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Q01361

- CP2DE_BOVIN

UniProt

Q01361 - CP2DE_BOVIN

Protein

Cytochrome P450 2D14

Gene

CYP2D14

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 2 (31 Oct 2006)
      Previous versions | rss
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    Functioni

    Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi446 – 4461Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 2D14 (EC:1.14.14.1)
    Alternative name(s):
    CYPIID14
    Gene namesi
    Name:CYP2D14
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 500500Cytochrome P450 2D14PRO_0000051738Add
    BLAST

    Proteomic databases

    PRIDEiQ01361.

    Expressioni

    Inductioni

    P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

    Interactioni

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000000869.

    Structurei

    3D structure databases

    ProteinModelPortaliQ01361.
    SMRiQ01361. Positions 37-500.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    HOGENOMiHOG000036991.
    HOVERGENiHBG015789.
    InParanoidiQ01361.
    KOiK07414.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR01686. EP450ICYP2D.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q01361-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGLLSGDTLG PLAVALLIFL LLLDLMHRRS RWAPRYPPGP TPLPVLGNLL    50
    QVDFEDPRPS FNQLRRRFGN VFSLQQVWTP VVVLNGLAAV REALVYRSQD 100
    TADRPPPAVY EHLGYGPRAE GVILARYGDA WREQRRFSLT TLRNFGLGKK 150
    SLEQWVTEEA SCLCAAFADQ AGRPFSPMDL LNKAVSNVIA SLTFGCRFEY 200
    NDPRIIKLLD LTEDGLKEEF NLVRKVVEAV PVLLSIPGLA ARVFPAQKAF 250
    MALIDELIAE QKMTRDPTQP PRHLTDAFLD EVKEAKGNPE SSFNDENLRL 300
    VVADLFSAGM VTTSTTLAWA LLLMILHPDV QRRVQQEIDE VIGQVRRPEM 350
    GDQALMPFTV AVVHEVQRFA DIVPLGLPHM TSRDIEVQGF HIPKGTTLIT 400
    NLSSVLKDET VWEKPFRFHP EHFLDAQGRF VKQEAFIPFS AGRRACLGEP 450
    LARMELFLFF TSLLQHFSFS VPAGQPRPSE HGVFAFLVTP APYQLCAVPR 500
    Length:500
    Mass (Da):56,083
    Last modified:October 31, 2006 - v2
    Checksum:iD356E8736A04C92A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti112 – 1121H → R in CAA48149. (PubMed:1396678)Curated
    Sequence conflicti132 – 1321R → A in CAA48501. (PubMed:1396678)Curated
    Sequence conflicti163 – 1631L → S in CAA48501. (PubMed:1396678)Curated
    Sequence conflicti179 – 1791D → G in CAA48149. (PubMed:1396678)Curated
    Sequence conflicti220 – 2201F → P in CAA48501. (PubMed:1396678)Curated
    Sequence conflicti248 – 2481K → R in CAA48149. (PubMed:1396678)Curated
    Sequence conflicti256 – 2561E → G in CAA48149. (PubMed:1396678)Curated
    Sequence conflicti368 – 3681R → A in CAA48149. (PubMed:1396678)Curated
    Sequence conflicti413 – 4131E → Q in CAA48149. (PubMed:1396678)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X68013 mRNA. Translation: CAA48149.1.
    X68481 mRNA. Translation: CAA48501.1.
    PIRiS37284.
    RefSeqiNP_776954.1. NM_174529.2.
    UniGeneiBt.665.

    Genome annotation databases

    GeneIDi282211.
    KEGGibta:282211.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X68013 mRNA. Translation: CAA48149.1 .
    X68481 mRNA. Translation: CAA48501.1 .
    PIRi S37284.
    RefSeqi NP_776954.1. NM_174529.2.
    UniGenei Bt.665.

    3D structure databases

    ProteinModelPortali Q01361.
    SMRi Q01361. Positions 37-500.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000000869.

    Proteomic databases

    PRIDEi Q01361.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 282211.
    KEGGi bta:282211.

    Organism-specific databases

    CTDi 282211.

    Phylogenomic databases

    eggNOGi COG2124.
    HOGENOMi HOG000036991.
    HOVERGENi HBG015789.
    InParanoidi Q01361.
    KOi K07414.

    Miscellaneous databases

    NextBioi 20806035.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR01686. EP450ICYP2D.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of the cytochrome P-450IID subfamily in bovine liver. Nucleotide sequences and microheterogeneity."
      Tsuneoka Y., Matsuo Y., Higuchi R., Ichikawa Y.
      Eur. J. Biochem. 208:739-746(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.

    Entry informationi

    Entry nameiCP2DE_BOVIN
    AccessioniPrimary (citable) accession number: Q01361
    Secondary accession number(s): Q29454
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: October 31, 2006
    Last modified: October 1, 2014
    This is version 102 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3