Q01440 (GTR1_LEIDO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Membrane transporter D1
Organism	Leishmania donovani
Taxonomic identifier	5661 [NCBI]
Taxonomic lineage	Eukaryota › Euglenozoa › Kinetoplastida › Trypanosomatidae › Leishmania

Protein attributes

Sequence length	547 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. [View classification]

Ontologies

Keywords
Biological process	Sugar transport Transport
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Gene Ontology (GO)
Biological process	carbohydrate transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	substrate-specific transmembrane transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 547	547	Membrane transporter D1		PRO_0000050451
Regions
	Topological domain	1 – 2	2	Cytoplasmic Potential
	Transmembrane	3 – 25	23	Helical; Name=1; Potential
	Topological domain	26 – 43	18	Extracellular Potential
	Transmembrane	44 – 64	21	Helical; Name=2; Potential
	Topological domain	65 – 78	14	Cytoplasmic Potential
	Transmembrane	79 – 99	21	Helical; Name=3; Potential
	Topological domain	100 – 101	2	Extracellular Potential
	Transmembrane	102 – 122	21	Helical; Name=4; Potential
	Topological domain	123 – 136	14	Cytoplasmic Potential
	Transmembrane	137 – 157	21	Helical; Name=5; Potential
	Topological domain	158 – 164	7	Extracellular Potential
	Transmembrane	165 – 185	21	Helical; Name=6; Potential
	Topological domain	186 – 245	60	Cytoplasmic Potential
	Transmembrane	246 – 266	21	Helical; Name=7; Potential
	Topological domain	267 – 276	10	Extracellular Potential
	Transmembrane	277 – 297	21	Helical; Name=8; Potential
	Topological domain	298 – 308	11	Cytoplasmic Potential
	Transmembrane	309 – 329	21	Helical; Name=9; Potential
	Topological domain	330 – 339	10	Extracellular Potential
	Transmembrane	340 – 360	21	Helical; Name=10; Potential
	Topological domain	361 – 385	25	Cytoplasmic Potential
	Transmembrane	386 – 406	21	Helical; Name=11; Potential
	Topological domain	407	1	Extracellular Potential
	Transmembrane	408 – 428	21	Helical; Name=12; Potential
	Topological domain	429 – 547	119	Cytoplasmic Potential

Sequences

	Sequence		Length	Mass (Da)
	Q01440 [UniParc]. Last modified June 1, 1994. Version 1. Checksum: CA8EEF16EB0FF514	FASTA	547	58,788
	10 20 30 40 50 60 MRASVMLCAA LGGFLFGYDT GVINAALFQM KDHFGFSEHS WQYALIVAIA IAGAFVGAFI 70 80 90 100 110 120 SGFISAAFGR RPCIAVADAL FVIGSVLMGA APNVEVVLVS RVIVGLAIGI SSATIPVYLA 130 140 150 160 170 180 EVTSPKHRGA TIVLNNLFLT GGQFVAAGFT AIMVVFTSKN IGWRVAIGIG ALPAVVQAFC 190 200 210 220 230 240 LLFFLPESPR WLLSKGHADR AKAVADKFEV DLCEFQEGDE LPSVRIDYRP LMARDMRFRV 250 260 270 280 290 300 VLSSGLQIIQ QFSGINTIMY YSSVILYDAG FRDAIMPVVL SIPLAFMNAL FTAVAIFTVD 310 320 330 340 350 360 RFGRRRMLLI SVFGCLVLLV VIAIIGFFIG TRISYSVGGG LFLALLAVFL ALYAPGIGCI 370 380 390 400 410 420 PWVIMGEIFP THLRTSAASV ATMANWGANV LVSQVFPILM GAIGVGGTFT IISGLMALGC 430 440 450 460 470 480 IFVYFFAVET KGLTLEQIDN MFRKRAGLPP RFHEEGESGE SGAGYREDGD LGRLATEDVC 490 500 510 520 530 540 DLSSLGNRVV SFAKAEDAFT EVAMPDRHAV SNKFEERATS SSSDPQSLEN QDEVRQAAIK AAPHEPK

References

[1]

"Molecular characterization of two genes encoding members of the glucose transporter superfamily in the parasitic protozoan Leishmania donovani." Langford C.K., Ewbank S.A., Hanson S.S., Ullman B., Landfear S.M. Mol. Biochem. Parasitol. 55:51-64(1992) [PubMed: 1435876] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	M85072 Genomic DNA. Translation: AAA29230.1.
PIR	A48442.
3D structure databases
ProteinModelPortal	Q01440.
ModBase	Search...
Protein family/group databases
TCDB	2.A.1.1.20. major facilitator superfamily (MFS).
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR020846. MFS_dom. IPR016196. MFS_dom_general_subst_transpt. IPR005828. Sub_transporter. IPR003663. Sugar/inositol_transpt. IPR005829. Sugar_transporter_CS. [Graphical view]
Pfam	PF00083. Sugar_tr. 1 hit. [Graphical view]
PRINTS	PR00171. SUGRTRNSPORT.
SUPFAM	SSF103473. MFS_gen_substrate_transporter. 1 hit.
TIGRFAMs	TIGR00879. SP. 1 hit.
PROSITE	PS50850. MFS. 1 hit. PS00216. SUGAR_TRANSPORT_1. 1 hit. PS00217. SUGAR_TRANSPORT_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GTR1_LEIDO

Accession

Primary (citable) accession number: Q01440

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	May 31, 2011
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)