Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cytochrome P450 2D14

Gene

CYP2D14

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi446Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2D14 (EC:1.14.14.1)
Alternative name(s):
CYPIID14
Gene namesi
Name:CYP2D14
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000517381 – 500Cytochrome P450 2D14Add BLAST500

Proteomic databases

PaxDbiQ01361.
PeptideAtlasiQ01361.
PRIDEiQ01361.

Expressioni

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000000869.

Structurei

3D structure databases

ProteinModelPortaliQ01361.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
HOGENOMiHOG000036991.
HOVERGENiHBG015789.
InParanoidiQ01361.
KOiK07414.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01686. EP450ICYP2D.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q01361-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLLSGDTLG PLAVALLIFL LLLDLMHRRS RWAPRYPPGP TPLPVLGNLL
60 70 80 90 100
QVDFEDPRPS FNQLRRRFGN VFSLQQVWTP VVVLNGLAAV REALVYRSQD
110 120 130 140 150
TADRPPPAVY EHLGYGPRAE GVILARYGDA WREQRRFSLT TLRNFGLGKK
160 170 180 190 200
SLEQWVTEEA SCLCAAFADQ AGRPFSPMDL LNKAVSNVIA SLTFGCRFEY
210 220 230 240 250
NDPRIIKLLD LTEDGLKEEF NLVRKVVEAV PVLLSIPGLA ARVFPAQKAF
260 270 280 290 300
MALIDELIAE QKMTRDPTQP PRHLTDAFLD EVKEAKGNPE SSFNDENLRL
310 320 330 340 350
VVADLFSAGM VTTSTTLAWA LLLMILHPDV QRRVQQEIDE VIGQVRRPEM
360 370 380 390 400
GDQALMPFTV AVVHEVQRFA DIVPLGLPHM TSRDIEVQGF HIPKGTTLIT
410 420 430 440 450
NLSSVLKDET VWEKPFRFHP EHFLDAQGRF VKQEAFIPFS AGRRACLGEP
460 470 480 490 500
LARMELFLFF TSLLQHFSFS VPAGQPRPSE HGVFAFLVTP APYQLCAVPR
Length:500
Mass (Da):56,083
Last modified:October 31, 2006 - v2
Checksum:iD356E8736A04C92A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti112H → R in CAA48149 (PubMed:1396678).Curated1
Sequence conflicti132R → A in CAA48501 (PubMed:1396678).Curated1
Sequence conflicti163L → S in CAA48501 (PubMed:1396678).Curated1
Sequence conflicti179D → G in CAA48149 (PubMed:1396678).Curated1
Sequence conflicti220F → P in CAA48501 (PubMed:1396678).Curated1
Sequence conflicti248K → R in CAA48149 (PubMed:1396678).Curated1
Sequence conflicti256E → G in CAA48149 (PubMed:1396678).Curated1
Sequence conflicti368R → A in CAA48149 (PubMed:1396678).Curated1
Sequence conflicti413E → Q in CAA48149 (PubMed:1396678).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68013 mRNA. Translation: CAA48149.1.
X68481 mRNA. Translation: CAA48501.1.
PIRiS37284.
RefSeqiNP_776954.1. NM_174529.2.
UniGeneiBt.665.

Genome annotation databases

GeneIDi282211.
KEGGibta:282211.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68013 mRNA. Translation: CAA48149.1.
X68481 mRNA. Translation: CAA48501.1.
PIRiS37284.
RefSeqiNP_776954.1. NM_174529.2.
UniGeneiBt.665.

3D structure databases

ProteinModelPortaliQ01361.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000000869.

Proteomic databases

PaxDbiQ01361.
PeptideAtlasiQ01361.
PRIDEiQ01361.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi282211.
KEGGibta:282211.

Organism-specific databases

CTDi282211.

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
HOGENOMiHOG000036991.
HOVERGENiHBG015789.
InParanoidiQ01361.
KOiK07414.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01686. EP450ICYP2D.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCP2DE_BOVIN
AccessioniPrimary (citable) accession number: Q01361
Secondary accession number(s): Q29454
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: October 31, 2006
Last modified: October 5, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.