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Q01449 (MLRA_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Myosin regulatory light chain 2, atrial isoform

Short name=MLC-2a
Short name=MLC2a
Short name=Myosin light chain 2a
Alternative name(s):
Myosin regulatory light chain 7
Gene names
Name:MYL7
Synonyms:MYL2A, MYLC2A
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length175 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Myosin is a hexamer of 2 heavy chains and 4 light chains.

Tissue specificity

Predominantly expressed in adult atrial muscle. Ref.1

Miscellaneous

This chain binds calcium.

Sequence similarities

Contains 3 EF-hand domains.

Ontologies

Keywords
   DomainRepeat
   LigandCalcium
Metal-binding
   Molecular functionMotor protein
Muscle protein
Myosin
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentA band

Inferred from direct assay PubMed 15621049. Source: BHF-UCL

dendritic spine

Inferred from electronic annotation. Source: Ensembl

myosin complex

Non-traceable author statement Ref.1. Source: UniProtKB

   Molecular_functioncalcium ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 175175Myosin regulatory light chain 2, atrial isoform
PRO_0000198725

Regions

Domain32 – 6736EF-hand 1
Domain102 – 13736EF-hand 2
Domain138 – 17336EF-hand 3
Calcium binding45 – 5612

Sequences

Sequence LengthMass (Da)Tools
Q01449 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: A21DBD518CAB90EB

FASTA17519,448
        10         20         30         40         50         60 
MASRKAGTRG KVAATKQAQR GSSNVFSMFE QAQIQEFKEA FSCIDQNRDG IICKADLRET 

        70         80         90        100        110        120 
YSQLGKVSVP EEELDAMLQE GKGPINFTVF LTLFGEKLNG TDPEEAILSA FRMFDPSGKG 

       130        140        150        160        170 
VVNKDEFKQL LLTQADKFSP AEVEQMFALT PMDLAGNIDY KSLCYIITHG DEKEE 

« Hide

References

« Hide 'large scale' references
[1]"Differential regulation of the atrial isoforms of the myosin light chains during striated muscle development."
Hailstones D.L., Barton P., Chan-Thomas P., Sutherland C.J., Hardeman E.C., Gunning P.W.
J. Biol. Chem. 267:23295-23300(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Heart.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Pancreas.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M94547 mRNA. Translation: AAA59889.1.
AK311869 mRNA. Translation: BAG34810.1.
BC027915 mRNA. Translation: AAH27915.1.
CCDSCCDS5478.1.
PIRA44451.
RefSeqNP_067046.1. NM_021223.2.
UniGeneHs.75636.

3D structure databases

ProteinModelPortalQ01449.
SMRQ01449. Positions 24-173.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000223364.

PTM databases

PhosphoSiteQ01449.

Polymorphism databases

DMDM38604716.

Proteomic databases

PaxDbQ01449.
PRIDEQ01449.

Protocols and materials databases

DNASU58498.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000223364; ENSP00000223364; ENSG00000106631.
GeneID58498.
KEGGhsa:58498.
UCSCuc003tkg.3. human.

Organism-specific databases

CTD58498.
GeneCardsGC07M044178.
HGNCHGNC:21719. MYL7.
HPACAB033884.
HPA013331.
MIM613993. gene.
neXtProtNX_Q01449.
PharmGKBPA134939476.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5126.
HOGENOMHOG000233018.
HOVERGENHBG012180.
InParanoidQ01449.
KOK12754.
PhylomeDBQ01449.
TreeFamTF314218.

Gene expression databases

ArrayExpressQ01449.
BgeeQ01449.
CleanExHS_MYL7.
GenevestigatorQ01449.

Family and domain databases

Gene3D1.10.238.10. 2 hits.
InterProIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamPF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTSM00054. EFh. 2 hits.
[Graphical view]
PROSITEPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSMYL7. human.
GeneWikiMYL7.
GenomeRNAi58498.
NextBio64996.
PROQ01449.
SOURCESearch...

Entry information

Entry nameMLRA_HUMAN
AccessionPrimary (citable) accession number: Q01449
Secondary accession number(s): B2R4L3
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM