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Protein

Protein transport protein Sec23A

Gene

Sec23a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • ER to Golgi vesicle-mediated transport Source: InterPro
  • intracellular protein transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-MMU-2132295. MHC class II antigen presentation.
R-MMU-5694530. Cargo concentration in the ER.
R-MMU-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein transport protein Sec23A
Alternative name(s):
SEC23-related protein A
Gene namesi
Name:Sec23a
Synonyms:Sec23, Sec23r
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1349635. Sec23a.

Subcellular locationi

GO - Cellular componenti

  • COPII vesicle coat Source: InterPro
  • endoplasmic reticulum membrane Source: Reactome
  • ER to Golgi transport vesicle Source: MGI
  • Golgi membrane Source: MGI
  • perinuclear region of cytoplasm Source: MGI
  • smooth endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 765764Protein transport protein Sec23APRO_0000205147Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylthreonineBy similarity
Modified residuei308 – 3081PhosphothreonineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ01405.
MaxQBiQ01405.
PaxDbiQ01405.
PeptideAtlasiQ01405.
PRIDEiQ01405.

PTM databases

iPTMnetiQ01405.
PhosphoSiteiQ01405.
SwissPalmiQ01405.

Expressioni

Tissue specificityi

High levels in brain and fibroblasts.

Gene expression databases

BgeeiENSMUSG00000020986.
CleanExiMM_SEC23A.
ExpressionAtlasiQ01405. baseline and differential.
GenevisibleiQ01405. MM.

Interactioni

Subunit structurei

COPII is composed of at least five proteins: the Sec23/24 complex, the Sec13/31 complex and Sar1. Interacts with SEC23IP. Interacts with HTR4. Interacts with SEC16A (By similarity). Interacts with SLC6A4.By similarity3 Publications

Protein-protein interaction databases

BioGridi203150. 3 interactions.
DIPiDIP-32032N.
IntActiQ01405. 6 interactions.
MINTiMINT-4997079.
STRINGi10090.ENSMUSP00000021375.

Structurei

3D structure databases

ProteinModelPortaliQ01405.
SMRiQ01405. Positions 3-762.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SEC23/SEC24 family. SEC23 subfamily.Curated

Phylogenomic databases

eggNOGiKOG1986. Eukaryota.
COG5047. LUCA.
GeneTreeiENSGT00390000006916.
HOGENOMiHOG000231690.
HOVERGENiHBG055039.
InParanoidiQ01405.
KOiK14006.
OMAiGDYHKDD.
OrthoDBiEOG091G063R.
PhylomeDBiQ01405.
TreeFamiTF300693.

Family and domain databases

Gene3Di3.40.20.10. 1 hit.
3.40.50.410. 1 hit.
InterProiIPR029006. ADF-H/Gelsolin-like_dom.
IPR007123. Gelsolin-like_dom.
IPR006900. Sec23/24_helical_dom.
IPR006896. Sec23/24_trunk_dom.
IPR012990. Sec23_24_beta_S.
IPR002035. VWF_A.
IPR006895. Znf_Sec23_Sec24.
[Graphical view]
PfamiPF00626. Gelsolin. 1 hit.
PF08033. Sec23_BS. 1 hit.
PF04815. Sec23_helical. 1 hit.
PF04811. Sec23_trunk. 1 hit.
PF04810. zf-Sec23_Sec24. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
SSF81811. SSF81811. 1 hit.
SSF82754. SSF82754. 1 hit.
SSF82919. SSF82919. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q01405-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTYLEFIQQ NEERDGVRFS WNVWPSSRLE ATRMVVPVAA LFTPLKERPD
60 70 80 90 100
LPPIQYEPVL CSRTTCRAVL NPLCQVDYRA KLWACNFCYQ RNQFPPTYAG
110 120 130 140 150
ISELNQPAEL LPQFSSIEYV VLRGPQMPLI FLYVVDTCIE DEDLQALKES
160 170 180 190 200
MQMSLSLLPP TALVGLITFG RMVQVHELGC EGISKSYVFR GTKDLSAKQL
210 220 230 240 250
QEMLGLSKVP VTQATRGPQV QQPPPSNRFL QPVQKIDMNL TDLLGELQRD
260 270 280 290 300
PWPVPQGKRP LRSSGVALSI AVGLLECTFP NTGARIMMFI GGPATQGPGM
310 320 330 340 350
VVGDELKTPI RSWHDIEKDN AKYVKKGTKH FEALANRAAT TGHVIDIYAC
360 370 380 390 400
ALDQTGLLEM KCCPNLTGGY MVMGDSFNTS LFKQTFQRVF TKDIHGQFKM
410 420 430 440 450
GFGGTLEIKT SREIKISGAI GPCVSLNSKG PCVSENEIGT GGTCQWKICG
460 470 480 490 500
LSPTTTLAIY FEVVNQHNAP IPQGGRGAVQ FVTQYQHSSG QRRIRVTTIA
510 520 530 540 550
RNWADAQTQI QNIAASFDQE AAAILMARLA IYRAETEEGP DVLRWLDRQL
560 570 580 590 600
IRLCQKFGEY HKDDPNSFRF SETFSLYPQF MFHLRRSPFL QVFNNSPDES
610 620 630 640 650
SYYRHHFMRQ DLTQSLIMIQ PILYAYSFSG PPEPVLLDSS SILADRILLM
660 670 680 690 700
DTFFQILIYH GETIAQWRKS GYQDMPEYEN FRHLLQAPVD DAQEILHSRF
710 720 730 740 750
PMPRYIDTEH GGSQARFLLS KVNPSQTHNN MYAWGQESGA PILTDDVSLQ
760
VFMDHLKKLA VSSAA
Length:765
Mass (Da):86,162
Last modified:January 10, 2003 - v2
Checksum:iC0FD4C2C1578B6A5
GO

Sequence cautioni

The sequence BAA02209 differs from that shown. Reason: Frameshift at positions 88, 94, 110, 113, 116, 182, 184, 226, 279, 292, 296, 321, 352, 425, 452 and 567. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti81 – 833KLW → TR in BAA02209 (PubMed:8417978).Curated
Sequence conflicti91 – 922RN → D in BAA02209 (PubMed:8417978).Curated
Sequence conflicti99 – 991A → S in BAA02209 (PubMed:8417978).Curated
Sequence conflicti108 – 1081A → R in BAA02209 (PubMed:8417978).Curated
Sequence conflicti115 – 1173SSI → QS in BAA02209 (PubMed:8417978).Curated
Sequence conflicti129 – 1291L → F in BAA02209 (PubMed:8417978).Curated
Sequence conflicti153 – 1575MSLSL → TTFS in BAA02209 (PubMed:8417978).Curated
Sequence conflicti172 – 1721M → I in BAA02209 (PubMed:8417978).Curated
Sequence conflicti216 – 2172RG → S in BAA02209 (PubMed:8417978).Curated
Sequence conflicti263 – 2631S → P in BAA02209 (PubMed:8417978).Curated
Sequence conflicti293 – 2931P → S in BAA02209 (PubMed:8417978).Curated
Sequence conflicti310 – 3101I → M in BAA02209 (PubMed:8417978).Curated
Sequence conflicti515 – 5151A → R in BAA02209 (PubMed:8417978).Curated
Sequence conflicti523 – 5231A → P in BAA02209 (PubMed:8417978).Curated
Sequence conflicti631 – 6311P → R in BAA02209 (PubMed:8417978).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY082671 mRNA. Translation: AAL92480.1.
BC034610 mRNA. Translation: AAH34610.1.
D12713 Genomic DNA. Translation: BAA02209.1. Frameshift.
CCDSiCCDS25931.1.
PIRiS28142. I60247.
RefSeqiNP_033173.2. NM_009147.2.
XP_006515691.1. XM_006515628.2.
UniGeneiMm.491137.

Genome annotation databases

EnsembliENSMUST00000021375; ENSMUSP00000021375; ENSMUSG00000020986.
GeneIDi20334.
KEGGimmu:20334.
UCSCiuc007npw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY082671 mRNA. Translation: AAL92480.1.
BC034610 mRNA. Translation: AAH34610.1.
D12713 Genomic DNA. Translation: BAA02209.1. Frameshift.
CCDSiCCDS25931.1.
PIRiS28142. I60247.
RefSeqiNP_033173.2. NM_009147.2.
XP_006515691.1. XM_006515628.2.
UniGeneiMm.491137.

3D structure databases

ProteinModelPortaliQ01405.
SMRiQ01405. Positions 3-762.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203150. 3 interactions.
DIPiDIP-32032N.
IntActiQ01405. 6 interactions.
MINTiMINT-4997079.
STRINGi10090.ENSMUSP00000021375.

PTM databases

iPTMnetiQ01405.
PhosphoSiteiQ01405.
SwissPalmiQ01405.

Proteomic databases

EPDiQ01405.
MaxQBiQ01405.
PaxDbiQ01405.
PeptideAtlasiQ01405.
PRIDEiQ01405.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021375; ENSMUSP00000021375; ENSMUSG00000020986.
GeneIDi20334.
KEGGimmu:20334.
UCSCiuc007npw.1. mouse.

Organism-specific databases

CTDi10484.
MGIiMGI:1349635. Sec23a.

Phylogenomic databases

eggNOGiKOG1986. Eukaryota.
COG5047. LUCA.
GeneTreeiENSGT00390000006916.
HOGENOMiHOG000231690.
HOVERGENiHBG055039.
InParanoidiQ01405.
KOiK14006.
OMAiGDYHKDD.
OrthoDBiEOG091G063R.
PhylomeDBiQ01405.
TreeFamiTF300693.

Enzyme and pathway databases

ReactomeiR-MMU-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-MMU-2132295. MHC class II antigen presentation.
R-MMU-5694530. Cargo concentration in the ER.
R-MMU-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Miscellaneous databases

PROiQ01405.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020986.
CleanExiMM_SEC23A.
ExpressionAtlasiQ01405. baseline and differential.
GenevisibleiQ01405. MM.

Family and domain databases

Gene3Di3.40.20.10. 1 hit.
3.40.50.410. 1 hit.
InterProiIPR029006. ADF-H/Gelsolin-like_dom.
IPR007123. Gelsolin-like_dom.
IPR006900. Sec23/24_helical_dom.
IPR006896. Sec23/24_trunk_dom.
IPR012990. Sec23_24_beta_S.
IPR002035. VWF_A.
IPR006895. Znf_Sec23_Sec24.
[Graphical view]
PfamiPF00626. Gelsolin. 1 hit.
PF08033. Sec23_BS. 1 hit.
PF04815. Sec23_helical. 1 hit.
PF04811. Sec23_trunk. 1 hit.
PF04810. zf-Sec23_Sec24. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
SSF81811. SSF81811. 1 hit.
SSF82754. SSF82754. 1 hit.
SSF82919. SSF82919. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSC23A_MOUSE
AccessioniPrimary (citable) accession number: Q01405
Secondary accession number(s): Q8JZL4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 10, 2003
Last modified: September 7, 2016
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.