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Q01361

- CP2DE_BOVIN

UniProt

Q01361 - CP2DE_BOVIN

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Protein

Cytochrome P450 2D14

Gene

CYP2D14

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi446 – 4461Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2D14 (EC:1.14.14.1)
Alternative name(s):
CYPIID14
Gene namesi
Name:CYP2D14
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 500500Cytochrome P450 2D14PRO_0000051738Add
BLAST

Proteomic databases

PRIDEiQ01361.

Expressioni

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000000869.

Structurei

3D structure databases

ProteinModelPortaliQ01361.
SMRiQ01361. Positions 37-500.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000036991.
HOVERGENiHBG015789.
InParanoidiQ01361.
KOiK07414.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01686. EP450ICYP2D.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q01361 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGLLSGDTLG PLAVALLIFL LLLDLMHRRS RWAPRYPPGP TPLPVLGNLL
60 70 80 90 100
QVDFEDPRPS FNQLRRRFGN VFSLQQVWTP VVVLNGLAAV REALVYRSQD
110 120 130 140 150
TADRPPPAVY EHLGYGPRAE GVILARYGDA WREQRRFSLT TLRNFGLGKK
160 170 180 190 200
SLEQWVTEEA SCLCAAFADQ AGRPFSPMDL LNKAVSNVIA SLTFGCRFEY
210 220 230 240 250
NDPRIIKLLD LTEDGLKEEF NLVRKVVEAV PVLLSIPGLA ARVFPAQKAF
260 270 280 290 300
MALIDELIAE QKMTRDPTQP PRHLTDAFLD EVKEAKGNPE SSFNDENLRL
310 320 330 340 350
VVADLFSAGM VTTSTTLAWA LLLMILHPDV QRRVQQEIDE VIGQVRRPEM
360 370 380 390 400
GDQALMPFTV AVVHEVQRFA DIVPLGLPHM TSRDIEVQGF HIPKGTTLIT
410 420 430 440 450
NLSSVLKDET VWEKPFRFHP EHFLDAQGRF VKQEAFIPFS AGRRACLGEP
460 470 480 490 500
LARMELFLFF TSLLQHFSFS VPAGQPRPSE HGVFAFLVTP APYQLCAVPR
Length:500
Mass (Da):56,083
Last modified:October 31, 2006 - v2
Checksum:iD356E8736A04C92A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti112 – 1121H → R in CAA48149. (PubMed:1396678)Curated
Sequence conflicti132 – 1321R → A in CAA48501. (PubMed:1396678)Curated
Sequence conflicti163 – 1631L → S in CAA48501. (PubMed:1396678)Curated
Sequence conflicti179 – 1791D → G in CAA48149. (PubMed:1396678)Curated
Sequence conflicti220 – 2201F → P in CAA48501. (PubMed:1396678)Curated
Sequence conflicti248 – 2481K → R in CAA48149. (PubMed:1396678)Curated
Sequence conflicti256 – 2561E → G in CAA48149. (PubMed:1396678)Curated
Sequence conflicti368 – 3681R → A in CAA48149. (PubMed:1396678)Curated
Sequence conflicti413 – 4131E → Q in CAA48149. (PubMed:1396678)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X68013 mRNA. Translation: CAA48149.1.
X68481 mRNA. Translation: CAA48501.1.
PIRiS37284.
RefSeqiNP_776954.1. NM_174529.2.
UniGeneiBt.665.

Genome annotation databases

GeneIDi282211.
KEGGibta:282211.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X68013 mRNA. Translation: CAA48149.1 .
X68481 mRNA. Translation: CAA48501.1 .
PIRi S37284.
RefSeqi NP_776954.1. NM_174529.2.
UniGenei Bt.665.

3D structure databases

ProteinModelPortali Q01361.
SMRi Q01361. Positions 37-500.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000000869.

Proteomic databases

PRIDEi Q01361.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 282211.
KEGGi bta:282211.

Organism-specific databases

CTDi 282211.

Phylogenomic databases

eggNOGi COG2124.
HOGENOMi HOG000036991.
HOVERGENi HBG015789.
InParanoidi Q01361.
KOi K07414.

Miscellaneous databases

NextBioi 20806035.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR01686. EP450ICYP2D.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Characterization of the cytochrome P-450IID subfamily in bovine liver. Nucleotide sequences and microheterogeneity."
    Tsuneoka Y., Matsuo Y., Higuchi R., Ichikawa Y.
    Eur. J. Biochem. 208:739-746(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiCP2DE_BOVIN
AccessioniPrimary (citable) accession number: Q01361
Secondary accession number(s): Q29454
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: October 31, 2006
Last modified: October 29, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3