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Protein

Septum site-determining protein MinC

Gene

minC

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization. The MinCD complex plays an important role in asymmetric septum formation during sporulation of B.subtilis cells.

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Septation

Enzyme and pathway databases

BioCyciBSUB:BSU28000-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Septum site-determining protein MinC
Gene namesi
Name:minC
Ordered Locus Names:BSU28000
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001890171 – 226Septum site-determining protein MinCAdd BLAST226

Proteomic databases

PaxDbiQ01463

Interactioni

Subunit structurei

Interacts with MinD and FtsZ.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
minDQ014643EBI-9304968,EBI-6502875

Protein-protein interaction databases

IntActiQ01463, 2 interactors
STRINGi224308.Bsubs1_010100015306

Structurei

Secondary structure

1226
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi9 – 12Combined sources4
Beta strandi14 – 22Combined sources9
Helixi30 – 42Combined sources13
Beta strandi51 – 56Combined sources6
Helixi65 – 76Combined sources12
Beta strandi81 – 86Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2M4INMR-A1-102[»]
ProteinModelPortaliQ01463
SMRiQ01463
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MinC family.Curated

Phylogenomic databases

eggNOGiENOG4107YDG Bacteria
COG0850 LUCA
HOGENOMiHOG000012641
InParanoidiQ01463
KOiK03610
OMAiEMECAYI
PhylomeDBiQ01463

Family and domain databases

Gene3Di2.160.20.70, 1 hit
HAMAPiMF_00267 MinC, 1 hit
InterProiView protein in InterPro
IPR016098 CAP/MinC_C
IPR013033 MinC
IPR036145 MinC_C_sf
IPR005526 Septum_form_inhib_MinC_C
PANTHERiPTHR34108 PTHR34108, 1 hit
PfamiView protein in Pfam
PF03775 MinC_C, 1 hit
SUPFAMiSSF63848 SSF63848, 1 hit
TIGRFAMsiTIGR01222 minC, 1 hit

Sequencei

Sequence statusi: Complete.

Q01463-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTKKQQYVT IKGTKNGLTL HLDDACSFDE LLDGLQNMLS IEQYTDGKGQ
60 70 80 90 100
KISVHVKLGN RFLYKEQEEQ LTELIASKKD LFVHSIDSEV ITKKEAQQIR
110 120 130 140 150
EEAEIISVSK IVRSGQVLQV KGDLLLIGDV NPGGTVRAGG NIFVLGSLKG
160 170 180 190 200
IAHAGFNGNN QAVIAASEML PTQLRINHVL NRSPDHIQKG NEMECAYLDT
210 220
DGNMVIERLQ HLAHLRPDLT RLEGGM
Length:226
Mass (Da):24,998
Last modified:July 1, 1993 - v1
Checksum:i25C8F1503F89BF60
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95582 Genomic DNA Translation: AAA22608.1
Z15113 Genomic DNA Translation: CAA78817.1
M96343 Genomic DNA Translation: AAA22400.1
AL009126 Genomic DNA Translation: CAB14760.1
PIRiS31204 F45239
RefSeqiNP_390678.1, NC_000964.3
WP_004398901.1, NZ_JNCM01000036.1

Genome annotation databases

EnsemblBacteriaiCAB14760; CAB14760; BSU28000
GeneIDi937500
KEGGibsu:BSU28000
PATRICifig|224308.179.peg.3042

Similar proteinsi

Entry informationi

Entry nameiMINC_BACSU
AccessioniPrimary (citable) accession number: Q01463
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: April 25, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health