370 380 390 400
INEGYDNAAF ATLERWIETK YPEVAERARN ANPDIQADDR FSLNKRVTQL
410 420 430 440 450
FIKAAQLSPE GANMDSEVQT GLGVLFYSME EYSKTLDCFQ AAIEHNPNDA
460 470 480 490 500
LAWNRLGASL ANSNKPEQAI EAYSRTLQLN PNFVRARYNL GVSFINMGMY
510 520 530 540 550
RDAVDHLLTG LSMHEVESLD GSSSVARSNQ STSLIETLKR AFLAMDRRDL
560
IDKVKPGLNV ESFRKTYDI
Length:569
Mass (Da):63,910
Last modified:November 1, 1997 - v1
Checksum:iA407FC5808C8885A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti202A → E in AAC49040 (PubMed:7615522).Curated1
Sequence conflicti476T → A in AAC49040 (PubMed:7615522).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U22930 Genomic DNA. Translation: AAC49059.1.
U26678 Genomic DNA. Translation: AAC49040.1.
PIRiJC4177.

Similar proteinsi

Entry informationi

Entry nameiPEX5_PICAN
AccessioniPrimary (citable) accession number: Q01495
Secondary accession number(s): Q01496
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: August 30, 2017
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families