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Protein

Di-N-acetylchitobiase

Gene

CTBS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the degradation of asparagine-linked glycoproteins. Hydrolyze of N-acetyl-beta-D-glucosamine (1-4)N-acetylglucosamine chitobiose core from the reducing end of the bond, it requires prior cleavage by glycosylasparaginase.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei143Proton donorPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase

Protein family/group databases

CAZyiGH18. Glycoside Hydrolase Family 18.

Names & Taxonomyi

Protein namesi
Recommended name:
Di-N-acetylchitobiase (EC:3.2.1.-)
Gene namesi
Name:CTBS
Synonyms:CTB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000117151.12.
HGNCiHGNC:2496. CTBS.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Lysosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi1486.
OpenTargetsiENSG00000117151.
PharmGKBiPA26997.

Polymorphism and mutation databases

BioMutaiCTBS.
DMDMi399376.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 38By similarityAdd BLAST38
ChainiPRO_000001196139 – 385Di-N-acetylchitobiaseAdd BLAST347

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi193N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi228N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi262N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi299N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ01459.
PaxDbiQ01459.
PeptideAtlasiQ01459.
PRIDEiQ01459.

PTM databases

iPTMnetiQ01459.
PhosphoSitePlusiQ01459.

Expressioni

Gene expression databases

BgeeiENSG00000117151.
CleanExiHS_CTBS.
ExpressionAtlasiQ01459. baseline and differential.
GenevisibleiQ01459. HS.

Organism-specific databases

HPAiCAB017043.
HPA023594.
HPA048810.

Interactioni

Protein-protein interaction databases

BioGridi107868. 5 interactors.
IntActiQ01459. 3 interactors.
STRINGi9606.ENSP00000359664.

Structurei

3D structure databases

ProteinModelPortaliQ01459.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 18 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IMSI. Eukaryota.
COG3858. LUCA.
GeneTreeiENSGT00390000012891.
HOGENOMiHOG000007829.
HOVERGENiHBG005486.
InParanoidiQ01459.
KOiK12310.
OMAiDEQSQIW.
OrthoDBiEOG091G0CA1.
PhylomeDBiQ01459.
TreeFamiTF332677.

Family and domain databases

InterProiView protein in InterPro
IPR011583. Chitinase_II.
IPR001223. Glyco_hydro18_cat.
IPR001579. Glyco_hydro_18_chit_AS.
IPR017853. Glycoside_hydrolase_SF.
PfamiView protein in Pfam
PF00704. Glyco_hydro_18. 1 hit.
SMARTiView protein in SMART
SM00636. Glyco_18. 1 hit.
SUPFAMiSSF51445. SSF51445. 2 hits.
PROSITEiView protein in PROSITE
PS01095. CHITINASE_18. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q01459-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRPQLRRWR LVSSPPSGVP GLALLALLAL LALRLAAGTD CPCPEPELCR
60 70 80 90 100
PIRHHPDFEV FVFDVGQKTW KSYDWSQITT VATFGKYDSE LMCYAHSKGA
110 120 130 140 150
RVVLKGDVSL KDIIDPAFRA SWIAQKLNLA KTQYMDGINI DIEQEVNCLS
160 170 180 190 200
PEYDALTALV KETTDSFHRE IEGSQVTFDV AWSPKNIDRR CYNYTGIADA
210 220 230 240 250
CDFLFVMSYD EQSQIWSECI AAANAPYNQT LTGYNDYIKM SINPKKLVMG
260 270 280 290 300
VPWYGYDYTC LNLSEDHVCT IAKVPFRGAP CSDAAGRQVP YKTIMKQINS
310 320 330 340 350
SISGNLWDKD QRAPYYNYKD PAGHFHQVWY DNPQSISLKA TYIQNYRLRG
360 370 380
IGMWNANCLD YSGDAVAKQQ TEEMWEVLKP KLLQR
Length:385
Mass (Da):43,760
Last modified:July 1, 1993 - v1
Checksum:i0A9D14C8B26B52EE
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049197274V → I. Corresponds to variant dbSNP:rs15911Ensembl.1
Natural variantiVAR_020160310D → Y. Corresponds to variant dbSNP:rs3768249Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95767 mRNA. Translation: AAA35684.1.
AF085706
, AF085700, AF085701, AF085702, AF085703, AF085704, AF085705 Genomic DNA. Translation: AAC35852.1.
AL359762 Genomic DNA. Translation: CAH70207.1.
CH471097 Genomic DNA. Translation: EAW73232.1.
CH471097 Genomic DNA. Translation: EAW73233.1.
BC126333 mRNA. Translation: AAI26334.1.
BC126335 mRNA. Translation: AAI26336.1.
CCDSiCCDS698.1.
PIRiA44102.
RefSeqiNP_004379.1. NM_004388.2.
UniGeneiHs.513557.

Genome annotation databases

EnsembliENST00000370630; ENSP00000359664; ENSG00000117151.
GeneIDi1486.
KEGGihsa:1486.
UCSCiuc001dka.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiDIAC_HUMAN
AccessioniPrimary (citable) accession number: Q01459
Secondary accession number(s): Q5VX50
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: September 27, 2017
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families