Q01362 (FCERB_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
High affinity immunoglobulin epsilon receptor subunit beta
Short name=FcERI

Alternative name(s):
Fc epsilon receptor I beta-chain
IgE Fc receptor subunit beta
Membrane-spanning 4-domains subfamily A member 2

Gene names

Name:	MS4A2
Synonyms:	APY, FCER1B, IGER

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	244 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by multivalent antigens is required for the full mast cell response, including the release of preformed mediators (such as histamine) by degranulation and de novo production of lipid mediators and cytokines. Also mediates the secretion of important lymphokines. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators responsible for the manifestations of allergy.
Subunit structure	Tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains. Binds LILRB1. Interacts with FGR, FES/FPS and LYN By similarity.
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Found on the surface of mast cells and basophils.
Post-translational modification	Phosphorylated on tyrosine residues by LYN By similarity.
Polymorphism	Variant Glu-237 has been found to be present in about 5.3% of a 1004 individuals population sample in Australia. It seems to be a risk factor for atopic dermatitis and asthma.
Sequence similarities	Belongs to the MS4A family.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Ligand	IgE-binding protein
Molecular function	Receptor
PTM	Disulfide bond Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	G-protein coupled receptor signaling pathway Traceable author statement PubMed 9169438. Source: ProtInc activation of phospholipase C activity Inferred from electronic annotation. Source: Compara cell proliferation Traceable author statement PubMed 2448768. Source: ProtInc cytokine secretion Inferred from electronic annotation. Source: Compara humoral immune response Traceable author statement PubMed 2448768. Source: ProtInc inflammatory response Inferred from electronic annotation. Source: Compara positive regulation of mast cell degranulation Inferred from electronic annotation. Source: Compara protein kinase C-activating G-protein coupled receptor signaling pathway Inferred from electronic annotation. Source: Compara regulation of release of sequestered calcium ion into cytosol Inferred from electronic annotation. Source: Compara
Cellular_component	Fc-epsilon receptor I complex Inferred from electronic annotation. Source: Compara endosome Inferred from electronic annotation. Source: Compara external side of plasma membrane Inferred from electronic annotation. Source: Compara integral to plasma membrane Traceable author statement PubMed 2448768. Source: ProtInc membrane raft Inferred from electronic annotation. Source: Compara
Molecular_function	calcium channel activity Traceable author statement PubMed 9169438. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 244	244	High affinity immunoglobulin epsilon receptor subunit beta		PRO_0000158629
Regions
	Topological domain	1 – 59	59	Cytoplasmic Potential
	Transmembrane	60 – 79	20	Helical; Potential
	Topological domain	80 – 97	18	Extracellular Potential
	Transmembrane	98 – 117	20	Helical; Potential
	Topological domain	118 – 130	13	Cytoplasmic Potential
	Transmembrane	131 – 150	20	Helical; Potential
	Topological domain	151 – 180	30	Extracellular Potential
	Transmembrane	181 – 200	20	Helical; Potential
	Topological domain	201 – 244	44	Cytoplasmic Potential
Amino acid modifications
	Modified residue	219	1	Phosphotyrosine By similarity
	Modified residue	225	1	Phosphotyrosine By similarity
	Modified residue	226	1	Phosphoserine By similarity
	Modified residue	229	1	Phosphotyrosine By similarity
Natural variations
	Natural variant	143	1	T → M. Corresponds to variant rs35033981 [ dbSNP | Ensembl ].		VAR_053515
	Natural variant	211	1	N → K. Corresponds to variant rs535630 [ dbSNP | Ensembl ].		VAR_053516
	Natural variant	237	1	E → G. Ref.5 Ref.6 Corresponds to variant rs569108 [ dbSNP | Ensembl ].		VAR_003965

Sequences

	Sequence		Length	Mass (Da)
	Q01362 [UniParc]. Last modified April 1, 1993. Version 1. Checksum: CE523102D5F567AF	FASTA	244	26,534
	10 20 30 40 50 60 MDTESNRRAN LALPQEPSSV PAFEVLEISP QEVSSGRLLK SASSPPLHTW LTVLKKEQEF 70 80 90 100 110 120 LGVTQILTAM ICLCFGTVVC SVLDISHIEG DIFSSFKAGY PFWGAIFFSI SGMLSIISER 130 140 150 160 170 180 RNATYLVRGS LGANTASSIA GGTGITILII NLKKSLAYIH IHSCQKFFET KCFMASFSTE 190 200 210 220 230 240 IVVMMLFLTI LGLGSAVSLT ICGAGEELKG NKVPEDRVYE ELNIYSATYS ELEDPGEMSP PIDL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The gene and cDNA for the human high affinity immunoglobulin E receptor beta chain and expression of the complete human receptor." Kuester H., Zhang L., Brini A.T., Macglashan D.W., Kinet J.-P. J. Biol. Chem. 267:12782-12787(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Determination of the sequence coding for the beta subunit of the human high-affinity IgE receptor." Maekawa K., Imagawa N., Tanaka Y., Harada S. FEBS Lett. 302:161-165(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Regulation of human FcepsilonRI beta chain gene expression by Oct-1." Akizawa Y., Nishiyama C., Hasegawa M., Maeda K., Nakahata T., Okumura K., Ra C., Ogawa H. Int. Immunol. 15:549-556(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[5]	"A new variant of the beta subunit of the high-affinity receptor for immunoglobulin E (Fc epsilon RI-beta E237G): associations with measures of atopy and bronchial hyper-responsiveness." Hill M.R., Cookson W.O. Hum. Mol. Genet. 5:959-962(1996) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT GLY-237.
[6]	"Association between atopic asthma and a coding variant of Fc-epsilon-RI-beta in a Japanese population." Shirakawa T., Mao X.-Q., Sasaki S., Enomoto T., Kawai M., Morimoto K., Hopkin J. Hum. Mol. Genet. 5:1129-1130(1996) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT GLY-237.
[7]	Erratum Shirakawa T., Mao X.-Q., Sasaki S., Enomoto T., Kawai M., Morimoto K., Hopkin J. Hum. Mol. Genet. 5:2068-2068(1996) [PubMed] [Europe PMC] [Abstract]
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D10583 mRNA. Translation: BAA01440.1. M89796 Genomic DNA. Translation: AAA60269.1. AB080913 Genomic DNA. Translation: BAC66486.1. BC074800 mRNA. Translation: AAH74800.1. BC074843 mRNA. Translation: AAH74843.1.
IPI	IPI00007153.
PIR	A42806.
RefSeq	NP_000130.1. NM_000139.4.
UniGene	Hs.386748.
3D structure databases
ProteinModelPortal	Q01362.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000278888.
PTM databases
PhosphoSite	Q01362.
Polymorphism databases
DMDM	232084.
Proteomic databases
PRIDE	Q01362.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000278888; ENSP00000278888; ENSG00000149534.
GeneID	2206.
KEGG	hsa:2206.
UCSC	uc001nop.3. human.
Organism-specific databases
CTD	2206.
GeneCards	GC11P059856.
HGNC	HGNC:7316. MS4A2.
MIM	147138. gene.
neXtProt	NX_Q01362.
PharmGKB	PA31109.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG47093.
HOGENOM	HOG000060211.
HOVERGEN	HBG051600.
InParanoid	Q01362.
KO	K08090.
OMA	LTILGFC.
OrthoDB	EOG4F4SBZ.
PhylomeDB	Q01362.
Enzyme and pathway databases
Pathway_Interaction_DB	fcer1pathway. Fc-epsilon receptor I signaling in mast cells.
Gene expression databases
ArrayExpress	Q01362.
Bgee	Q01362.
CleanEx	HS_MS4A2.
Genevestigator	Q01362.
GermOnline	ENSG00000149534. Homo sapiens.
Family and domain databases
InterPro	IPR007237. CD20-like. [Graphical view]
Pfam	PF04103. CD20. 1 hit. [Graphical view]
ProtoNet	Search...
Other
DrugBank	DB00043. Omalizumab.
GenomeRNAi	2206.
NextBio	8935.
SOURCE	Search...

Entry information

Entry name

FCERB_HUMAN

Accession

Primary (citable) accession number: Q01362
Secondary accession number(s): Q54A81

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
Last sequence update:	April 1, 1993
Last modified:	April 3, 2013
This is version 115 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.