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Q01449

- MLRA_HUMAN

UniProt

Q01449 - MLRA_HUMAN

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Protein

Myosin regulatory light chain 2, atrial isoform

Gene

MYL7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi45 – 5612Add
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Muscle protein, Myosin

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin regulatory light chain 2, atrial isoform
Short name:
MLC-2a
Short name:
MLC2a
Short name:
Myosin light chain 2a
Alternative name(s):
Myosin regulatory light chain 7
Gene namesi
Name:MYL7
Synonyms:MYL2A, MYLC2A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:21719. MYL7.

Subcellular locationi

GO - Cellular componenti

  1. A band Source: BHF-UCL
  2. dendritic spine Source: Ensembl
  3. myosin complex Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134939476.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 175175Myosin regulatory light chain 2, atrial isoformPRO_0000198725Add
BLAST

Proteomic databases

PaxDbiQ01449.
PRIDEiQ01449.

PTM databases

PhosphoSiteiQ01449.

Expressioni

Tissue specificityi

Predominantly expressed in adult atrial muscle.1 Publication

Gene expression databases

BgeeiQ01449.
CleanExiHS_MYL7.
ExpressionAtlasiQ01449. baseline and differential.
GenevestigatoriQ01449.

Organism-specific databases

HPAiCAB033884.
HPA013331.

Interactioni

Subunit structurei

Myosin is a hexamer of 2 heavy chains and 4 light chains.

Protein-protein interaction databases

STRINGi9606.ENSP00000223364.

Structurei

3D structure databases

ProteinModelPortaliQ01449.
SMRiQ01449. Positions 24-173.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 6736EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini102 – 13736EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini138 – 17336EF-hand 3PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 3 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5126.
GeneTreeiENSGT00760000119196.
HOGENOMiHOG000233018.
HOVERGENiHBG012180.
InParanoidiQ01449.
KOiK12754.
PhylomeDBiQ01449.
TreeFamiTF314218.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q01449 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASRKAGTRG KVAATKQAQR GSSNVFSMFE QAQIQEFKEA FSCIDQNRDG
60 70 80 90 100
IICKADLRET YSQLGKVSVP EEELDAMLQE GKGPINFTVF LTLFGEKLNG
110 120 130 140 150
TDPEEAILSA FRMFDPSGKG VVNKDEFKQL LLTQADKFSP AEVEQMFALT
160 170
PMDLAGNIDY KSLCYIITHG DEKEE
Length:175
Mass (Da):19,448
Last modified:November 1, 1996 - v1
Checksum:iA21DBD518CAB90EB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M94547 mRNA. Translation: AAA59889.1.
AK311869 mRNA. Translation: BAG34810.1.
BC027915 mRNA. Translation: AAH27915.1.
CCDSiCCDS5478.1.
PIRiA44451.
RefSeqiNP_067046.1. NM_021223.2.
UniGeneiHs.75636.

Genome annotation databases

EnsembliENST00000223364; ENSP00000223364; ENSG00000106631.
GeneIDi58498.
KEGGihsa:58498.
UCSCiuc003tkg.3. human.

Polymorphism databases

DMDMi38604716.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M94547 mRNA. Translation: AAA59889.1 .
AK311869 mRNA. Translation: BAG34810.1 .
BC027915 mRNA. Translation: AAH27915.1 .
CCDSi CCDS5478.1.
PIRi A44451.
RefSeqi NP_067046.1. NM_021223.2.
UniGenei Hs.75636.

3D structure databases

ProteinModelPortali Q01449.
SMRi Q01449. Positions 24-173.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000223364.

PTM databases

PhosphoSitei Q01449.

Polymorphism databases

DMDMi 38604716.

Proteomic databases

PaxDbi Q01449.
PRIDEi Q01449.

Protocols and materials databases

DNASUi 58498.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000223364 ; ENSP00000223364 ; ENSG00000106631 .
GeneIDi 58498.
KEGGi hsa:58498.
UCSCi uc003tkg.3. human.

Organism-specific databases

CTDi 58498.
GeneCardsi GC07M044178.
HGNCi HGNC:21719. MYL7.
HPAi CAB033884.
HPA013331.
MIMi 613993. gene.
neXtProti NX_Q01449.
PharmGKBi PA134939476.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5126.
GeneTreei ENSGT00760000119196.
HOGENOMi HOG000233018.
HOVERGENi HBG012180.
InParanoidi Q01449.
KOi K12754.
PhylomeDBi Q01449.
TreeFami TF314218.

Miscellaneous databases

ChiTaRSi MYL7. human.
GeneWikii MYL7.
GenomeRNAii 58498.
NextBioi 64996.
PROi Q01449.
SOURCEi Search...

Gene expression databases

Bgeei Q01449.
CleanExi HS_MYL7.
ExpressionAtlasi Q01449. baseline and differential.
Genevestigatori Q01449.

Family and domain databases

Gene3Di 1.10.238.10. 2 hits.
InterProi IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view ]
Pfami PF13499. EF-hand_7. 1 hit.
[Graphical view ]
SMARTi SM00054. EFh. 2 hits.
[Graphical view ]
PROSITEi PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Differential regulation of the atrial isoforms of the myosin light chains during striated muscle development."
    Hailstones D.L., Barton P., Chan-Thomas P., Sutherland C.J., Hardeman E.C., Gunning P.W.
    J. Biol. Chem. 267:23295-23300(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pancreas.

Entry informationi

Entry nameiMLRA_HUMAN
AccessioniPrimary (citable) accession number: Q01449
Secondary accession number(s): B2R4L3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

This chain binds calcium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3