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Q01362 (FCERB_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 124. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
High affinity immunoglobulin epsilon receptor subunit beta

Short name=FcERI
Alternative name(s):
Fc epsilon receptor I beta-chain
IgE Fc receptor subunit beta
Membrane-spanning 4-domains subfamily A member 2
Gene names
Name:MS4A2
Synonyms:APY, FCER1B, IGER
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length244 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by multivalent antigens is required for the full mast cell response, including the release of preformed mediators (such as histamine) by degranulation and de novo production of lipid mediators and cytokines. Also mediates the secretion of important lymphokines. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators responsible for the manifestations of allergy.

Subunit structure

Tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains. Binds LILRB1. Interacts with FGR, FES/FPS and LYN By similarity.

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Found on the surface of mast cells and basophils.

Post-translational modification

Phosphorylated on tyrosine residues by LYN By similarity.

Polymorphism

Variant Glu-237 has been found to be present in about 5.3% of a 1004 individuals population sample in Australia. It seems to be a risk factor for atopic dermatitis and asthma.

Sequence similarities

Belongs to the MS4A family.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   LigandIgE-binding protein
   Molecular functionReceptor
   PTMDisulfide bond
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processFc-epsilon receptor signaling pathway

Traceable author statement. Source: Reactome

activation of phospholipase C activity

Inferred from electronic annotation. Source: Ensembl

cytokine secretion

Inferred from electronic annotation. Source: Ensembl

immune response

Inferred from mutant phenotype PubMed 7920628. Source: UniProtKB

inflammatory response

Inferred from electronic annotation. Source: Ensembl

innate immune response

Traceable author statement. Source: Reactome

positive regulation of mast cell degranulation

Inferred from electronic annotation. Source: Ensembl

protein kinase C-activating G-protein coupled receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

regulation of release of sequestered calcium ion into cytosol

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentFc-epsilon receptor I complex

Inferred from electronic annotation. Source: Ensembl

endosome

Inferred from electronic annotation. Source: Ensembl

external side of plasma membrane

Inferred from electronic annotation. Source: Ensembl

integral component of plasma membrane

Non-traceable author statement Ref.1. Source: UniProtKB

membrane raft

Inferred from electronic annotation. Source: Ensembl

plasma membrane

Traceable author statement. Source: Reactome

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 244244High affinity immunoglobulin epsilon receptor subunit beta
PRO_0000158629

Regions

Topological domain1 – 5959Cytoplasmic Potential
Transmembrane60 – 7920Helical; Potential
Topological domain80 – 9718Extracellular Potential
Transmembrane98 – 11720Helical; Potential
Topological domain118 – 13013Cytoplasmic Potential
Transmembrane131 – 15020Helical; Potential
Topological domain151 – 18030Extracellular Potential
Transmembrane181 – 20020Helical; Potential
Topological domain201 – 24444Cytoplasmic Potential

Amino acid modifications

Modified residue2191Phosphotyrosine By similarity
Modified residue2251Phosphotyrosine By similarity
Modified residue2261Phosphoserine By similarity
Modified residue2291Phosphotyrosine By similarity

Natural variations

Natural variant1431T → M.
Corresponds to variant rs35033981 [ dbSNP | Ensembl ].
VAR_053515
Natural variant2111N → K.
Corresponds to variant rs535630 [ dbSNP | Ensembl ].
VAR_053516
Natural variant2371E → G. Ref.5 Ref.6
Corresponds to variant rs569108 [ dbSNP | Ensembl ].
VAR_003965

Sequences

Sequence LengthMass (Da)Tools
Q01362 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: CE523102D5F567AF

FASTA24426,534
        10         20         30         40         50         60 
MDTESNRRAN LALPQEPSSV PAFEVLEISP QEVSSGRLLK SASSPPLHTW LTVLKKEQEF 

        70         80         90        100        110        120 
LGVTQILTAM ICLCFGTVVC SVLDISHIEG DIFSSFKAGY PFWGAIFFSI SGMLSIISER 

       130        140        150        160        170        180 
RNATYLVRGS LGANTASSIA GGTGITILII NLKKSLAYIH IHSCQKFFET KCFMASFSTE 

       190        200        210        220        230        240 
IVVMMLFLTI LGLGSAVSLT ICGAGEELKG NKVPEDRVYE ELNIYSATYS ELEDPGEMSP 


PIDL 

« Hide

References

« Hide 'large scale' references
[1]"The gene and cDNA for the human high affinity immunoglobulin E receptor beta chain and expression of the complete human receptor."
Kuester H., Zhang L., Brini A.T., Macglashan D.W., Kinet J.-P.
J. Biol. Chem. 267:12782-12787(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Determination of the sequence coding for the beta subunit of the human high-affinity IgE receptor."
Maekawa K., Imagawa N., Tanaka Y., Harada S.
FEBS Lett. 302:161-165(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Regulation of human FcepsilonRI beta chain gene expression by Oct-1."
Akizawa Y., Nishiyama C., Hasegawa M., Maeda K., Nakahata T., Okumura K., Ra C., Ogawa H.
Int. Immunol. 15:549-556(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
[5]"A new variant of the beta subunit of the high-affinity receptor for immunoglobulin E (Fc epsilon RI-beta E237G): associations with measures of atopy and bronchial hyper-responsiveness."
Hill M.R., Cookson W.O.
Hum. Mol. Genet. 5:959-962(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT GLY-237.
[6]"Association between atopic asthma and a coding variant of Fc-epsilon-RI-beta in a Japanese population."
Shirakawa T., Mao X.-Q., Sasaki S., Enomoto T., Kawai M., Morimoto K., Hopkin J.
Hum. Mol. Genet. 5:1129-1130(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT GLY-237.
[7]Erratum
Shirakawa T., Mao X.-Q., Sasaki S., Enomoto T., Kawai M., Morimoto K., Hopkin J.
Hum. Mol. Genet. 5:2068-2068(1996) [PubMed] [Europe PMC] [Abstract]
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D10583 mRNA. Translation: BAA01440.1.
M89796 Genomic DNA. Translation: AAA60269.1.
AB080913 Genomic DNA. Translation: BAC66486.1.
BC074800 mRNA. Translation: AAH74800.1.
BC074843 mRNA. Translation: AAH74843.1.
PIRA42806.
RefSeqNP_000130.1. NM_000139.4.
UniGeneHs.386748.

3D structure databases

ProteinModelPortalQ01362.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid108500. 3 interactions.
STRING9606.ENSP00000278888.

Chemistry

DrugBankDB00043. Omalizumab.

PTM databases

PhosphoSiteQ01362.

Polymorphism databases

DMDM232084.

Proteomic databases

PRIDEQ01362.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000278888; ENSP00000278888; ENSG00000149534.
GeneID2206.
KEGGhsa:2206.
UCSCuc001nop.3. human.

Organism-specific databases

CTD2206.
GeneCardsGC11P059856.
HGNCHGNC:7316. MS4A2.
HPAHPA059967.
MIM147138. gene.
neXtProtNX_Q01362.
PharmGKBPA31109.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG47093.
HOGENOMHOG000060211.
HOVERGENHBG051600.
InParanoidQ01362.
KOK08090.
OMASTEIVVM.
PhylomeDBQ01362.
TreeFamTF335157.

Enzyme and pathway databases

ReactomeREACT_6900. Immune System.
SignaLinkQ01362.

Gene expression databases

ArrayExpressQ01362.
BgeeQ01362.
CleanExHS_MS4A2.
GenevestigatorQ01362.

Family and domain databases

InterProIPR007237. CD20-like.
[Graphical view]
PfamPF04103. CD20. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiMS4A2.
GenomeRNAi2206.
NextBio8935.
PROQ01362.
SOURCESearch...

Entry information

Entry nameFCERB_HUMAN
AccessionPrimary (citable) accession number: Q01362
Secondary accession number(s): Q54A81
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: April 16, 2014
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM