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Protein

Haloacetate dehalogenase H-2

Gene

dehH2

Organism
Moraxella sp. (strain B)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Haloacetate + H2O = glycolate + halide.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei10 – 101NucleophileBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Haloacetate dehalogenase H-2 (EC:3.8.1.3)
Gene namesi
Name:dehH2
Encoded oniPlasmid POU10 Publication
OrganismiMoraxella sp. (strain B)
Taxonomic identifieri118147 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeMoraxella

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 224224Haloacetate dehalogenase H-2PRO_0000079167Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ01399.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di1.10.150.240. 1 hit.
3.40.50.1000. 1 hit.
InterProiIPR023214. HAD-like_dom.
IPR006439. HAD-SF_hydro_IA.
IPR006328. HAD_II.
IPR023198. PGP_dom2.
[Graphical view]
PfamiPF13419. HAD_2. 1 hit.
[Graphical view]
PRINTSiPR00413. HADHALOGNASE.
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01493. HAD-SF-IA-v2. 1 hit.
TIGR01509. HAD-SF-IA-v3. 1 hit.
TIGR01428. HAD_type_II. 1 hit.

Sequencei

Sequence statusi: Complete.

Q01399-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKIEAIAFD MYGTLYDVHS VVDACEKQYP GKGKDISVLW RQKQLEYAWL
60 70 80 90 100
RCLMGQYIKF EEATANALTY TCNQMKLDCD EGSAMRLTEE YLRLKPFPEV
110 120 130 140 150
RGALRALRQR GMRLAILSNG STETIHDVVH NSGVEGEFEH LISVDSARAY
160 170 180 190 200
KPHPLAYELG EEAFGISRES ILFVSSNPWD VSGAKAFGYQ VCWINRYGFA
210 220
FDELGQTPDF TVPVMDAIVH LIAV
Length:224
Mass (Da):25,346
Last modified:February 1, 1994 - v1
Checksum:iCE80D0272DF89495
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D90423 Genomic DNA. Translation: BAA14413.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D90423 Genomic DNA. Translation: BAA14413.1.

3D structure databases

ProteinModelPortaliQ01399.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.10.150.240. 1 hit.
3.40.50.1000. 1 hit.
InterProiIPR023214. HAD-like_dom.
IPR006439. HAD-SF_hydro_IA.
IPR006328. HAD_II.
IPR023198. PGP_dom2.
[Graphical view]
PfamiPF13419. HAD_2. 1 hit.
[Graphical view]
PRINTSiPR00413. HADHALOGNASE.
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01493. HAD-SF-IA-v2. 1 hit.
TIGR01509. HAD-SF-IA-v3. 1 hit.
TIGR01428. HAD_type_II. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Lack of homology between two haloacetate dehalogenase genes encoded on a plasmid from Moraxella sp. strain B."
    Kawasaki H., Tsuda K., Matsushita I., Tonomura K.
    J. Gen. Microbiol. 138:1317-1323(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-10.

Entry informationi

Entry nameiDEH2_MORSB
AccessioniPrimary (citable) accession number: Q01399
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: May 11, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Two haloacetate dehalogenase enzymes exist in Moraxella strain B. DehH1 acts predominantly on fluoroacetate, dehH2 acts on chloro-, bromo- and iodoacetate, but not on fluoroacetate.

Keywords - Technical termi

Direct protein sequencing, Plasmid

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.