Q01449 (MLRA_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Myosin regulatory light chain 2, atrial isoform
Short name=MLC-2a
Short name=MLC2a
Short name=Myosin light chain 2a

Alternative name(s):
Myosin regulatory light chain 7

Gene names

Name:	MYL7
Synonyms:	MYL2A, MYLC2A

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	175 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Myosin is a hexamer of 2 heavy chains and 4 light chains.
Tissue specificity	Predominantly expressed in adult atrial muscle. Ref.1
Miscellaneous	This chain binds calcium.
Sequence similarities	Contains 3 EF-hand domains.

Ontologies

Keywords
Domain	Repeat
Ligand	Calcium Metal-binding
Molecular function	Motor protein Muscle protein Myosin
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	actin filament-based movement Non-traceable author statement. Source: UniProtKB smooth muscle contraction Non-traceable author statement. Source: UniProtKB
Cellular_component	A band Inferred from direct assay PubMed 15621049. Source: BHF-UCL dendritic spine Inferred from electronic annotation. Source: Compara myosin complex Non-traceable author statement Ref.1. Source: UniProtKB
Molecular_function	ATPase activity, coupled Non-traceable author statement. Source: UniProtKB calcium ion binding Non-traceable author statement. Source: UniProtKB microfilament motor activity Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 175	175	Myosin regulatory light chain 2, atrial isoform		PRO_0000198725
Regions
	Domain	32 – 67	36	EF-hand 1
	Domain	102 – 137	36	EF-hand 2
	Domain	138 – 173	36	EF-hand 3
	Calcium binding	45 – 56	12

Sequences

	Sequence		Length	Mass (Da)
	Q01449 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: A21DBD518CAB90EB	FASTA	175	19,448
	10 20 30 40 50 60 MASRKAGTRG KVAATKQAQR GSSNVFSMFE QAQIQEFKEA FSCIDQNRDG IICKADLRET 70 80 90 100 110 120 YSQLGKVSVP EEELDAMLQE GKGPINFTVF LTLFGEKLNG TDPEEAILSA FRMFDPSGKG 130 140 150 160 170 VVNKDEFKQL LLTQADKFSP AEVEQMFALT PMDLAGNIDY KSLCYIITHG DEKEE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Differential regulation of the atrial isoforms of the myosin light chains during striated muscle development." Hailstones D.L., Barton P., Chan-Thomas P., Sutherland C.J., Hardeman E.C., Gunning P.W. J. Biol. Chem. 267:23295-23300(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Heart.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pancreas.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M94547 mRNA. Translation: AAA59889.1. AK311869 mRNA. Translation: BAG34810.1. BC027915 mRNA. Translation: AAH27915.1.
IPI	IPI00009677.
PIR	A44451.
RefSeq	NP_067046.1. NM_021223.2.
UniGene	Hs.75636.
3D structure databases
ProteinModelPortal	Q01449.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000223364.
PTM databases
PhosphoSite	Q01449.
Polymorphism databases
DMDM	38604716.
Proteomic databases
PaxDb	Q01449.
PRIDE	Q01449.
Protocols and materials databases
DNASU	58498.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000223364; ENSP00000223364; ENSG00000106631.
GeneID	58498.
KEGG	hsa:58498.
UCSC	uc003tkg.3. human.
Organism-specific databases
CTD	58498.
GeneCards	GC07M044178.
HGNC	HGNC:21719. MYL7.
HPA	CAB033884. HPA013331.
MIM	613993. gene.
neXtProt	NX_Q01449.
PharmGKB	PA134939476.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5126.
HOGENOM	HOG000233018.
HOVERGEN	HBG012180.
InParanoid	Q01449.
KO	K12754.
OrthoDB	EOG4PG622.
PhylomeDB	Q01449.
Gene expression databases
ArrayExpress	Q01449.
Bgee	Q01449.
CleanEx	HS_MYL7.
Genevestigator	Q01449.
GermOnline	ENSG00000106631. Homo sapiens.
Family and domain databases
Gene3D	1.10.238.10. 2 hits.
InterPro	IPR011992. EF-hand-like_dom. IPR018247. EF_Hand_1_Ca_BS. IPR002048. EF_hand_dom. [Graphical view]
Pfam	PF13499. EF_hand_5. 1 hit. [Graphical view]
SMART	SM00054. EFh. 2 hits. [Graphical view]
PROSITE	PS00018. EF_HAND_1. 1 hit. PS50222. EF_HAND_2. 3 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	MYL7. human.
GenomeRNAi	58498.
NextBio	64996.
SOURCE	Search...

Entry information

Entry name

MLRA_HUMAN

Accession

Primary (citable) accession number: Q01449
Secondary accession number(s): B2R4L3

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2003
Last sequence update:	November 1, 1996
Last modified:	May 1, 2013
This is version 105 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.