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Protein

cAMP-dependent protein kinase regulatory subunit

Gene

mcb

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei207cAMP 1By similarity1
Binding sitei216cAMP 1By similarity1
Binding sitei328cAMP 2By similarity1
Binding sitei337cAMP 2By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi129 – 260cAMP 1Add BLAST132
Nucleotide bindingi261 – 378cAMP 2Add BLAST118

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

cAMP, cAMP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
cAMP-dependent protein kinase regulatory subunit
Short name:
PKA regulatory subunit
Alternative name(s):
Microcycle blastoconidiation protein
Gene namesi
Name:mcb
ORF Names:123A4.120, NCU01166
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
Proteomesi
  • UP000001805 Componenti: Chromosome 2, Linkage Group V

Organism-specific databases

EuPathDBiFungiDB:NCU01166.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002054121 – 385cAMP-dependent protein kinase regulatory subunitAdd BLAST385

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei89PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Tetramer, composed of 2 regulatory (R) and 2 catalytic (C) subunits. In the presence of cAMP it dissociates into 2 active monomeric C subunits and an R dimer (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ01386.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 128Dimerization and phosphorylationSequence analysisAdd BLAST128

Sequence similaritiesi

Contains 2 cyclic nucleotide-binding domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000196669.
InParanoidiQ01386.
KOiK04739.
OMAiGDPGHSF.
OrthoDBiEOG092C3TMX.

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
InterProiIPR012198. cAMP_dep_PK_reg_su.
IPR018490. cNMP-bd-like.
IPR018488. cNMP-bd_CS.
IPR000595. cNMP-bd_dom.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 2 hits.
[Graphical view]
PIRSFiPIRSF000548. PK_regulatory. 1 hit.
SMARTiSM00100. cNMP. 2 hits.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 2 hits.
PROSITEiPS00888. CNMP_BINDING_1. 2 hits.
PS00889. CNMP_BINDING_2. 2 hits.
PS50042. CNMP_BINDING_3. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q01386-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSTGFTSPF GNANPFGSSG RSESGPMHRL VEEDENDTIT SPTTPHFGVK
60 70 80 90 100
NNAAPAFWNG FGGDAPSDMP VRRQPDDFPA HYNLGRRTSV SAESLKPVTD
110 120 130 140 150
NSDNWSPPVH PKTAEQLERL KKAISGNFLF NHLEDDQSAQ VLGALVEKPV
160 170 180 190 200
PAKGIKVITQ GDAGDYFYVV EKGRFEVYVN STGALQPGPD GMGQKVGEIA
210 220 230 240 250
EGGSFGELAL MYNAPRAATV VSAEPQCTLW ALDRVTFRRI LMESTFSRRR
260 270 280 290 300
MYESFLEEVP ILKTLTPYER SKIADALESQ KYPAGHEIIL EGDPGHSFFL
310 320 330 340 350
LEAGEAAAFK RGNDSPVKNY KKGDFFGELA LLNDAPRAAS VISQTEVKVA
360 370 380
RLGKNAFQRL LGPIESILRR TRYVEAEEVD PLQVS
Length:385
Mass (Da):42,156
Last modified:November 1, 1996 - v1
Checksum:i4B3F52B7486735D4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L78009 Genomic DNA. Translation: AAB00121.1.
AL670009 Genomic DNA. Translation: CAD21365.1.
CM002240 Genomic DNA. Translation: ESA42511.1.
CM002240 Genomic DNA. Translation: ESA42512.1.
RefSeqiXP_011394477.1. XM_011396175.1.
XP_011394478.1. XM_011396176.1.

Genome annotation databases

EnsemblFungiiESA42511; ESA42511; NCU01166.
ESA42512; ESA42512; NCU01166.
GeneIDi3877728.
KEGGincr:NCU01166.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L78009 Genomic DNA. Translation: AAB00121.1.
AL670009 Genomic DNA. Translation: CAD21365.1.
CM002240 Genomic DNA. Translation: ESA42511.1.
CM002240 Genomic DNA. Translation: ESA42512.1.
RefSeqiXP_011394477.1. XM_011396175.1.
XP_011394478.1. XM_011396176.1.

3D structure databases

ProteinModelPortaliQ01386.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiESA42511; ESA42511; NCU01166.
ESA42512; ESA42512; NCU01166.
GeneIDi3877728.
KEGGincr:NCU01166.

Organism-specific databases

EuPathDBiFungiDB:NCU01166.

Phylogenomic databases

HOGENOMiHOG000196669.
InParanoidiQ01386.
KOiK04739.
OMAiGDPGHSF.
OrthoDBiEOG092C3TMX.

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
InterProiIPR012198. cAMP_dep_PK_reg_su.
IPR018490. cNMP-bd-like.
IPR018488. cNMP-bd_CS.
IPR000595. cNMP-bd_dom.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 2 hits.
[Graphical view]
PIRSFiPIRSF000548. PK_regulatory. 1 hit.
SMARTiSM00100. cNMP. 2 hits.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 2 hits.
PROSITEiPS00888. CNMP_BINDING_1. 2 hits.
PS00889. CNMP_BINDING_2. 2 hits.
PS50042. CNMP_BINDING_3. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKAPR_NEUCR
AccessioniPrimary (citable) accession number: Q01386
Secondary accession number(s): Q7RVE4, V5ILJ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.