Q01410 (MANC_SALMO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mannose-1-phosphate guanylyltransferase
EC=2.7.7.13

Alternative name(s):
GDP-mannose pyrophosphorylase
Short name=GMP
Short name=GMPP

Gene names

Name:	manC
Synonyms:	rfbM

Organism

Salmonella montevideo

Taxonomic identifier

115981 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella

Protein attributes

Sequence length	471 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in GDP-mannose biosynthesis which serves as the activated sugar nucleotide precursor for mannose residues in cell surface polysaccharides. This enzyme participates in synthesis of the LPS O antigen.
Catalytic activity	GTP + alpha-D-mannose 1-phosphate = diphosphate + GDP-mannose.
Pathway	Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.
Sequence similarities	Belongs to the mannose-6-phosphate isomerase type 2 family.

Ontologies

Keywords
Biological process	Lipopolysaccharide biosynthesis
Ligand	GTP-binding Nucleotide-binding
Molecular function	Nucleotidyltransferase Transferase
Gene Ontology (GO)
Biological process	lipopolysaccharide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW mannose-1-phosphate guanylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 471	471	Mannose-1-phosphate guanylyltransferase		PRO_0000194256

Sequences

	Sequence		Length	Mass (Da)
	Q01410 [UniParc]. Last modified April 1, 1993. Version 1. Checksum: 56CFB825278FE0B7	FASTA	471	52,634
	10 20 30 40 50 60 MITPIIMAGG NGSRLWPLSR TLYPKQFLCL DGSQSMLQTT ITRINNLNAS DPIVICNEQH 70 80 90 100 110 120 RFIVAEQLKE LSKSSGDIIL EPVGRNTAPA VALAALKCLK KNALLLVLAA DHIIKDEETF 130 140 150 160 170 180 CKTIQDARKY AEAGKLVTFG IVPTMPETGY GYIRRGQALF SAENDCSLAF RVAEFVEKPN 190 200 210 220 230 240 LETAQSYLDS GEYYWNSGMF LFRADRYIEE LKIRPDIYKA CSLAMESAVT DLDFIRVDED 250 260 270 280 290 300 SFCACPDESI DYAVMEKTND AVVVPLNAGW SDVGSWSSLW EISDKDSNGN VTKGDVLSHN 310 320 330 340 350 360 ADNCYLHAET GLVTAVGVKD LIVVQTKDAV LVANTNCVQD VKKIVEKIKL ENRHEHITHR 370 380 390 400 410 420 EVYRPWGKYD SIDFGERYQV KRITVKPGEG ISEQQHYHRA EHWIIVAGTA KITIKGEVKI 430 440 450 460 470 LTENESVYIP VGVKHCLENP GKIALELIEV RSGAYLGEDD IVRFSDKYGR N

References

[1]	"Sequence and structural analysis of the rfb (O antigen) gene cluster from a group C1 Salmonella enterica strain." Lee S.J., Romana L.K., Reeves P.R. J. Gen. Microbiol. 138:1843-1855(1992) [PubMed: 1383393] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: M40.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M84642 Genomic DNA. Translation: AAB49390.1.
PIR	S27676.
3D structure databases
ProteinModelPortal	Q01410.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR011051. Cupin_RmlC_type. IPR018247. EF_Hand_1_Ca_BS. IPR006375. Man1P_GuaTrfase/Man6P_Isoase. IPR001538. Man6P_isomerase-2_C. IPR005835. NTP_transferase. IPR014710. RmlC-like_jellyroll. [Graphical view]
Gene3D	G3DSA:2.60.120.10. RmlC-like_jellyroll. 1 hit.
Pfam	PF01050. MannoseP_isomer. 1 hit. PF00483. NTP_transferase. 1 hit. [Graphical view]
SUPFAM	SSF51182. RmlC_like_cupin. 1 hit.
TIGRFAMs	TIGR01479. GMP_PMI. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MANC_SALMO

Accession

Primary (citable) accession number: Q01410

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
Last sequence update:	April 1, 1993
Last modified:	September 21, 2011
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program