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Q01378 (PYRF_CANBO) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Orotidine 5'-phosphate decarboxylase

EC=4.1.1.23
Alternative name(s):
OMP decarboxylase
Short name=OMPDCase
Short name=OMPdecase
Uridine 5'-monophosphate synthase
Short name=UMP synthase
Gene names
Name:URA3
OrganismCandida boidinii (Yeast)
Taxonomic identifier5477 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length270 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Orotidine 5'-phosphate = UMP + CO2.

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.

Sequence similarities

Belongs to the OMP decarboxylase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 270270Orotidine 5'-phosphate decarboxylase
PRO_0000134647

Regions

Region63 – 653Substrate binding By similarity
Region95 – 10410Substrate binding By similarity

Sites

Active site971Proton donor By similarity
Binding site411Substrate By similarity
Binding site2211Substrate By similarity
Binding site2391Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q01378 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: 5AB108743FCD5007

FASTA27029,659
        10         20         30         40         50         60 
MSETLKTQPY SKRAEVHPSP VARRLFNLME TKKTNLCASV DLTTTKEILD LLEKVGPYIC 

        70         80         90        100        110        120 
LVKTHIDIVS DFSYEGTIVP LLALAKKYNF MIFEDRKFAD IGNTVKSQYK GGVYQIAKWS 

       130        140        150        160        170        180 
DITNAHGVTG SGIVTGLKQA AEEVTDEPRG LLMLAELSSK GAIAHGKYTE ETVEIAKTDK 

       190        200        210        220        230        240 
DFVIGFIAQN QMGGSDEGFD WIIMTPGVGL DDKGDALGQQ YRTVSEVMST GTDIIIVGRG 

       250        260        270 
LFGKGRDPSV EGERYMKAGW NAYLARTNQL 

« Hide

References

[1]"The orotidine-5'-phosphate decarboxylase gene (URA3) of a methylotrophic yeast, Candida boidinii: nucleotide sequence and its expression in Escherichia coli."
Sakai Y., Kazarimoto T., Tani Y.
J. Ferment. Bioeng. 73:255-260(1992)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M86236 Genomic DNA. Translation: AAA34376.1.

3D structure databases

ProteinModelPortalQ01378.
SMRQ01378. Positions 10-269.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00070; UER00120.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
TIGRFAMsTIGR01740. pyrF. 1 hit.
PROSITEPS00156. OMPDECASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRF_CANBO
AccessionPrimary (citable) accession number: Q01378
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: October 16, 2013
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways