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Q01378

- PYRF_CANBO

UniProt

Q01378 - PYRF_CANBO

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Protein

Orotidine 5'-phosphate decarboxylase

Gene

URA3

Organism
Candida boidinii (Yeast)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei41 – 411SubstrateBy similarity
Active sitei97 – 971Proton donorPROSITE-ProRule annotation
Binding sitei221 – 2211SubstrateBy similarity
Binding sitei239 – 2391SubstrateBy similarity

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-EC

GO - Biological processi

  1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
  2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Uridine 5'-monophosphate synthase
Short name:
UMP synthase
Gene namesi
Name:URA3
OrganismiCandida boidinii (Yeast)
Taxonomic identifieri5477 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesPichiaceaeOgataeaOgataea/Candida clade

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 270270Orotidine 5'-phosphate decarboxylasePRO_0000134647Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ01378.
SMRiQ01378. Positions 10-269.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni63 – 653Substrate bindingBy similarity
Regioni95 – 10410Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the OMP decarboxylase family.Curated

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01740. pyrF. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q01378-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSETLKTQPY SKRAEVHPSP VARRLFNLME TKKTNLCASV DLTTTKEILD
60 70 80 90 100
LLEKVGPYIC LVKTHIDIVS DFSYEGTIVP LLALAKKYNF MIFEDRKFAD
110 120 130 140 150
IGNTVKSQYK GGVYQIAKWS DITNAHGVTG SGIVTGLKQA AEEVTDEPRG
160 170 180 190 200
LLMLAELSSK GAIAHGKYTE ETVEIAKTDK DFVIGFIAQN QMGGSDEGFD
210 220 230 240 250
WIIMTPGVGL DDKGDALGQQ YRTVSEVMST GTDIIIVGRG LFGKGRDPSV
260 270
EGERYMKAGW NAYLARTNQL
Length:270
Mass (Da):29,659
Last modified:April 1, 1993 - v1
Checksum:i5AB108743FCD5007
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M86236 Genomic DNA. Translation: AAA34376.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M86236 Genomic DNA. Translation: AAA34376.1 .

3D structure databases

ProteinModelPortali Q01378.
SMRi Q01378. Positions 10-269.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR01740. pyrF. 1 hit.
PROSITEi PS00156. OMPDECASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The orotidine-5'-phosphate decarboxylase gene (URA3) of a methylotrophic yeast, Candida boidinii: nucleotide sequence and its expression in Escherichia coli."
    Sakai Y., Kazarimoto T., Tani Y.
    J. Ferment. Bioeng. 73:255-260(1992)
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiPYRF_CANBO
AccessioniPrimary (citable) accession number: Q01378
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: October 29, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3