Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q01405 (SC23A_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein transport protein Sec23A
Alternative name(s):
SEC23-related protein A
Gene names
Name:Sec23a
Synonyms:Sec23, Sec23r
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length765 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex By similarity.

Subunit structure

COPII is composed of at least five proteins: the Sec23/24 complex, the Sec13/31 complex and Sar1. Interacts with SEC23IP. Interacts with HTR4. Interacts with SEC16A By similarity. Interacts with SLC6A4. Ref.4 Ref.5 Ref.6

Subcellular location

Smooth endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein Potential. Note: In the ribosome-free transitional face of the ER and associated vesicles.

Tissue specificity

High levels in brain and fibroblasts.

Sequence similarities

Belongs to the SEC23/SEC24 family. SEC23 subfamily.

Sequence caution

The sequence BAA02209.1 differs from that shown. Reason: Frameshift at positions 88, 94, 110, 113, 116, 182, 184, 226, 279, 292, 296, 321, 352, 425, 452 and 567.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 765764Protein transport protein Sec23A
PRO_0000205147

Amino acid modifications

Modified residue21N-acetylthreonine By similarity
Modified residue3081Phosphothreonine By similarity

Experimental info

Sequence conflict81 – 833KLW → TR in BAA02209. Ref.3
Sequence conflict91 – 922RN → D in BAA02209. Ref.3
Sequence conflict991A → S in BAA02209. Ref.3
Sequence conflict1081A → R in BAA02209. Ref.3
Sequence conflict115 – 1173SSI → QS in BAA02209. Ref.3
Sequence conflict1291L → F in BAA02209. Ref.3
Sequence conflict153 – 1575MSLSL → TTFS in BAA02209. Ref.3
Sequence conflict1721M → I in BAA02209. Ref.3
Sequence conflict216 – 2172RG → S in BAA02209. Ref.3
Sequence conflict2631S → P in BAA02209. Ref.3
Sequence conflict2931P → S in BAA02209. Ref.3
Sequence conflict3101I → M in BAA02209. Ref.3
Sequence conflict5151A → R in BAA02209. Ref.3
Sequence conflict5231A → P in BAA02209. Ref.3
Sequence conflict6311P → R in BAA02209. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q01405 [UniParc].

Last modified January 10, 2003. Version 2.
Checksum: C0FD4C2C1578B6A5

FASTA76586,162
        10         20         30         40         50         60 
MTTYLEFIQQ NEERDGVRFS WNVWPSSRLE ATRMVVPVAA LFTPLKERPD LPPIQYEPVL 

        70         80         90        100        110        120 
CSRTTCRAVL NPLCQVDYRA KLWACNFCYQ RNQFPPTYAG ISELNQPAEL LPQFSSIEYV 

       130        140        150        160        170        180 
VLRGPQMPLI FLYVVDTCIE DEDLQALKES MQMSLSLLPP TALVGLITFG RMVQVHELGC 

       190        200        210        220        230        240 
EGISKSYVFR GTKDLSAKQL QEMLGLSKVP VTQATRGPQV QQPPPSNRFL QPVQKIDMNL 

       250        260        270        280        290        300 
TDLLGELQRD PWPVPQGKRP LRSSGVALSI AVGLLECTFP NTGARIMMFI GGPATQGPGM 

       310        320        330        340        350        360 
VVGDELKTPI RSWHDIEKDN AKYVKKGTKH FEALANRAAT TGHVIDIYAC ALDQTGLLEM 

       370        380        390        400        410        420 
KCCPNLTGGY MVMGDSFNTS LFKQTFQRVF TKDIHGQFKM GFGGTLEIKT SREIKISGAI 

       430        440        450        460        470        480 
GPCVSLNSKG PCVSENEIGT GGTCQWKICG LSPTTTLAIY FEVVNQHNAP IPQGGRGAVQ 

       490        500        510        520        530        540 
FVTQYQHSSG QRRIRVTTIA RNWADAQTQI QNIAASFDQE AAAILMARLA IYRAETEEGP 

       550        560        570        580        590        600 
DVLRWLDRQL IRLCQKFGEY HKDDPNSFRF SETFSLYPQF MFHLRRSPFL QVFNNSPDES 

       610        620        630        640        650        660 
SYYRHHFMRQ DLTQSLIMIQ PILYAYSFSG PPEPVLLDSS SILADRILLM DTFFQILIYH 

       670        680        690        700        710        720 
GETIAQWRKS GYQDMPEYEN FRHLLQAPVD DAQEILHSRF PMPRYIDTEH GGSQARFLLS 

       730        740        750        760 
KVNPSQTHNN MYAWGQESGA PILTDDVSLQ VFMDHLKKLA VSSAA 

« Hide

References

« Hide 'large scale' references
[1]"Sterols block binding of COPII proteins to SCAP, thereby controlling SCAP sorting in ER."
Espenshade P.J., Li W.-P., Yabe D.
Proc. Natl. Acad. Sci. U.S.A. 99:11694-11699(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6J.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Retina.
[3]"Identification and differential expression of yeast SEC23-related gene (Msec23) in mouse tissues."
Wadhwa R., Kaul S.C., Komatsu Y., Ikawa Y., Sarai A., Sugimoto Y.
FEBS Lett. 315:193-196(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-631.
Tissue: Fibroblast.
[4]"p125 is a novel mammalian Sec23p-interacting protein with structural similarity to phospholipid-modifying proteins."
Tani K., Mizoguchi T., Iwamatsu A., Hatsuzawa K., Tagaya M.
J. Biol. Chem. 274:20505-20512(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH SEC23IP.
[5]"New sorting nexin (SNX27) and NHERF specifically interact with the 5-HT4a receptor splice variant: roles in receptor targeting."
Joubert L., Hanson B., Barthet G., Sebben M., Claeysen S., Hong W., Marin P., Dumuis A., Bockaert J.
J. Cell Sci. 117:5367-5379(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH HTR4.
[6]"Physical interaction between the serotonin transporter and neuronal nitric oxide synthase underlies reciprocal modulation of their activity."
Chanrion B., Mannoury la Cour C., Bertaso F., Lerner-Natoli M., Freissmuth M., Millan M.J., Bockaert J., Marin P.
Proc. Natl. Acad. Sci. U.S.A. 104:8119-8124(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH SLC6A4.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY082671 mRNA. Translation: AAL92480.1.
BC034610 mRNA. Translation: AAH34610.1.
D12713 Genomic DNA. Translation: BAA02209.1. Frameshift.
PIRI60247. S28142.
RefSeqNP_033173.2. NM_009147.2.
XP_006515691.1. XM_006515628.1.
UniGeneMm.491137.

3D structure databases

ProteinModelPortalQ01405.
SMRQ01405. Positions 3-762.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid203150. 1 interaction.
DIPDIP-32032N.
IntActQ01405. 6 interactions.
MINTMINT-4997079.

PTM databases

PhosphoSiteQ01405.

Proteomic databases

PaxDbQ01405.
PRIDEQ01405.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000021375; ENSMUSP00000021375; ENSMUSG00000020986.
GeneID20334.
KEGGmmu:20334.
UCSCuc007npw.1. mouse.

Organism-specific databases

CTD10484.
MGIMGI:1349635. Sec23a.

Phylogenomic databases

eggNOGCOG5047.
GeneTreeENSGT00390000006916.
HOGENOMHOG000231690.
HOVERGENHBG055039.
InParanoidQ01405.
KOK14006.
OMAWICPFCY.
OrthoDBEOG72C4ZP.
PhylomeDBQ01405.
TreeFamTF300693.

Enzyme and pathway databases

ReactomeREACT_147890. SREBP2:SCAP Binds CopII Coat Complex.
REACT_147893. SREBP2:SCAP Transits to the Golgi.

Gene expression databases

ArrayExpressQ01405.
BgeeQ01405.
CleanExMM_SEC23A.
GenevestigatorQ01405.

Family and domain databases

Gene3D3.40.50.410. 1 hit.
InterProIPR007123. Gelsolin-like_dom.
IPR006900. Sec23/24_helical_dom.
IPR006896. Sec23/24_trunk_dom.
IPR012990. Sec23_24_beta_S.
IPR002035. VWF_A.
IPR006895. Znf_Sec23_Sec24.
[Graphical view]
PfamPF00626. Gelsolin. 1 hit.
PF08033. Sec23_BS. 1 hit.
PF04815. Sec23_helical. 1 hit.
PF04811. Sec23_trunk. 1 hit.
PF04810. zf-Sec23_Sec24. 1 hit.
[Graphical view]
SUPFAMSSF53300. SSF53300. 1 hit.
SSF81811. SSF81811. 1 hit.
SSF82919. SSF82919. 1 hit.
ProtoNetSearch...

Other

NextBio298139.
PROQ01405.
SOURCESearch...

Entry information

Entry nameSC23A_MOUSE
AccessionPrimary (citable) accession number: Q01405
Secondary accession number(s): Q8JZL4
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 10, 2003
Last modified: April 16, 2014
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot