Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q01341

- ADCY6_MOUSE

UniProt

Q01341 - ADCY6_MOUSE

Protein

Adenylate cyclase type 6

Gene

Adcy6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 131 (01 Oct 2014)
      Sequence version 1 (01 Apr 1993)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Membrane-bound, calcium-inhibitable adenylyl cyclase.

    Catalytic activityi

    ATP = 3',5'-cyclic AMP + diphosphate.

    Cofactori

    Binds 2 magnesium ions per subunit.By similarity

    Enzyme regulationi

    Inhibition by calcium in the submicromolar concentration range. Phosphorylation by RAF1 results in its activation By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi382 – 3821Magnesium 1PROSITE-ProRule annotation
    Metal bindingi382 – 3821Magnesium 2PROSITE-ProRule annotation
    Metal bindingi383 – 3831Magnesium 2; via carbonyl oxygenPROSITE-ProRule annotation
    Metal bindingi426 – 4261Magnesium 1PROSITE-ProRule annotation
    Metal bindingi426 – 4261Magnesium 2PROSITE-ProRule annotation

    GO - Molecular functioni

    1. adenylate cyclase activity Source: MGI
    2. ATP binding Source: UniProtKB-KW
    3. metal ion binding Source: UniProtKB-KW
    4. protein kinase binding Source: BHF-UCL

    GO - Biological processi

    1. activation of adenylate cyclase activity Source: MGI
    2. cAMP biosynthetic process Source: MGI
    3. intracellular signal transduction Source: InterPro
    4. negative regulation of neuron projection development Source: ParkinsonsUK-UCL

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    cAMP biosynthesis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Adenylate cyclase type 6 (EC:4.6.1.1)
    Alternative name(s):
    ATP pyrophosphate-lyase 6
    Adenylate cyclase type VI
    Adenylyl cyclase 6
    Ca(2+)-inhibitable adenylyl cyclase
    Gene namesi
    Name:Adcy6
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:87917. Adcy6.

    Subcellular locationi

    Membrane 1 Publication; Multi-pass membrane protein 1 Publication. Cell projectioncilium 1 Publication

    GO - Cellular componenti

    1. cilium Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. membrane Source: BHF-UCL
    4. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Cell projection, Cilium, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11651165Adenylate cyclase type 6PRO_0000195700Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi277 – 2771N-linked (GlcNAc...)Sequence Analysis
    Modified residuei553 – 5531PhosphoserineBy similarity
    Modified residuei573 – 5731PhosphoserineBy similarity
    Modified residuei659 – 6591PhosphoserineBy similarity
    Glycosylationi790 – 7901N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi875 – 8751N-linked (GlcNAc...)Sequence Analysis
    Modified residuei916 – 9161PhosphothreonineBy similarity

    Post-translational modificationi

    Phosphorylated by RAF1.By similarity

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiQ01341.
    PRIDEiQ01341.

    PTM databases

    PhosphoSiteiQ01341.

    Expressioni

    Tissue specificityi

    Most abundant in heart but weakly detectable in brain, intestine, lung and spleen.

    Gene expression databases

    CleanExiMM_ADCY6.
    GenevestigatoriQ01341.

    Interactioni

    Subunit structurei

    Part of a complex containing AKAP5, ADCY5, PDE4C and PKD2. Interacts with RAF1 By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000093939.

    Structurei

    3D structure databases

    ProteinModelPortaliQ01341.
    SMRiQ01341. Positions 362-550, 967-1142.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 149149CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini304 – 670367CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini757 – 81660ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini911 – 1165255CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei150 – 16617HelicalSequence AnalysisAdd
    BLAST
    Transmembranei179 – 19517HelicalSequence AnalysisAdd
    BLAST
    Transmembranei212 – 22817HelicalSequence AnalysisAdd
    BLAST
    Transmembranei237 – 25317HelicalSequence AnalysisAdd
    BLAST
    Transmembranei257 – 27317HelicalSequence AnalysisAdd
    BLAST
    Transmembranei287 – 30317HelicalSequence AnalysisAdd
    BLAST
    Transmembranei671 – 68818HelicalSequence AnalysisAdd
    BLAST
    Transmembranei699 – 71517HelicalSequence AnalysisAdd
    BLAST
    Transmembranei740 – 75617HelicalSequence AnalysisAdd
    BLAST
    Transmembranei817 – 83317HelicalSequence AnalysisAdd
    BLAST
    Transmembranei836 – 85217HelicalSequence AnalysisAdd
    BLAST
    Transmembranei894 – 91017HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.PROSITE-ProRule annotation
    Contains 2 guanylate cyclase domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2114.
    HOGENOMiHOG000006941.
    HOVERGENiHBG050458.
    InParanoidiQ01341.
    KOiK08046.
    PhylomeDBiQ01341.

    Family and domain databases

    Gene3Di3.30.70.1230. 2 hits.
    InterProiIPR001054. A/G_cyclase.
    IPR018297. A/G_cyclase_CS.
    IPR009398. Adenylate_cyclase-like.
    [Graphical view]
    PfamiPF06327. DUF1053. 1 hit.
    PF00211. Guanylate_cyc. 2 hits.
    [Graphical view]
    SMARTiSM00044. CYCc. 2 hits.
    [Graphical view]
    SUPFAMiSSF55073. SSF55073. 2 hits.
    PROSITEiPS00452. GUANYLATE_CYCLASE_1. 2 hits.
    PS50125. GUANYLATE_CYCLASE_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q01341-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSWFSGLLVP KVDERKTAWG ERNGQKRPRH ANRASGFCAP RYMSCLKNAE     50
    PPSPTPAAHT RCPWQDEAFI RRAGPGRGVE LGLRSVALGF DDTEVTTPMG 100
    TAEVAPDTSP RSGPSCWHRL VQVFQSKQFR SAKLERLYQR YFFQMNQSSL 150
    TLLMAVLVLL MAVLLTFHAA PAQPQPAYVA LLTCASVLFV VLMVVCNRHS 200
    FRQDSMWVVS YVVLGILAAV QVGGALAANP HSPSAGLWCP VFFVYITYTL 250
    LPIRMRAAVL SGLGLSTLHL ILAWQLNSSD PFLWKQLGAN VVLFLCTNAI 300
    GVCTHYPAEV SQRQAFQETR GYIQARLHLQ HENRQQERLL LSVLPQHVAM 350
    EMKEDINTKK EDMMFHKIYI QKHDNVSILF ADIEGFTSLA SQCTAQELVM 400
    TLNELFARFD KLAAENHCLR IKILGDCYYC VSGLPEARAD HAHCCVEMGV 450
    DMIEAISLVR EVTGVNVNMR VGIHSGRVHC GVLGLRKWQF DVWSNDVTLA 500
    NHMEAGGGRR IHITRATLQY LNGDYEVEPG RGGERNAYLK EQCIETFLIL 550
    GASQKRKEEK AMLAKLQRTR ANSMEGLMPR WVPDRAFSRT KDSKAFRQMG 600
    IDDSSKDNRG AQDALNPEDE VDEFLGRAID ARSIDQLRKD HVRRFLLTFQ 650
    REDLEKKYSR KVDPRFGAYV ACALLVFCFI CFIQLLVFPY STLILGIYAA 700
    IFLLLLVTVL ICAVCSCGSF FPKALQRLSR NIVRSRVHST AVGIFSVLLV 750
    FISAIANMFT CNHTPIRTCA ARMLNLTPAD VTACHLQQLN YSLGLDAPLC 800
    EGTAPTCSFP EYFVGNVLLS LLASSVFLHI SSIGKLAMTF ILGFTYLVLL 850
    LLGPPAAIFD NYDLLLGVHG LASSNETFDG LDCPAVGRVA LKYMTPVILL 900
    VFALALYLHA QQVESTARLD FLWKLQATGE KEEMEELQAY NRRLLHNILP 950
    KDVAAHFLAR ERRNDELYYQ SCECVAVMFA SIANFSEFYV ELEANNEGVE 1000
    CLRLLNEIIA DFDEIISEER FRQLEKIKTI GSTYMAASGL NASTYDQVGR 1050
    SHITALADYA MRLMEQMKHI NEHSFNNFQM KIGLNMGPVV AGVIGARKPQ 1100
    YDIWGNTVNV SSRMDSTGVP DRIQVTTDLY QVLAAKGYQL ECRGVVKVKG 1150
    KGEMTTYFLN GGPSS 1165
    Length:1,165
    Mass (Da):130,319
    Last modified:April 1, 1993 - v1
    Checksum:i24EE1BB45DF1E87E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti47 – 471K → N in AAA37182. (PubMed:1332848)Curated
    Sequence conflicti76 – 761G → A in AAA37182. (PubMed:1332848)Curated
    Sequence conflicti508 – 5092GR → RAG in AAA37182. (PubMed:1332848)Curated
    Sequence conflicti737 – 7371V → G in AAA37182. (PubMed:1332848)Curated
    Sequence conflicti881 – 8811L → Q in AAA37182. (PubMed:1332848)Curated
    Sequence conflicti990 – 9901V → M in AAA37182. (PubMed:1332848)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M93422 mRNA. Translation: AAA37174.1.
    M96653 mRNA. Translation: AAA37182.1.
    PIRiA49201.
    RefSeqiNP_031431.2. NM_007405.2.
    UniGeneiMm.157091.

    Genome annotation databases

    GeneIDi11512.
    KEGGimmu:11512.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M93422 mRNA. Translation: AAA37174.1 .
    M96653 mRNA. Translation: AAA37182.1 .
    PIRi A49201.
    RefSeqi NP_031431.2. NM_007405.2.
    UniGenei Mm.157091.

    3D structure databases

    ProteinModelPortali Q01341.
    SMRi Q01341. Positions 362-550, 967-1142.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000093939.

    Chemistry

    BindingDBi Q01341.

    PTM databases

    PhosphoSitei Q01341.

    Proteomic databases

    PaxDbi Q01341.
    PRIDEi Q01341.

    Protocols and materials databases

    DNASUi 11512.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 11512.
    KEGGi mmu:11512.

    Organism-specific databases

    CTDi 112.
    MGIi MGI:87917. Adcy6.

    Phylogenomic databases

    eggNOGi COG2114.
    HOGENOMi HOG000006941.
    HOVERGENi HBG050458.
    InParanoidi Q01341.
    KOi K08046.
    PhylomeDBi Q01341.

    Miscellaneous databases

    ChiTaRSi ADCY6. mouse.
    NextBioi 278914.
    PROi Q01341.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_ADCY6.
    Genevestigatori Q01341.

    Family and domain databases

    Gene3Di 3.30.70.1230. 2 hits.
    InterProi IPR001054. A/G_cyclase.
    IPR018297. A/G_cyclase_CS.
    IPR009398. Adenylate_cyclase-like.
    [Graphical view ]
    Pfami PF06327. DUF1053. 1 hit.
    PF00211. Guanylate_cyc. 2 hits.
    [Graphical view ]
    SMARTi SM00044. CYCc. 2 hits.
    [Graphical view ]
    SUPFAMi SSF55073. SSF55073. 2 hits.
    PROSITEi PS00452. GUANYLATE_CYCLASE_1. 2 hits.
    PS50125. GUANYLATE_CYCLASE_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and expression of a Ca(2+)-inhibitable adenylyl cyclase from NCB-20 cells."
      Yoshimura M., Cooper D.M.F.
      Proc. Natl. Acad. Sci. U.S.A. 89:6716-6720(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Lowered responsiveness of the catalyst of adenylyl cyclase to stimulation by GS in heterologous desensitization: a role for adenosine 3',5'-monophosphate-dependent phosphorylation."
      Premont R.T., Jacobowitz O., Iyengar R.
      Endocrinology 131:2774-2784(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 10-1165.
    3. "Polycystin-2 and phosphodiesterase 4C are components of a ciliary A-kinase anchoring protein complex that is disrupted in cystic kidney diseases."
      Choi Y.H., Suzuki A., Hajarnis S., Ma Z., Chapin H.C., Caplan M.J., Pontoglio M., Somlo S., Igarashi P.
      Proc. Natl. Acad. Sci. U.S.A. 108:10679-10684(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, INTERACTION WITH AKAP5; ADCY5; PDE4C AND PKD2.

    Entry informationi

    Entry nameiADCY6_MOUSE
    AccessioniPrimary (citable) accession number: Q01341
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: April 1, 1993
    Last modified: October 1, 2014
    This is version 131 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3