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Q01362

- FCERB_HUMAN

UniProt

Q01362 - FCERB_HUMAN

Protein

High affinity immunoglobulin epsilon receptor subunit beta

Gene

MS4A2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 1 (01 Apr 1993)
      Previous versions | rss
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    Functioni

    High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by multivalent antigens is required for the full mast cell response, including the release of preformed mediators (such as histamine) by degranulation and de novo production of lipid mediators and cytokines. Also mediates the secretion of important lymphokines. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators responsible for the manifestations of allergy.

    GO - Biological processi

    1. activation of phospholipase C activity Source: Ensembl
    2. cytokine secretion Source: Ensembl
    3. Fc-epsilon receptor signaling pathway Source: Reactome
    4. immune response Source: UniProtKB
    5. inflammatory response Source: Ensembl
    6. innate immune response Source: Reactome
    7. positive regulation of mast cell degranulation Source: Ensembl
    8. protein kinase C-activating G-protein coupled receptor signaling pathway Source: Ensembl
    9. regulation of release of sequestered calcium ion into cytosol Source: Ensembl

    Keywords - Molecular functioni

    Receptor

    Keywords - Ligandi

    IgE-binding protein

    Enzyme and pathway databases

    ReactomeiREACT_163701. FCERI mediated MAPK activation.
    REACT_163769. Role of LAT2/NTAL/LAB on calcium mobilization.
    REACT_163834. FCERI mediated Ca+2 mobilization.
    REACT_163936. Fc epsilon receptor (FCERI) signaling.
    REACT_163994. FCERI mediated NF-kB activation.
    SignaLinkiQ01362.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    High affinity immunoglobulin epsilon receptor subunit beta
    Short name:
    FcERI
    Alternative name(s):
    Fc epsilon receptor I beta-chain
    IgE Fc receptor subunit beta
    Membrane-spanning 4-domains subfamily A member 2
    Gene namesi
    Name:MS4A2
    Synonyms:APY, FCER1B, IGER
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:7316. MS4A2.

    Subcellular locationi

    GO - Cellular componenti

    1. endosome Source: Ensembl
    2. external side of plasma membrane Source: Ensembl
    3. Fc-epsilon receptor I complex Source: Ensembl
    4. integral component of plasma membrane Source: UniProtKB
    5. membrane raft Source: Ensembl
    6. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31109.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 244244High affinity immunoglobulin epsilon receptor subunit betaPRO_0000158629Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei219 – 2191PhosphotyrosineBy similarity
    Modified residuei225 – 2251PhosphotyrosineBy similarity
    Modified residuei226 – 2261PhosphoserineBy similarity
    Modified residuei229 – 2291PhosphotyrosineBy similarity

    Post-translational modificationi

    Phosphorylated on tyrosine residues by LYN.By similarity

    Keywords - PTMi

    Disulfide bond, Phosphoprotein

    Proteomic databases

    PRIDEiQ01362.

    PTM databases

    PhosphoSiteiQ01362.

    Expressioni

    Tissue specificityi

    Found on the surface of mast cells and basophils.

    Gene expression databases

    ArrayExpressiQ01362.
    BgeeiQ01362.
    CleanExiHS_MS4A2.
    GenevestigatoriQ01362.

    Organism-specific databases

    HPAiHPA059967.

    Interactioni

    Subunit structurei

    Tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains. Binds LILRB1. Interacts with FGR, FES/FPS and LYN By similarity.By similarity

    Protein-protein interaction databases

    BioGridi108500. 3 interactions.
    STRINGi9606.ENSP00000278888.

    Structurei

    3D structure databases

    ProteinModelPortaliQ01362.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 5959CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini80 – 9718ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini118 – 13013CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini151 – 18030ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini201 – 24444CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei60 – 7920HelicalSequence AnalysisAdd
    BLAST
    Transmembranei98 – 11720HelicalSequence AnalysisAdd
    BLAST
    Transmembranei131 – 15020HelicalSequence AnalysisAdd
    BLAST
    Transmembranei181 – 20020HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the MS4A family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG47093.
    HOGENOMiHOG000060211.
    HOVERGENiHBG051600.
    InParanoidiQ01362.
    KOiK08090.
    OMAiSTEIVVM.
    PhylomeDBiQ01362.
    TreeFamiTF335157.

    Family and domain databases

    InterProiIPR007237. CD20-like.
    [Graphical view]
    PfamiPF04103. CD20. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q01362-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDTESNRRAN LALPQEPSSV PAFEVLEISP QEVSSGRLLK SASSPPLHTW    50
    LTVLKKEQEF LGVTQILTAM ICLCFGTVVC SVLDISHIEG DIFSSFKAGY 100
    PFWGAIFFSI SGMLSIISER RNATYLVRGS LGANTASSIA GGTGITILII 150
    NLKKSLAYIH IHSCQKFFET KCFMASFSTE IVVMMLFLTI LGLGSAVSLT 200
    ICGAGEELKG NKVPEDRVYE ELNIYSATYS ELEDPGEMSP PIDL 244
    Length:244
    Mass (Da):26,534
    Last modified:April 1, 1993 - v1
    Checksum:iCE523102D5F567AF
    GO

    Polymorphismi

    Variant Glu-237 has been found to be present in about 5.3% of a 1004 individuals population sample in Australia. It seems to be a risk factor for atopic dermatitis and asthma.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti143 – 1431T → M.
    Corresponds to variant rs35033981 [ dbSNP | Ensembl ].
    VAR_053515
    Natural varianti211 – 2111N → K.
    Corresponds to variant rs535630 [ dbSNP | Ensembl ].
    VAR_053516
    Natural varianti237 – 2371E → G.2 Publications
    Corresponds to variant rs569108 [ dbSNP | Ensembl ].
    VAR_003965

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D10583 mRNA. Translation: BAA01440.1.
    M89796 Genomic DNA. Translation: AAA60269.1.
    AB080913 Genomic DNA. Translation: BAC66486.1.
    BC074800 mRNA. Translation: AAH74800.1.
    BC074843 mRNA. Translation: AAH74843.1.
    CCDSiCCDS7980.1.
    PIRiA42806.
    RefSeqiNP_000130.1. NM_000139.4.
    UniGeneiHs.386748.

    Genome annotation databases

    EnsembliENST00000278888; ENSP00000278888; ENSG00000149534.
    GeneIDi2206.
    KEGGihsa:2206.
    UCSCiuc001nop.3. human.

    Polymorphism databases

    DMDMi232084.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D10583 mRNA. Translation: BAA01440.1 .
    M89796 Genomic DNA. Translation: AAA60269.1 .
    AB080913 Genomic DNA. Translation: BAC66486.1 .
    BC074800 mRNA. Translation: AAH74800.1 .
    BC074843 mRNA. Translation: AAH74843.1 .
    CCDSi CCDS7980.1.
    PIRi A42806.
    RefSeqi NP_000130.1. NM_000139.4.
    UniGenei Hs.386748.

    3D structure databases

    ProteinModelPortali Q01362.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108500. 3 interactions.
    STRINGi 9606.ENSP00000278888.

    Chemistry

    DrugBanki DB00043. Omalizumab.

    PTM databases

    PhosphoSitei Q01362.

    Polymorphism databases

    DMDMi 232084.

    Proteomic databases

    PRIDEi Q01362.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000278888 ; ENSP00000278888 ; ENSG00000149534 .
    GeneIDi 2206.
    KEGGi hsa:2206.
    UCSCi uc001nop.3. human.

    Organism-specific databases

    CTDi 2206.
    GeneCardsi GC11P059856.
    HGNCi HGNC:7316. MS4A2.
    HPAi HPA059967.
    MIMi 147138. gene.
    neXtProti NX_Q01362.
    PharmGKBi PA31109.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG47093.
    HOGENOMi HOG000060211.
    HOVERGENi HBG051600.
    InParanoidi Q01362.
    KOi K08090.
    OMAi STEIVVM.
    PhylomeDBi Q01362.
    TreeFami TF335157.

    Enzyme and pathway databases

    Reactomei REACT_163701. FCERI mediated MAPK activation.
    REACT_163769. Role of LAT2/NTAL/LAB on calcium mobilization.
    REACT_163834. FCERI mediated Ca+2 mobilization.
    REACT_163936. Fc epsilon receptor (FCERI) signaling.
    REACT_163994. FCERI mediated NF-kB activation.
    SignaLinki Q01362.

    Miscellaneous databases

    GeneWikii MS4A2.
    GenomeRNAii 2206.
    NextBioi 8935.
    PROi Q01362.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q01362.
    Bgeei Q01362.
    CleanExi HS_MS4A2.
    Genevestigatori Q01362.

    Family and domain databases

    InterProi IPR007237. CD20-like.
    [Graphical view ]
    Pfami PF04103. CD20. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The gene and cDNA for the human high affinity immunoglobulin E receptor beta chain and expression of the complete human receptor."
      Kuester H., Zhang L., Brini A.T., Macglashan D.W., Kinet J.-P.
      J. Biol. Chem. 267:12782-12787(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Determination of the sequence coding for the beta subunit of the human high-affinity IgE receptor."
      Maekawa K., Imagawa N., Tanaka Y., Harada S.
      FEBS Lett. 302:161-165(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Regulation of human FcepsilonRI beta chain gene expression by Oct-1."
      Akizawa Y., Nishiyama C., Hasegawa M., Maeda K., Nakahata T., Okumura K., Ra C., Ogawa H.
      Int. Immunol. 15:549-556(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    5. "A new variant of the beta subunit of the high-affinity receptor for immunoglobulin E (Fc epsilon RI-beta E237G): associations with measures of atopy and bronchial hyper-responsiveness."
      Hill M.R., Cookson W.O.
      Hum. Mol. Genet. 5:959-962(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT GLY-237.
    6. "Association between atopic asthma and a coding variant of Fc-epsilon-RI-beta in a Japanese population."
      Shirakawa T., Mao X.-Q., Sasaki S., Enomoto T., Kawai M., Morimoto K., Hopkin J.
      Hum. Mol. Genet. 5:1129-1130(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT GLY-237.
    7. Erratum
      Shirakawa T., Mao X.-Q., Sasaki S., Enomoto T., Kawai M., Morimoto K., Hopkin J.
      Hum. Mol. Genet. 5:2068-2068(1996) [PubMed] [Europe PMC] [Abstract]

    Entry informationi

    Entry nameiFCERB_HUMAN
    AccessioniPrimary (citable) accession number: Q01362
    Secondary accession number(s): Q54A81
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: April 1, 1993
    Last modified: October 1, 2014
    This is version 127 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3