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Protein

High affinity immunoglobulin epsilon receptor subunit beta

Gene

MS4A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by multivalent antigens is required for the full mast cell response, including the release of preformed mediators (such as histamine) by degranulation and de novo production of lipid mediators and cytokines. Also mediates the secretion of important lymphokines. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators responsible for the manifestations of allergy.

GO - Biological processi

  • Fc-epsilon receptor signaling pathway Source: Reactome
  • immune response Source: UniProtKB
  • inflammatory response Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Ligandi

IgE-binding protein

Enzyme and pathway databases

BioCyciZFISH:ENSG00000149534-MONOMER.
ReactomeiR-HSA-2454202. Fc epsilon receptor (FCERI) signaling.
R-HSA-2730905. Role of LAT2/NTAL/LAB on calcium mobilization.
R-HSA-2871796. FCERI mediated MAPK activation.
R-HSA-2871809. FCERI mediated Ca+2 mobilization.
R-HSA-2871837. FCERI mediated NF-kB activation.
SignaLinkiQ01362.

Protein family/group databases

TCDBi1.A.37.3.2. the cd20 ca(2+) channel (cd20) family.

Names & Taxonomyi

Protein namesi
Recommended name:
High affinity immunoglobulin epsilon receptor subunit beta
Short name:
FcERI
Alternative name(s):
Fc epsilon receptor I beta-chain
IgE Fc receptor subunit beta
Membrane-spanning 4-domains subfamily A member 2
Gene namesi
Name:MS4A2
Synonyms:APY, FCER1B, IGER
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:7316. MS4A2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 59CytoplasmicSequence analysisAdd BLAST59
Transmembranei60 – 79HelicalSequence analysisAdd BLAST20
Topological domaini80 – 97ExtracellularSequence analysisAdd BLAST18
Transmembranei98 – 117HelicalSequence analysisAdd BLAST20
Topological domaini118 – 130CytoplasmicSequence analysisAdd BLAST13
Transmembranei131 – 150HelicalSequence analysisAdd BLAST20
Topological domaini151 – 180ExtracellularSequence analysisAdd BLAST30
Transmembranei181 – 200HelicalSequence analysisAdd BLAST20
Topological domaini201 – 244CytoplasmicSequence analysisAdd BLAST44

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2206.
MalaCardsiMS4A2.
OpenTargetsiENSG00000149534.
PharmGKBiPA31109.

Chemistry databases

DrugBankiDB00043. Omalizumab.

Polymorphism and mutation databases

BioMutaiMS4A2.
DMDMi232084.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001586291 – 244High affinity immunoglobulin epsilon receptor subunit betaAdd BLAST244

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei219PhosphotyrosineBy similarity1
Modified residuei225PhosphotyrosineBy similarity1
Modified residuei226PhosphoserineBy similarity1
Modified residuei229PhosphotyrosineBy similarity1

Post-translational modificationi

Phosphorylated on tyrosine residues by LYN.By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiQ01362.
PRIDEiQ01362.

PTM databases

iPTMnetiQ01362.
PhosphoSitePlusiQ01362.

Expressioni

Tissue specificityi

Found on the surface of mast cells and basophils.

Gene expression databases

BgeeiENSG00000149534.
CleanExiHS_MS4A2.
ExpressionAtlasiQ01362. baseline and differential.
GenevisibleiQ01362. HS.

Organism-specific databases

HPAiHPA059967.

Interactioni

Subunit structurei

Tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains. Binds LILRB1. Interacts with FGR, FES/FPS and LYN (By similarity).By similarity

Protein-protein interaction databases

BioGridi108500. 4 interactors.
STRINGi9606.ENSP00000278888.

Structurei

3D structure databases

ProteinModelPortaliQ01362.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MS4A family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J28C. Eukaryota.
ENOG4111DU9. LUCA.
GeneTreeiENSGT00730000110654.
HOGENOMiHOG000060211.
HOVERGENiHBG051600.
InParanoidiQ01362.
KOiK08090.
OMAiSTEIVVM.
OrthoDBiEOG091G0IBB.
PhylomeDBiQ01362.
TreeFamiTF335157.

Family and domain databases

InterProiIPR007237. CD20-like.
IPR030417. MS4A.
IPR030420. MS4A2.
[Graphical view]
PANTHERiPTHR23320. PTHR23320. 1 hit.
PTHR23320:SF66. PTHR23320:SF66. 1 hit.
PfamiPF04103. CD20. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q01362-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTESNRRAN LALPQEPSSV PAFEVLEISP QEVSSGRLLK SASSPPLHTW
60 70 80 90 100
LTVLKKEQEF LGVTQILTAM ICLCFGTVVC SVLDISHIEG DIFSSFKAGY
110 120 130 140 150
PFWGAIFFSI SGMLSIISER RNATYLVRGS LGANTASSIA GGTGITILII
160 170 180 190 200
NLKKSLAYIH IHSCQKFFET KCFMASFSTE IVVMMLFLTI LGLGSAVSLT
210 220 230 240
ICGAGEELKG NKVPEDRVYE ELNIYSATYS ELEDPGEMSP PIDL
Length:244
Mass (Da):26,534
Last modified:April 1, 1993 - v1
Checksum:iCE523102D5F567AF
GO

Polymorphismi

Variant Glu-237 has been found to be present in about 5.3% of a 1004 individuals population sample in Australia (PubMed:8817330).1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053515143T → M.Corresponds to variant rs35033981dbSNPEnsembl.1
Natural variantiVAR_053516211N → K.Corresponds to variant rs535630dbSNPEnsembl.1
Natural variantiVAR_003965237E → G Polymorphism; risk factor for atopic dermatitis and asthma. 2 PublicationsCorresponds to variant rs569108dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10583 mRNA. Translation: BAA01440.1.
M89796 Genomic DNA. Translation: AAA60269.1.
AB080913 Genomic DNA. Translation: BAC66486.1.
BC074800 mRNA. Translation: AAH74800.1.
BC074843 mRNA. Translation: AAH74843.1.
CCDSiCCDS7980.1.
PIRiA42806.
RefSeqiNP_000130.1. NM_000139.4.
XP_011543152.1. XM_011544850.2.
UniGeneiHs.386748.

Genome annotation databases

EnsembliENST00000278888; ENSP00000278888; ENSG00000149534.
GeneIDi2206.
KEGGihsa:2206.
UCSCiuc001nop.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10583 mRNA. Translation: BAA01440.1.
M89796 Genomic DNA. Translation: AAA60269.1.
AB080913 Genomic DNA. Translation: BAC66486.1.
BC074800 mRNA. Translation: AAH74800.1.
BC074843 mRNA. Translation: AAH74843.1.
CCDSiCCDS7980.1.
PIRiA42806.
RefSeqiNP_000130.1. NM_000139.4.
XP_011543152.1. XM_011544850.2.
UniGeneiHs.386748.

3D structure databases

ProteinModelPortaliQ01362.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108500. 4 interactors.
STRINGi9606.ENSP00000278888.

Chemistry databases

DrugBankiDB00043. Omalizumab.

Protein family/group databases

TCDBi1.A.37.3.2. the cd20 ca(2+) channel (cd20) family.

PTM databases

iPTMnetiQ01362.
PhosphoSitePlusiQ01362.

Polymorphism and mutation databases

BioMutaiMS4A2.
DMDMi232084.

Proteomic databases

PaxDbiQ01362.
PRIDEiQ01362.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000278888; ENSP00000278888; ENSG00000149534.
GeneIDi2206.
KEGGihsa:2206.
UCSCiuc001nop.4. human.

Organism-specific databases

CTDi2206.
DisGeNETi2206.
GeneCardsiMS4A2.
HGNCiHGNC:7316. MS4A2.
HPAiHPA059967.
MalaCardsiMS4A2.
MIMi147138. gene.
neXtProtiNX_Q01362.
OpenTargetsiENSG00000149534.
PharmGKBiPA31109.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J28C. Eukaryota.
ENOG4111DU9. LUCA.
GeneTreeiENSGT00730000110654.
HOGENOMiHOG000060211.
HOVERGENiHBG051600.
InParanoidiQ01362.
KOiK08090.
OMAiSTEIVVM.
OrthoDBiEOG091G0IBB.
PhylomeDBiQ01362.
TreeFamiTF335157.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000149534-MONOMER.
ReactomeiR-HSA-2454202. Fc epsilon receptor (FCERI) signaling.
R-HSA-2730905. Role of LAT2/NTAL/LAB on calcium mobilization.
R-HSA-2871796. FCERI mediated MAPK activation.
R-HSA-2871809. FCERI mediated Ca+2 mobilization.
R-HSA-2871837. FCERI mediated NF-kB activation.
SignaLinkiQ01362.

Miscellaneous databases

GeneWikiiMS4A2.
GenomeRNAii2206.
PROiQ01362.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000149534.
CleanExiHS_MS4A2.
ExpressionAtlasiQ01362. baseline and differential.
GenevisibleiQ01362. HS.

Family and domain databases

InterProiIPR007237. CD20-like.
IPR030417. MS4A.
IPR030420. MS4A2.
[Graphical view]
PANTHERiPTHR23320. PTHR23320. 1 hit.
PTHR23320:SF66. PTHR23320:SF66. 1 hit.
PfamiPF04103. CD20. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFCERB_HUMAN
AccessioniPrimary (citable) accession number: Q01362
Secondary accession number(s): Q54A81
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: November 30, 2016
This is version 146 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.