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Q01341

- ADCY6_MOUSE

UniProt

Q01341 - ADCY6_MOUSE

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Protein

Adenylate cyclase type 6

Gene
Adcy6
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Membrane-bound, calcium-inhibitable adenylyl cyclase.

Catalytic activityi

ATP = 3',5'-cyclic AMP + diphosphate.

Cofactori

Binds 2 magnesium ions per subunit By similarity.

Enzyme regulationi

Inhibition by calcium in the submicromolar concentration range. Phosphorylation by RAF1 results in its activation By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi382 – 3821Magnesium 1 By similarity
Metal bindingi382 – 3821Magnesium 2 By similarity
Metal bindingi383 – 3831Magnesium 2; via carbonyl oxygen By similarity
Metal bindingi426 – 4261Magnesium 1 By similarity
Metal bindingi426 – 4261Magnesium 2 By similarity

GO - Molecular functioni

  1. adenylate cyclase activity Source: MGI
  2. ATP binding Source: UniProtKB-KW
  3. metal ion binding Source: UniProtKB-KW
  4. protein kinase binding Source: BHF-UCL

GO - Biological processi

  1. activation of adenylate cyclase activity Source: MGI
  2. cAMP biosynthetic process Source: MGI
  3. intracellular signal transduction Source: InterPro
  4. negative regulation of neuron projection development Source: ParkinsonsUK-UCL
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

cAMP biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylate cyclase type 6 (EC:4.6.1.1)
Alternative name(s):
ATP pyrophosphate-lyase 6
Adenylate cyclase type VI
Adenylyl cyclase 6
Ca(2+)-inhibitable adenylyl cyclase
Gene namesi
Name:Adcy6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:87917. Adcy6.

Subcellular locationi

Membrane; Multi-pass membrane protein. Cell projectioncilium 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 149149Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei150 – 16617Helical; Reviewed predictionAdd
BLAST
Transmembranei179 – 19517Helical; Reviewed predictionAdd
BLAST
Transmembranei212 – 22817Helical; Reviewed predictionAdd
BLAST
Transmembranei237 – 25317Helical; Reviewed predictionAdd
BLAST
Transmembranei257 – 27317Helical; Reviewed predictionAdd
BLAST
Transmembranei287 – 30317Helical; Reviewed predictionAdd
BLAST
Topological domaini304 – 670367Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei671 – 68818Helical; Reviewed predictionAdd
BLAST
Transmembranei699 – 71517Helical; Reviewed predictionAdd
BLAST
Transmembranei740 – 75617Helical; Reviewed predictionAdd
BLAST
Topological domaini757 – 81660Extracellular Reviewed predictionAdd
BLAST
Transmembranei817 – 83317Helical; Reviewed predictionAdd
BLAST
Transmembranei836 – 85217Helical; Reviewed predictionAdd
BLAST
Transmembranei894 – 91017Helical; Reviewed predictionAdd
BLAST
Topological domaini911 – 1165255Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. cilium Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. membrane Source: BHF-UCL
  4. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11651165Adenylate cyclase type 6PRO_0000195700Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi277 – 2771N-linked (GlcNAc...) Reviewed prediction
Modified residuei553 – 5531Phosphoserine By similarity
Modified residuei573 – 5731Phosphoserine By similarity
Modified residuei659 – 6591Phosphoserine By similarity
Glycosylationi790 – 7901N-linked (GlcNAc...) Reviewed prediction
Glycosylationi875 – 8751N-linked (GlcNAc...) Reviewed prediction
Modified residuei916 – 9161Phosphothreonine By similarity

Post-translational modificationi

Phosphorylated by RAF1 By similarity.

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ01341.
PRIDEiQ01341.

PTM databases

PhosphoSiteiQ01341.

Expressioni

Tissue specificityi

Most abundant in heart but weakly detectable in brain, intestine, lung and spleen.

Gene expression databases

CleanExiMM_ADCY6.
GenevestigatoriQ01341.

Interactioni

Subunit structurei

Part of a complex containing AKAP5, ADCY5, PDE4C and PKD2. Interacts with RAF1 By similarity.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000093939.

Structurei

3D structure databases

ProteinModelPortaliQ01341.
SMRiQ01341. Positions 362-550, 967-1142.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2114.
HOGENOMiHOG000006941.
HOVERGENiHBG050458.
InParanoidiQ01341.
KOiK08046.
PhylomeDBiQ01341.

Family and domain databases

Gene3Di3.30.70.1230. 2 hits.
InterProiIPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR009398. Adenylate_cyclase-like.
[Graphical view]
PfamiPF06327. DUF1053. 1 hit.
PF00211. Guanylate_cyc. 2 hits.
[Graphical view]
SMARTiSM00044. CYCc. 2 hits.
[Graphical view]
SUPFAMiSSF55073. SSF55073. 2 hits.
PROSITEiPS00452. GUANYLATE_CYCLASE_1. 2 hits.
PS50125. GUANYLATE_CYCLASE_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q01341-1 [UniParc]FASTAAdd to Basket

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MSWFSGLLVP KVDERKTAWG ERNGQKRPRH ANRASGFCAP RYMSCLKNAE     50
PPSPTPAAHT RCPWQDEAFI RRAGPGRGVE LGLRSVALGF DDTEVTTPMG 100
TAEVAPDTSP RSGPSCWHRL VQVFQSKQFR SAKLERLYQR YFFQMNQSSL 150
TLLMAVLVLL MAVLLTFHAA PAQPQPAYVA LLTCASVLFV VLMVVCNRHS 200
FRQDSMWVVS YVVLGILAAV QVGGALAANP HSPSAGLWCP VFFVYITYTL 250
LPIRMRAAVL SGLGLSTLHL ILAWQLNSSD PFLWKQLGAN VVLFLCTNAI 300
GVCTHYPAEV SQRQAFQETR GYIQARLHLQ HENRQQERLL LSVLPQHVAM 350
EMKEDINTKK EDMMFHKIYI QKHDNVSILF ADIEGFTSLA SQCTAQELVM 400
TLNELFARFD KLAAENHCLR IKILGDCYYC VSGLPEARAD HAHCCVEMGV 450
DMIEAISLVR EVTGVNVNMR VGIHSGRVHC GVLGLRKWQF DVWSNDVTLA 500
NHMEAGGGRR IHITRATLQY LNGDYEVEPG RGGERNAYLK EQCIETFLIL 550
GASQKRKEEK AMLAKLQRTR ANSMEGLMPR WVPDRAFSRT KDSKAFRQMG 600
IDDSSKDNRG AQDALNPEDE VDEFLGRAID ARSIDQLRKD HVRRFLLTFQ 650
REDLEKKYSR KVDPRFGAYV ACALLVFCFI CFIQLLVFPY STLILGIYAA 700
IFLLLLVTVL ICAVCSCGSF FPKALQRLSR NIVRSRVHST AVGIFSVLLV 750
FISAIANMFT CNHTPIRTCA ARMLNLTPAD VTACHLQQLN YSLGLDAPLC 800
EGTAPTCSFP EYFVGNVLLS LLASSVFLHI SSIGKLAMTF ILGFTYLVLL 850
LLGPPAAIFD NYDLLLGVHG LASSNETFDG LDCPAVGRVA LKYMTPVILL 900
VFALALYLHA QQVESTARLD FLWKLQATGE KEEMEELQAY NRRLLHNILP 950
KDVAAHFLAR ERRNDELYYQ SCECVAVMFA SIANFSEFYV ELEANNEGVE 1000
CLRLLNEIIA DFDEIISEER FRQLEKIKTI GSTYMAASGL NASTYDQVGR 1050
SHITALADYA MRLMEQMKHI NEHSFNNFQM KIGLNMGPVV AGVIGARKPQ 1100
YDIWGNTVNV SSRMDSTGVP DRIQVTTDLY QVLAAKGYQL ECRGVVKVKG 1150
KGEMTTYFLN GGPSS 1165
Length:1,165
Mass (Da):130,319
Last modified:April 1, 1993 - v1
Checksum:i24EE1BB45DF1E87E
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti47 – 471K → N in AAA37182. 1 Publication
Sequence conflicti76 – 761G → A in AAA37182. 1 Publication
Sequence conflicti508 – 5092GR → RAG in AAA37182. 1 Publication
Sequence conflicti737 – 7371V → G in AAA37182. 1 Publication
Sequence conflicti881 – 8811L → Q in AAA37182. 1 Publication
Sequence conflicti990 – 9901V → M in AAA37182. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M93422 mRNA. Translation: AAA37174.1.
M96653 mRNA. Translation: AAA37182.1.
PIRiA49201.
RefSeqiNP_031431.2. NM_007405.2.
UniGeneiMm.157091.

Genome annotation databases

GeneIDi11512.
KEGGimmu:11512.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M93422 mRNA. Translation: AAA37174.1 .
M96653 mRNA. Translation: AAA37182.1 .
PIRi A49201.
RefSeqi NP_031431.2. NM_007405.2.
UniGenei Mm.157091.

3D structure databases

ProteinModelPortali Q01341.
SMRi Q01341. Positions 362-550, 967-1142.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000093939.

Chemistry

BindingDBi Q01341.

PTM databases

PhosphoSitei Q01341.

Proteomic databases

PaxDbi Q01341.
PRIDEi Q01341.

Protocols and materials databases

DNASUi 11512.
Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 11512.
KEGGi mmu:11512.

Organism-specific databases

CTDi 112.
MGIi MGI:87917. Adcy6.

Phylogenomic databases

eggNOGi COG2114.
HOGENOMi HOG000006941.
HOVERGENi HBG050458.
InParanoidi Q01341.
KOi K08046.
PhylomeDBi Q01341.

Miscellaneous databases

ChiTaRSi ADCY6. mouse.
NextBioi 278914.
PROi Q01341.
SOURCEi Search...

Gene expression databases

CleanExi MM_ADCY6.
Genevestigatori Q01341.

Family and domain databases

Gene3Di 3.30.70.1230. 2 hits.
InterProi IPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR009398. Adenylate_cyclase-like.
[Graphical view ]
Pfami PF06327. DUF1053. 1 hit.
PF00211. Guanylate_cyc. 2 hits.
[Graphical view ]
SMARTi SM00044. CYCc. 2 hits.
[Graphical view ]
SUPFAMi SSF55073. SSF55073. 2 hits.
PROSITEi PS00452. GUANYLATE_CYCLASE_1. 2 hits.
PS50125. GUANYLATE_CYCLASE_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and expression of a Ca(2+)-inhibitable adenylyl cyclase from NCB-20 cells."
    Yoshimura M., Cooper D.M.F.
    Proc. Natl. Acad. Sci. U.S.A. 89:6716-6720(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Lowered responsiveness of the catalyst of adenylyl cyclase to stimulation by GS in heterologous desensitization: a role for adenosine 3',5'-monophosphate-dependent phosphorylation."
    Premont R.T., Jacobowitz O., Iyengar R.
    Endocrinology 131:2774-2784(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 10-1165.
  3. "Polycystin-2 and phosphodiesterase 4C are components of a ciliary A-kinase anchoring protein complex that is disrupted in cystic kidney diseases."
    Choi Y.H., Suzuki A., Hajarnis S., Ma Z., Chapin H.C., Caplan M.J., Pontoglio M., Somlo S., Igarashi P.
    Proc. Natl. Acad. Sci. U.S.A. 108:10679-10684(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INTERACTION WITH AKAP5; ADCY5; PDE4C AND PKD2.

Entry informationi

Entry nameiADCY6_MOUSE
AccessioniPrimary (citable) accession number: Q01341
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: September 3, 2014
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi