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Q01449

- MLRA_HUMAN

UniProt

Q01449 - MLRA_HUMAN

Protein

Myosin regulatory light chain 2, atrial isoform

Gene

MYL7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi45 – 5612Add
    BLAST

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    Keywords - Molecular functioni

    Motor protein, Muscle protein, Myosin

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Myosin regulatory light chain 2, atrial isoform
    Short name:
    MLC-2a
    Short name:
    MLC2a
    Short name:
    Myosin light chain 2a
    Alternative name(s):
    Myosin regulatory light chain 7
    Gene namesi
    Name:MYL7
    Synonyms:MYL2A, MYLC2A
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:21719. MYL7.

    Subcellular locationi

    GO - Cellular componenti

    1. A band Source: BHF-UCL
    2. dendritic spine Source: Ensembl
    3. myosin complex Source: UniProtKB

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134939476.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 175175Myosin regulatory light chain 2, atrial isoformPRO_0000198725Add
    BLAST

    Proteomic databases

    PaxDbiQ01449.
    PRIDEiQ01449.

    PTM databases

    PhosphoSiteiQ01449.

    Expressioni

    Tissue specificityi

    Predominantly expressed in adult atrial muscle.1 Publication

    Gene expression databases

    ArrayExpressiQ01449.
    BgeeiQ01449.
    CleanExiHS_MYL7.
    GenevestigatoriQ01449.

    Organism-specific databases

    HPAiCAB033884.
    HPA013331.

    Interactioni

    Subunit structurei

    Myosin is a hexamer of 2 heavy chains and 4 light chains.

    Protein-protein interaction databases

    STRINGi9606.ENSP00000223364.

    Structurei

    3D structure databases

    ProteinModelPortaliQ01449.
    SMRiQ01449. Positions 24-173.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini32 – 6736EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini102 – 13736EF-hand 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini138 – 17336EF-hand 3PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 3 EF-hand domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG5126.
    HOGENOMiHOG000233018.
    HOVERGENiHBG012180.
    InParanoidiQ01449.
    KOiK12754.
    PhylomeDBiQ01449.
    TreeFamiTF314218.

    Family and domain databases

    Gene3Di1.10.238.10. 2 hits.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    [Graphical view]
    PfamiPF13499. EF-hand_7. 1 hit.
    [Graphical view]
    SMARTiSM00054. EFh. 2 hits.
    [Graphical view]
    PROSITEiPS00018. EF_HAND_1. 1 hit.
    PS50222. EF_HAND_2. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q01449-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASRKAGTRG KVAATKQAQR GSSNVFSMFE QAQIQEFKEA FSCIDQNRDG    50
    IICKADLRET YSQLGKVSVP EEELDAMLQE GKGPINFTVF LTLFGEKLNG 100
    TDPEEAILSA FRMFDPSGKG VVNKDEFKQL LLTQADKFSP AEVEQMFALT 150
    PMDLAGNIDY KSLCYIITHG DEKEE 175
    Length:175
    Mass (Da):19,448
    Last modified:November 1, 1996 - v1
    Checksum:iA21DBD518CAB90EB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M94547 mRNA. Translation: AAA59889.1.
    AK311869 mRNA. Translation: BAG34810.1.
    BC027915 mRNA. Translation: AAH27915.1.
    CCDSiCCDS5478.1.
    PIRiA44451.
    RefSeqiNP_067046.1. NM_021223.2.
    UniGeneiHs.75636.

    Genome annotation databases

    EnsembliENST00000223364; ENSP00000223364; ENSG00000106631.
    GeneIDi58498.
    KEGGihsa:58498.
    UCSCiuc003tkg.3. human.

    Polymorphism databases

    DMDMi38604716.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M94547 mRNA. Translation: AAA59889.1 .
    AK311869 mRNA. Translation: BAG34810.1 .
    BC027915 mRNA. Translation: AAH27915.1 .
    CCDSi CCDS5478.1.
    PIRi A44451.
    RefSeqi NP_067046.1. NM_021223.2.
    UniGenei Hs.75636.

    3D structure databases

    ProteinModelPortali Q01449.
    SMRi Q01449. Positions 24-173.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000223364.

    PTM databases

    PhosphoSitei Q01449.

    Polymorphism databases

    DMDMi 38604716.

    Proteomic databases

    PaxDbi Q01449.
    PRIDEi Q01449.

    Protocols and materials databases

    DNASUi 58498.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000223364 ; ENSP00000223364 ; ENSG00000106631 .
    GeneIDi 58498.
    KEGGi hsa:58498.
    UCSCi uc003tkg.3. human.

    Organism-specific databases

    CTDi 58498.
    GeneCardsi GC07M044178.
    HGNCi HGNC:21719. MYL7.
    HPAi CAB033884.
    HPA013331.
    MIMi 613993. gene.
    neXtProti NX_Q01449.
    PharmGKBi PA134939476.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5126.
    HOGENOMi HOG000233018.
    HOVERGENi HBG012180.
    InParanoidi Q01449.
    KOi K12754.
    PhylomeDBi Q01449.
    TreeFami TF314218.

    Miscellaneous databases

    ChiTaRSi MYL7. human.
    GeneWikii MYL7.
    GenomeRNAii 58498.
    NextBioi 64996.
    PROi Q01449.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q01449.
    Bgeei Q01449.
    CleanExi HS_MYL7.
    Genevestigatori Q01449.

    Family and domain databases

    Gene3Di 1.10.238.10. 2 hits.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    [Graphical view ]
    Pfami PF13499. EF-hand_7. 1 hit.
    [Graphical view ]
    SMARTi SM00054. EFh. 2 hits.
    [Graphical view ]
    PROSITEi PS00018. EF_HAND_1. 1 hit.
    PS50222. EF_HAND_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Differential regulation of the atrial isoforms of the myosin light chains during striated muscle development."
      Hailstones D.L., Barton P., Chan-Thomas P., Sutherland C.J., Hardeman E.C., Gunning P.W.
      J. Biol. Chem. 267:23295-23300(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Heart.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Pancreas.

    Entry informationi

    Entry nameiMLRA_HUMAN
    AccessioniPrimary (citable) accession number: Q01449
    Secondary accession number(s): B2R4L3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2003
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 114 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    This chain binds calcium.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3