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Reviewed, UniProtKB/Swiss-Prot Q01341 (ADCY6_MOUSE)

Last modified October 13, 2009. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Adenylate cyclase type 6
    EC=4.6.1.1
Alternative name(s):
    Adenylate cyclase type VI
    ATP pyrophosphate-lyase 6
    Adenylyl cyclase 6
    Ca(2+)-inhibitable adenylyl cyclase
Gene names
Name: Adcy6
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMus

Protein attributes

Sequence length1165 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Membrane-bound, calcium-inhibitable adenylyl cyclase.

Catalytic activity

ATP = 3',5'-cyclic AMP + diphosphate.

Cofactor

Binds 2 magnesium ions per subunit By similarity.

Enzyme regulation

Inhibition by calcium in the submicromolar concentration range.

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Most abundant in heart but weakly detectable in brain, intestine, lung and spleen.

Sequence similarities

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

Contains 2 guanylate cyclase domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11651165Adenylate cyclase type 6
PRO_0000195700

Regions

Topological domain1 – 149149Cytoplasmic Potential
Transmembrane150 – 16617 Potential
Transmembrane179 – 19517 Potential
Transmembrane212 – 22817 Potential
Transmembrane237 – 25317 Potential
Transmembrane257 – 27317 Potential
Transmembrane287 – 30317 Potential
Topological domain304 – 670367Cytoplasmic Potential
Transmembrane671 – 68818 Potential
Transmembrane699 – 71517 Potential
Transmembrane740 – 75617 Potential
Topological domain757 – 81660Extracellular Potential
Transmembrane817 – 83317 Potential
Transmembrane836 – 85217 Potential
Transmembrane894 – 91017 Potential
Topological domain911 – 1165255Cytoplasmic Potential

Sites

Metal binding3821Magnesium 1 By similarity
Metal binding3821Magnesium 2 By similarity
Metal binding3831Magnesium 2; via carbonyl oxygen By similarity
Metal binding4261Magnesium 1 By similarity
Metal binding4261Magnesium 2 By similarity

Amino acid modifications

Modified residue531Phosphoserine By similarity
Modified residue5731Phosphoserine By similarity
Glycosylation2771N-linked (GlcNAc...) Potential
Glycosylation7901N-linked (GlcNAc...) Potential
Glycosylation8751N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict471K → N in AAA37182. Ref.2
Sequence conflict761G → A in AAA37182. Ref.2
Sequence conflict508 – 5092GR → RAG in AAA37182. Ref.2
Sequence conflict7371V → G in AAA37182. Ref.2
Sequence conflict8811L → Q in AAA37182. Ref.2
Sequence conflict9901V → M in AAA37182. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q01341-1 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: 24EE1BB45DF1E87E

FASTA1,165130,319
        10         20         30         40         50         60 
MSWFSGLLVP KVDERKTAWG ERNGQKRPRH ANRASGFCAP RYMSCLKNAE PPSPTPAAHT 

        70         80         90        100        110        120 
RCPWQDEAFI RRAGPGRGVE LGLRSVALGF DDTEVTTPMG TAEVAPDTSP RSGPSCWHRL 

       130        140        150        160        170        180 
VQVFQSKQFR SAKLERLYQR YFFQMNQSSL TLLMAVLVLL MAVLLTFHAA PAQPQPAYVA 

       190        200        210        220        230        240 
LLTCASVLFV VLMVVCNRHS FRQDSMWVVS YVVLGILAAV QVGGALAANP HSPSAGLWCP 

       250        260        270        280        290        300 
VFFVYITYTL LPIRMRAAVL SGLGLSTLHL ILAWQLNSSD PFLWKQLGAN VVLFLCTNAI 

       310        320        330        340        350        360 
GVCTHYPAEV SQRQAFQETR GYIQARLHLQ HENRQQERLL LSVLPQHVAM EMKEDINTKK 

       370        380        390        400        410        420 
EDMMFHKIYI QKHDNVSILF ADIEGFTSLA SQCTAQELVM TLNELFARFD KLAAENHCLR 

       430        440        450        460        470        480 
IKILGDCYYC VSGLPEARAD HAHCCVEMGV DMIEAISLVR EVTGVNVNMR VGIHSGRVHC 

       490        500        510        520        530        540 
GVLGLRKWQF DVWSNDVTLA NHMEAGGGRR IHITRATLQY LNGDYEVEPG RGGERNAYLK 

       550        560        570        580        590        600 
EQCIETFLIL GASQKRKEEK AMLAKLQRTR ANSMEGLMPR WVPDRAFSRT KDSKAFRQMG 

       610        620        630        640        650        660 
IDDSSKDNRG AQDALNPEDE VDEFLGRAID ARSIDQLRKD HVRRFLLTFQ REDLEKKYSR 

       670        680        690        700        710        720 
KVDPRFGAYV ACALLVFCFI CFIQLLVFPY STLILGIYAA IFLLLLVTVL ICAVCSCGSF 

       730        740        750        760        770        780 
FPKALQRLSR NIVRSRVHST AVGIFSVLLV FISAIANMFT CNHTPIRTCA ARMLNLTPAD 

       790        800        810        820        830        840 
VTACHLQQLN YSLGLDAPLC EGTAPTCSFP EYFVGNVLLS LLASSVFLHI SSIGKLAMTF 

       850        860        870        880        890        900 
ILGFTYLVLL LLGPPAAIFD NYDLLLGVHG LASSNETFDG LDCPAVGRVA LKYMTPVILL 

       910        920        930        940        950        960 
VFALALYLHA QQVESTARLD FLWKLQATGE KEEMEELQAY NRRLLHNILP KDVAAHFLAR 

       970        980        990       1000       1010       1020 
ERRNDELYYQ SCECVAVMFA SIANFSEFYV ELEANNEGVE CLRLLNEIIA DFDEIISEER 

      1030       1040       1050       1060       1070       1080 
FRQLEKIKTI GSTYMAASGL NASTYDQVGR SHITALADYA MRLMEQMKHI NEHSFNNFQM 

      1090       1100       1110       1120       1130       1140 
KIGLNMGPVV AGVIGARKPQ YDIWGNTVNV SSRMDSTGVP DRIQVTTDLY QVLAAKGYQL 

      1150       1160 
ECRGVVKVKG KGEMTTYFLN GGPSS 

« Hide

References

[1]"Cloning and expression of a Ca(2+)-inhibitable adenylyl cyclase from NCB-20 cells."
Yoshimura M., Cooper D.M.F.
Proc. Natl. Acad. Sci. U.S.A. 89:6716-6720(1992) [PubMed: 1379717] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Lowered responsiveness of the catalyst of adenylyl cyclase to stimulation by GS in heterologous desensitization: a role for adenosine 3',5'-monophosphate-dependent phosphorylation."
Premont R.T., Jacobowitz O., Iyengar R.
Endocrinology 131:2774-2784(1992) [PubMed: 1332848] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 10-1165.
+Additional computationally mapped references.

Cross-references

Sequence databases

M93422 mRNA. Translation: AAA37174.1.
M96653 mRNA. Translation: AAA37182.1.
IPIIPI00122297.
PIRA49201.
RefSeqNP_031431.2.
UniGeneMm.157091

3D structure databases

HSSPHSSP built from PDB template 1AZS based on UniProtKB P30803.
SMRQ01341. Positions 362-550.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ01341.

PTM databases

PhosphoSiteQ01341.

Proteomic databases

PRIDEQ01341.

Genome annotation databases

EnsemblENSMUST00000096224; ENSMUSP00000093939; ENSMUSG00000022994; Mus musculus. [Genome view]
GeneID11512.
KEGGmmu:11512.
UCSCuc007xmz.1. mouse.

Organism-specific databases

CTD11512.
MGIMGI:87917. Adcy6.

Phylogenomic databases

HOGENOMQ01341.
HOVERGENQ01341.

Enzyme and pathway databases

BRENDA4.6.1.1. 244.

Gene expression databases

ArrayExpressQ01341.
BgeeQ01341.
CleanExMM_ADCY6.
GenevestigatorQ01341.
GermOnlineENSMUSG00000022994. Mus musculus.

Family and domain databases

InterProIPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR009398. Aden_cycl-like.
[Graphical view]
Gene3DG3DSA:3.30.70.1230. A/G_cyclase. 2 hits.
PfamPF06327. DUF1053. 1 hit.
PF00211. Guanylate_cyc. 2 hits.
[Graphical view]
SMARTSM00044. CYCc. 2 hits.
[Graphical view]
PROSITEPS00452. GUANYLATE_CYCLASE_1. 2 hits.
PS50125. GUANYLATE_CYCLASE_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio278914.
SOURCESearch...

Entry information

Entry nameADCY6_MOUSE
AccessionPrimary (citable) accession number: Q01341
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: October 13, 2009
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents