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Protein

Adenylate cyclase type 6

Gene

Adcy6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Membrane-bound, calcium-inhibitable adenylyl cyclase.

Catalytic activityi

ATP = 3',5'-cyclic AMP + diphosphate.

Cofactori

Mg2+By similarityNote: Binds 2 magnesium ions per subunit.By similarity

Enzyme regulationi

Inhibition by calcium in the submicromolar concentration range. Phosphorylation by RAF1 results in its activation (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi382 – 3821Magnesium 1PROSITE-ProRule annotation
Metal bindingi382 – 3821Magnesium 2PROSITE-ProRule annotation
Metal bindingi383 – 3831Magnesium 2; via carbonyl oxygenPROSITE-ProRule annotation
Metal bindingi426 – 4261Magnesium 1PROSITE-ProRule annotation
Metal bindingi426 – 4261Magnesium 2PROSITE-ProRule annotation

GO - Molecular functioni

  1. adenylate cyclase activity Source: MGI
  2. ATP binding Source: UniProtKB-KW
  3. metal ion binding Source: UniProtKB-KW
  4. protein kinase binding Source: BHF-UCL

GO - Biological processi

  1. activation of adenylate cyclase activity Source: MGI
  2. cAMP biosynthetic process Source: MGI
  3. cellular response to catecholamine stimulus Source: MGI
  4. cellular response to prostaglandin E stimulus Source: MGI
  5. dopamine receptor signaling pathway Source: MGI
  6. intracellular signal transduction Source: InterPro
  7. negative regulation of neuron projection development Source: ParkinsonsUK-UCL
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

cAMP biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylate cyclase type 6 (EC:4.6.1.1)
Alternative name(s):
ATP pyrophosphate-lyase 6
Adenylate cyclase type VI
Adenylyl cyclase 6
Ca(2+)-inhibitable adenylyl cyclase
Gene namesi
Name:Adcy6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:87917. Adcy6.

Subcellular locationi

Membrane 1 Publication; Multi-pass membrane protein 1 Publication. Cell projectioncilium 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 149149CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei150 – 16617HelicalSequence AnalysisAdd
BLAST
Transmembranei179 – 19517HelicalSequence AnalysisAdd
BLAST
Transmembranei212 – 22817HelicalSequence AnalysisAdd
BLAST
Transmembranei237 – 25317HelicalSequence AnalysisAdd
BLAST
Transmembranei257 – 27317HelicalSequence AnalysisAdd
BLAST
Transmembranei287 – 30317HelicalSequence AnalysisAdd
BLAST
Topological domaini304 – 670367CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei671 – 68818HelicalSequence AnalysisAdd
BLAST
Transmembranei699 – 71517HelicalSequence AnalysisAdd
BLAST
Transmembranei740 – 75617HelicalSequence AnalysisAdd
BLAST
Topological domaini757 – 81660ExtracellularSequence AnalysisAdd
BLAST
Transmembranei817 – 83317HelicalSequence AnalysisAdd
BLAST
Transmembranei836 – 85217HelicalSequence AnalysisAdd
BLAST
Transmembranei894 – 91017HelicalSequence AnalysisAdd
BLAST
Topological domaini911 – 1165255CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cilium Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. membrane Source: BHF-UCL
  4. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11651165Adenylate cyclase type 6PRO_0000195700Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi277 – 2771N-linked (GlcNAc...)Sequence Analysis
Modified residuei553 – 5531PhosphoserineBy similarity
Modified residuei573 – 5731PhosphoserineBy similarity
Modified residuei659 – 6591PhosphoserineBy similarity
Glycosylationi790 – 7901N-linked (GlcNAc...)Sequence Analysis
Glycosylationi875 – 8751N-linked (GlcNAc...)Sequence Analysis
Modified residuei916 – 9161PhosphothreonineBy similarity

Post-translational modificationi

Phosphorylated by RAF1.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ01341.
PaxDbiQ01341.
PRIDEiQ01341.

PTM databases

PhosphoSiteiQ01341.

Expressioni

Tissue specificityi

Most abundant in heart but weakly detectable in brain, intestine, lung and spleen.

Gene expression databases

CleanExiMM_ADCY6.
GenevestigatoriQ01341.

Interactioni

Subunit structurei

Part of a complex containing AKAP5, ADCY5, PDE4C and PKD2. Interacts with RAF1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000093939.

Structurei

3D structure databases

ProteinModelPortaliQ01341.
SMRiQ01341. Positions 362-550, 967-1142.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.PROSITE-ProRule annotation
Contains 2 guanylate cyclase domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2114.
HOGENOMiHOG000006941.
HOVERGENiHBG050458.
InParanoidiQ01341.
KOiK08046.
PhylomeDBiQ01341.

Family and domain databases

Gene3Di3.30.70.1230. 2 hits.
InterProiIPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR009398. Adenylate_cyclase-like.
IPR029787. Nucleotide_cyclase.
[Graphical view]
PfamiPF06327. DUF1053. 1 hit.
PF00211. Guanylate_cyc. 2 hits.
[Graphical view]
SMARTiSM00044. CYCc. 2 hits.
[Graphical view]
SUPFAMiSSF55073. SSF55073. 2 hits.
PROSITEiPS00452. GUANYLATE_CYCLASE_1. 2 hits.
PS50125. GUANYLATE_CYCLASE_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q01341-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWFSGLLVP KVDERKTAWG ERNGQKRPRH ANRASGFCAP RYMSCLKNAE
60 70 80 90 100
PPSPTPAAHT RCPWQDEAFI RRAGPGRGVE LGLRSVALGF DDTEVTTPMG
110 120 130 140 150
TAEVAPDTSP RSGPSCWHRL VQVFQSKQFR SAKLERLYQR YFFQMNQSSL
160 170 180 190 200
TLLMAVLVLL MAVLLTFHAA PAQPQPAYVA LLTCASVLFV VLMVVCNRHS
210 220 230 240 250
FRQDSMWVVS YVVLGILAAV QVGGALAANP HSPSAGLWCP VFFVYITYTL
260 270 280 290 300
LPIRMRAAVL SGLGLSTLHL ILAWQLNSSD PFLWKQLGAN VVLFLCTNAI
310 320 330 340 350
GVCTHYPAEV SQRQAFQETR GYIQARLHLQ HENRQQERLL LSVLPQHVAM
360 370 380 390 400
EMKEDINTKK EDMMFHKIYI QKHDNVSILF ADIEGFTSLA SQCTAQELVM
410 420 430 440 450
TLNELFARFD KLAAENHCLR IKILGDCYYC VSGLPEARAD HAHCCVEMGV
460 470 480 490 500
DMIEAISLVR EVTGVNVNMR VGIHSGRVHC GVLGLRKWQF DVWSNDVTLA
510 520 530 540 550
NHMEAGGGRR IHITRATLQY LNGDYEVEPG RGGERNAYLK EQCIETFLIL
560 570 580 590 600
GASQKRKEEK AMLAKLQRTR ANSMEGLMPR WVPDRAFSRT KDSKAFRQMG
610 620 630 640 650
IDDSSKDNRG AQDALNPEDE VDEFLGRAID ARSIDQLRKD HVRRFLLTFQ
660 670 680 690 700
REDLEKKYSR KVDPRFGAYV ACALLVFCFI CFIQLLVFPY STLILGIYAA
710 720 730 740 750
IFLLLLVTVL ICAVCSCGSF FPKALQRLSR NIVRSRVHST AVGIFSVLLV
760 770 780 790 800
FISAIANMFT CNHTPIRTCA ARMLNLTPAD VTACHLQQLN YSLGLDAPLC
810 820 830 840 850
EGTAPTCSFP EYFVGNVLLS LLASSVFLHI SSIGKLAMTF ILGFTYLVLL
860 870 880 890 900
LLGPPAAIFD NYDLLLGVHG LASSNETFDG LDCPAVGRVA LKYMTPVILL
910 920 930 940 950
VFALALYLHA QQVESTARLD FLWKLQATGE KEEMEELQAY NRRLLHNILP
960 970 980 990 1000
KDVAAHFLAR ERRNDELYYQ SCECVAVMFA SIANFSEFYV ELEANNEGVE
1010 1020 1030 1040 1050
CLRLLNEIIA DFDEIISEER FRQLEKIKTI GSTYMAASGL NASTYDQVGR
1060 1070 1080 1090 1100
SHITALADYA MRLMEQMKHI NEHSFNNFQM KIGLNMGPVV AGVIGARKPQ
1110 1120 1130 1140 1150
YDIWGNTVNV SSRMDSTGVP DRIQVTTDLY QVLAAKGYQL ECRGVVKVKG
1160
KGEMTTYFLN GGPSS
Length:1,165
Mass (Da):130,319
Last modified:April 1, 1993 - v1
Checksum:i24EE1BB45DF1E87E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti47 – 471K → N in AAA37182 (PubMed:1332848).Curated
Sequence conflicti76 – 761G → A in AAA37182 (PubMed:1332848).Curated
Sequence conflicti508 – 5092GR → RAG in AAA37182 (PubMed:1332848).Curated
Sequence conflicti737 – 7371V → G in AAA37182 (PubMed:1332848).Curated
Sequence conflicti881 – 8811L → Q in AAA37182 (PubMed:1332848).Curated
Sequence conflicti990 – 9901V → M in AAA37182 (PubMed:1332848).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M93422 mRNA. Translation: AAA37174.1.
M96653 mRNA. Translation: AAA37182.1.
PIRiA49201.
RefSeqiNP_031431.2. NM_007405.2.
UniGeneiMm.157091.

Genome annotation databases

GeneIDi11512.
KEGGimmu:11512.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M93422 mRNA. Translation: AAA37174.1.
M96653 mRNA. Translation: AAA37182.1.
PIRiA49201.
RefSeqiNP_031431.2. NM_007405.2.
UniGeneiMm.157091.

3D structure databases

ProteinModelPortaliQ01341.
SMRiQ01341. Positions 362-550, 967-1142.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000093939.

PTM databases

PhosphoSiteiQ01341.

Proteomic databases

MaxQBiQ01341.
PaxDbiQ01341.
PRIDEiQ01341.

Protocols and materials databases

DNASUi11512.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi11512.
KEGGimmu:11512.

Organism-specific databases

CTDi112.
MGIiMGI:87917. Adcy6.

Phylogenomic databases

eggNOGiCOG2114.
HOGENOMiHOG000006941.
HOVERGENiHBG050458.
InParanoidiQ01341.
KOiK08046.
PhylomeDBiQ01341.

Miscellaneous databases

ChiTaRSiAdcy6. mouse.
NextBioi278914.
PROiQ01341.
SOURCEiSearch...

Gene expression databases

CleanExiMM_ADCY6.
GenevestigatoriQ01341.

Family and domain databases

Gene3Di3.30.70.1230. 2 hits.
InterProiIPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR009398. Adenylate_cyclase-like.
IPR029787. Nucleotide_cyclase.
[Graphical view]
PfamiPF06327. DUF1053. 1 hit.
PF00211. Guanylate_cyc. 2 hits.
[Graphical view]
SMARTiSM00044. CYCc. 2 hits.
[Graphical view]
SUPFAMiSSF55073. SSF55073. 2 hits.
PROSITEiPS00452. GUANYLATE_CYCLASE_1. 2 hits.
PS50125. GUANYLATE_CYCLASE_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and expression of a Ca(2+)-inhibitable adenylyl cyclase from NCB-20 cells."
    Yoshimura M., Cooper D.M.F.
    Proc. Natl. Acad. Sci. U.S.A. 89:6716-6720(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Lowered responsiveness of the catalyst of adenylyl cyclase to stimulation by GS in heterologous desensitization: a role for adenosine 3',5'-monophosphate-dependent phosphorylation."
    Premont R.T., Jacobowitz O., Iyengar R.
    Endocrinology 131:2774-2784(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 10-1165.
  3. "Polycystin-2 and phosphodiesterase 4C are components of a ciliary A-kinase anchoring protein complex that is disrupted in cystic kidney diseases."
    Choi Y.H., Suzuki A., Hajarnis S., Ma Z., Chapin H.C., Caplan M.J., Pontoglio M., Somlo S., Igarashi P.
    Proc. Natl. Acad. Sci. U.S.A. 108:10679-10684(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INTERACTION WITH AKAP5; ADCY5; PDE4C AND PKD2.

Entry informationi

Entry nameiADCY6_MOUSE
AccessioniPrimary (citable) accession number: Q01341
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: March 4, 2015
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.