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Protein

2-hydroxymuconate tautomerase

Gene

xylH

Organism
Pseudomonas putida (Arthrobacter siderocapsulatus)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the ketonization of 2-hydroxymuconate stereoselectively to yield 2-oxo-3-hexenedioate.1 Publication

Catalytic activityi

(2Z,4E)-2-hydroxyhexa-2,4-dienedioate = (3E)-2-oxohex-3-enedioate.1 Publication

Pathwayi: toluene degradation

This protein is involved in the pathway toluene degradation, which is part of Xenobiotic degradation.
View all proteins of this organism that are known to be involved in the pathway toluene degradation and in Xenobiotic degradation.

Pathwayi: xylene degradation

This protein is involved in the pathway xylene degradation, which is part of Xenobiotic degradation.
View all proteins of this organism that are known to be involved in the pathway xylene degradation and in Xenobiotic degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei2Proton acceptor; via imino nitrogen1 Publication1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-12750.
UniPathwayiUPA00228.
UPA00273.

Names & Taxonomyi

Protein namesi
Recommended name:
2-hydroxymuconate tautomerase (EC:5.3.2.6)
Alternative name(s):
4-oxalocrotonate tautomerase
Short name:
4-OT
Gene namesi
Name:xylH
Encoded oniPlasmid TOL pWW00 Publication
OrganismiPseudomonas putida (Arthrobacter siderocapsulatus)
Taxonomic identifieri303 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00002095142 – 632-hydroxymuconate tautomeraseAdd BLAST62

Interactioni

Subunit structurei

Homohexamer.1 Publication

Structurei

Secondary structure

163
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 9Combined sources6
Helixi14 – 32Combined sources19
Helixi36 – 38Combined sources3
Beta strandi40 – 46Combined sources7
Helixi48 – 50Combined sources3
Beta strandi51 – 53Combined sources3
Helixi58 – 60Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BJPX-ray2.40A/B/C/D/E2-63[»]
2FM7X-ray2.80A/B/C/D/E/F2-62[»]
4OTAX-ray2.75A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R2-63[»]
4OTBX-ray2.50A/B/C/D/E/F/G/H/I/J/K/L2-63[»]
4OTCX-ray2.28A/B/C/D/E/F/G/H/I2-63[»]
4X19X-ray1.94A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X/Y/Z/a/b/c/d2-63[»]
4X1CX-ray1.70A/B/C/D/E/F/G/H/I/J/K/L/M/N/O2-63[»]
5CLNX-ray2.71A/B/C/D/E/F/G/H/I/J/K/L2-58[»]
5CLOX-ray2.30A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R2-60[»]
ProteinModelPortaliQ01468.
SMRiQ01468.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ01468.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK01821.

Family and domain databases

InterProiIPR004370. 4-oxalocrotonate_tautomerase.
IPR014347. Tautomerase/MIF_sf.
IPR018191. Tautomerase_Pseudo-typ.
[Graphical view]
PfamiPF01361. Tautomerase. 1 hit.
[Graphical view]
SUPFAMiSSF55331. SSF55331. 1 hit.
TIGRFAMsiTIGR00013. taut. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q01468-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPIAQIHILE GRSDEQKETL IREVSEAISR SLDAPLTSVR VIITEMAKGH
60
FGIGGELASK VRR
Length:63
Mass (Da):6,942
Last modified:January 23, 2007 - v2
Checksum:i23804AB94A126802
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95650 Genomic DNA. Translation: AAA26046.1.
M94186 Genomic DNA. Translation: AAA25694.1.
AJ344068 Genomic DNA. Translation: CAC86799.1.
PIRiA43397.
RefSeqiNP_542859.1. NC_003350.1.
WP_011005902.1. NC_003350.1.

Genome annotation databases

GeneIDi1218749.
KEGGiag:AAA26046.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95650 Genomic DNA. Translation: AAA26046.1.
M94186 Genomic DNA. Translation: AAA25694.1.
AJ344068 Genomic DNA. Translation: CAC86799.1.
PIRiA43397.
RefSeqiNP_542859.1. NC_003350.1.
WP_011005902.1. NC_003350.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BJPX-ray2.40A/B/C/D/E2-63[»]
2FM7X-ray2.80A/B/C/D/E/F2-62[»]
4OTAX-ray2.75A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R2-63[»]
4OTBX-ray2.50A/B/C/D/E/F/G/H/I/J/K/L2-63[»]
4OTCX-ray2.28A/B/C/D/E/F/G/H/I2-63[»]
4X19X-ray1.94A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X/Y/Z/a/b/c/d2-63[»]
4X1CX-ray1.70A/B/C/D/E/F/G/H/I/J/K/L/M/N/O2-63[»]
5CLNX-ray2.71A/B/C/D/E/F/G/H/I/J/K/L2-58[»]
5CLOX-ray2.30A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R2-60[»]
ProteinModelPortaliQ01468.
SMRiQ01468.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1218749.
KEGGiag:AAA26046.

Phylogenomic databases

KOiK01821.

Enzyme and pathway databases

UniPathwayiUPA00228.
UPA00273.
BioCyciMetaCyc:MONOMER-12750.

Miscellaneous databases

EvolutionaryTraceiQ01468.

Family and domain databases

InterProiIPR004370. 4-oxalocrotonate_tautomerase.
IPR014347. Tautomerase/MIF_sf.
IPR018191. Tautomerase_Pseudo-typ.
[Graphical view]
PfamiPF01361. Tautomerase. 1 hit.
[Graphical view]
SUPFAMiSSF55331. SSF55331. 1 hit.
TIGRFAMsiTIGR00013. taut. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry namei4OT1_PSEPU
AccessioniPrimary (citable) accession number: Q01468
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Plasmid

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.