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Q01433 (AMPD2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 134. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
AMP deaminase 2

EC=3.5.4.6
Alternative name(s):
AMP deaminase isoform L
Gene names
Name:AMPD2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length879 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

AMP deaminase plays a critical role in energy metabolism.

Catalytic activity

AMP + H2O = IMP + NH3.

Cofactor

Binds 1 zinc ion per subunit By similarity.

Pathway

Purine metabolism; IMP biosynthesis via salvage pathway; IMP from AMP: step 1/1.

Subunit structure

Homotetramer.

Tissue specificity

Three isoforms are present in mammals: AMP deaminase 1 is the predominant form in skeletal muscle; AMP deaminase 2 predominates in smooth muscle, non-muscle tissue, embryonic muscle and undifferentiated myoblasts; AMP deaminase 3 is found in erythrocytes.

Sequence similarities

Belongs to the adenosine and AMP deaminases family.

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]
Isoform Ex1B-2-3 (identifier: Q01433-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform Ex1A-2-3 (identifier: Q01433-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-81: Missing.
     82-84: AAP → MAS
Isoform Ex1A-3 (identifier: Q01433-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-128: MRNRGQGLFR...MDGKCKEIAE → MLTFLPSPQ
Isoform Ex1B-3 (identifier: Q01433-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-128: MRNRGQGLFR...MDGKCKEIAE → MWQSQAPAGA...PACRPPLQLQ
Isoform 5 (identifier: Q01433-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-118: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 879879AMP deaminase 2
PRO_0000194407

Regions

Region489 – 4946Substrate binding By similarity
Region765 – 7684Substrate binding By similarity

Sites

Active site7091Proton acceptor By similarity
Metal binding4181Zinc; catalytic By similarity
Metal binding4201Zinc; catalytic By similarity
Metal binding6871Zinc; catalytic By similarity
Metal binding7641Zinc; catalytic By similarity
Binding site4201Substrate By similarity
Binding site6901Substrate By similarity

Amino acid modifications

Modified residue761Phosphoserine Ref.11
Modified residue1181Phosphoserine Ref.10
Modified residue1451Phosphotyrosine By similarity
Modified residue1511Phosphoserine Ref.10
Modified residue1681Phosphoserine Ref.8 Ref.12 Ref.14
Modified residue1881Phosphothreonine Ref.10
Modified residue1901Phosphoserine Ref.10 Ref.11 Ref.12 Ref.14

Natural variations

Alternative sequence1 – 128128MRNRG…KEIAE → MLTFLPSPQ in isoform Ex1A-3.
VSP_001274
Alternative sequence1 – 128128MRNRG…KEIAE → MWQSQAPAGAAQTPPLSPPW SQPWHPIHLALASPRPNIPL RSGPACRPPLQLQ in isoform Ex1B-3.
VSP_001273
Alternative sequence1 – 118118Missing in isoform 5.
VSP_045975
Alternative sequence1 – 8181Missing in isoform Ex1A-2-3.
VSP_001271
Alternative sequence82 – 843AAP → MAS in isoform Ex1A-2-3.
VSP_001272
Natural variant5221I → V. Ref.4
Corresponds to variant rs201254826 [ dbSNP | Ensembl ].
VAR_069105

Experimental info

Sequence conflict2071R → G in AAA11725. Ref.1
Sequence conflict8111V → I in BAG59062. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Isoform Ex1B-2-3 [UniParc].

Last modified December 1, 2000. Version 2.
Checksum: 5BD9BBF5AA41BE8F

FASTA879100,688
        10         20         30         40         50         60 
MRNRGQGLFR LRSRCFLHQS LPLGAGRRKG LDVAEPGPSR CRSDSPAVAA VVPAMASYPS 

        70         80         90        100        110        120 
GSGKPKAKYP FKKRASLQAS TAAPEARGGL GAPPLQSARS LPGPAPCLKH FPLDLRTSMD 

       130        140        150        160        170        180 
GKCKEIAEEL FTRSLAESEL RSAPYEFPEE SPIEQLEERR QRLERQISQD VKLEPDILLR 

       190        200        210        220        230        240 
AKQDFLKTDS DSDLQLYKEQ GEGQGDRSLR ERDVLEREFQ RVTISGEEKC GVPFTDLLDA 

       250        260        270        280        290        300 
AKSVVRALFI REKYMALSLQ SFCPTTRRYL QQLAEKPLET RTYEQGPDTP VSADAPVHPP 

       310        320        330        340        350        360 
ALEQHPYEHC EPSTMPGDLG LGLRMVRGVV HVYTRREPDE HCSEVELPYP DLQEFVADVN 

       370        380        390        400        410        420 
VLMALIINGP IKSFCYRRLQ YLSSKFQMHV LLNEMKELAA QKKVPHRDFY NIRKVDTHIH 

       430        440        450        460        470        480 
ASSCMNQKHL LRFIKRAMKR HLEEIVHVEQ GREQTLREVF ESMNLTAYDL SVDTLDVHAD 

       490        500        510        520        530        540 
RNTFHRFDKF NAKYNPIGES VLREIFIKTD NRVSGKYFAH IIKEVMSDLE ESKYQNAELR 

       550        560        570        580        590        600 
LSIYGRSRDE WDKLARWAVM HRVHSPNVRW LVQVPRLFDV YRTKGQLANF QEMLENIFLP 

       610        620        630        640        650        660 
LFEATVHPAS HPELHLFLEH VDGFDSVDDE SKPENHVFNL ESPLPEAWVE EDNPPYAYYL 

       670        680        690        700        710        720 
YYTFANMAML NHLRRQRGFH TFVLRPHCGE AGPIHHLVSA FMLAENISHG LLLRKAPVLQ 

       730        740        750        760        770        780 
YLYYLAQIGI AMSPLSNNSL FLSYHRNPLP EYLSRGLMVS LSTDDPLQFH FTKEPLMEEY 

       790        800        810        820        830        840 
SIATQVWKLS SCDMCELARN SVLMSGFSHK VKSHWLGPNY TKEGPEGNDI RRTNVPDIRV 

       850        860        870 
GYRYETLCQE LALITQAVQS EMLETIPEEA GITMSPGPQ 

« Hide

Isoform Ex1A-2-3 [UniParc].

Checksum: A31876E9F8CC93EB
Show »

FASTA79892,071
Isoform Ex1A-3 [UniParc].

Checksum: AF0EF5DDE5DEBEE3
Show »

FASTA76088,198
Isoform Ex1B-3 [UniParc].

Checksum: 753154327F2740E4
Show »

FASTA80492,918
Isoform 5 [UniParc].

Checksum: A3BD94E9D6226281
Show »

FASTA76188,288

References

« Hide 'large scale' references
[1]"Molecular cloning of AMP deaminase isoform L. Sequence and bacterial expression of human AMPD2 cDNA."
Bausch-Jurken M.T., Mahnke-Zizelman D.K., Morisaki T., Sabina R.L.
J. Biol. Chem. 267:22407-22413(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Placenta.
[2]"Characterization of human AMP deaminase 2 (AMPD2) gene expression reveals alternative transcripts encoding variable N-terminal extensions of isoform L."
Van den Bergh F., Sabina R.L.
Biochem. J. 312:401-410(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], ALTERNATIVE SPLICING.
[3]"Cloning, sequence and characterization of the human AMPD2 gene: evidence for transcriptional regulation by two closely spaced promoters."
Mahnke-Zizelman D.K., van den Bergh F., Bausch-Jurken M.T., Eddy R., Sait S., Shows T.B., Sabina R.L.
Biochim. Biophys. Acta 1308:122-132(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING.
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS EX1B-3 AND 5), VARIANT VAL-522.
Tissue: Testis and Thalamus.
[5]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM EX1A-2-3).
Tissue: Brain.
[8]"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-168, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[9]"Phosphoproteome of resting human platelets."
Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J., Schuetz C., Walter U., Gambaryan S., Sickmann A.
J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Platelet.
[10]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-118; SER-151; THR-188 AND SER-190, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[11]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-76 AND SER-190, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[12]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-168 AND SER-190, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[13]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[14]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-168 AND SER-190, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M91029 mRNA. Translation: AAA62127.1.
M91029 mRNA. Translation: AAA62126.1.
S47833 mRNA. Translation: AAA11725.1.
U16267 mRNA. Translation: AAC50306.1.
U16268 mRNA. Translation: AAC50307.1.
U16269 Genomic RNA. Translation: AAB06511.1.
U16270 mRNA. Translation: AAC50308.1.
U16272, U16271 Genomic DNA. Translation: AAD56302.1.
U16272, U16271 Genomic DNA. Translation: AAC50309.2.
U16272, U16271 Genomic DNA. Translation: AAD56303.1.
AK296394 mRNA. Translation: BAG59062.1.
AK302939 mRNA. Translation: BAG64097.1.
AL355310 Genomic DNA. Translation: CAI19305.1.
AL355310 Genomic DNA. Translation: CAI19307.1.
CH471122 Genomic DNA. Translation: EAW56396.1.
CH471122 Genomic DNA. Translation: EAW56399.1.
CH471122 Genomic DNA. Translation: EAW56401.1.
BC007711 mRNA. Translation: AAH07711.1.
BC075844 mRNA. Translation: AAH75844.1.
CCDSCCDS30796.1. [Q01433-3]
CCDS58016.1. [Q01433-5]
CCDS804.1. [Q01433-2]
CCDS805.1. [Q01433-1]
PIRA44313.
S59994.
S59995.
S59998.
S59999.
S60000.
RefSeqNP_001244289.1. NM_001257360.1. [Q01433-1]
NP_001244290.1. NM_001257361.1. [Q01433-5]
NP_004028.3. NM_004037.7. [Q01433-1]
NP_631895.1. NM_139156.3. [Q01433-2]
NP_981949.1. NM_203404.1. [Q01433-3]
XP_005270809.1. XM_005270752.1. [Q01433-4]
UniGeneHs.82927.

3D structure databases

ProteinModelPortalQ01433.
SMRQ01433. Positions 306-843.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid106768. 9 interactions.
IntActQ01433. 1 interaction.

Chemistry

BindingDBQ01433.
ChEMBLCHEMBL2997.

PTM databases

PhosphoSiteQ01433.

Polymorphism databases

DMDM12644375.

Proteomic databases

MaxQBQ01433.
PaxDbQ01433.
PRIDEQ01433.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000256578; ENSP00000256578; ENSG00000116337. [Q01433-1]
ENST00000342115; ENSP00000345498; ENSG00000116337. [Q01433-2]
ENST00000358729; ENSP00000351573; ENSG00000116337. [Q01433-4]
ENST00000393688; ENSP00000377292; ENSG00000116337. [Q01433-3]
ENST00000528454; ENSP00000437164; ENSG00000116337. [Q01433-5]
ENST00000528667; ENSP00000436541; ENSG00000116337. [Q01433-1]
GeneID271.
KEGGhsa:271.
UCSCuc001dyb.2. human. [Q01433-2]
uc001dyc.2. human. [Q01433-1]
uc001dyd.1. human. [Q01433-3]
uc010ovr.1. human. [Q01433-4]

Organism-specific databases

CTD271.
GeneCardsGC01P110162.
HGNCHGNC:469. AMPD2.
HPAHPA027137.
HPA045760.
HPA050590.
MIM102771. gene.
neXtProtNX_Q01433.
Orphanet369920. Pontocerebellar hypoplasia type 9.
PharmGKBPA24777.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG1816.
HOVERGENHBG050494.
KOK01490.
OMARYETLCQ.
OrthoDBEOG70ZZMQ.
PhylomeDBQ01433.
TreeFamTF300439.

Enzyme and pathway databases

BioCycMetaCyc:HS04008-MONOMER.
ReactomeREACT_111217. Metabolism.
SABIO-RKQ01433.
UniPathwayUPA00591; UER00663.

Gene expression databases

ArrayExpressQ01433.
BgeeQ01433.
GenevestigatorQ01433.

Family and domain databases

InterProIPR006650. A/AMP_deam_AS.
IPR001365. A/AMP_deaminase_dom.
IPR006329. AMP_deaminase.
[Graphical view]
PANTHERPTHR11359. PTHR11359. 1 hit.
PfamPF00962. A_deaminase. 1 hit.
[Graphical view]
PIRSFPIRSF001251. AMP_deaminase_met. 1 hit.
TIGRFAMsTIGR01429. AMP_deaminase. 1 hit.
PROSITEPS00485. A_DEAMINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiAMPD2.
GenomeRNAi271.
NextBio1065.
PROQ01433.
SOURCESearch...

Entry information

Entry nameAMPD2_HUMAN
AccessionPrimary (citable) accession number: Q01433
Secondary accession number(s): B4DK50 expand/collapse secondary AC list , B4DZI5, E9PNG0, Q14856, Q14857, Q16686, Q16687, Q16688, Q16729, Q5T693, Q5T695, Q96IA1, Q9UDX8, Q9UDX9, Q9UMU4
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: December 1, 2000
Last modified: July 9, 2014
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM