Adenylate cyclase type 6 - Mus musculus (Mouse)

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Reviewed, UniProtKB/Swiss-Prot Q01341 (ADCY6_MOUSE)

Last modified October 13, 2009. Version 90. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Adenylate cyclase type 6
    EC=4.6.1.1
Alternative name(s):
    Adenylate cyclase type VI
    ATP pyrophosphate-lyase 6
    Adenylyl cyclase 6
    Ca(2+)-inhibitable adenylyl cyclase

Gene names

Name:

Adcy6

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length	1165 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

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General annotation (Comments)

Function	Membrane-bound, calcium-inhibitable adenylyl cyclase.
Catalytic activity	ATP = 3',5'-cyclic AMP + diphosphate.
Cofactor	Binds 2 magnesium ions per subunit By similarity.
Enzyme regulation	Inhibition by calcium in the submicromolar concentration range.
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Most abundant in heart but weakly detectable in brain, intestine, lung and spleen.
Sequence similarities	Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. Contains 2 guanylate cyclase domains.

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Ontologies

Keywords
Biological process	cAMP biosynthesis
Cellular component	Membrane
Domain	Repeat Transmembrane
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Lyase
PTM	Glycoprotein Phosphoprotein
Gene Ontology (GO)
Biological process	activation of adenylate cyclase activity Ref.1 Traceable author statement. Source: MGI cAMP biosynthetic process Ref.1 Traceable author statement. Source: MGI intracellular signaling cascade Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Ref.1 Traceable author statement. Source: MGI
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW adenylate cyclase activity Ref.1 Traceable author statement. Source: MGI magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1165

1165

Adenylate cyclase type 6

PRO_0000195700

Regions

Topological domain

1 – 149

149

Cytoplasmic Potential

Transmembrane

150 – 166

Potential

Transmembrane

179 – 195

Potential

Transmembrane

212 – 228

Potential

Transmembrane

237 – 253

Potential

Transmembrane

257 – 273

Potential

Transmembrane

287 – 303

Potential

Topological domain

304 – 670

367

Cytoplasmic Potential

Transmembrane

671 – 688

Potential

Transmembrane

699 – 715

Potential

Transmembrane

740 – 756

Potential

Topological domain

757 – 816

Extracellular Potential

Transmembrane

817 – 833

Potential

Transmembrane

836 – 852

Potential

Transmembrane

894 – 910

Potential

Topological domain

911 – 1165

255

Cytoplasmic Potential

Sites

Metal binding

382

Magnesium 1 By similarity

Metal binding

382

Magnesium 2 By similarity

Metal binding

383

Magnesium 2; via carbonyl oxygen By similarity

Metal binding

426

Magnesium 1 By similarity

Metal binding

426

Magnesium 2 By similarity

Amino acid modifications

Modified residue

Phosphoserine By similarity

Modified residue

573

Phosphoserine By similarity

Glycosylation

277

N-linked (GlcNAc...) Potential

Glycosylation

790

N-linked (GlcNAc...) Potential

Glycosylation

875

N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict

K → N in AAA37182. Ref.2

Sequence conflict

G → A in AAA37182. Ref.2

Sequence conflict

508 – 509

GR → RAG in AAA37182. Ref.2

Sequence conflict

737

V → G in AAA37182. Ref.2

Sequence conflict

881

L → Q in AAA37182. Ref.2

Sequence conflict

990

V → M in AAA37182. Ref.2

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Sequences

Sequence

Length

Mass (Da)

Tools

Q01341-1 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: 24EE1BB45DF1E87E
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FASTA

1,165

130,319

        10         20         30         40         50         60 
MSWFSGLLVP KVDERKTAWG ERNGQKRPRH ANRASGFCAP RYMSCLKNAE PPSPTPAAHT 

        70         80         90        100        110        120 
RCPWQDEAFI RRAGPGRGVE LGLRSVALGF DDTEVTTPMG TAEVAPDTSP RSGPSCWHRL 

       130        140        150        160        170        180 
VQVFQSKQFR SAKLERLYQR YFFQMNQSSL TLLMAVLVLL MAVLLTFHAA PAQPQPAYVA 

       190        200        210        220        230        240 
LLTCASVLFV VLMVVCNRHS FRQDSMWVVS YVVLGILAAV QVGGALAANP HSPSAGLWCP 

       250        260        270        280        290        300 
VFFVYITYTL LPIRMRAAVL SGLGLSTLHL ILAWQLNSSD PFLWKQLGAN VVLFLCTNAI 

       310        320        330        340        350        360 
GVCTHYPAEV SQRQAFQETR GYIQARLHLQ HENRQQERLL LSVLPQHVAM EMKEDINTKK 

       370        380        390        400        410        420 
EDMMFHKIYI QKHDNVSILF ADIEGFTSLA SQCTAQELVM TLNELFARFD KLAAENHCLR 

       430        440        450        460        470        480 
IKILGDCYYC VSGLPEARAD HAHCCVEMGV DMIEAISLVR EVTGVNVNMR VGIHSGRVHC 

       490        500        510        520        530        540 
GVLGLRKWQF DVWSNDVTLA NHMEAGGGRR IHITRATLQY LNGDYEVEPG RGGERNAYLK 

       550        560        570        580        590        600 
EQCIETFLIL GASQKRKEEK AMLAKLQRTR ANSMEGLMPR WVPDRAFSRT KDSKAFRQMG 

       610        620        630        640        650        660 
IDDSSKDNRG AQDALNPEDE VDEFLGRAID ARSIDQLRKD HVRRFLLTFQ REDLEKKYSR 

       670        680        690        700        710        720 
KVDPRFGAYV ACALLVFCFI CFIQLLVFPY STLILGIYAA IFLLLLVTVL ICAVCSCGSF 

       730        740        750        760        770        780 
FPKALQRLSR NIVRSRVHST AVGIFSVLLV FISAIANMFT CNHTPIRTCA ARMLNLTPAD 

       790        800        810        820        830        840 
VTACHLQQLN YSLGLDAPLC EGTAPTCSFP EYFVGNVLLS LLASSVFLHI SSIGKLAMTF 

       850        860        870        880        890        900 
ILGFTYLVLL LLGPPAAIFD NYDLLLGVHG LASSNETFDG LDCPAVGRVA LKYMTPVILL 

       910        920        930        940        950        960 
VFALALYLHA QQVESTARLD FLWKLQATGE KEEMEELQAY NRRLLHNILP KDVAAHFLAR 

       970        980        990       1000       1010       1020 
ERRNDELYYQ SCECVAVMFA SIANFSEFYV ELEANNEGVE CLRLLNEIIA DFDEIISEER 

      1030       1040       1050       1060       1070       1080 
FRQLEKIKTI GSTYMAASGL NASTYDQVGR SHITALADYA MRLMEQMKHI NEHSFNNFQM 

      1090       1100       1110       1120       1130       1140 
KIGLNMGPVV AGVIGARKPQ YDIWGNTVNV SSRMDSTGVP DRIQVTTDLY QVLAAKGYQL 

      1150       1160 
ECRGVVKVKG KGEMTTYFLN GGPSS

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References

[1]	"Cloning and expression of a Ca(2+)-inhibitable adenylyl cyclase from NCB-20 cells." Yoshimura M., Cooper D.M.F. Proc. Natl. Acad. Sci. U.S.A. 89:6716-6720(1992) [PubMed: 1379717] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Lowered responsiveness of the catalyst of adenylyl cyclase to stimulation by GS in heterologous desensitization: a role for adenosine 3',5'-monophosphate-dependent phosphorylation." Premont R.T., Jacobowitz O., Iyengar R. Endocrinology 131:2774-2784(1992) [PubMed: 1332848] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 10-1165.
+	Additional computationally mapped references.

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Cross-references

Sequence databases
	M93422 mRNA. Translation: AAA37174.1. M96653 mRNA. Translation: AAA37182.1.
IPI	IPI00122297.
PIR	A49201.
RefSeq	NP_031431.2.
UniGene	Mm.157091
3D structure databases
HSSP	HSSP built from PDB template 1AZS based on UniProtKB P30803.
SMR	Q01341. Positions 362-550.
ModBase	Search...
Protein-protein interaction databases
STRING	Q01341.
PTM databases
PhosphoSite	Q01341.
Proteomic databases
PRIDE	Q01341.
Genome annotation databases
Ensembl	ENSMUST00000096224; ENSMUSP00000093939; ENSMUSG00000022994; Mus musculus. [Genome view]
GeneID	11512.
KEGG	mmu:11512.
UCSC	uc007xmz.1. mouse.
Organism-specific databases
CTD	11512.
MGI	MGI:87917. Adcy6.
Phylogenomic databases
HOGENOM	Q01341.
HOVERGEN	Q01341.
Enzyme and pathway databases
BRENDA	4.6.1.1. 244.
Gene expression databases
ArrayExpress	Q01341.
Bgee	Q01341.
CleanEx	MM_ADCY6.
Genevestigator	Q01341.
GermOnline	ENSMUSG00000022994. Mus musculus.
Family and domain databases
InterPro	IPR001054. A/G_cyclase. IPR018297. A/G_cyclase_CS. IPR009398. Aden_cycl-like. [Graphical view]
Gene3D	G3DSA:3.30.70.1230. A/G_cyclase. 2 hits.
Pfam	PF06327. DUF1053. 1 hit. PF00211. Guanylate_cyc. 2 hits. [Graphical view]
SMART	SM00044. CYCc. 2 hits. [Graphical view]
PROSITE	PS00452. GUANYLATE_CYCLASE_1. 2 hits. PS50125. GUANYLATE_CYCLASE_2. 2 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	278914.
SOURCE	Search...

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Entry information

Entry name

ADCY6_MOUSE

Accession

Primary (citable) accession number: Q01341

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
Last sequence update:	April 1, 1993
Last modified:	October 13, 2009
This is version 90 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents