AMP deaminase 3

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>This subsection of the ‘Function’ section describes the catalytic activity of an enzyme, i.e. the chemical reaction it catalyzes. This information usually correlates with the presence of an EC (Enzyme Commission) number in the ‘Names and taxonomy’ section.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityⁱ

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactorⁱ

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• AMP deaminase activity Source: ReactomeInferred from experimentⁱ
  • 1429593
  • 7287721
  • 9857047
• metal ion binding Source: UniProtKB-KW

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processⁱ

• ADP metabolic process Source: Ensembl
• AMP catabolic process Source: ProtInc <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • 9291127
• ATP metabolic process Source: Ensembl
• energy homeostasis Source: Ensembl
• erythrocyte homeostasis Source: Ensembl
• GTP metabolic process Source: Ensembl
• IMP salvage Source: UniProtKB-UniPathway
• neutrophil degranulation Source: Reactome
• purine-containing compound salvage Source: Reactome

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componentⁱ

• cytosol Source: Reactome
• extracellular region Source: Reactome
• ficolin-1-rich granule lumen Source: Reactome
• secretory granule lumen Source: Reactome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim"><span class="caps">OMIM</span></a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseaseⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Diseaseⁱ

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">‘Interaction’</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the ‘Interaction’ section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6)ⁱ

<p>This subsection of the ‘Sequence’ section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsⁱ produced by alternative splicing. AlignAdd to basketAdded to basket

        10         20         30         40         50
MPRQFPKLNI SEVDEQVRLL AEKVFAKVLR EEDSKDALSL FTVPEDCPIG 
        60         70         80         90        100
QKEAKERELQ KELAEQKSVE TAKRKKSFKM IRSQSLSLQM PPQQDWKGPP 
       110        120        130        140        150
AASPAMSPTT PVVTGATSLP TPAPYAMPEF QRVTISGDYC AGITLEDYEQ 
       160        170        180        190        200
AAKSLAKALM IREKYARLAY HRFPRITSQY LGHPRADTAP PEEGLPDFHP 
       210        220        230        240        250
PPLPQEDPYC LDDAPPNLDY LVHMQGGILF VYDNKKMLEH QEPHSLPYPD 
       260        270        280        290        300
LETYTVDMSH ILALITDGPT KTYCHRRLNF LESKFSLHEM LNEMSEFKEL 
       310        320        330        340        350
KSNPHRDFYN VRKVDTHIHA AACMNQKHLL RFIKHTYQTE PDRTVAEKRG 
       360        370        380        390        400
RKITLRQVFD GLHMDPYDLT VDSLDVHAGR QTFHRFDKFN SKYNPVGASE 
       410        420        430        440        450
LRDLYLKTEN YLGGEYFARM VKEVARELEE SKYQYSEPRL SIYGRSPEEW 
       460        470        480        490        500
PNLAYWFIQH KVYSPNMRWI IQVPRIYDIF RSKKLLPNFG KMLENIFLPL 
       510        520        530        540        550
FKATINPQDH RELHLFLKYV TGFDSVDDES KHSDHMFSDK SPNPDVWTSE 
       560        570        580        590        600
QNPPYSYYLY YMYANIMVLN NLRRERGLST FLFRPHCGEA GSITHLVSAF 
       610        620        630        640        650
LTADNISHGL LLKKSPVLQY LYYLAQIPIA MSPLSNNSLF LEYSKNPLRE 
       660        670        680        690        700
FLHKGLHVSL STDDPMQFHY TKEALMEEYA IAAQVWKLST CDLCEIARNS 
       710        720        730        740        750
VLQSGLSHQE KQKFLGQNYY KEGPEGNDIR KTNVAQIRMA FRYETLCNEL 
       760 
SFLSDAMKSE EITALTN                                  

        10         20         30         40         50
MALSSEPAEM PRQFPKLNIS EVDEQVRLLA EKVFAKVLRE EDSKDALSLF 
        60         70         80         90        100
TVPEDCPIGQ KEAKERELQK ELAEQKSVET AKRKKSFKMI RSQSLSLQMP 
       110        120        130        140        150
PQQDWKGPPA ASPAMSPTTP VVTGATSLPT PAPYAMPEFQ RVTISGDYCA 
       160        170        180        190        200
GITLEDYEQA AKSLAKALMI REKYARLAYH RFPRITSQYL GHPRADTAPP 
       210 
EEGLPDFHPP PLPQED                                  

        10         20         30         40         50
MEPGSAEMPR QFPKLNISEV DEQVRLLAEK VFAKVLREED SKDALSLFTV 
        60         70         80         90        100
PEDCPIGQKE AKERELQKEL AEQKSVETAK RKKSFKMIRS QSLSLQMPPQ 
       110        120        130        140        150
QDWKGPPAAS PAMSPTTPVV TGATSLPTPA PYAMPEFQRV TISGDYCAGI 
       160        170        180        190        200
TLEDYEQAAK SLAKALMIRE KYARLAYHRF PRITSQYLGH PRADTAPPEE 
       210        220        230        240        250
GLPDFHPPPL PQEDPYCLDD APPNLDYLVH MQGGILFVYD NKKMLEHQEP 
       260        270        280        290        300
HSLPYPDLET YTVDMSHILA LITDGPTKTY CHRRLNFLES KFSLHEMLNE 
       310        320        330        340        350
MSEFKELKSN PHRDFYNVRK VDTHIHAAAC MNQKHLLRFI KHTYQTEPDR 
       360        370        380        390        400
TVAEKRGRKI TLRQVFDGLH MDPYDLTVDS LDVHAGRQTF HRFDKFNSKY 
       410        420        430        440        450
NPVGASELRD LYLKTENYLG GEYFARMVKE VARELEESKY QYSEPRLSIY 
       460        470        480        490        500
GRSPEEWPNL AYWFIQHKVY SPNMRWIIQV PRIYDIFRSK KLLPNFGKML 
       510        520        530        540        550
ENIFLPLFKA TINPQDHREL HLFLKYVTGF DSVDDESKHS DHMFSDKSPN 
       560        570        580        590        600
PDVWTSEQNP PYSYYLYYMY ANIMVLNNLR RERGLSTFLF RPHCGEAGSI 
       610        620        630        640        650
THLVSAFLTA DNISHGLLLK KSPVLQYLYY LAQIPIAMSP LSNNSLFLEY 

SKNPLREF                                             

        10         20         30         40         50
MALSSEPAEM PRQFPKLNIS EVDEQVRLLA EKVFAKVLRE EDSKDALSLF 
        60         70         80         90        100
TVPEDCPIGQ KEAKERELQK ELAEQKSVET AKRKKSFKMI RSQSLSLQMP 
       110        120        130        140        150
PQQDWKGPPA ASPAMSPTTP VVTGATSLPT PAPYAMPEFQ RVTISGDYCA 
       160        170        180        190        200
GITLEDYEQA AKSLAKALMI REKYARLAYH RFPRITSQYL GHPRADTAPP 
       210        220        230        240        250
EEGLPDFHPP PLPQEDPYCL DDAPPNLDYL VHMQGGILFV YDNKKMLEHQ 
       260        270        280        290        300
EPHSLPYPDL ETYTVDMSHI LALITDGPTK TYCHRRLNFL ESKFSLHEML 
       310        320        330        340        350
NEMSEFKELK SNPHRDFYNV RKVDTHIHAA ACMNQKHLLR FIKHTYQTEP 
       360        370        380        390        400
DRTVAEKRGR KITLRQVFDG LHMDPYDLTV DSLDVHAGRQ TFHRFDKFNS 
       410        420        430        440        450
KYNPVGASEL RDLYLKTENY LGGEYFARMV KEVARELEES KYQYSEPRLS 
       460        470        480        490        500
IYGRSPEEWP NLAYWFIQHK VYSPNMRWII QVPRIYDIFR SKKLLPNFGK 
       510        520        530        540        550
MLENIFLPLF KATINPQDHR ELHLFLKYVT GFDSVDDESK HSDHMFSDKS 
       560        570        580        590        600
PNPDVWTSEQ NPPYSYYLYY MYANIMVLNN LRRERGLSTF LFRPHCGEAG 
       610        620        630        640        650
SITHLVSAFL TADNISHGLL LKKSPVLQYL YYLAQIPIAM SPLSNNSLFL 
       660        670        680        690        700
EYSKNPLREF LHKGLHVSLS TDDPMQFHYT KEALMEEYAI AAQVWKLSTC 
       710        720        730        740        750
DLCEIARNSV LQSGLSHQEK QKFLGQNYYK EGPEGNDIRK TNVAQIRMAF 
       760        770 
RYETLCNELS FLSDAMKSEE ITALTN                       

        10         20         30         40         50
MEPGSAEMPR QFPKLNISEV DEQVRLLAEK VFAKVLREED SKDALSLFTV 
        60         70         80         90        100
PEDCPIGQKE AKERELQKEL AEQKSVETAK RKKSFKMIRS QSLSLQMPPQ 
       110        120        130        140        150
QDWKGPPAAS PAMSPTTPVV TGATSLPTPA PYAMPEFQRV TISGDYCAGI 
       160        170        180        190        200
TLEDYEQAAK SLAKALMIRE KYARLAYHRF PRITSQYLGH PRADTAPPEE 
       210        220        230        240        250
GLPDFHPPPL PQEDPYCLDD APPNLDYLVH MQGGILFVYD NKKMLEHQEP 
       260        270        280        290        300
HSLPYPDLET YTVDMSHILA LITDGPTKTY CHRRLNFLES KFSLHEMLNE 
       310        320        330        340        350
MSEFKELKSN PHRDFYNVRK VDTHIHAAAC MNQKHLLRFI KHTYQTEPDR 
       360        370        380        390        400
TVAEKRGRKI TLRQVFDGLH MDPYDLTVDS LDVHAGRQTF HRFDKFNSKY 
       410        420        430        440        450
NPVGASELRD LYLKTENYLG GEYFARMVKE VARELEESKY QYSEPRLSIY 
       460        470        480        490        500
GRSPEEWPNL AYWFIQHKVY SPNMRWIIQV PRIYDIFRSK KLLPNFGKML 
       510        520        530        540        550
ENIFLPLFKA TINPQDHREL HLFLKYVTGF DSVDDESKHS DHMFSDKSPN 
       560        570        580        590        600
PDVWTSEQNP PYSYYLYYMY ANIMVLNNLR RERGLSTFLF RPHCGEAGSI 
       610        620        630        640        650
THLVSAFLTA DNISHGLLLK KSPVLQYLYY LAQIPIAMSP LSNNSLFLEY 
       660        670        680        690        700
SKNPLREFLH KGLHVSLSTD DPMQFHYTKE ALMEEYAIAA QVWKLSTCDL 
       710        720        730        740        750
CEIARNSVLQ SGLSHQEKQK FLGQNYYKEG PEGNDIRKTN VAQIRMAFRY 
       760        770 
ETLCNELSFL SDAMKSEEIT ALTN                       

        10         20         30         40         50
MIREKYARLA YHRFPRITSQ YLGHPRADTA PPEEGLPDFH PPPLPQEDPY 
        60         70         80         90        100
CLDDAPPNLD YLVHMQGGIL FVYDNKKMLE HQEPHSLPYP DLETYTVDMS 
       110        120        130        140        150
HILALITDGP TKTYCHRRLN FLESKFSLHE MLNEMSEFKE LKSNPHRDFY 
       160        170        180        190        200
NVRKVDTHIH AAACMNQKHL LRFIKHTYQT EPDRTVAEKR GRKITLRQVF 
       210        220        230        240        250
DGLHMDPYDL TVDSLDVHAG RQTFHRFDKF NSKYNPVGAS ELRDLYLKTE 
       260        270        280        290        300
NYLGGEYFAR MVKEVARELE ESKYQYSEPR LSIYGRSPEE WPNLAYWFIQ 
       310        320        330        340        350
HKVYSPNMRW IIQVPRIYDI FRSKKLLPNF GKMLENIFLP LFKATINPQD 
       360        370        380        390        400
HRELHLFLKY VTGFDSVDDE SKHSDHMFSD KSPNPDVWTS EQNPPYSYYL 
       410        420        430        440        450
YYMYANIMVL NNLRRERGLS TFLFRPHCGE AGSITHLVSA FLTADNISHG 
       460        470        480        490        500
LLLKKSPVLQ YLYYLAQIPI AMSPLSNNSL FLEYSKNPLR EFLHKGLHVS 
       510        520        530        540        550
LSTDDPMQFH YTKEALMEEY AIAAQVWKLS TCDLCEIARN SVLQSGLSHQ 
       560        570        580        590        600
EKQKFLGQNY YKEGPEGNDI RKTNVAQIRM AFRYETLCNE LSFLSDAMKS 

EEITALTN                                             

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityⁱ

<p>This section provides links to the UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>). UniRef consists of clusters for UniProtKB sequences (including isoforms) and selected UniParc sequences, in order to obtain complete coverage of the sequence space at resolutions of 100%, 90% and 50% identity.<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termⁱ

Documents

1. Human chromosome 11
   Human chromosome 11: entries, gene names and cross-references to MIM
2. Human entries with polymorphisms or disease mutations
   List of human entries with polymorphisms or disease mutations
3. Human polymorphisms and disease mutations
   Index of human polymorphisms and disease mutations
4. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
5. PATHWAY comments
   Index of metabolic and biosynthesis pathways
6. SIMILARITY comments
   Index of protein domains and families