Reviewed, UniProtKB/Swiss-Prot Q01484 (ANK2_HUMAN)

Names and origin

Protein names

Recommended name:
    Ankyrin-2
      Short name=ANK-2
Alternative name(s):
    Brain ankyrin
    Ankyrin-B
    Non-erythroid ankyrin

Gene names

Name:

ANK2

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	3924 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Attaches integral membrane proteins to cytoskeletal elements. Also binds to cytoskeletal proteins. Required for coordinate assembly of Na/Ca exchanger, Na/K ATPase and InsP3 receptor at sarcoplasmic reticulum sites in cardiomyocytes. Required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) in the inner segment of rod photoreceptors. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate. Ref.8
Subunit structure	Interacts with RHBG and SPTBN1. Ref.9 Ref.10 Ref.14
Subcellular location	Cytoplasm › cytoskeleton. Membrane. Cytoplasm › myofibril › sarcomere › M-band By similarity. Apical cell membrane By similarity. Cell membrane. Note: Expressed at the apical membrane of airway lung epithelial cells By similarity. Localized to the plasma membrane of the inner segments of photoreceptors in retina. Colocalizes with SPTBN1 in a distict intracellular compartment of neonatal cardiomyocytes By similarity. Ref.14
Tissue specificity	Present in plasma membrane of neurons as well as glial cells throughout the brain. Expressed in fetal brain and in temporal cortex of adult brain. Also expressed in the inner segments of rod photoreceptors in retina. Ref.14 Ref.1 Ref.7
Post-translational modification	Phosphorylated at multiple sites by different protein kinases and each phosphorylation event regulates the protein's structure and function Potential. Ref.11 Ref.12 Ref.13
Involvement in disease	Defects in ANK2 are the cause of long QT syndrome type 4 (LQT4) [MIM:600919]; also known as sick sinus syndrome with bradycardia. Long QT syndromes are heart disorders characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress. LQT4 displays many atypical features compared to classical long QT syndromes, including pronounced sinus bradycardia, polyphasic T waves and atrial fibrillation. Cardiac repolarization defects may be not as severe as in classical LQT syndromes and prolonged QT interval on EKG is not a consistent feature. Ref.8 Ref.16
Sequence similarities	Contains 24 ANK repeats. Contains 1 death domain. Contains 1 ZU5 domain.
Sequence caution	The sequence AAI25237.1 differs from that shown. Reason: Frameshift at position 1372. The sequence CAB42644.1 differs from that shown. Reason: Miscellaneous discrepancy. CDS lacks C-terminal region which is nevertheless present in the underlying cDNA.

Ontologies

Keywords
Cellular component	Cell membrane Cytoplasm Cytoskeleton Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Disease mutation Long QT syndrome
Domain	ANK repeat Repeat
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	signal transduction Inferred from electronic annotation. Source: InterPro
Cellular component	M band Inferred from electronic annotation. Source: UniProtKB-SubCell apical plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell basolateral plasma membrane Ref.10 Inferred from direct assay. Source: UniProtKB cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein binding Ref.9 Inferred from physical interaction. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
DCTN4	Q9UJW0	1	EBI-941975,EBI-2134033
DMD	P11532-5	1	EBI-941975,EBI-1018651
GRB2	P62993	1	EBI-941975,EBI-401755
NCK1	P16333	1	EBI-941975,EBI-389883
OBSCN	Q5VST9-3	1	EBI-941994,EBI-941921

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q01484-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q01484-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1039-1039: Q → QFLGKLHLPTAPPPLNEGESLVSRILQLGPPGTK
     1444-3528: Missing.

Isoform 3 (identifier: Q01484-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1039-1039: Q → QFLGKLHLPTAPPPLNEGESLVSRILQLGPPGTK

Isoform 4 (identifier: Q01484-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-27: MMNEDAAQKSDSGEKFNGSSQRRKRPK → MTTMLQ
     967-967: G → GRASPCLERDNSS
     1039-1039: Q → QFLGKLHLPTAPPPLNEGESLVSRILQLGPPGTK
     1444-3528: Missing.

Note: No experimental confirmation available.

Isoform 5 (identifier: Q01484-7)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1315: Missing.
     1444-3528: Missing.
     3837-3837: K → KELTEELGELEASSDEEAMVTTRVVRRRVIIQ

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 3924	3924	Ankyrin-2		PRO_0000066885
Regions
	Repeat	30 – 62	33	ANK 1
	Repeat	63 – 92	30	ANK 2
	Repeat	96 – 125	30	ANK 3
	Repeat	129 – 158	30	ANK 4
	Repeat	162 – 191	30	ANK 5
	Repeat	193 – 220	28	ANK 6
	Repeat	232 – 261	30	ANK 7
	Repeat	265 – 294	30	ANK 8
	Repeat	298 – 327	30	ANK 9
	Repeat	331 – 360	30	ANK 10
	Repeat	364 – 393	30	ANK 11
	Repeat	397 – 426	30	ANK 12
	Repeat	430 – 459	30	ANK 13
	Repeat	463 – 492	30	ANK 14
	Repeat	496 – 525	30	ANK 15
	Repeat	529 – 558	30	ANK 16
	Repeat	562 – 591	30	ANK 17
	Repeat	595 – 624	30	ANK 18
	Repeat	628 – 657	30	ANK 19
	Repeat	661 – 690	30	ANK 20
	Repeat	694 – 723	30	ANK 21
	Repeat	727 – 756	30	ANK 22
	Repeat	760 – 789	30	ANK 23
	Repeat	793 – 822	30	ANK 24
	Domain	966 – 1073	108	ZU5
	Repeat	1773 – 1784	12	Repeat A
	Repeat	1785 – 1796	12	Repeat A
	Repeat	1797 – 1808	12	Repeat A
	Repeat	1809 – 1820	12	Repeat A
	Repeat	1821 – 1832	12	Repeat A
	Repeat	1833 – 1844	12	Repeat A
	Repeat	1845 – 1856	12	Repeat A
	Repeat	1857 – 1867	11	Repeat A; approximate
	Repeat	1868 – 1879	12	Repeat A
	Repeat	1880 – 1891	12	Repeat A
	Repeat	1892 – 1902	11	Repeat A; approximate
	Repeat	1903 – 1914	12	Repeat A
	Repeat	1915 – 1926	12	Repeat A
	Repeat	1927 – 1938	12	Repeat A
	Repeat	1939 – 1950	12	Repeat A
	Domain	3536 – 3620	85	Death
	Region	966 – 1125	160	Interaction with SPTBN1
	Region	1773 – 1950	178	Repeat-rich region
Amino acid modifications
	Modified residue	31	1	Phosphoserine By similarity
	Modified residue	34	1	Phosphoserine By similarity
	Modified residue	378	1	Phosphotyrosine By similarity
	Modified residue	531	1	Phosphotyrosine By similarity
	Modified residue	846	1	Phosphoserine By similarity
	Modified residue	898	1	Phosphoserine By similarity
	Modified residue	911	1	Phosphoserine Ref.12
	Modified residue	1349	1	Phosphotyrosine By similarity
	Modified residue	1428	1	Phosphoserine By similarity
	Modified residue	1475	1	Phosphoserine Ref.12
	Modified residue	1490	1	Phosphothreonine Ref.12
	Modified residue	2550	1	Phosphothreonine Ref.11
	Modified residue	3060	1	Phosphothreonine By similarity
	Modified residue	3240	1	Phosphoserine By similarity
	Modified residue	3329	1	Phosphoserine By similarity
	Modified residue	3357	1	Phosphoserine By similarity
	Modified residue	3376	1	Phosphoserine By similarity
	Modified residue	3377	1	Phosphotyrosine By similarity
	Modified residue	3702	1	Phosphoserine By similarity
	Modified residue	3743	1	Phosphothreonine By similarity
	Modified residue	3760	1	Phosphoserine Ref.13
	Modified residue	3762	1	Phosphoserine Ref.13
	Modified residue	3764	1	Phosphothreonine Ref.13
	Modified residue	3769	1	Phosphoserine By similarity
	Modified residue	3770	1	Phosphothreonine By similarity
	Modified residue	3790	1	Phosphoserine By similarity
	Modified residue	3811	1	Phosphothreonine By similarity
Natural variations
	Alternative sequence	1 – 1315	1315	Missing in isoform 5.		VSP_037057
	Alternative sequence	1 – 27	27	MMNED…RKRPK → MTTMLQ in isoform 4.		VSP_037058
	Alternative sequence	967	1	G → GRASPCLERDNSS in isoform 4.		VSP_037059
	Alternative sequence	1039	1	Q → QFLGKLHLPTAPPPLNEGES LVSRILQLGPPGTK in isoform 2, isoform 3 and isoform 4.		VSP_000267
	Alternative sequence	1444 – 3528	2085	Missing in isoform 2, isoform 4 and isoform 5.		VSP_000268
	Alternative sequence	3837	1	K → KELTEELGELEASSDEEAMV TTRVVRRRVIIQ in isoform 5.		VSP_037060
	Natural variant	685	1	G → E in a breast cancer sample; somatic mutation. Ref.17		VAR_035606
	Natural variant	687	1	N → S: dbSNP rs29372.		VAR_055504
	Natural variant	1234	1	G → R in a colorectal cancer sample; somatic mutation. Ref.17		VAR_035607
	Natural variant	1425	1	E → G in LQT4; loss of function. Ref.8 Ref.16		VAR_022934
	Natural variant	2336	1	V → A: dbSNP rs28377576.		VAR_055505
	Natural variant	3620	1	T → K in a colorectal cancer sample; somatic mutation. Ref.17		VAR_035608
	Natural variant	3707	1	L → I in LQT4; loss of function. Ref.16		VAR_022935
	Natural variant	3711	1	T → N in LQT4; loss of function. Ref.16		VAR_022936
	Natural variant	3873	1	R → W in LQT4; loss of function. Ref.16		VAR_022937
	Natural variant	3898	1	E → K in LQT4; loss of function. Ref.16		VAR_022938
Experimental info
	Mutagenesis	975 – 977	3	DAR → AAA: Prevents binding to SPTBN1.
	Mutagenesis	1000	1	A → P: Prevents binding to SPTBN1. Ref.9
	Mutagenesis	1067 – 1070	4	ENGD → AAGA: Weak binding to SPTBN1. Ref.9
	Sequence conflict	220	1	V → I in CAD97827. Ref.4
	Sequence conflict	475 – 476	2	GQ → PE in AAA62828. Ref.7
	Sequence conflict	2754	1	A → R in CAB42644. Ref.3
	Sequence conflict	2966	1	Q → L in CAB42644. Ref.3
	Sequence conflict	3107 – 3108	2	EE → RY in AC093879. Ref.5
	Sequence conflict	3152	1	D → S in CAB42644. Ref.3
	Sequence conflict	3666	1	V → A in CAD97827. Ref.4
	Sequence conflict	3704	1	A → S in CAA40279. Ref.1
	Sequence conflict	3704	1	A → S in CAB42644. Ref.3
	Sequence conflict	3922 – 3923	2	NN → SM in AC093879. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 25, 2008. Version 3. Checksum: C8C426698EBE2FDB	FASTA	3,924	430,255
	10 20 30 40 50 60 MMNEDAAQKS DSGEKFNGSS QRRKRPKKSD SNASFLRAAR AGNLDKVVEY LKGGIDINTC 70 80 90 100 110 120 NQNGLNALHL AAKEGHVGLV QELLGRGSSV DSATKKGNTA LHIASLAGQA EVVKVLVKEG 130 140 150 160 170 180 ANINAQSQNG FTPLYMAAQE NHIDVVKYLL ENGANQSTAT EDGFTPLAVA LQQGHNQAVA 190 200 210 220 230 240 ILLENDTKGK VRLPALHIAA RKDDTKSAAL LLQNDHNADV QSKMMVNRTT ESGFTPLHIA 250 260 270 280 290 300 AHYGNVNVAT LLLNRGAAVD FTARNGITPL HVASKRGNTN MVKLLLDRGG QIDAKTRDGL 310 320 330 340 350 360 TPLHCAARSG HDQVVELLLE RGAPLLARTK NGLSPLHMAA QGDHVECVKH LLQHKAPVDD 370 380 390 400 410 420 VTLDYLTALH VAAHCGHYRV TKLLLDKRAN PNARALNGFT PLHIACKKNR IKVMELLVKY 430 440 450 460 470 480 GASIQAITES GLTPIHVAAF MGHLNIVLLL LQNGASPDVT NIRGETALHM AARAGQVEVV 490 500 510 520 530 540 RCLLRNGALV DARAREEQTP LHIASRLGKT EIVQLLLQHM AHPDAATTNG YTPLHISARE 550 560 570 580 590 600 GQVDVASVLL EAGAAHSLAT KKGFTPLHVA AKYGSLDVAK LLLQRRAAAD SAGKNGLTPL 610 620 630 640 650 660 HVAAHYDNQK VALLLLEKGA SPHATAKNGY TPLHIAAKKN QMQIASTLLN YGAETNIVTK 670 680 690 700 710 720 QGVTPLHLAS QEGHTDMVTL LLDKGANIHM STKSGLTSLH LAAQEDKVNV ADILTKHGAD 730 740 750 760 770 780 QDAHTKLGYT PLIVACHYGN VKMVNFLLKQ GANVNAKTKN GYTPLHQAAQ QGHTHIINVL 790 800 810 820 830 840 LQHGAKPNAT TANGNTALAI AKRLGYISVV DTLKVVTEEV TTTTTTITEK HKLNVPETMT 850 860 870 880 890 900 EVLDVSDEEG DDTMTGDGGE YLRPEDLKEL GDDSLPSSQF LDGMNYLRYS LEGGRSDSLR 910 920 930 940 950 960 SFSSDRSHTL SHASYLRDSA VMDDSVVIPS HQVSTLAKEA ERNSYRLSWG TENLDNVALS 970 980 990 1000 1010 1020 SSPIHSGFLV SFMVDARGGA MRGCRHNGLR IIIPPRKCTA PTRVTCRLVK RHRLATMPPM 1030 1040 1050 1060 1070 1080 VEGEGLASRL IEVGPSGAQF LGPVIVEIPH FAALRGKERE LVVLRSENGD SWKEHFCDYT 1090 1100 1110 1120 1130 1140 EDELNEILNG MDEVLDSPED LEKKRICRII TRDFPQYFAV VSRIKQDSNL IGPEGGVLSS 1150 1160 1170 1180 1190 1200 TVVPQVQAVF PEGALTKRIR VGLQAQPMHS ELVKKILGNK ATFSPIVTLE PRRRKFHKPI 1210 1220 1230 1240 1250 1260 TMTIPVPKAS SDVMLNGFGG DAPTLRLLCS ITGGTTPAQW EDITGTTPLT FVNECVSFTT 1270 1280 1290 1300 1310 1320 NVSARFWLID CRQIQESVTF ASQVYREIIC VPYMAKFVVF AKSHDPIEAR LRCFCMTDDK 1330 1340 1350 1360 1370 1380 VDKTLEQQEN FAEVARSRDV EVLEGKPIYV DCFGNLVPLT KSGQHHIFSF FAFKENRLPL 1390 1400 1410 1420 1430 1440 FVKVRDTTQE PCGRLSFMKE PKSTRGLVHQ AICNLNITLP IYTKESESDQ EQEEEIDMTS 1450 1460 1470 1480 1490 1500 EKNDETESTE TSVLKSHLVN EVPVLASPDL LSEVSEMKQD LIKMTAILTT DVSDKAGSIK 1510 1520 1530 1540 1550 1560 VKELVKAAEE EPGEPFEIVE RVKEDLEKVN EILRSGTCTR DESSVQSSRS ERGLVEEEWV 1570 1580 1590 1600 1610 1620 IVSDEEIEEA RQKAPLEITE YPCVEVRIDK EIKGKVEKDS TGLVNYLTDD LNTCVPLPKE 1630 1640 1650 1660 1670 1680 QLQTVQDKAG KKCEALAVGR SSEKEGKDIP PDETQSTQKQ HKPSLGIKKP VRRKLKEKQK 1690 1700 1710 1720 1730 1740 QKEEGLQASA EKAELKKGSS EESLGEDPGL APEPLPTVKA TSPLIEETPI GSIKDKVKAL 1750 1760 1770 1780 1790 1800 QKRVEDEQKG RSKLPIRVKG KEDVPKKTTH RPHPAASPSL KSERHAPGSP SPKTERHSTL 1810 1820 1830 1840 1850 1860 SSSAKTERHP PVSPSSKTEK HSPVSPSAKT ERHSPASSSS KTEKHSPVSP STKTERHSPV 1870 1880 1890 1900 1910 1920 SSTKTERHPP VSPSGKTDKR PPVSPSGRTE KHPPVSPGRT EKRLPVSPSG RTDKHQPVST 1930 1940 1950 1960 1970 1980 AGKTEKHLPV SPSGKTEKQP PVSPTSKTER IEETMSVREL MKAFQSGQDP SKHKTGLFEH 1990 2000 2010 2020 2030 2040 KSAKQKQPQE KGKVRVEKEK GPILTQREAQ KTENQTIKRG QRLPVTGTAE SKRGVRVSSI 2050 2060 2070 2080 2090 2100 GVKKEDAAGG KEKVLSHKIP EPVQSVPEEE SHRESEVPKE KMADEQGDMD LQISPDRKTS 2110 2120 2130 2140 2150 2160 TDFSEVIKQE LEDNDKYQQF RLSEETEKAQ LHLDQVLTSP FNTTFPLDYM KDEFLPALSL 2170 2180 2190 2200 2210 2220 QSGALDGSSE SLKNEGVAGS PCGSLMEGTP QISSEESYKH EGLAETPETS PESLSFSPKK 2230 2240 2250 2260 2270 2280 SEEQTGETKE STKTETTTEI RSEKEHPTTK DITGGSEERG ATVTEDSETS TESFQKEATL 2290 2300 2310 2320 2330 2340 GSPKDTSPKR QDDCTGSCSV ALAKETPTGL TEEAACDEGQ RTFGSSAHKT QTDSEVQEST 2350 2360 2370 2380 2390 2400 ATSDETKALP LPEASVKTDT GTESKPQGVI RSPQGLELAL PSRDSEVLSA VADDSLAVSH 2410 2420 2430 2440 2450 2460 KDSLEASPVL EDNSSHKTPD SLEPSPLKES PCRDSLESSP VEPKMKAGIF PSHFPLPAAV 2470 2480 2490 2500 2510 2520 AKTELLTEVA SVRSRLLRDP DGSAEDDSLE QTSLMESSGK SPLSPDTPSS EEVSYEVTPK 2530 2540 2550 2560 2570 2580 TTDVSTPKPA VIHECAEEDD SENGEKKRFT PEEEMFKMVT KIKMFDELEQ EAKQKRDYKK 2590 2600 2610 2620 2630 2640 EPKQEESSSS SDPDADCSVD VDEPKHTGSG EDESGVPVLV TSESRKVSSS SESEPELAQL 2650 2660 2670 2680 2690 2700 KKGADSGLLP EPVIRVQPPS PLPSSMDSNS SPEEVQFQPV VSKQYTFKMN EDTQEEPGKS 2710 2720 2730 2740 2750 2760 EEEKDSESHL AEDRHAVSTE AEDRSYDKLN RDTDQPKICD GHGCEAMSPS SSAAPVSSGL 2770 2780 2790 2800 2810 2820 QSPTGDDVDE QPVIYKESLA LQGTHEKDTE GEELDVSRAE SPQADCPSES FSSSSSLPHC 2830 2840 2850 2860 2870 2880 LVSEGKELDE DISATSSIQK TEVTKTDETF ENLPKDCPSQ DSSITTQTDR FSMDVPVSDL 2890 2900 2910 2920 2930 2940 AENDEIYDPQ ITSPYENVPS QSFFSSEESK TQTDANHTTS FHSSEVYSVT ITSPVEDVVV 2950 2960 2970 2980 2990 3000 ASSSSGTVLS KESNFEGQDI KMESQQESTL WEMQSDSVSS SFEPTMSATT TVVGEQISKV 3010 3020 3030 3040 3050 3060 IITKTDVDSD SWSEIREDDE AFEARVKEEE QKIFGLMVDR QSQGTTPDTT PARTPTEEGT 3070 3080 3090 3100 3110 3120 PTSEQNPFLF QEGKLFEMTR SGAIDMTKRS YADESFHFFQ IGQESREETL SEDVKEGATG 3130 3140 3150 3160 3170 3180 ADPLPLETSA ESLALSESKE TVDDEADLLP DDVSEEVEEI PASDAQLNSQ MGISASTETP 3190 3200 3210 3220 3230 3240 TKEAVSVGTK DLPTVQTGDI PPLSGVKQIS CPDSSEPAVQ VQLDFSTLTR SVYSDRGDDS 3250 3260 3270 3280 3290 3300 PDSSPEEQKS VIEIPTAPME NVPFTESKSK IPVRTMPTST PAPPSAEYES SVSEDFLSSV 3310 3320 3330 3340 3350 3360 DEENKADEAK PKSKLPVKVP LQRVEQQLSD LDTSVQKTVA PQGQDMASIA PDNRSKSESD 3370 3380 3390 3400 3410 3420 ASSLDSKTKC PVKTRSYTET ETESRERAEE LELESEEGAT RPKILTSRLP VKSRSTTSSC 3430 3440 3450 3460 3470 3480 RGGTSPTKES KEHFFDLYRN SIEFFEEISD EASKLVDRLT QSEREQEIVS DDESSSALEV 3490 3500 3510 3520 3530 3540 SVIENLPPVE TEHSVPEDIF DTRPIWDESI ETLIERIPDE NGHDHAEDPQ DEQERIEERL 3550 3560 3570 3580 3590 3600 AYIADHLGFS WTELARELDF TEEQIHQIRI ENPNSLQDQS HALLKYWLER DGKHATDTNL 3610 3620 3630 3640 3650 3660 VECLTKINRM DIVHLMETNT EPLQERISHS YAEIEQTITL DHSEGFSVLQ EELCTAQHKQ 3670 3680 3690 3700 3710 3720 KEEQAVSKES ETCDHPPIVS EEDISVGYST FQDGVPKTEG DSSATALFPQ THKEQVQQDF 3730 3740 3750 3760 3770 3780 SGKMQDLPEE SSLEYQQEYF VTTPGTETSE TQKAMIVPSS PSKTPEEVST PAEEEKLYLQ 3790 3800 3810 3820 3830 3840 TPTSSERGGS PIIQEPEEPS EHREESSPRK TSLVIVESAD NQPETCERLD EDAAFEKGDD 3850 3860 3870 3880 3890 3900 MPEIPPETVT EEEYIDEHGH TVVKKVTRKI IRRYVSSEGT EKEEIMVQGM PQEPVNIEEG 3910 3920 DGYSKVIKRV VLKSDTEQSE DNNE
	Isoform 2. Checksum: 425D5422CF5CE930	FASTA	1,872	205,795
	10 20 30 40 50 60 MMNEDAAQKS DSGEKFNGSS QRRKRPKKSD SNASFLRAAR AGNLDKVVEY LKGGIDINTC 70 80 90 100 110 120 NQNGLNALHL AAKEGHVGLV QELLGRGSSV DSATKKGNTA LHIASLAGQA EVVKVLVKEG 130 140 150 160 170 180 ANINAQSQNG FTPLYMAAQE NHIDVVKYLL ENGANQSTAT EDGFTPLAVA LQQGHNQAVA 190 200 210 220 230 240 ILLENDTKGK VRLPALHIAA RKDDTKSAAL LLQNDHNADV QSKMMVNRTT ESGFTPLHIA 250 260 270 280 290 300 AHYGNVNVAT LLLNRGAAVD FTARNGITPL HVASKRGNTN MVKLLLDRGG QIDAKTRDGL 310 320 330 340 350 360 TPLHCAARSG HDQVVELLLE RGAPLLARTK NGLSPLHMAA QGDHVECVKH LLQHKAPVDD 370 380 390 400 410 420 VTLDYLTALH VAAHCGHYRV TKLLLDKRAN PNARALNGFT PLHIACKKNR IKVMELLVKY 430 440 450 460 470 480 GASIQAITES GLTPIHVAAF MGHLNIVLLL LQNGASPDVT NIRGETALHM AARAGQVEVV 490 500 510 520 530 540 RCLLRNGALV DARAREEQTP LHIASRLGKT EIVQLLLQHM AHPDAATTNG YTPLHISARE 550 560 570 580 590 600 GQVDVASVLL EAGAAHSLAT KKGFTPLHVA AKYGSLDVAK LLLQRRAAAD SAGKNGLTPL 610 620 630 640 650 660 HVAAHYDNQK VALLLLEKGA SPHATAKNGY TPLHIAAKKN QMQIASTLLN YGAETNIVTK 670 680 690 700 710 720 QGVTPLHLAS QEGHTDMVTL LLDKGANIHM STKSGLTSLH LAAQEDKVNV ADILTKHGAD 730 740 750 760 770 780 QDAHTKLGYT PLIVACHYGN VKMVNFLLKQ GANVNAKTKN GYTPLHQAAQ QGHTHIINVL 790 800 810 820 830 840 LQHGAKPNAT TANGNTALAI AKRLGYISVV DTLKVVTEEV TTTTTTITEK HKLNVPETMT 850 860 870 880 890 900 EVLDVSDEEG DDTMTGDGGE YLRPEDLKEL GDDSLPSSQF LDGMNYLRYS LEGGRSDSLR 910 920 930 940 950 960 SFSSDRSHTL SHASYLRDSA VMDDSVVIPS HQVSTLAKEA ERNSYRLSWG TENLDNVALS 970 980 990 1000 1010 1020 SSPIHSGFLV SFMVDARGGA MRGCRHNGLR IIIPPRKCTA PTRVTCRLVK RHRLATMPPM 1030 1040 1050 1060 1070 1080 VEGEGLASRL IEVGPSGAQF LGKLHLPTAP PPLNEGESLV SRILQLGPPG TKFLGPVIVE 1090 1100 1110 1120 1130 1140 IPHFAALRGK ERELVVLRSE NGDSWKEHFC DYTEDELNEI LNGMDEVLDS PEDLEKKRIC 1150 1160 1170 1180 1190 1200 RIITRDFPQY FAVVSRIKQD SNLIGPEGGV LSSTVVPQVQ AVFPEGALTK RIRVGLQAQP 1210 1220 1230 1240 1250 1260 MHSELVKKIL GNKATFSPIV TLEPRRRKFH KPITMTIPVP KASSDVMLNG FGGDAPTLRL 1270 1280 1290 1300 1310 1320 LCSITGGTTP AQWEDITGTT PLTFVNECVS FTTNVSARFW LIDCRQIQES VTFASQVYRE 1330 1340 1350 1360 1370 1380 IICVPYMAKF VVFAKSHDPI EARLRCFCMT DDKVDKTLEQ QENFAEVARS RDVEVLEGKP 1390 1400 1410 1420 1430 1440 IYVDCFGNLV PLTKSGQHHI FSFFAFKENR LPLFVKVRDT TQEPCGRLSF MKEPKSTRGL 1450 1460 1470 1480 1490 1500 VHQAICNLNI TLPIYTKESE SDQEQEEEID MTSEKNPQDE QERIEERLAY IADHLGFSWT 1510 1520 1530 1540 1550 1560 ELARELDFTE EQIHQIRIEN PNSLQDQSHA LLKYWLERDG KHATDTNLVE CLTKINRMDI 1570 1580 1590 1600 1610 1620 VHLMETNTEP LQERISHSYA EIEQTITLDH SEGFSVLQEE LCTAQHKQKE EQAVSKESET 1630 1640 1650 1660 1670 1680 CDHPPIVSEE DISVGYSTFQ DGVPKTEGDS SATALFPQTH KEQVQQDFSG KMQDLPEESS 1690 1700 1710 1720 1730 1740 LEYQQEYFVT TPGTETSETQ KAMIVPSSPS KTPEEVSTPA EEEKLYLQTP TSSERGGSPI 1750 1760 1770 1780 1790 1800 IQEPEEPSEH REESSPRKTS LVIVESADNQ PETCERLDED AAFEKGDDMP EIPPETVTEE 1810 1820 1830 1840 1850 1860 EYIDEHGHTV VKKVTRKIIR RYVSSEGTEK EEIMVQGMPQ EPVNIEEGDG YSKVIKRVVL 1870 KSDTEQSEDN NE
	Isoform 3. Checksum: 41C1A240CC5A3B72	FASTA	3,957	433,715
	10 20 30 40 50 60 MMNEDAAQKS DSGEKFNGSS QRRKRPKKSD SNASFLRAAR AGNLDKVVEY LKGGIDINTC 70 80 90 100 110 120 NQNGLNALHL AAKEGHVGLV QELLGRGSSV DSATKKGNTA LHIASLAGQA EVVKVLVKEG 130 140 150 160 170 180 ANINAQSQNG FTPLYMAAQE NHIDVVKYLL ENGANQSTAT EDGFTPLAVA LQQGHNQAVA 190 200 210 220 230 240 ILLENDTKGK VRLPALHIAA RKDDTKSAAL LLQNDHNADV QSKMMVNRTT ESGFTPLHIA 250 260 270 280 290 300 AHYGNVNVAT LLLNRGAAVD FTARNGITPL HVASKRGNTN MVKLLLDRGG QIDAKTRDGL 310 320 330 340 350 360 TPLHCAARSG HDQVVELLLE RGAPLLARTK NGLSPLHMAA QGDHVECVKH LLQHKAPVDD 370 380 390 400 410 420 VTLDYLTALH VAAHCGHYRV TKLLLDKRAN PNARALNGFT PLHIACKKNR IKVMELLVKY 430 440 450 460 470 480 GASIQAITES GLTPIHVAAF MGHLNIVLLL LQNGASPDVT NIRGETALHM AARAGQVEVV 490 500 510 520 530 540 RCLLRNGALV DARAREEQTP LHIASRLGKT EIVQLLLQHM AHPDAATTNG YTPLHISARE 550 560 570 580 590 600 GQVDVASVLL EAGAAHSLAT KKGFTPLHVA AKYGSLDVAK LLLQRRAAAD SAGKNGLTPL 610 620 630 640 650 660 HVAAHYDNQK VALLLLEKGA SPHATAKNGY TPLHIAAKKN QMQIASTLLN YGAETNIVTK 670 680 690 700 710 720 QGVTPLHLAS QEGHTDMVTL LLDKGANIHM STKSGLTSLH LAAQEDKVNV ADILTKHGAD 730 740 750 760 770 780 QDAHTKLGYT PLIVACHYGN VKMVNFLLKQ GANVNAKTKN GYTPLHQAAQ QGHTHIINVL 790 800 810 820 830 840 LQHGAKPNAT TANGNTALAI AKRLGYISVV DTLKVVTEEV TTTTTTITEK HKLNVPETMT 850 860 870 880 890 900 EVLDVSDEEG DDTMTGDGGE YLRPEDLKEL GDDSLPSSQF LDGMNYLRYS LEGGRSDSLR 910 920 930 940 950 960 SFSSDRSHTL SHASYLRDSA VMDDSVVIPS HQVSTLAKEA ERNSYRLSWG TENLDNVALS 970 980 990 1000 1010 1020 SSPIHSGFLV SFMVDARGGA MRGCRHNGLR IIIPPRKCTA PTRVTCRLVK RHRLATMPPM 1030 1040 1050 1060 1070 1080 VEGEGLASRL IEVGPSGAQF LGKLHLPTAP PPLNEGESLV SRILQLGPPG TKFLGPVIVE 1090 1100 1110 1120 1130 1140 IPHFAALRGK ERELVVLRSE NGDSWKEHFC DYTEDELNEI LNGMDEVLDS PEDLEKKRIC 1150 1160 1170 1180 1190 1200 RIITRDFPQY FAVVSRIKQD SNLIGPEGGV LSSTVVPQVQ AVFPEGALTK RIRVGLQAQP 1210 1220 1230 1240 1250 1260 MHSELVKKIL GNKATFSPIV TLEPRRRKFH KPITMTIPVP KASSDVMLNG FGGDAPTLRL 1270 1280 1290 1300 1310 1320 LCSITGGTTP AQWEDITGTT PLTFVNECVS FTTNVSARFW LIDCRQIQES VTFASQVYRE 1330 1340 1350 1360 1370 1380 IICVPYMAKF VVFAKSHDPI EARLRCFCMT DDKVDKTLEQ QENFAEVARS RDVEVLEGKP 1390 1400 1410 1420 1430 1440 IYVDCFGNLV PLTKSGQHHI FSFFAFKENR LPLFVKVRDT TQEPCGRLSF MKEPKSTRGL 1450 1460 1470 1480 1490 1500 VHQAICNLNI TLPIYTKESE SDQEQEEEID MTSEKNDETE STETSVLKSH LVNEVPVLAS 1510 1520 1530 1540 1550 1560 PDLLSEVSEM KQDLIKMTAI LTTDVSDKAG SIKVKELVKA AEEEPGEPFE IVERVKEDLE 1570 1580 1590 1600 1610 1620 KVNEILRSGT CTRDESSVQS SRSERGLVEE EWVIVSDEEI EEARQKAPLE ITEYPCVEVR 1630 1640 1650 1660 1670 1680 IDKEIKGKVE KDSTGLVNYL TDDLNTCVPL PKEQLQTVQD KAGKKCEALA VGRSSEKEGK 1690 1700 1710 1720 1730 1740 DIPPDETQST QKQHKPSLGI KKPVRRKLKE KQKQKEEGLQ ASAEKAELKK GSSEESLGED 1750 1760 1770 1780 1790 1800 PGLAPEPLPT VKATSPLIEE TPIGSIKDKV KALQKRVEDE QKGRSKLPIR VKGKEDVPKK 1810 1820 1830 1840 1850 1860 TTHRPHPAAS PSLKSERHAP GSPSPKTERH STLSSSAKTE RHPPVSPSSK TEKHSPVSPS 1870 1880 1890 1900 1910 1920 AKTERHSPAS SSSKTEKHSP VSPSTKTERH SPVSSTKTER HPPVSPSGKT DKRPPVSPSG 1930 1940 1950 1960 1970 1980 RTEKHPPVSP GRTEKRLPVS PSGRTDKHQP VSTAGKTEKH LPVSPSGKTE KQPPVSPTSK 1990 2000 2010 2020 2030 2040 TERIEETMSV RELMKAFQSG QDPSKHKTGL FEHKSAKQKQ PQEKGKVRVE KEKGPILTQR 2050 2060 2070 2080 2090 2100 EAQKTENQTI KRGQRLPVTG TAESKRGVRV SSIGVKKEDA AGGKEKVLSH KIPEPVQSVP 2110 2120 2130 2140 2150 2160 EEESHRESEV PKEKMADEQG DMDLQISPDR KTSTDFSEVI KQELEDNDKY QQFRLSEETE 2170 2180 2190 2200 2210 2220 KAQLHLDQVL TSPFNTTFPL DYMKDEFLPA LSLQSGALDG SSESLKNEGV AGSPCGSLME 2230 2240 2250 2260 2270 2280 GTPQISSEES YKHEGLAETP ETSPESLSFS PKKSEEQTGE TKESTKTETT TEIRSEKEHP 2290 2300 2310 2320 2330 2340 TTKDITGGSE ERGATVTEDS ETSTESFQKE ATLGSPKDTS PKRQDDCTGS CSVALAKETP 2350 2360 2370 2380 2390 2400 TGLTEEAACD EGQRTFGSSA HKTQTDSEVQ ESTATSDETK ALPLPEASVK TDTGTESKPQ 2410 2420 2430 2440 2450 2460 GVIRSPQGLE LALPSRDSEV LSAVADDSLA VSHKDSLEAS PVLEDNSSHK TPDSLEPSPL 2470 2480 2490 2500 2510 2520 KESPCRDSLE SSPVEPKMKA GIFPSHFPLP AAVAKTELLT EVASVRSRLL RDPDGSAEDD 2530 2540 2550 2560 2570 2580 SLEQTSLMES SGKSPLSPDT PSSEEVSYEV TPKTTDVSTP KPAVIHECAE EDDSENGEKK 2590 2600 2610 2620 2630 2640 RFTPEEEMFK MVTKIKMFDE LEQEAKQKRD YKKEPKQEES SSSSDPDADC SVDVDEPKHT 2650 2660 2670 2680 2690 2700 GSGEDESGVP VLVTSESRKV SSSSESEPEL AQLKKGADSG LLPEPVIRVQ PPSPLPSSMD 2710 2720 2730 2740 2750 2760 SNSSPEEVQF QPVVSKQYTF KMNEDTQEEP GKSEEEKDSE SHLAEDRHAV STEAEDRSYD 2770 2780 2790 2800 2810 2820 KLNRDTDQPK ICDGHGCEAM SPSSSAAPVS SGLQSPTGDD VDEQPVIYKE SLALQGTHEK 2830 2840 2850 2860 2870 2880 DTEGEELDVS RAESPQADCP SESFSSSSSL PHCLVSEGKE LDEDISATSS IQKTEVTKTD 2890 2900 2910 2920 2930 2940 ETFENLPKDC PSQDSSITTQ TDRFSMDVPV SDLAENDEIY DPQITSPYEN VPSQSFFSSE 2950 2960 2970 2980 2990 3000 ESKTQTDANH TTSFHSSEVY SVTITSPVED VVVASSSSGT VLSKESNFEG QDIKMESQQE 3010 3020 3030 3040 3050 3060 STLWEMQSDS VSSSFEPTMS ATTTVVGEQI SKVIITKTDV DSDSWSEIRE DDEAFEARVK 3070 3080 3090 3100 3110 3120 EEEQKIFGLM VDRQSQGTTP DTTPARTPTE EGTPTSEQNP FLFQEGKLFE MTRSGAIDMT 3130 3140 3150 3160 3170 3180 KRSYADESFH FFQIGQESRE ETLSEDVKEG ATGADPLPLE TSAESLALSE SKETVDDEAD 3190 3200 3210 3220 3230 3240 LLPDDVSEEV EEIPASDAQL NSQMGISAST ETPTKEAVSV GTKDLPTVQT GDIPPLSGVK 3250 3260 3270 3280 3290 3300 QISCPDSSEP AVQVQLDFST LTRSVYSDRG DDSPDSSPEE QKSVIEIPTA PMENVPFTES 3310 3320 3330 3340 3350 3360 KSKIPVRTMP TSTPAPPSAE YESSVSEDFL SSVDEENKAD EAKPKSKLPV KVPLQRVEQQ 3370 3380 3390 3400 3410 3420 LSDLDTSVQK TVAPQGQDMA SIAPDNRSKS ESDASSLDSK TKCPVKTRSY TETETESRER 3430 3440 3450 3460 3470 3480 AEELELESEE GATRPKILTS RLPVKSRSTT SSCRGGTSPT KESKEHFFDL YRNSIEFFEE 3490 3500 3510 3520 3530 3540 ISDEASKLVD RLTQSEREQE IVSDDESSSA LEVSVIENLP PVETEHSVPE DIFDTRPIWD 3550 3560 3570 3580 3590 3600 ESIETLIERI PDENGHDHAE DPQDEQERIE ERLAYIADHL GFSWTELARE LDFTEEQIHQ 3610 3620 3630 3640 3650 3660 IRIENPNSLQ DQSHALLKYW LERDGKHATD TNLVECLTKI NRMDIVHLME TNTEPLQERI 3670 3680 3690 3700 3710 3720 SHSYAEIEQT ITLDHSEGFS VLQEELCTAQ HKQKEEQAVS KESETCDHPP IVSEEDISVG 3730 3740 3750 3760 3770 3780 YSTFQDGVPK TEGDSSATAL FPQTHKEQVQ QDFSGKMQDL PEESSLEYQQ EYFVTTPGTE 3790 3800 3810 3820 3830 3840 TSETQKAMIV PSSPSKTPEE VSTPAEEEKL YLQTPTSSER GGSPIIQEPE EPSEHREESS 3850 3860 3870 3880 3890 3900 PRKTSLVIVE SADNQPETCE RLDEDAAFEK GDDMPEIPPE TVTEEEYIDE HGHTVVKKVT 3910 3920 3930 3940 3950 RKIIRRYVSS EGTEKEEIMV QGMPQEPVNI EEGDGYSKVI KRVVLKSDTE QSEDNNE
	Isoform 4. Checksum: 4E2B2DB97E1DDC0A	FASTA	1,863	204,752
	10 20 30 40 50 60 MTTMLQKSDS NASFLRAARA GNLDKVVEYL KGGIDINTCN QNGLNALHLA AKEGHVGLVQ 70 80 90 100 110 120 ELLGRGSSVD SATKKGNTAL HIASLAGQAE VVKVLVKEGA NINAQSQNGF TPLYMAAQEN 130 140 150 160 170 180 HIDVVKYLLE NGANQSTATE DGFTPLAVAL QQGHNQAVAI LLENDTKGKV RLPALHIAAR 190 200 210 220 230 240 KDDTKSAALL LQNDHNADVQ SKMMVNRTTE SGFTPLHIAA HYGNVNVATL LLNRGAAVDF 250 260 270 280 290 300 TARNGITPLH VASKRGNTNM VKLLLDRGGQ IDAKTRDGLT PLHCAARSGH DQVVELLLER 310 320 330 340 350 360 GAPLLARTKN GLSPLHMAAQ GDHVECVKHL LQHKAPVDDV TLDYLTALHV AAHCGHYRVT 370 380 390 400 410 420 KLLLDKRANP NARALNGFTP LHIACKKNRI KVMELLVKYG ASIQAITESG LTPIHVAAFM 430 440 450 460 470 480 GHLNIVLLLL QNGASPDVTN IRGETALHMA ARAGQVEVVR CLLRNGALVD ARAREEQTPL 490 500 510 520 530 540 HIASRLGKTE IVQLLLQHMA HPDAATTNGY TPLHISAREG QVDVASVLLE AGAAHSLATK 550 560 570 580 590 600 KGFTPLHVAA KYGSLDVAKL LLQRRAAADS AGKNGLTPLH VAAHYDNQKV ALLLLEKGAS 610 620 630 640 650 660 PHATAKNGYT PLHIAAKKNQ MQIASTLLNY GAETNIVTKQ GVTPLHLASQ EGHTDMVTLL 670 680 690 700 710 720 LDKGANIHMS TKSGLTSLHL AAQEDKVNVA DILTKHGADQ DAHTKLGYTP LIVACHYGNV 730 740 750 760 770 780 KMVNFLLKQG ANVNAKTKNG YTPLHQAAQQ GHTHIINVLL QHGAKPNATT ANGNTALAIA 790 800 810 820 830 840 KRLGYISVVD TLKVVTEEVT TTTTTITEKH KLNVPETMTE VLDVSDEEGD DTMTGDGGEY 850 860 870 880 890 900 LRPEDLKELG DDSLPSSQFL DGMNYLRYSL EGGRSDSLRS FSSDRSHTLS HASYLRDSAV 910 920 930 940 950 960 MDDSVVIPSH QVSTLAKEAE RNSYRLSWGT ENLDNVALSS SPIHSGRASP CLERDNSSFL 970 980 990 1000 1010 1020 VSFMVDARGG AMRGCRHNGL RIIIPPRKCT APTRVTCRLV KRHRLATMPP MVEGEGLASR 1030 1040 1050 1060 1070 1080 LIEVGPSGAQ FLGKLHLPTA PPPLNEGESL VSRILQLGPP GTKFLGPVIV EIPHFAALRG 1090 1100 1110 1120 1130 1140 KERELVVLRS ENGDSWKEHF CDYTEDELNE ILNGMDEVLD SPEDLEKKRI CRIITRDFPQ 1150 1160 1170 1180 1190 1200 YFAVVSRIKQ DSNLIGPEGG VLSSTVVPQV QAVFPEGALT KRIRVGLQAQ PMHSELVKKI 1210 1220 1230 1240 1250 1260 LGNKATFSPI VTLEPRRRKF HKPITMTIPV PKASSDVMLN GFGGDAPTLR LLCSITGGTT 1270 1280 1290 1300 1310 1320 PAQWEDITGT TPLTFVNECV SFTTNVSARF WLIDCRQIQE SVTFASQVYR EIICVPYMAK 1330 1340 1350 1360 1370 1380 FVVFAKSHDP IEARLRCFCM TDDKVDKTLE QQENFAEVAR SRDVEVLEGK PIYVDCFGNL 1390 1400 1410 1420 1430 1440 VPLTKSGQHH IFSFFAFKEN RLPLFVKVRD TTQEPCGRLS FMKEPKSTRG LVHQAICNLN 1450 1460 1470 1480 1490 1500 ITLPIYTKES ESDQEQEEEI DMTSEKNPQD EQERIEERLA YIADHLGFSW TELARELDFT 1510 1520 1530 1540 1550 1560 EEQIHQIRIE NPNSLQDQSH ALLKYWLERD GKHATDTNLV ECLTKINRMD IVHLMETNTE 1570 1580 1590 1600 1610 1620 PLQERISHSY AEIEQTITLD HSEGFSVLQE ELCTAQHKQK EEQAVSKESE TCDHPPIVSE 1630 1640 1650 1660 1670 1680 EDISVGYSTF QDGVPKTEGD SSATALFPQT HKEQVQQDFS GKMQDLPEES SLEYQQEYFV 1690 1700 1710 1720 1730 1740 TTPGTETSET QKAMIVPSSP SKTPEEVSTP AEEEKLYLQT PTSSERGGSP IIQEPEEPSE 1750 1760 1770 1780 1790 1800 HREESSPRKT SLVIVESADN QPETCERLDE DAAFEKGDDM PEIPPETVTE EEYIDEHGHT 1810 1820 1830 1840 1850 1860 VVKKVTRKII RRYVSSEGTE KEEIMVQGMP QEPVNIEEGD GYSKVIKRVV LKSDTEQSED NNE
	Isoform 5. Checksum: C0C03881D8E0EFD9	FASTA	555	63,361
	10 20 30 40 50 60 MTDDKVDKTL EQQENFAEVA RSRDVEVLEG KPIYVDCFGN LVPLTKSGQH HIFSFFAFKE 70 80 90 100 110 120 NRLPLFVKVR DTTQEPCGRL SFMKEPKSTR GLVHQAICNL NITLPIYTKE SESDQEQEEE 130 140 150 160 170 180 IDMTSEKNPQ DEQERIEERL AYIADHLGFS WTELARELDF TEEQIHQIRI ENPNSLQDQS 190 200 210 220 230 240 HALLKYWLER DGKHATDTNL VECLTKINRM DIVHLMETNT EPLQERISHS YAEIEQTITL 250 260 270 280 290 300 DHSEGFSVLQ EELCTAQHKQ KEEQAVSKES ETCDHPPIVS EEDISVGYST FQDGVPKTEG 310 320 330 340 350 360 DSSATALFPQ THKEQVQQDF SGKMQDLPEE SSLEYQQEYF VTTPGTETSE TQKAMIVPSS 370 380 390 400 410 420 PSKTPEEVST PAEEEKLYLQ TPTSSERGGS PIIQEPEEPS EHREESSPRK TSLVIVESAD 430 440 450 460 470 480 NQPETCERLD EDAAFEKELT EELGELEASS DEEAMVTTRV VRRRVIIQGD DMPEIPPETV 490 500 510 520 530 540 TEEEYIDEHG HTVVKKVTRK IIRRYVSSEG TEKEEIMVQG MPQEPVNIEE GDGYSKVIKR 550 VVLKSDTEQS EDNNE

References

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[1]	"Isolation and characterization of cDNAs encoding human brain ankyrins reveal a family of alternatively spliced genes." Otto E., Kunimoto M., McLaughlin T., Bennett V. J. Cell Biol. 114:241-253(1991) [PubMed: 1830053] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY. Tissue: Brain stem.
[2]	Carpenter S. Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.
[3]	"440-kD ankyrinB: structure of the major developmentally regulated domain and selective localization in unmyelinated axons." Chan W., Kordeli E., Bennett V. J. Cell Biol. 123:1463-1473(1993) [PubMed: 8253844] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3). Tissue: Brain stem.
[4]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Retina.
[5]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed: 15815621] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
[7]	"Isolation and chromosomal localization of a novel nonerythroid ankyrin gene." Tse W.T., Menninger J.C., Yang-Feng T.L., Francke U., Sahr K.E., Lux S.E., Ward D.C., Forget B.G. Genomics 10:858-866(1991) [PubMed: 1833308] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 463-495, TISSUE SPECIFICITY.
[8]	"Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death." Mohler P.J., Schott J.-J., Gramolini A.O., Dilly K.W., Guatimosim S., duBell W.H., Song L.-S., Haurogne K., Kyndt F., Ali M.E., Rogers T.B., Lederer W.J., Escande D., Le Marec H., Bennett V. Nature 421:634-639(2003) [PubMed: 12571597] [Abstract] Cited for: FUNCTION, VARIANT LQT4 GLY-1425.
[9]	"Ankyrin-B targets beta2-spectrin to an intracellular compartment in neonatal cardiomyocytes." Mohler P.J., Yoon W., Bennett V. J. Biol. Chem. 279:40185-40193(2004) [PubMed: 15262991] [Abstract] Cited for: INTERACTION WITH SPTBN1, MUTAGENESIS OF 975-ASP--ARG-977; ALA-1000 AND 1067-GLU--ASP-1070.
[10]	"The ammonium transporter RhBG: requirement of a tyrosine-based signal and ankyrin-G for basolateral targeting and membrane anchorage in polarized kidney epithelial cells." Lopez C., Metral S., Eladari D., Drevensek S., Gane P., Chambrey R., Bennett V., Cartron J.-P., Le Van Kim C., Colin Y. J. Biol. Chem. 280:8221-8228(2005) [PubMed: 15611082] [Abstract] Cited for: INTERACTION WITH RHBG.
[11]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-2550, MASS SPECTROMETRY. Tissue: Epithelium.
[12]	"Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry." Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A. Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007) [PubMed: 17287340] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-911; SER-1475 AND THR-1490, MASS SPECTROMETRY.
[13]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3760; SER-3762 AND THR-3764, MASS SPECTROMETRY.
[14]	"Ankyrin-B is required for coordinated expression of beta-2-spectrin, the Na/K-ATPase and the Na/Ca exchanger in the inner segment of rod photoreceptors." Kizhatil K., Sandhu N.K., Peachey N.S., Bennett V. Exp. Eye Res. 88:57-64(2009) [PubMed: 19007774] [Abstract] Cited for: SUBUNIT, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[15]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[16]	"A cardiac arrhythmia syndrome caused by loss of ankyrin-B function." Mohler P.J., Splawski I., Napolitano C., Bottelli G., Sharpe L., Timothy K., Priori S.G., Keating M.T., Bennett V. Proc. Natl. Acad. Sci. U.S.A. 101:9137-9142(2004) [PubMed: 15178757] [Abstract] Cited for: VARIANTS LQT4 GLY-1425; ILE-3707; ASN-3711; TRP-3873 AND LYS-3898, CHARACTERIZATION OF VARIANTS LQT4.
[17]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed: 16959974] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] GLU-685; ARG-1234 AND LYS-3620.
+	Additional computationally mapped references.

Web resources

GeneReviews

Wikipedia

Ankyrin entry

Cross-references

Sequence databases
EMBL GenBank DDBJ	X56957 mRNA. Translation: CAA40278.1. X56958 mRNA. Translation: CAA40279.2. Z26634 mRNA. Translation: CAB42644.1. Sequence problems. BX537758 mRNA. Translation: CAD97827.1. AC004057 Genomic DNA. No translation available. AC093617 Genomic DNA. No translation available. AC093879 Genomic DNA. No translation available. AC093900 Genomic DNA. No translation available. BC125235 mRNA. Translation: AAI25236.1. BC125236 mRNA. Translation: AAI25237.1. Frameshift. M37123 Genomic DNA. Translation: AAA62828.1.
IPI	IPI00007834. IPI00074962. IPI00305279. IPI00384928. IPI00895856.
PIR	S37431.
RefSeq	NP_001120965.1. NP_001139.3. NP_066187.2.
UniGene	Hs.620557
3D structure databases
DisProt	DP00467.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q01484. 6 interactions.
STRING	Q01484.
Protein family/group databases
TCDB	8.A.28.1.1. ankyrin family.
PTM databases
PhosphoSite	Q01484.
Genome annotation databases
Ensembl	ENST00000361149; ENSP00000354873; ENSG00000145362; Homo sapiens. [Genome view]
GeneID	287.
KEGG	hsa:287.
UCSC	uc003ibe.2. human. uc003ibf.2. human.
Organism-specific databases
CTD	287.
GeneCards	GC04P114132.
HGNC	HGNC:493. ANK2.
MIM	106410. gene. 600919. phenotype.
Orphanet	768. Long QT syndrome, familial.
PharmGKB	PA24799.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG17755.
HOVERGEN	Q01484.
OMA	KTEKHSP.
OrthoDB	EOG9VHNS3.
Gene expression databases
ArrayExpress	Q01484.
Bgee	Q01484.
CleanEx	HS_ANK2.
Genevestigator	Q01484.
GermOnline	ENSG00000145362. Homo sapiens.
Family and domain databases
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. IPR000488. Death. IPR011029. DEATH-like. IPR000906. ZU5. [Graphical view]
Gene3D	G3DSA:1.25.40.20. ANK. 4 hits. G3DSA:1.10.533.10. DEATH_like. 1 hit.
Pfam	PF00023. Ank. 19 hits. PF00531. Death. 1 hit. PF00791. ZU5. 1 hit. [Graphical view]
SMART	SM00248. ANK. 23 hits. SM00005. DEATH. 1 hit. SM00218. ZU5. 1 hit. [Graphical view]
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 20 hits. PS50017. DEATH_DOMAIN. 1 hit. PS51145. ZU5. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
SOURCE	Search...

Entry information

Entry name

ANK2_HUMAN

Accession

Primary (citable) accession number: Q01484
Secondary accession number(s): Q01485 , Q08AC7, Q08AC8, Q7Z3L5

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
Last sequence update:	November 25, 2008
Last modified:	February 9, 2010
This is version 105 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.