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Q01361 (CP2DE_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 22, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 2D14

EC=1.14.14.1
Alternative name(s):
CYPIID14
Gene names
Name:CYP2D14
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length500 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Induction

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Sequence similarities

Belongs to the cytochrome P450 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 500500Cytochrome P450 2D14
PRO_0000051738

Sites

Metal binding4461Iron (heme axial ligand) By similarity

Experimental info

Sequence conflict1121H → R in CAA48149. Ref.1
Sequence conflict1321R → A in CAA48501. Ref.1
Sequence conflict1631L → S in CAA48501. Ref.1
Sequence conflict1791D → G in CAA48149. Ref.1
Sequence conflict2201F → P in CAA48501. Ref.1
Sequence conflict2481K → R in CAA48149. Ref.1
Sequence conflict2561E → G in CAA48149. Ref.1
Sequence conflict3681R → A in CAA48149. Ref.1
Sequence conflict4131E → Q in CAA48149. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q01361 [UniParc].

Last modified October 31, 2006. Version 2.
Checksum: D356E8736A04C92A

FASTA50056,083
        10         20         30         40         50         60 
MGLLSGDTLG PLAVALLIFL LLLDLMHRRS RWAPRYPPGP TPLPVLGNLL QVDFEDPRPS 

        70         80         90        100        110        120 
FNQLRRRFGN VFSLQQVWTP VVVLNGLAAV REALVYRSQD TADRPPPAVY EHLGYGPRAE 

       130        140        150        160        170        180 
GVILARYGDA WREQRRFSLT TLRNFGLGKK SLEQWVTEEA SCLCAAFADQ AGRPFSPMDL 

       190        200        210        220        230        240 
LNKAVSNVIA SLTFGCRFEY NDPRIIKLLD LTEDGLKEEF NLVRKVVEAV PVLLSIPGLA 

       250        260        270        280        290        300 
ARVFPAQKAF MALIDELIAE QKMTRDPTQP PRHLTDAFLD EVKEAKGNPE SSFNDENLRL 

       310        320        330        340        350        360 
VVADLFSAGM VTTSTTLAWA LLLMILHPDV QRRVQQEIDE VIGQVRRPEM GDQALMPFTV 

       370        380        390        400        410        420 
AVVHEVQRFA DIVPLGLPHM TSRDIEVQGF HIPKGTTLIT NLSSVLKDET VWEKPFRFHP 

       430        440        450        460        470        480 
EHFLDAQGRF VKQEAFIPFS AGRRACLGEP LARMELFLFF TSLLQHFSFS VPAGQPRPSE 

       490        500 
HGVFAFLVTP APYQLCAVPR 

« Hide

References

[1]"Characterization of the cytochrome P-450IID subfamily in bovine liver. Nucleotide sequences and microheterogeneity."
Tsuneoka Y., Matsuo Y., Higuchi R., Ichikawa Y.
Eur. J. Biochem. 208:739-746(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X68013 mRNA. Translation: CAA48149.1.
X68481 mRNA. Translation: CAA48501.1.
PIRS37284.
RefSeqNP_776954.1. NM_174529.2.
UniGeneBt.665.

3D structure databases

ProteinModelPortalQ01361.
SMRQ01361. Positions 37-500.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000000869.

Proteomic databases

PRIDEQ01361.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID282211.
KEGGbta:282211.

Organism-specific databases

CTD282211.

Phylogenomic databases

eggNOGCOG2124.
HOGENOMHOG000036991.
HOVERGENHBG015789.
InParanoidQ01361.
KOK07414.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR01686. EP450ICYP2D.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20806035.

Entry information

Entry nameCP2DE_BOVIN
AccessionPrimary (citable) accession number: Q01361
Secondary accession number(s): Q29454
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: October 31, 2006
Last modified: January 22, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families