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Protein

High affinity immunoglobulin epsilon receptor subunit beta

Gene

MS4A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by multivalent antigens is required for the full mast cell response, including the release of preformed mediators (such as histamine) by degranulation and de novo production of lipid mediators and cytokines. Also mediates the secretion of important lymphokines. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators responsible for the manifestations of allergy.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIgE-binding protein, Receptor

Enzyme and pathway databases

ReactomeiR-HSA-2454202. Fc epsilon receptor (FCERI) signaling.
R-HSA-2730905. Role of LAT2/NTAL/LAB on calcium mobilization.
R-HSA-2871796. FCERI mediated MAPK activation.
R-HSA-2871809. FCERI mediated Ca+2 mobilization.
R-HSA-2871837. FCERI mediated NF-kB activation.
SignaLinkiQ01362.

Protein family/group databases

TCDBi1.A.37.3.2. the cd20 ca(2+) channel (cd20) family.

Names & Taxonomyi

Protein namesi
Recommended name:
High affinity immunoglobulin epsilon receptor subunit beta
Short name:
FcERI
Alternative name(s):
Fc epsilon receptor I beta-chain
IgE Fc receptor subunit beta
Membrane-spanning 4-domains subfamily A member 2
Gene namesi
Name:MS4A2
Synonyms:APY, FCER1B, IGER
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000149534.8.
HGNCiHGNC:7316. MS4A2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 59CytoplasmicIEP:Add BLAST59
Transmembranei60 – 79HelicalIEP:Add BLAST20
Topological domaini80 – 97ExtracellularIEP:Add BLAST18
Transmembranei98 – 117HelicalIEP:Add BLAST20
Topological domaini118 – 130CytoplasmicIEP:Add BLAST13
Transmembranei131 – 150HelicalIEP:Add BLAST20
Topological domaini151 – 180ExtracellularIEP:Add BLAST30
Transmembranei181 – 200HelicalIEP:Add BLAST20
Topological domaini201 – 244CytoplasmicIEP:Add BLAST44

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2206.
MalaCardsiMS4A2.
OpenTargetsiENSG00000149534.
PharmGKBiPA31109.

Chemistry databases

DrugBankiDB00043. Omalizumab.

Polymorphism and mutation databases

BioMutaiMS4A2.
DMDMi232084.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001586291 – 244High affinity immunoglobulin epsilon receptor subunit betaAdd BLAST244

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei219PhosphotyrosineHMP:1
Modified residuei225PhosphotyrosineHMP:1
Modified residuei226PhosphoserineHMP:1
Modified residuei229PhosphotyrosineHMP:1

Post-translational modificationi

Phosphorylated on tyrosine residues by LYN.HMP:

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiQ01362.
PeptideAtlasiQ01362.
PRIDEiQ01362.

PTM databases

iPTMnetiQ01362.
PhosphoSitePlusiQ01362.

Expressioni

Tissue specificityi

Found on the surface of mast cells and basophils.

Gene expression databases

BgeeiENSG00000149534.
CleanExiHS_MS4A2.
ExpressionAtlasiQ01362. baseline and differential.
GenevisibleiQ01362. HS.

Organism-specific databases

HPAiHPA059967.

Interactioni

Subunit structurei

Tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains. Binds LILRB1. Interacts with FGR, FES/FPS and LYN (By similarity).HMP:

GO - Molecular functioni

Protein-protein interaction databases

BioGridi108500. 4 interactors.
IntActiQ01362. 1 interactor.
STRINGi9606.ENSP00000278888.

Structurei

3D structure databases

ProteinModelPortaliQ01362.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MS4A family.IKR:

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J28C. Eukaryota.
ENOG4111DU9. LUCA.
GeneTreeiENSGT00870000136511.
HOGENOMiHOG000060211.
HOVERGENiHBG051600.
InParanoidiQ01362.
KOiK08090.
OMAiSTEIVVM.
OrthoDBiEOG091G0IBB.
PhylomeDBiQ01362.
TreeFamiTF335157.

Family and domain databases

InterProiView protein in InterPro
IPR007237. CD20-like.
IPR030417. MS4A.
IPR030420. MS4A2.
PANTHERiPTHR23320. PTHR23320. 1 hit.
PTHR23320:SF66. PTHR23320:SF66. 1 hit.
PfamiView protein in Pfam
PF04103. CD20. 1 hit.

Sequencei

Sequence statusi: Complete.

Q01362-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTESNRRAN LALPQEPSSV PAFEVLEISP QEVSSGRLLK SASSPPLHTW
60 70 80 90 100
LTVLKKEQEF LGVTQILTAM ICLCFGTVVC SVLDISHIEG DIFSSFKAGY
110 120 130 140 150
PFWGAIFFSI SGMLSIISER RNATYLVRGS LGANTASSIA GGTGITILII
160 170 180 190 200
NLKKSLAYIH IHSCQKFFET KCFMASFSTE IVVMMLFLTI LGLGSAVSLT
210 220 230 240
ICGAGEELKG NKVPEDRVYE ELNIYSATYS ELEDPGEMSP PIDL
Length:244
Mass (Da):26,534
Last modified:April 1, 1993 - v1
Checksum:iCE523102D5F567AF
GO

Polymorphismi

Variant Glu-237 has been found to be present in about 5.3% of a 1004 individuals population sample in Australia (PubMed:8817330).1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053515143T → M. Corresponds to variant dbSNP:rs35033981Ensembl.1
Natural variantiVAR_053516211N → K. Corresponds to variant dbSNP:rs535630Ensembl.1
Natural variantiVAR_003965237E → G Polymorphism; risk factor for atopic dermatitis and asthma. 2 PublicationsCorresponds to variant dbSNP:rs569108Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10583 mRNA. Translation: BAA01440.1.
M89796 Genomic DNA. Translation: AAA60269.1.
AB080913 Genomic DNA. Translation: BAC66486.1.
BC074800 mRNA. Translation: AAH74800.1.
BC074843 mRNA. Translation: AAH74843.1.
CCDSiCCDS7980.1.
PIRiA42806.
RefSeqiNP_000130.1. NM_000139.4.
XP_011543152.1. XM_011544850.2.
UniGeneiHs.386748.

Genome annotation databases

EnsembliENST00000278888; ENSP00000278888; ENSG00000149534.
GeneIDi2206.
KEGGihsa:2206.
UCSCiuc001nop.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiFCERB_HUMAN
AccessioniPrimary (citable) accession number: Q01362
Secondary accession number(s): Q54A81
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: October 25, 2017
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families