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Q01406

- SRC8_CHICK

UniProt

Q01406 - SRC8_CHICK

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Protein

Src substrate protein p85

Gene
CTTN1, EMS1, P85.25
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Contributes to the organization of the actin cytoskeleton and cell structure. May be involved in the regulation of neuronal spine density By similarity. Plays a role in the regulation of cell migration.

GO - Molecular functioni

  1. protein binding Source: IntAct
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Src substrate protein p85
Alternative name(s):
Cortactin
p80
Gene namesi
Name:CTTN1
Synonyms:EMS1, P85.25
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Cell membrane. Endoplasmic reticulum. Cytoplasmcytoskeleton. Cell projectionlamellipodium By similarity. Cell projectionruffle By similarity. Cell projectiondendritic spine By similarity. Cell projectiondendrite By similarity
Note: Associated with membrane ruffles and lamellipodia. In normal cells, probably in association with the plasma membrane and possibly the endoplasmic reticulum. p80/85 colocalizes with F-actin in peripheral extensions of normal cells and rosettes (podosomes) of src-transformed cells. p80/85 probably associates with components of the cytoskeleton. In response to neuronal activation by glutamate, redistributes from dendritic spines to the dendritic shaft By similarity.

GO - Cellular componenti

  1. cytoskeleton Source: UniProtKB-SubCell
  2. dendritic spine Source: UniProtKB-SubCell
  3. endoplasmic reticulum Source: UniProtKB-SubCell
  4. lamellipodium Source: UniProtKB-SubCell
  5. plasma membrane Source: UniProtKB-SubCell
  6. ruffle Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 563563Src substrate protein p85PRO_0000022411Add
BLAST

Post-translational modificationi

In normal cells, appears to be phosphorylated on serine and threonine; in cells expressing activated forms of pp60-src, they become heavily phosphorylated on tyrosine in vitro. Tyrosine phosphorylation in transformed cells may contribute to cellular growth regulation and transformation.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ01406.
PRIDEiQ01406.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Dnm2P390542EBI-2530463,EBI-642337From a different organism.
KCNMA1Q8AYS82EBI-2530463,EBI-1635766

Protein-protein interaction databases

BioGridi676704. 1 interaction.
IntActiQ01406. 2 interactions.
MINTiMINT-1507003.
STRINGi9031.ENSGALP00000012463.

Structurei

3D structure databases

ProteinModelPortaliQ01406.
SMRiQ01406. Positions 498-563.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati89 – 12537Cortactin 1Add
BLAST
Repeati126 – 16237Cortactin 2Add
BLAST
Repeati163 – 19937Cortactin 3Add
BLAST
Repeati200 – 23637Cortactin 4Add
BLAST
Repeati237 – 27337Cortactin 5Add
BLAST
Repeati274 – 31037Cortactin 6Add
BLAST
Repeati311 – 33323Cortactin 7; truncatedAdd
BLAST
Domaini505 – 56359SH3Add
BLAST

Domaini

The SH3 motif may mediate binding to the cytoskeleton.

Sequence similaritiesi

Contains 7 cortactin repeats.
Contains 1 SH3 domain.

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

eggNOGiNOG123488.
HOGENOMiHOG000006523.
HOVERGENiHBG005994.
InParanoidiQ01406.
KOiK06106.
PhylomeDBiQ01406.

Family and domain databases

InterProiIPR015503. Cortactin.
IPR003134. Hs1_Cortactin.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR10829:SF15. PTHR10829:SF15. 1 hit.
PfamiPF02218. HS1_rep. 7 hits.
PF14604. SH3_9. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 2 hits.
PROSITEiPS51090. CORTACTIN. 7 hits.
PS50002. SH3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative initiation. Align

Isoform p85 (identifier: Q01406-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MTVLLLVVLQ MWKATAGHSI AVSQDDGADD WETDPDFVND VSEKEQRWGA    50
KTVKGSGHQE HINIHQLREN VFQEHQTIKE KELETGPKAS HGYGGKFGVE 100
QDRMDKSAVG HEYQSKLSKH CSQVDSVKGF GGKFGVQTDR VDQSAVGFEY 150
QGKTEKHASQ KDYSSGFGGK YGVQADRVDK SAVGFDYQGK TEKHESQKDY 200
SKGFGGKYGV DKDKVDKSAV GFEYQGKTEK HESQKDYVKG FGGKFGVQTD 250
RQDKCALGWD HQEKVQLHES QKDYKSGFGG KFGVQTERQD PSAVGFDYKE 300
KLAKHESQQD YSKGFGGKYG VQKDRMDKNA ATFEDIEKPT STYQKTKPVE 350
RVANKTSSIR ANLENLAKEK EQEDRRKAEA ERAQRMAREK QEQEEARRKL 400
EEQAKAKKQT PPPSPTTQPA EPKTPSSPVY QDAVSYDAES AYKNSSTTYS 450
AEHEPESGYK TTGSDYQEAV SQREAEYEPE TVYEVAGAGD HYQAEENTYD 500
EYENELGITA IALYDYQAAG DDEISFDPDD IITNIEMIDD GWWRGVCKGR 550
YGLFPANYVE LRQ 563
Length:563
Mass (Da):63,329
Last modified:April 1, 1993 - v1
Checksum:i22A824A08B8D654C
GO
Isoform p80 (identifier: Q01406-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: Missing.

Note: No experimental confirmation available.

Show »
Length:553
Mass (Da):62,219
Checksum:i5E714902628217E8
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1010Missing in isoform p80. VSP_018797

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M73705 mRNA. Translation: AAA49031.1.
PIRiA41530.
RefSeqiNP_990799.1. NM_205468.1. [Q01406-1]
UniGeneiGga.37455.

Genome annotation databases

GeneIDi396455.
KEGGigga:396455.

Keywords - Coding sequence diversityi

Alternative initiation

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M73705 mRNA. Translation: AAA49031.1 .
PIRi A41530.
RefSeqi NP_990799.1. NM_205468.1. [Q01406-1 ]
UniGenei Gga.37455.

3D structure databases

ProteinModelPortali Q01406.
SMRi Q01406. Positions 498-563.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 676704. 1 interaction.
IntActi Q01406. 2 interactions.
MINTi MINT-1507003.
STRINGi 9031.ENSGALP00000012463.

Proteomic databases

PaxDbi Q01406.
PRIDEi Q01406.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 396455.
KEGGi gga:396455.

Organism-specific databases

CTDi 2017.

Phylogenomic databases

eggNOGi NOG123488.
HOGENOMi HOG000006523.
HOVERGENi HBG005994.
InParanoidi Q01406.
KOi K06106.
PhylomeDBi Q01406.

Miscellaneous databases

NextBioi 20816496.
PROi Q01406.

Family and domain databases

InterProi IPR015503. Cortactin.
IPR003134. Hs1_Cortactin.
IPR001452. SH3_domain.
[Graphical view ]
PANTHERi PTHR10829:SF15. PTHR10829:SF15. 1 hit.
Pfami PF02218. HS1_rep. 7 hits.
PF14604. SH3_9. 1 hit.
[Graphical view ]
PRINTSi PR00452. SH3DOMAIN.
SMARTi SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 2 hits.
PROSITEi PS51090. CORTACTIN. 7 hits.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification and characterization of a novel cytoskeleton-associated pp60src substrate."
    Wu H., Reynolds A.B., Kanner S.B., Vines R.R., Parsons J.T.
    Mol. Cell. Biol. 11:5113-5124(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiSRC8_CHICK
AccessioniPrimary (citable) accession number: Q01406
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: June 11, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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