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Protein

Di-N-acetylchitobiase

Gene

Ctbs

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the degradation of asparagine-linked glycoproteins. Hydrolyze of N-acetyl-beta-D-glucosamine (1-4)N-acetylglucosamine chitobiose core from the reducing end of the bond, it requires prior cleavage by glycosylasparaginase.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei128Proton donorPROSITE-ProRule annotation1

GO - Molecular functioni

  • chitinase activity Source: RGD
  • chitin binding Source: GO_Central
  • hydrolase activity, acting on glycosyl bonds Source: RGD

GO - Biological processi

  • chitin catabolic process Source: RGD
  • oligosaccharide catabolic process Source: RGD

Keywordsi

Molecular functionGlycosidase, Hydrolase

Protein family/group databases

CAZyiGH18. Glycoside Hydrolase Family 18.

Names & Taxonomyi

Protein namesi
Recommended name:
Di-N-acetylchitobiase (EC:3.2.1.-)
Gene namesi
Name:Ctbs
Synonyms:Ctb
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi621338. Ctbs.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 231 PublicationAdd BLAST23
ChainiPRO_000001196324 – 367Di-N-acetylchitobiaseAdd BLAST344

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi100N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi178N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi213N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi247N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi284N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ01460.
PRIDEiQ01460.

Expressioni

Gene expression databases

BgeeiENSRNOG00000015573.
GenevisibleiQ01460. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020972.

Structurei

3D structure databases

ProteinModelPortaliQ01460.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 18 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IMSI. Eukaryota.
COG3858. LUCA.
GeneTreeiENSGT00390000012891.
HOGENOMiHOG000007829.
HOVERGENiHBG005486.
InParanoidiQ01460.
KOiK12310.
OMAiDEQSQIW.
OrthoDBiEOG091G0CA1.
PhylomeDBiQ01460.
TreeFamiTF332677.

Family and domain databases

InterProiView protein in InterPro
IPR011583. Chitinase_II.
IPR001223. Glyco_hydro18_cat.
IPR001579. Glyco_hydro_18_chit_AS.
IPR017853. Glycoside_hydrolase_SF.
PfamiView protein in Pfam
PF00704. Glyco_hydro_18. 1 hit.
SMARTiView protein in SMART
SM00636. Glyco_18. 1 hit.
SUPFAMiSSF51445. SSF51445. 2 hits.
PROSITEiView protein in PROSITE
PS01095. CHITINASE_18. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q01460-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALSDLLELT LLLLLPLLER LSAEDCPCSE ASLCRPIRHH RDFEVFVFDV
60 70 80 90 100
GQKTWKSYDW SQITTVAVFG KYDSELMCYA HSKGARVVLK GDVALKDIIN
110 120 130 140 150
PTFRASWIAQ KVALAKAQHM DGINIDIEQE VDCSSPEYEA LTALVRETTE
160 170 180 190 200
GFHREIEGSQ VTFDVAWSPK GIDKRCYNYT GIADACDFLF VMSYDEQSQI
210 220 230 240 250
WSECIAAANA PYNQTLTGYG DYLRMGISPR KLVMGIPWYG YDYICLNLSK
260 270 280 290 300
DDVCAIAKVP FRGAPCSDAA GHQVPYRVIM KQVNSSVSGS QWNQDQQAPY
310 320 330 340 350
YNYKDPTGRL HQVWYDNPRS ISLKAAFVKH YGLRGIGMWN ANCLDYSDDA
360
LAREQTEEMW GALRPRL
Length:367
Mass (Da):41,531
Last modified:July 1, 1993 - v1
Checksum:i29AB8BE4FC157C16
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95768 mRNA. Translation: AAA40924.1.
BC088129 mRNA. Translation: AAH88129.1.
PIRiC44102.
RefSeqiNP_112285.1. NM_031023.1.
UniGeneiRn.11199.

Genome annotation databases

EnsembliENSRNOT00000020972; ENSRNOP00000020972; ENSRNOG00000015573.
GeneIDi81652.
KEGGirno:81652.

Similar proteinsi

Entry informationi

Entry nameiDIAC_RAT
AccessioniPrimary (citable) accession number: Q01460
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: November 22, 2017
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families