ID   WC1_NEUCR               Reviewed;        1167 AA.
AC   Q01371; Q7RVA7;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2001, sequence version 2.
DT   22-SEP-2009, entry version 68.
DE   RecName: Full=White collar 1 protein;
DE            Short=WC1;
GN   Name=wc-1; ORFNames=NCU02356;
OS   Neurospora crassa.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
OC   Sordariomycetes; Sordariomycetidae; Sordariales; Sordariaceae;
OC   Neurospora.
OX   NCBI_TaxID=5141;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   MEDLINE=96203083; PubMed=8612589;
RA   Ballario P., Vittorioso P., Magrelli A., Talora C., Cabibbo A.,
RA   Macino G.;
RT   "White collar-1, a central regulator of blue light responses in
RT   Neurospora, is a zinc finger protein.";
RL   EMBO J. 15:1650-1657(1996).
RN   [2]
RP   SEQUENCE REVISION TO C-TERMINUS.
RA   Ballario P.;
RL   Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   MEDLINE=22598136; PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A.,
RA   Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L.,
RA   Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C.,
RA   Marcotte E., Greenberg D., Roy A., Foley K., Naylor J.,
RA   Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M.,
RA   Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S.,
RA   Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C.,
RA   Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M.,
RA   Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: May function as a transcription factor involved in light
CC       regulation. Binds and affects blue light regulation of the AL-3
CC       gene. WC1 and WC2 proteins interact via homologous PAS domains,
CC       bind to promoters of light regulated genes such as FRQ, and
CC       activate transcription.
CC   -!- SUBUNIT: Heterodimer of WC1 and WC2 (Potential).
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- INDUCTION: By blue light.
CC   -!- DOMAIN: The glutamine-rich domain might function in activating
CC       gene expression.
CC   -!- PTM: FMN binds covalently to cysteine after exposure to blue light
CC       and is reversed in the dark (By similarity).
CC   -!- SIMILARITY: Contains 1 GATA-type zinc finger.
CC   -!- SIMILARITY: Contains 2 PAC (PAS-associated C-terminal) domains.
CC   -!- SIMILARITY: Contains 3 PAS (PER-ARNT-SIM) domains.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAA30541.2; Type=Erroneous gene model prediction;
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DR   EMBL; X94300; CAA63964.2; -; Genomic_DNA.
DR   EMBL; AABX02000010; EAA30541.2; ALT_SEQ; Genomic_DNA.
DR   HSSP; P17679; 1GNF.
DR   DIP; DIP:1155N; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0009881; F:photoreceptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0003700; F:transcription factor activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0018298; P:protein-chromophore linkage; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA:InterPro.
DR   GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   GO; GO:0006350; P:transcription; IEA:UniProtKB-KW.
DR   InterPro; IPR001610; PAC.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR013655; PAS_fold_3.
DR   InterPro; IPR000679; Znf_GATA.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   Gene3D; G3DSA:3.30.50.10; Znf_NHR/GATA; 1.
DR   Pfam; PF00320; GATA; 1.
DR   Pfam; PF08447; PAS_3; 1.
DR   SMART; SM00086; PAC; 2.
DR   SMART; SM00091; PAS; 3.
DR   SMART; SM00401; ZnF_GATA; 1.
DR   TIGRFAMs; TIGR00229; sensory_box; 1.
DR   PROSITE; PS00344; GATA_ZN_FINGER_1; 1.
DR   PROSITE; PS50114; GATA_ZN_FINGER_2; 1.
DR   PROSITE; PS50113; PAC; FALSE_NEG.
DR   PROSITE; PS50112; PAS; 3.
PE   2: Evidence at transcript level;
KW   Activator; Chromophore; Complete proteome; DNA-binding; Flavoprotein;
KW   FMN; Metal-binding; Nucleus; Photoreceptor protein; Receptor; Repeat;
KW   Sensory transduction; Transcription; Transcription regulation; Zinc;
KW   Zinc-finger.
FT   CHAIN         1   1167       White collar 1 protein.
FT                                /FTId=PRO_0000083489.
FT   DOMAIN      381    452       PAS 1.
FT   DOMAIN      469    508       PAC 1.
FT   DOMAIN      574    644       PAS 2.
FT   DOMAIN      650    691       PAC 2.
FT   DOMAIN      693    763       PAS 3.
FT   ZN_FING     934    959       GATA-type.
FT   COMPBIAS     16     61       Gln-rich.
FT   COMPBIAS     21     57       Poly-Gln.
FT   COMPBIAS    329    333       Poly-Pro.
FT   MOD_RES     428    428       S-4a-FMN cysteine (By similarity).
FT   CONFLICT   1167   1167       V -> Q (in Ref. 3; EAA30541).
SQ   SEQUENCE   1167 AA;  127454 MW;  6489D04DAB50EE38 CRC64;
     MNNNYYGSPL SPEELQHQMH QHQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ HQHQQQQKTN
     QHRNAGMMNT PPTTNQGNST IHASDVTMSG GSDSLDEIIQ QNLDEMHRRR SVPQPYGGQT
     RRLSMFDYAN PNDGFSDYQL DNMSGNYGDM TGGMGMSGHS SPYAGQNIMA MSDHSGGYSH
     MSPNVMGNMM TYPNLNMYHS PPIENPYSSA GLDTIRTDFS MDMNMDSGSV SAASVHPTPG
     LNKQDDEMMT MEQGFGGGDD ANASHQAQQN MGGLTPAMTP AMTPAMTPGV SNFAQGMATP
     VSQDAASTPA TTFQSPSLSA TTQTIRIGPP PPPSVTNAPT PAPFTSTPSG GGASQTKSIY
     SKSGFDMLRA LWYVASRKDP KLKLGAVDMS CAFVVCDVTL NDCPIIYVSD NFQNLTGYSR
     HEIVGRNCRF LQAPDGNVEA GTKREFVENN AVYTLKKTIA EGQEIQQSLI NYRKGGKPFL
     NLLTMIPIPW DTEEIRYFIG FQIDLVECPD AIIGQEGNGP MQVNYTHSDI GQYIWTPPTQ
     KQLEPADGQT LGVDDVSTLL QQCNSKGVAS DWHKQSWDKM LLENADDVVH VLSLKGLFLY
     LSPACKKVLE YDASDLVGTS LSSICHPSDI VPVTRELKEA QQHTPVNIVF RIRRKNSGYT
     WFESHGTLFN EQGKGRKCII LVGRKRPVFA LHRKDLELNG GIGDSEIWTK VSTSGMFLFV
     SSNVRSLLDL LPENLQGTSM QDLMRKESRA EFGRTIEKAR KGKIASCKHE VQNKRGQVLQ
     AYTTFYPGDG GEGQRPTFLL AQTKLLKASS RTLAPATVTV KNMSPGGVPL SPMKGIQTDS
     DSNTLMGGMS KSGSSDSTGA MVSARSSAGP GQDAALDADN IFDELKTTRC TSWQYELRQM
     EKVNRMLAEE LAQLLSNKKK RKRRKGGGNM VRDCANCHTR NTPEWRRGPS GNRDLCNSCG
     LRWAKQTGRV SPRTSSRGGN GDSMSKKSNS PSHSSPLHRE VGNDSPSTTT ATKNSPSLRG
     SSTTAPGTIT TDSGPAVASS ASGTGSTTIA TSANSAASTV NALGPPATGP SGGSPAQHLP
     PHLQGTHLNA QAMQRVHQHK QHQQHQQQHQ QQHQQQHQQQ HQQLQQHQFN PPQSQPLLEG
     GSGFRGSGME MTSIREEMGE HQQGLSV
//