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Protein

Protein transport protein Sec23A

Gene

Sec23a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi61ZincBy similarity1
Metal bindingi66ZincBy similarity1
Metal bindingi85ZincBy similarity1
Metal bindingi88ZincBy similarity1

GO - Molecular functioni

GO - Biological processi

  • cargo loading into COPII-coated vesicle Source: UniProtKB
  • intracellular protein transport Source: MGI

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-MMU-2132295. MHC class II antigen presentation.
R-MMU-5694530. Cargo concentration in the ER.
R-MMU-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein transport protein Sec23ACurated
Alternative name(s):
SEC23-related protein A
Gene namesi
Name:Sec23aImported
Synonyms:Sec23, Sec23r
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1349635. Sec23a.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002051472 – 765Protein transport protein Sec23AAdd BLAST764

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylthreonineBy similarity1
Modified residuei308PhosphothreonineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ01405.
MaxQBiQ01405.
PaxDbiQ01405.
PeptideAtlasiQ01405.
PRIDEiQ01405.

PTM databases

iPTMnetiQ01405.
PhosphoSitePlusiQ01405.
SwissPalmiQ01405.

Expressioni

Tissue specificityi

High levels in brain and fibroblasts.1 Publication

Gene expression databases

BgeeiENSMUSG00000020986.
CleanExiMM_SEC23A.
ExpressionAtlasiQ01405. baseline and differential.
GenevisibleiQ01405. MM.

Interactioni

Subunit structurei

COPII is composed of at least five proteins: the Sec23/24 complex, the Sec13/31 complex and Sar1 (By similarity). Interacts with SEC23IP (PubMed:10400679). Interacts with HTR4 (PubMed:15466885). Interacts with SEC16A (By similarity). Interacts with SLC6A4 (PubMed:17452640). Interacts (as part of the Sec23/24 complex) with SEC22B; recruits SEC22B into COPII-coated vesicles and allows the transport of this cargo from the endoplasmic reticulum to the Golgi. Interacts (via Gelsolin-like repeat) with CTAGE5 and MIA3; specifically involved in the transport of large cargos like the collagen COL7A1 (By similarity).By similarity3 Publications

Protein-protein interaction databases

BioGridi203150. 3 interactors.
DIPiDIP-32032N.
IntActiQ01405. 6 interactors.
MINTiMINT-4997079.
STRINGi10090.ENSMUSP00000021375.

Structurei

3D structure databases

ProteinModelPortaliQ01405.
SMRiQ01405.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati632 – 718Gelsolin-likeSequence analysisAdd BLAST87

Domaini

The Gelsolin-like repeat mediates interaction with proteins containing PPP motifs that include CTAGE5, MIA3 but also SEC31A. These interactions are probably competitive.By similarity

Sequence similaritiesi

Belongs to the SEC23/SEC24 family. SEC23 subfamily.Curated

Phylogenomic databases

eggNOGiKOG1986. Eukaryota.
COG5047. LUCA.
GeneTreeiENSGT00390000006916.
HOGENOMiHOG000231690.
HOVERGENiHBG055039.
InParanoidiQ01405.
KOiK14006.
OMAiCPFCLSR.
OrthoDBiEOG091G063R.
PhylomeDBiQ01405.
TreeFamiTF300693.

Family and domain databases

Gene3Di3.40.20.10. 1 hit.
3.40.50.410. 1 hit.
InterProiView protein in InterPro
IPR029006. ADF-H/Gelsolin-like_dom.
IPR007123. Gelsolin-like_dom.
IPR006900. Sec23/24_helical_dom.
IPR006896. Sec23/24_trunk_dom.
IPR012990. Sec23_24_beta_S.
IPR002035. VWF_A.
IPR006895. Znf_Sec23_Sec24.
PfamiView protein in Pfam
PF00626. Gelsolin. 1 hit.
PF08033. Sec23_BS. 1 hit.
PF04815. Sec23_helical. 1 hit.
PF04811. Sec23_trunk. 1 hit.
PF04810. zf-Sec23_Sec24. 1 hit.
SUPFAMiSSF53300. SSF53300. 1 hit.
SSF81811. SSF81811. 1 hit.
SSF82754. SSF82754. 1 hit.
SSF82919. SSF82919. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q01405-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTYLEFIQQ NEERDGVRFS WNVWPSSRLE ATRMVVPVAA LFTPLKERPD
60 70 80 90 100
LPPIQYEPVL CSRTTCRAVL NPLCQVDYRA KLWACNFCYQ RNQFPPTYAG
110 120 130 140 150
ISELNQPAEL LPQFSSIEYV VLRGPQMPLI FLYVVDTCIE DEDLQALKES
160 170 180 190 200
MQMSLSLLPP TALVGLITFG RMVQVHELGC EGISKSYVFR GTKDLSAKQL
210 220 230 240 250
QEMLGLSKVP VTQATRGPQV QQPPPSNRFL QPVQKIDMNL TDLLGELQRD
260 270 280 290 300
PWPVPQGKRP LRSSGVALSI AVGLLECTFP NTGARIMMFI GGPATQGPGM
310 320 330 340 350
VVGDELKTPI RSWHDIEKDN AKYVKKGTKH FEALANRAAT TGHVIDIYAC
360 370 380 390 400
ALDQTGLLEM KCCPNLTGGY MVMGDSFNTS LFKQTFQRVF TKDIHGQFKM
410 420 430 440 450
GFGGTLEIKT SREIKISGAI GPCVSLNSKG PCVSENEIGT GGTCQWKICG
460 470 480 490 500
LSPTTTLAIY FEVVNQHNAP IPQGGRGAVQ FVTQYQHSSG QRRIRVTTIA
510 520 530 540 550
RNWADAQTQI QNIAASFDQE AAAILMARLA IYRAETEEGP DVLRWLDRQL
560 570 580 590 600
IRLCQKFGEY HKDDPNSFRF SETFSLYPQF MFHLRRSPFL QVFNNSPDES
610 620 630 640 650
SYYRHHFMRQ DLTQSLIMIQ PILYAYSFSG PPEPVLLDSS SILADRILLM
660 670 680 690 700
DTFFQILIYH GETIAQWRKS GYQDMPEYEN FRHLLQAPVD DAQEILHSRF
710 720 730 740 750
PMPRYIDTEH GGSQARFLLS KVNPSQTHNN MYAWGQESGA PILTDDVSLQ
760
VFMDHLKKLA VSSAA
Length:765
Mass (Da):86,162
Last modified:January 10, 2003 - v2
Checksum:iC0FD4C2C1578B6A5
GO

Sequence cautioni

The sequence BAA02209 differs from that shown. Reason: Frameshift at positions 88, 94, 110, 113, 116, 182, 184, 226, 279, 292, 296, 321, 352, 425, 452 and 567.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti81 – 83KLW → TR in BAA02209 (PubMed:8417978).Curated3
Sequence conflicti91 – 92RN → D in BAA02209 (PubMed:8417978).Curated2
Sequence conflicti99A → S in BAA02209 (PubMed:8417978).Curated1
Sequence conflicti108A → R in BAA02209 (PubMed:8417978).Curated1
Sequence conflicti115 – 117SSI → QS in BAA02209 (PubMed:8417978).Curated3
Sequence conflicti129L → F in BAA02209 (PubMed:8417978).Curated1
Sequence conflicti153 – 157MSLSL → TTFS in BAA02209 (PubMed:8417978).Curated5
Sequence conflicti172M → I in BAA02209 (PubMed:8417978).Curated1
Sequence conflicti216 – 217RG → S in BAA02209 (PubMed:8417978).Curated2
Sequence conflicti263S → P in BAA02209 (PubMed:8417978).Curated1
Sequence conflicti293P → S in BAA02209 (PubMed:8417978).Curated1
Sequence conflicti310I → M in BAA02209 (PubMed:8417978).Curated1
Sequence conflicti515A → R in BAA02209 (PubMed:8417978).Curated1
Sequence conflicti523A → P in BAA02209 (PubMed:8417978).Curated1
Sequence conflicti631P → R in BAA02209 (PubMed:8417978).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY082671 mRNA. Translation: AAL92480.1.
BC034610 mRNA. Translation: AAH34610.1.
D12713 Genomic DNA. Translation: BAA02209.1. Frameshift.
CCDSiCCDS25931.1.
PIRiS28142. I60247.
RefSeqiNP_033173.2. NM_009147.2.
XP_006515691.1. XM_006515628.3.
UniGeneiMm.491137.

Genome annotation databases

EnsembliENSMUST00000021375; ENSMUSP00000021375; ENSMUSG00000020986.
GeneIDi20334.
KEGGimmu:20334.
UCSCiuc007npw.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiSC23A_MOUSE
AccessioniPrimary (citable) accession number: Q01405
Secondary accession number(s): Q8JZL4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 10, 2003
Last modified: September 27, 2017
This is version 145 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families