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Protein

Myosin regulatory light chain 2, atrial isoform

Gene

MYL7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi45 – 5612Add
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Muscle protein, Myosin

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_20558. Smooth Muscle Contraction.

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin regulatory light chain 2, atrial isoform
Short name:
MLC-2a
Short name:
MLC2a
Short name:
Myosin light chain 2a
Alternative name(s):
Myosin regulatory light chain 7
Gene namesi
Name:MYL7
Synonyms:MYL2A, MYLC2A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:21719. MYL7.

Subcellular locationi

GO - Cellular componenti

  • A band Source: BHF-UCL
  • cytosol Source: Reactome
  • dendritic spine Source: Ensembl
  • myosin complex Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134939476.

Polymorphism and mutation databases

BioMutaiMYL7.
DMDMi38604716.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 175175Myosin regulatory light chain 2, atrial isoformPRO_0000198725Add
BLAST

Proteomic databases

PaxDbiQ01449.
PRIDEiQ01449.

PTM databases

PhosphoSiteiQ01449.

Expressioni

Tissue specificityi

Predominantly expressed in adult atrial muscle.1 Publication

Gene expression databases

BgeeiQ01449.
CleanExiHS_MYL7.
ExpressionAtlasiQ01449. baseline and differential.
GenevisibleiQ01449. HS.

Organism-specific databases

HPAiCAB033884.
HPA013331.
HPA039262.

Interactioni

Subunit structurei

Myosin is a hexamer of 2 heavy chains and 4 light chains.

Binary interactionsi

WithEntry#Exp.IntActNotes
TOX4O948423EBI-10222416,EBI-948613

Protein-protein interaction databases

BioGridi121828. 1 interaction.
IntActiQ01449. 1 interaction.
STRINGi9606.ENSP00000223364.

Structurei

3D structure databases

ProteinModelPortaliQ01449.
SMRiQ01449. Positions 24-173.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 6736EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini102 – 13736EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini138 – 17336EF-hand 3PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 3 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5126.
GeneTreeiENSGT00760000119196.
HOGENOMiHOG000233018.
HOVERGENiHBG012180.
InParanoidiQ01449.
KOiK12754.
PhylomeDBiQ01449.
TreeFamiTF314218.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q01449-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASRKAGTRG KVAATKQAQR GSSNVFSMFE QAQIQEFKEA FSCIDQNRDG
60 70 80 90 100
IICKADLRET YSQLGKVSVP EEELDAMLQE GKGPINFTVF LTLFGEKLNG
110 120 130 140 150
TDPEEAILSA FRMFDPSGKG VVNKDEFKQL LLTQADKFSP AEVEQMFALT
160 170
PMDLAGNIDY KSLCYIITHG DEKEE
Length:175
Mass (Da):19,448
Last modified:November 1, 1996 - v1
Checksum:iA21DBD518CAB90EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M94547 mRNA. Translation: AAA59889.1.
AK311869 mRNA. Translation: BAG34810.1.
BC027915 mRNA. Translation: AAH27915.1.
CCDSiCCDS5478.1.
PIRiA44451.
RefSeqiNP_067046.1. NM_021223.2.
UniGeneiHs.75636.

Genome annotation databases

EnsembliENST00000223364; ENSP00000223364; ENSG00000106631.
GeneIDi58498.
KEGGihsa:58498.
UCSCiuc003tkg.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M94547 mRNA. Translation: AAA59889.1.
AK311869 mRNA. Translation: BAG34810.1.
BC027915 mRNA. Translation: AAH27915.1.
CCDSiCCDS5478.1.
PIRiA44451.
RefSeqiNP_067046.1. NM_021223.2.
UniGeneiHs.75636.

3D structure databases

ProteinModelPortaliQ01449.
SMRiQ01449. Positions 24-173.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121828. 1 interaction.
IntActiQ01449. 1 interaction.
STRINGi9606.ENSP00000223364.

PTM databases

PhosphoSiteiQ01449.

Polymorphism and mutation databases

BioMutaiMYL7.
DMDMi38604716.

Proteomic databases

PaxDbiQ01449.
PRIDEiQ01449.

Protocols and materials databases

DNASUi58498.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000223364; ENSP00000223364; ENSG00000106631.
GeneIDi58498.
KEGGihsa:58498.
UCSCiuc003tkg.3. human.

Organism-specific databases

CTDi58498.
GeneCardsiGC07M044178.
HGNCiHGNC:21719. MYL7.
HPAiCAB033884.
HPA013331.
HPA039262.
MIMi613993. gene.
neXtProtiNX_Q01449.
PharmGKBiPA134939476.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5126.
GeneTreeiENSGT00760000119196.
HOGENOMiHOG000233018.
HOVERGENiHBG012180.
InParanoidiQ01449.
KOiK12754.
PhylomeDBiQ01449.
TreeFamiTF314218.

Enzyme and pathway databases

ReactomeiREACT_20558. Smooth Muscle Contraction.

Miscellaneous databases

ChiTaRSiMYL7. human.
GeneWikiiMYL7.
GenomeRNAii58498.
NextBioi64996.
PROiQ01449.
SOURCEiSearch...

Gene expression databases

BgeeiQ01449.
CleanExiHS_MYL7.
ExpressionAtlasiQ01449. baseline and differential.
GenevisibleiQ01449. HS.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Differential regulation of the atrial isoforms of the myosin light chains during striated muscle development."
    Hailstones D.L., Barton P., Chan-Thomas P., Sutherland C.J., Hardeman E.C., Gunning P.W.
    J. Biol. Chem. 267:23295-23300(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pancreas.

Entry informationi

Entry nameiMLRA_HUMAN
AccessioniPrimary (citable) accession number: Q01449
Secondary accession number(s): B2R4L3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: November 1, 1996
Last modified: June 24, 2015
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

This chain binds calcium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.