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Q01362

- FCERB_HUMAN

UniProt

Q01362 - FCERB_HUMAN

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Protein

High affinity immunoglobulin epsilon receptor subunit beta

Gene

MS4A2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by multivalent antigens is required for the full mast cell response, including the release of preformed mediators (such as histamine) by degranulation and de novo production of lipid mediators and cytokines. Also mediates the secretion of important lymphokines. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators responsible for the manifestations of allergy.

GO - Biological processi

  1. activation of phospholipase C activity Source: Ensembl
  2. cytokine secretion Source: Ensembl
  3. Fc-epsilon receptor signaling pathway Source: Reactome
  4. immune response Source: UniProtKB
  5. inflammatory response Source: Ensembl
  6. innate immune response Source: Reactome
  7. positive regulation of mast cell degranulation Source: Ensembl
  8. protein kinase C-activating G-protein coupled receptor signaling pathway Source: Ensembl
  9. regulation of release of sequestered calcium ion into cytosol Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Ligandi

IgE-binding protein

Enzyme and pathway databases

ReactomeiREACT_163701. FCERI mediated MAPK activation.
REACT_163769. Role of LAT2/NTAL/LAB on calcium mobilization.
REACT_163834. FCERI mediated Ca+2 mobilization.
REACT_163936. Fc epsilon receptor (FCERI) signaling.
REACT_163994. FCERI mediated NF-kB activation.
SignaLinkiQ01362.

Names & Taxonomyi

Protein namesi
Recommended name:
High affinity immunoglobulin epsilon receptor subunit beta
Short name:
FcERI
Alternative name(s):
Fc epsilon receptor I beta-chain
IgE Fc receptor subunit beta
Membrane-spanning 4-domains subfamily A member 2
Gene namesi
Name:MS4A2
Synonyms:APY, FCER1B, IGER
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:7316. MS4A2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5959CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei60 – 7920HelicalSequence AnalysisAdd
BLAST
Topological domaini80 – 9718ExtracellularSequence AnalysisAdd
BLAST
Transmembranei98 – 11720HelicalSequence AnalysisAdd
BLAST
Topological domaini118 – 13013CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei131 – 15020HelicalSequence AnalysisAdd
BLAST
Topological domaini151 – 18030ExtracellularSequence AnalysisAdd
BLAST
Transmembranei181 – 20020HelicalSequence AnalysisAdd
BLAST
Topological domaini201 – 24444CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endosome Source: Ensembl
  2. external side of plasma membrane Source: Ensembl
  3. Fc-epsilon receptor I complex Source: Ensembl
  4. integral component of plasma membrane Source: UniProtKB
  5. membrane raft Source: Ensembl
  6. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31109.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 244244High affinity immunoglobulin epsilon receptor subunit betaPRO_0000158629Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei219 – 2191PhosphotyrosineBy similarity
Modified residuei225 – 2251PhosphotyrosineBy similarity
Modified residuei226 – 2261PhosphoserineBy similarity
Modified residuei229 – 2291PhosphotyrosineBy similarity

Post-translational modificationi

Phosphorylated on tyrosine residues by LYN.By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PRIDEiQ01362.

PTM databases

PhosphoSiteiQ01362.

Expressioni

Tissue specificityi

Found on the surface of mast cells and basophils.

Gene expression databases

BgeeiQ01362.
CleanExiHS_MS4A2.
ExpressionAtlasiQ01362. baseline and differential.
GenevestigatoriQ01362.

Organism-specific databases

HPAiHPA059967.

Interactioni

Subunit structurei

Tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains. Binds LILRB1. Interacts with FGR, FES/FPS and LYN (By similarity).By similarity

Protein-protein interaction databases

BioGridi108500. 3 interactions.
STRINGi9606.ENSP00000278888.

Structurei

3D structure databases

ProteinModelPortaliQ01362.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MS4A family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG47093.
GeneTreeiENSGT00730000111024.
HOGENOMiHOG000060211.
HOVERGENiHBG051600.
InParanoidiQ01362.
KOiK08090.
OMAiSTEIVVM.
PhylomeDBiQ01362.
TreeFamiTF335157.

Family and domain databases

InterProiIPR007237. CD20-like.
[Graphical view]
PfamiPF04103. CD20. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q01362-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDTESNRRAN LALPQEPSSV PAFEVLEISP QEVSSGRLLK SASSPPLHTW
60 70 80 90 100
LTVLKKEQEF LGVTQILTAM ICLCFGTVVC SVLDISHIEG DIFSSFKAGY
110 120 130 140 150
PFWGAIFFSI SGMLSIISER RNATYLVRGS LGANTASSIA GGTGITILII
160 170 180 190 200
NLKKSLAYIH IHSCQKFFET KCFMASFSTE IVVMMLFLTI LGLGSAVSLT
210 220 230 240
ICGAGEELKG NKVPEDRVYE ELNIYSATYS ELEDPGEMSP PIDL
Length:244
Mass (Da):26,534
Last modified:April 1, 1993 - v1
Checksum:iCE523102D5F567AF
GO

Polymorphismi

Variant Glu-237 has been found to be present in about 5.3% of a 1004 individuals population sample in Australia. It seems to be a risk factor for atopic dermatitis and asthma.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti143 – 1431T → M.
Corresponds to variant rs35033981 [ dbSNP | Ensembl ].
VAR_053515
Natural varianti211 – 2111N → K.
Corresponds to variant rs535630 [ dbSNP | Ensembl ].
VAR_053516
Natural varianti237 – 2371E → G.2 Publications
Corresponds to variant rs569108 [ dbSNP | Ensembl ].
VAR_003965

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10583 mRNA. Translation: BAA01440.1.
M89796 Genomic DNA. Translation: AAA60269.1.
AB080913 Genomic DNA. Translation: BAC66486.1.
BC074800 mRNA. Translation: AAH74800.1.
BC074843 mRNA. Translation: AAH74843.1.
CCDSiCCDS7980.1.
PIRiA42806.
RefSeqiNP_000130.1. NM_000139.4.
UniGeneiHs.386748.

Genome annotation databases

EnsembliENST00000278888; ENSP00000278888; ENSG00000149534.
GeneIDi2206.
KEGGihsa:2206.
UCSCiuc001nop.3. human.

Polymorphism databases

DMDMi232084.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10583 mRNA. Translation: BAA01440.1 .
M89796 Genomic DNA. Translation: AAA60269.1 .
AB080913 Genomic DNA. Translation: BAC66486.1 .
BC074800 mRNA. Translation: AAH74800.1 .
BC074843 mRNA. Translation: AAH74843.1 .
CCDSi CCDS7980.1.
PIRi A42806.
RefSeqi NP_000130.1. NM_000139.4.
UniGenei Hs.386748.

3D structure databases

ProteinModelPortali Q01362.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 108500. 3 interactions.
STRINGi 9606.ENSP00000278888.

Chemistry

DrugBanki DB00043. Omalizumab.

PTM databases

PhosphoSitei Q01362.

Polymorphism databases

DMDMi 232084.

Proteomic databases

PRIDEi Q01362.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000278888 ; ENSP00000278888 ; ENSG00000149534 .
GeneIDi 2206.
KEGGi hsa:2206.
UCSCi uc001nop.3. human.

Organism-specific databases

CTDi 2206.
GeneCardsi GC11P059856.
HGNCi HGNC:7316. MS4A2.
HPAi HPA059967.
MIMi 147138. gene.
neXtProti NX_Q01362.
PharmGKBi PA31109.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG47093.
GeneTreei ENSGT00730000111024.
HOGENOMi HOG000060211.
HOVERGENi HBG051600.
InParanoidi Q01362.
KOi K08090.
OMAi STEIVVM.
PhylomeDBi Q01362.
TreeFami TF335157.

Enzyme and pathway databases

Reactomei REACT_163701. FCERI mediated MAPK activation.
REACT_163769. Role of LAT2/NTAL/LAB on calcium mobilization.
REACT_163834. FCERI mediated Ca+2 mobilization.
REACT_163936. Fc epsilon receptor (FCERI) signaling.
REACT_163994. FCERI mediated NF-kB activation.
SignaLinki Q01362.

Miscellaneous databases

GeneWikii MS4A2.
GenomeRNAii 2206.
NextBioi 8935.
PROi Q01362.
SOURCEi Search...

Gene expression databases

Bgeei Q01362.
CleanExi HS_MS4A2.
ExpressionAtlasi Q01362. baseline and differential.
Genevestigatori Q01362.

Family and domain databases

InterProi IPR007237. CD20-like.
[Graphical view ]
Pfami PF04103. CD20. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The gene and cDNA for the human high affinity immunoglobulin E receptor beta chain and expression of the complete human receptor."
    Kuester H., Zhang L., Brini A.T., Macglashan D.W., Kinet J.-P.
    J. Biol. Chem. 267:12782-12787(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Determination of the sequence coding for the beta subunit of the human high-affinity IgE receptor."
    Maekawa K., Imagawa N., Tanaka Y., Harada S.
    FEBS Lett. 302:161-165(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Regulation of human FcepsilonRI beta chain gene expression by Oct-1."
    Akizawa Y., Nishiyama C., Hasegawa M., Maeda K., Nakahata T., Okumura K., Ra C., Ogawa H.
    Int. Immunol. 15:549-556(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  5. "A new variant of the beta subunit of the high-affinity receptor for immunoglobulin E (Fc epsilon RI-beta E237G): associations with measures of atopy and bronchial hyper-responsiveness."
    Hill M.R., Cookson W.O.
    Hum. Mol. Genet. 5:959-962(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT GLY-237.
  6. "Association between atopic asthma and a coding variant of Fc-epsilon-RI-beta in a Japanese population."
    Shirakawa T., Mao X.-Q., Sasaki S., Enomoto T., Kawai M., Morimoto K., Hopkin J.
    Hum. Mol. Genet. 5:1129-1130(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT GLY-237.
  7. Erratum
    Shirakawa T., Mao X.-Q., Sasaki S., Enomoto T., Kawai M., Morimoto K., Hopkin J.
    Hum. Mol. Genet. 5:2068-2068(1996) [PubMed] [Europe PMC] [Abstract]

Entry informationi

Entry nameiFCERB_HUMAN
AccessioniPrimary (citable) accession number: Q01362
Secondary accession number(s): Q54A81
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: October 29, 2014
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3