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Protein

Septum site-determining protein MinC

Gene

minC

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization. The MinCD complex plays an important role in asymmetric septum formation during sporulation of B.subtilis cells.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Septation

Enzyme and pathway databases

BioCyciBSUB:BSU28000-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Septum site-determining protein MinC
Gene namesi
Name:minC
Ordered Locus Names:BSU28000
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001890171 – 226Septum site-determining protein MinCAdd BLAST226

Proteomic databases

PaxDbiQ01463.

Interactioni

Subunit structurei

Interacts with MinD and FtsZ.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
minDQ014643EBI-9304968,EBI-6502875

Protein-protein interaction databases

IntActiQ01463. 2 interactors.
STRINGi224308.Bsubs1_010100015306.

Structurei

Secondary structure

1226
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi9 – 12Combined sources4
Beta strandi14 – 22Combined sources9
Helixi30 – 42Combined sources13
Beta strandi51 – 56Combined sources6
Helixi65 – 76Combined sources12
Beta strandi81 – 86Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2M4INMR-A1-102[»]
ProteinModelPortaliQ01463.
SMRiQ01463.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MinC family.Curated

Phylogenomic databases

eggNOGiENOG4107YDG. Bacteria.
COG0850. LUCA.
HOGENOMiHOG000012641.
InParanoidiQ01463.
KOiK03610.
OMAiEMECAYI.
PhylomeDBiQ01463.

Family and domain databases

Gene3Di2.160.20.70. 1 hit.
HAMAPiMF_00267. MinC. 1 hit.
InterProiIPR016098. CAP/MinC_C.
IPR013033. MinC.
IPR005526. Septum_form_inhib_MinC_C.
[Graphical view]
PfamiPF03775. MinC_C. 1 hit.
[Graphical view]
SUPFAMiSSF63848. SSF63848. 1 hit.
TIGRFAMsiTIGR01222. minC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q01463-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTKKQQYVT IKGTKNGLTL HLDDACSFDE LLDGLQNMLS IEQYTDGKGQ
60 70 80 90 100
KISVHVKLGN RFLYKEQEEQ LTELIASKKD LFVHSIDSEV ITKKEAQQIR
110 120 130 140 150
EEAEIISVSK IVRSGQVLQV KGDLLLIGDV NPGGTVRAGG NIFVLGSLKG
160 170 180 190 200
IAHAGFNGNN QAVIAASEML PTQLRINHVL NRSPDHIQKG NEMECAYLDT
210 220
DGNMVIERLQ HLAHLRPDLT RLEGGM
Length:226
Mass (Da):24,998
Last modified:July 1, 1993 - v1
Checksum:i25C8F1503F89BF60
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95582 Genomic DNA. Translation: AAA22608.1.
Z15113 Genomic DNA. Translation: CAA78817.1.
M96343 Genomic DNA. Translation: AAA22400.1.
AL009126 Genomic DNA. Translation: CAB14760.1.
PIRiS31204. F45239.
RefSeqiNP_390678.1. NC_000964.3.
WP_004398901.1. NZ_JNCM01000036.1.

Genome annotation databases

EnsemblBacteriaiCAB14760; CAB14760; BSU28000.
GeneIDi937500.
KEGGibsu:BSU28000.
PATRICi18977472. VBIBacSub10457_2925.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95582 Genomic DNA. Translation: AAA22608.1.
Z15113 Genomic DNA. Translation: CAA78817.1.
M96343 Genomic DNA. Translation: AAA22400.1.
AL009126 Genomic DNA. Translation: CAB14760.1.
PIRiS31204. F45239.
RefSeqiNP_390678.1. NC_000964.3.
WP_004398901.1. NZ_JNCM01000036.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2M4INMR-A1-102[»]
ProteinModelPortaliQ01463.
SMRiQ01463.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ01463. 2 interactors.
STRINGi224308.Bsubs1_010100015306.

Proteomic databases

PaxDbiQ01463.

Protocols and materials databases

DNASUi937500.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB14760; CAB14760; BSU28000.
GeneIDi937500.
KEGGibsu:BSU28000.
PATRICi18977472. VBIBacSub10457_2925.

Phylogenomic databases

eggNOGiENOG4107YDG. Bacteria.
COG0850. LUCA.
HOGENOMiHOG000012641.
InParanoidiQ01463.
KOiK03610.
OMAiEMECAYI.
PhylomeDBiQ01463.

Enzyme and pathway databases

BioCyciBSUB:BSU28000-MONOMER.

Family and domain databases

Gene3Di2.160.20.70. 1 hit.
HAMAPiMF_00267. MinC. 1 hit.
InterProiIPR016098. CAP/MinC_C.
IPR013033. MinC.
IPR005526. Septum_form_inhib_MinC_C.
[Graphical view]
PfamiPF03775. MinC_C. 1 hit.
[Graphical view]
SUPFAMiSSF63848. SSF63848. 1 hit.
TIGRFAMsiTIGR01222. minC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMINC_BACSU
AccessioniPrimary (citable) accession number: Q01463
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: November 30, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.