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Q01406

- SRC8_CHICK

UniProt

Q01406 - SRC8_CHICK

Protein

Src substrate protein p85

Gene

CTTN1

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 Apr 1993)
      Previous versions | rss
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    Functioni

    Contributes to the organization of the actin cytoskeleton and cell structure. May be involved in the regulation of neuronal spine density By similarity. Plays a role in the regulation of cell migration.By similarity

    GO - Molecular functioni

    1. protein binding Source: IntAct

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Src substrate protein p85
    Alternative name(s):
    Cortactin
    p80
    Gene namesi
    Name:CTTN1
    Synonyms:EMS1, P85.25
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    Cell membrane. Endoplasmic reticulum. Cytoplasmcytoskeleton. Cell projectionlamellipodium By similarity. Cell projectionruffle By similarity. Cell projectiondendritic spine By similarity. Cell projectiondendrite By similarity
    Note: Associated with membrane ruffles and lamellipodia. In normal cells, probably in association with the plasma membrane and possibly the endoplasmic reticulum. p80/85 colocalizes with F-actin in peripheral extensions of normal cells and rosettes (podosomes) of src-transformed cells. p80/85 probably associates with components of the cytoskeleton. In response to neuronal activation by glutamate, redistributes from dendritic spines to the dendritic shaft By similarity.By similarity

    GO - Cellular componenti

    1. cytoskeleton Source: UniProtKB-SubCell
    2. dendritic spine Source: UniProtKB-SubCell
    3. endoplasmic reticulum Source: UniProtKB-SubCell
    4. lamellipodium Source: UniProtKB-SubCell
    5. plasma membrane Source: UniProtKB-SubCell
    6. ruffle Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 563563Src substrate protein p85PRO_0000022411Add
    BLAST

    Post-translational modificationi

    In normal cells, appears to be phosphorylated on serine and threonine; in cells expressing activated forms of pp60-src, they become heavily phosphorylated on tyrosine in vitro. Tyrosine phosphorylation in transformed cells may contribute to cellular growth regulation and transformation.

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ01406.
    PRIDEiQ01406.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Dnm2P390542EBI-2530463,EBI-642337From a different organism.
    KCNMA1Q8AYS82EBI-2530463,EBI-1635766

    Protein-protein interaction databases

    BioGridi676704. 1 interaction.
    IntActiQ01406. 2 interactions.
    MINTiMINT-1507003.
    STRINGi9031.ENSGALP00000012463.

    Structurei

    3D structure databases

    ProteinModelPortaliQ01406.
    SMRiQ01406. Positions 498-563.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati89 – 12537Cortactin 1Add
    BLAST
    Repeati126 – 16237Cortactin 2Add
    BLAST
    Repeati163 – 19937Cortactin 3Add
    BLAST
    Repeati200 – 23637Cortactin 4Add
    BLAST
    Repeati237 – 27337Cortactin 5Add
    BLAST
    Repeati274 – 31037Cortactin 6Add
    BLAST
    Repeati311 – 33323Cortactin 7; truncatedAdd
    BLAST
    Domaini505 – 56359SH3PROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The SH3 motif may mediate binding to the cytoskeleton.

    Sequence similaritiesi

    Contains 7 cortactin repeats.PROSITE-ProRule annotation
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, SH3 domain

    Phylogenomic databases

    eggNOGiNOG123488.
    HOGENOMiHOG000006523.
    HOVERGENiHBG005994.
    InParanoidiQ01406.
    KOiK06106.
    PhylomeDBiQ01406.

    Family and domain databases

    InterProiIPR015503. Cortactin.
    IPR003134. Hs1_Cortactin.
    IPR001452. SH3_domain.
    [Graphical view]
    PANTHERiPTHR10829:SF15. PTHR10829:SF15. 1 hit.
    PfamiPF02218. HS1_rep. 7 hits.
    PF14604. SH3_9. 1 hit.
    [Graphical view]
    PRINTSiPR00452. SH3DOMAIN.
    SMARTiSM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 2 hits.
    PROSITEiPS51090. CORTACTIN. 7 hits.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative initiation. Align

    Isoform p85 (identifier: Q01406-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTVLLLVVLQ MWKATAGHSI AVSQDDGADD WETDPDFVND VSEKEQRWGA    50
    KTVKGSGHQE HINIHQLREN VFQEHQTIKE KELETGPKAS HGYGGKFGVE 100
    QDRMDKSAVG HEYQSKLSKH CSQVDSVKGF GGKFGVQTDR VDQSAVGFEY 150
    QGKTEKHASQ KDYSSGFGGK YGVQADRVDK SAVGFDYQGK TEKHESQKDY 200
    SKGFGGKYGV DKDKVDKSAV GFEYQGKTEK HESQKDYVKG FGGKFGVQTD 250
    RQDKCALGWD HQEKVQLHES QKDYKSGFGG KFGVQTERQD PSAVGFDYKE 300
    KLAKHESQQD YSKGFGGKYG VQKDRMDKNA ATFEDIEKPT STYQKTKPVE 350
    RVANKTSSIR ANLENLAKEK EQEDRRKAEA ERAQRMAREK QEQEEARRKL 400
    EEQAKAKKQT PPPSPTTQPA EPKTPSSPVY QDAVSYDAES AYKNSSTTYS 450
    AEHEPESGYK TTGSDYQEAV SQREAEYEPE TVYEVAGAGD HYQAEENTYD 500
    EYENELGITA IALYDYQAAG DDEISFDPDD IITNIEMIDD GWWRGVCKGR 550
    YGLFPANYVE LRQ 563
    Length:563
    Mass (Da):63,329
    Last modified:April 1, 1993 - v1
    Checksum:i22A824A08B8D654C
    GO
    Isoform p80 (identifier: Q01406-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-10: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:553
    Mass (Da):62,219
    Checksum:i5E714902628217E8
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 1010Missing in isoform p80. CuratedVSP_018797

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M73705 mRNA. Translation: AAA49031.1.
    PIRiA41530.
    RefSeqiNP_990799.1. NM_205468.1. [Q01406-1]
    UniGeneiGga.37455.

    Genome annotation databases

    GeneIDi396455.
    KEGGigga:396455.

    Keywords - Coding sequence diversityi

    Alternative initiation

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M73705 mRNA. Translation: AAA49031.1 .
    PIRi A41530.
    RefSeqi NP_990799.1. NM_205468.1. [Q01406-1 ]
    UniGenei Gga.37455.

    3D structure databases

    ProteinModelPortali Q01406.
    SMRi Q01406. Positions 498-563.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 676704. 1 interaction.
    IntActi Q01406. 2 interactions.
    MINTi MINT-1507003.
    STRINGi 9031.ENSGALP00000012463.

    Proteomic databases

    PaxDbi Q01406.
    PRIDEi Q01406.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 396455.
    KEGGi gga:396455.

    Organism-specific databases

    CTDi 2017.

    Phylogenomic databases

    eggNOGi NOG123488.
    HOGENOMi HOG000006523.
    HOVERGENi HBG005994.
    InParanoidi Q01406.
    KOi K06106.
    PhylomeDBi Q01406.

    Miscellaneous databases

    NextBioi 20816496.
    PROi Q01406.

    Family and domain databases

    InterProi IPR015503. Cortactin.
    IPR003134. Hs1_Cortactin.
    IPR001452. SH3_domain.
    [Graphical view ]
    PANTHERi PTHR10829:SF15. PTHR10829:SF15. 1 hit.
    Pfami PF02218. HS1_rep. 7 hits.
    PF14604. SH3_9. 1 hit.
    [Graphical view ]
    PRINTSi PR00452. SH3DOMAIN.
    SMARTi SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 2 hits.
    PROSITEi PS51090. CORTACTIN. 7 hits.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of a novel cytoskeleton-associated pp60src substrate."
      Wu H., Reynolds A.B., Kanner S.B., Vines R.R., Parsons J.T.
      Mol. Cell. Biol. 11:5113-5124(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiSRC8_CHICK
    AccessioniPrimary (citable) accession number: Q01406
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: April 1, 1993
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3