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Q01339

- APOH_MOUSE

UniProt

Q01339 - APOH_MOUSE

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Protein

Beta-2-glycoprotein 1

Gene

Apoh

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.

GO - Molecular functioni

  1. heparin binding Source: UniProtKB-KW
  2. lipoprotein lipase activator activity Source: Ensembl
  3. phospholipid binding Source: Ensembl

GO - Biological processi

  1. blood coagulation, intrinsic pathway Source: Ensembl
  2. negative regulation of angiogenesis Source: Ensembl
  3. negative regulation of blood coagulation Source: Ensembl
  4. negative regulation of endothelial cell migration Source: Ensembl
  5. negative regulation of endothelial cell proliferation Source: Ensembl
  6. negative regulation of fibrinolysis Source: Ensembl
  7. negative regulation of myeloid cell apoptotic process Source: Ensembl
  8. negative regulation of smooth muscle cell apoptotic process Source: Ensembl
  9. plasminogen activation Source: Ensembl
  10. positive regulation of lipoprotein lipase activity Source: Ensembl
  11. regulation of blood coagulation Source: MGI
  12. triglyceride metabolic process Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Heparin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-2-glycoprotein 1
Alternative name(s):
APC inhibitor
Activated protein C-binding protein
Apolipoprotein H
Short name:
Apo-H
Beta-2-glycoprotein I
Short name:
B2GPI
Short name:
Beta(2)GPI
Gene namesi
Name:Apoh
Synonyms:B2gp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:88058. Apoh.

Subcellular locationi

GO - Cellular componenti

  1. cell surface Source: Ensembl
  2. chylomicron Source: Ensembl
  3. extracellular matrix Source: Ensembl
  4. extracellular space Source: MGI
  5. extracellular vesicular exosome Source: Ensembl
  6. high-density lipoprotein particle Source: Ensembl
  7. very-low-density lipoprotein particle Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Add
BLAST
Chaini20 – 345326Beta-2-glycoprotein 1PRO_0000002060Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi23 ↔ 66PROSITE-ProRule annotation
Disulfide bondi51 ↔ 79PROSITE-ProRule annotation
Disulfide bondi84 ↔ 124PROSITE-ProRule annotation
Glycosylationi105 – 1051N-linked (GlcNAc...)1 Publication
Disulfide bondi110 ↔ 137PROSITE-ProRule annotation
Glycosylationi117 – 1171N-linked (GlcNAc...)2 Publications
Disulfide bondi142 ↔ 188PROSITE-ProRule annotation
Glycosylationi162 – 1621N-linked (GlcNAc...)2 Publications
Disulfide bondi174 ↔ 200PROSITE-ProRule annotation
Glycosylationi183 – 1831N-linked (GlcNAc...)1 Publication
Glycosylationi193 – 1931N-linked (GlcNAc...)1 Publication
Disulfide bondi205 ↔ 248PROSITE-ProRule annotation
Disulfide bondi234 ↔ 260PROSITE-ProRule annotation
Disulfide bondi264 ↔ 315PROSITE-ProRule annotation
Disulfide bondi300 ↔ 325PROSITE-ProRule annotation
Disulfide bondi307 ↔ 345PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ01339.
PaxDbiQ01339.
PRIDEiQ01339.

PTM databases

PhosphoSiteiQ01339.

Expressioni

Tissue specificityi

Expressed by the liver and secreted in plasma.

Gene expression databases

BgeeiQ01339.
CleanExiMM_APOH.
ExpressionAtlasiQ01339. baseline and differential.
GenevestigatoriQ01339.

Interactioni

Protein-protein interaction databases

IntActiQ01339. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ01339.
SMRiQ01339. Positions 20-345.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 8161Sushi 1PROSITE-ProRule annotationAdd
BLAST
Domaini82 – 13958Sushi 2PROSITE-ProRule annotationAdd
BLAST
Domaini140 – 20263Sushi 3PROSITE-ProRule annotationAdd
BLAST
Domaini203 – 26260Sushi 4PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni263 – 34583Sushi-likeAdd
BLAST

Sequence similaritiesi

Contains 4 Sushi (CCP/SCR) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Sushi

Phylogenomic databases

eggNOGiNOG323950.
GeneTreeiENSGT00760000118803.
HOGENOMiHOG000034008.
HOVERGENiHBG004271.
InParanoidiQ01339.
KOiK17305.
OMAiRFTCPLT.
PhylomeDBiQ01339.
TreeFamiTF334137.

Family and domain databases

InterProiIPR015104. Sushi_2.
IPR000436. Sushi_SCR_CCP.
[Graphical view]
PfamiPF00084. Sushi. 4 hits.
PF09014. Sushi_2. 1 hit.
[Graphical view]
ProDomiPD012422. Sushi_2. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00032. CCP. 5 hits.
[Graphical view]
SUPFAMiSSF57535. SSF57535. 5 hits.
PROSITEiPS50923. SUSHI. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q01339 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVSPVLALFS AFLCHVAIAG RICPKPDDLP FATVVPLKTS YDPGEQIVYS
60 70 80 90 100
CKPGYVSRGG MRRFTCPLTG MWPINTLRCV PRVCPFAGIL ENGIVRYTSF
110 120 130 140 150
EYPKNISFAC NPGFFLNGTS SSKCTEEGKW SPDIPACARI TCPPPPVPKF
160 170 180 190 200
ALLKDYRPSA GNNSLYQDTV VFKCLPHFAM IGNDTVMCTE QGNWTRLPEC
210 220 230 240 250
LEVKCPFPPR PENGYVNYPA KPVLLYKDKA TFGCHETYKL DGPEEAECTK
260 270 280 290 300
TGTWSFLPTC RESCKLPVKK ATVLYQGMRV KIQEQFKNGM MHGDKIHFYC
310 320 330 340
KNKEKKCSYT VEAHCRDGTI EIPSCFKEHS SLAFWKTDAS ELTPC
Length:345
Mass (Da):38,619
Last modified:April 1, 1993 - v1
Checksum:iC83F8A6EBD51C940
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti252 – 2521G → R in AAB30789. (PubMed:7514402)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D10056 mRNA. Translation: BAA00945.1.
S70439 mRNA. Translation: AAB30789.1.
Y11356 mRNA. Translation: CAA72190.1.
BC019811 mRNA. Translation: AAH19811.1.
BC053338 mRNA. Translation: AAH53338.1.
CCDSiCCDS25574.1.
PIRiA43286. NBMS.
RefSeqiNP_038503.4. NM_013475.4.
UniGeneiMm.2266.

Genome annotation databases

EnsembliENSMUST00000000049; ENSMUSP00000000049; ENSMUSG00000000049.
GeneIDi11818.
KEGGimmu:11818.
UCSCiuc007mbp.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D10056 mRNA. Translation: BAA00945.1 .
S70439 mRNA. Translation: AAB30789.1 .
Y11356 mRNA. Translation: CAA72190.1 .
BC019811 mRNA. Translation: AAH19811.1 .
BC053338 mRNA. Translation: AAH53338.1 .
CCDSi CCDS25574.1.
PIRi A43286. NBMS.
RefSeqi NP_038503.4. NM_013475.4.
UniGenei Mm.2266.

3D structure databases

ProteinModelPortali Q01339.
SMRi Q01339. Positions 20-345.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q01339. 1 interaction.

PTM databases

PhosphoSitei Q01339.

Proteomic databases

MaxQBi Q01339.
PaxDbi Q01339.
PRIDEi Q01339.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000000049 ; ENSMUSP00000000049 ; ENSMUSG00000000049 .
GeneIDi 11818.
KEGGi mmu:11818.
UCSCi uc007mbp.2. mouse.

Organism-specific databases

CTDi 350.
MGIi MGI:88058. Apoh.

Phylogenomic databases

eggNOGi NOG323950.
GeneTreei ENSGT00760000118803.
HOGENOMi HOG000034008.
HOVERGENi HBG004271.
InParanoidi Q01339.
KOi K17305.
OMAi RFTCPLT.
PhylomeDBi Q01339.
TreeFami TF334137.

Miscellaneous databases

NextBioi 279707.
PROi Q01339.
SOURCEi Search...

Gene expression databases

Bgeei Q01339.
CleanExi MM_APOH.
ExpressionAtlasi Q01339. baseline and differential.
Genevestigatori Q01339.

Family and domain databases

InterProi IPR015104. Sushi_2.
IPR000436. Sushi_SCR_CCP.
[Graphical view ]
Pfami PF00084. Sushi. 4 hits.
PF09014. Sushi_2. 1 hit.
[Graphical view ]
ProDomi PD012422. Sushi_2. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00032. CCP. 5 hits.
[Graphical view ]
SUPFAMi SSF57535. SSF57535. 5 hits.
PROSITEi PS50923. SUSHI. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of mouse beta 2-glycoprotein I and mapping of the gene to chromosome 11."
    Nonaka M., Matsuda Y., Shiroishi T., Moriwak K., Natsuume-Sakai S.
    Genomics 13:1082-1087(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Characterization, expression and evolution of mouse beta 2-glycoprotein I (apolipoprotein H)."
    Sellar G.C., Steel D.M., Zafiropoulos A., Seery L.T., Whitehead A.S.
    Biochem. Biophys. Res. Commun. 200:1521-1528(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: CBA/J.
    Tissue: Liver.
  3. "Structure of the human beta-2-glycoprotein I gene."
    Kristensen T.
    Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Liver.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Liver.
  5. "Proteome-wide characterization of N-glycosylation events by diagonal chromatography."
    Ghesquiere B., Van Damme J., Martens L., Vandekerckhove J., Gevaert K.
    J. Proteome Res. 5:2438-2447(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-117 AND ASN-162.
    Strain: C57BL/6.
    Tissue: Plasma.
  6. "Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides."
    Bernhard O.K., Kapp E.A., Simpson R.J.
    J. Proteome Res. 6:987-995(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-105; ASN-117; ASN-162; ASN-183 AND ASN-193.
    Strain: C57BL/6.
    Tissue: Plasma.

Entry informationi

Entry nameiAPOH_MOUSE
AccessioniPrimary (citable) accession number: Q01339
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: October 29, 2014
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3