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Q01339

- APOH_MOUSE

UniProt

Q01339 - APOH_MOUSE

Protein

Beta-2-glycoprotein 1

Gene

Apoh

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 1 (01 Apr 1993)
      Previous versions | rss
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    Functioni

    Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.

    GO - Molecular functioni

    1. heparin binding Source: UniProtKB-KW
    2. lipoprotein lipase activator activity Source: Ensembl
    3. phospholipid binding Source: Ensembl

    GO - Biological processi

    1. blood coagulation, intrinsic pathway Source: Ensembl
    2. negative regulation of angiogenesis Source: Ensembl
    3. negative regulation of blood coagulation Source: Ensembl
    4. negative regulation of endothelial cell migration Source: Ensembl
    5. negative regulation of endothelial cell proliferation Source: Ensembl
    6. negative regulation of fibrinolysis Source: Ensembl
    7. negative regulation of myeloid cell apoptotic process Source: Ensembl
    8. negative regulation of smooth muscle cell apoptotic process Source: Ensembl
    9. plasminogen activation Source: Ensembl
    10. positive regulation of lipoprotein lipase activity Source: Ensembl
    11. regulation of blood coagulation Source: MGI
    12. triglyceride metabolic process Source: Ensembl

    Keywords - Ligandi

    Heparin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-2-glycoprotein 1
    Alternative name(s):
    APC inhibitor
    Activated protein C-binding protein
    Apolipoprotein H
    Short name:
    Apo-H
    Beta-2-glycoprotein I
    Short name:
    B2GPI
    Short name:
    Beta(2)GPI
    Gene namesi
    Name:Apoh
    Synonyms:B2gp1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:88058. Apoh.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: Ensembl
    2. chylomicron Source: Ensembl
    3. extracellular matrix Source: Ensembl
    4. extracellular space Source: MGI
    5. high-density lipoprotein particle Source: Ensembl
    6. very-low-density lipoprotein particle Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Add
    BLAST
    Chaini20 – 345326Beta-2-glycoprotein 1PRO_0000002060Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi23 ↔ 66PROSITE-ProRule annotation
    Disulfide bondi51 ↔ 79PROSITE-ProRule annotation
    Disulfide bondi84 ↔ 124PROSITE-ProRule annotation
    Glycosylationi105 – 1051N-linked (GlcNAc...)1 Publication
    Disulfide bondi110 ↔ 137PROSITE-ProRule annotation
    Glycosylationi117 – 1171N-linked (GlcNAc...)2 Publications
    Disulfide bondi142 ↔ 188PROSITE-ProRule annotation
    Glycosylationi162 – 1621N-linked (GlcNAc...)2 Publications
    Disulfide bondi174 ↔ 200PROSITE-ProRule annotation
    Glycosylationi183 – 1831N-linked (GlcNAc...)1 Publication
    Glycosylationi193 – 1931N-linked (GlcNAc...)1 Publication
    Disulfide bondi205 ↔ 248PROSITE-ProRule annotation
    Disulfide bondi234 ↔ 260PROSITE-ProRule annotation
    Disulfide bondi264 ↔ 315PROSITE-ProRule annotation
    Disulfide bondi300 ↔ 325PROSITE-ProRule annotation
    Disulfide bondi307 ↔ 345PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ01339.
    PaxDbiQ01339.
    PRIDEiQ01339.

    PTM databases

    PhosphoSiteiQ01339.

    Expressioni

    Tissue specificityi

    Expressed by the liver and secreted in plasma.

    Gene expression databases

    ArrayExpressiQ01339.
    BgeeiQ01339.
    CleanExiMM_APOH.
    GenevestigatoriQ01339.

    Interactioni

    Protein-protein interaction databases

    IntActiQ01339. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ01339.
    SMRiQ01339. Positions 20-345.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini21 – 8161Sushi 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini82 – 13958Sushi 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini140 – 20263Sushi 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini203 – 26260Sushi 4PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni263 – 34583Sushi-likeAdd
    BLAST

    Sequence similaritiesi

    Contains 4 Sushi (CCP/SCR) domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Sushi

    Phylogenomic databases

    eggNOGiNOG323950.
    GeneTreeiENSGT00750000117418.
    HOGENOMiHOG000034008.
    HOVERGENiHBG004271.
    InParanoidiQ01339.
    KOiK17305.
    OMAiRFTCPLT.
    PhylomeDBiQ01339.
    TreeFamiTF334137.

    Family and domain databases

    InterProiIPR015104. Sushi_2.
    IPR000436. Sushi_SCR_CCP.
    [Graphical view]
    PfamiPF00084. Sushi. 4 hits.
    PF09014. Sushi_2. 1 hit.
    [Graphical view]
    ProDomiPD012422. Sushi_2. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00032. CCP. 5 hits.
    [Graphical view]
    SUPFAMiSSF57535. SSF57535. 5 hits.
    PROSITEiPS50923. SUSHI. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q01339-1 [UniParc]FASTAAdd to Basket

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    MVSPVLALFS AFLCHVAIAG RICPKPDDLP FATVVPLKTS YDPGEQIVYS    50
    CKPGYVSRGG MRRFTCPLTG MWPINTLRCV PRVCPFAGIL ENGIVRYTSF 100
    EYPKNISFAC NPGFFLNGTS SSKCTEEGKW SPDIPACARI TCPPPPVPKF 150
    ALLKDYRPSA GNNSLYQDTV VFKCLPHFAM IGNDTVMCTE QGNWTRLPEC 200
    LEVKCPFPPR PENGYVNYPA KPVLLYKDKA TFGCHETYKL DGPEEAECTK 250
    TGTWSFLPTC RESCKLPVKK ATVLYQGMRV KIQEQFKNGM MHGDKIHFYC 300
    KNKEKKCSYT VEAHCRDGTI EIPSCFKEHS SLAFWKTDAS ELTPC 345
    Length:345
    Mass (Da):38,619
    Last modified:April 1, 1993 - v1
    Checksum:iC83F8A6EBD51C940
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti252 – 2521G → R in AAB30789. (PubMed:7514402)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D10056 mRNA. Translation: BAA00945.1.
    S70439 mRNA. Translation: AAB30789.1.
    Y11356 mRNA. Translation: CAA72190.1.
    BC019811 mRNA. Translation: AAH19811.1.
    BC053338 mRNA. Translation: AAH53338.1.
    CCDSiCCDS25574.1.
    PIRiA43286. NBMS.
    RefSeqiNP_038503.4. NM_013475.4.
    UniGeneiMm.2266.

    Genome annotation databases

    EnsembliENSMUST00000000049; ENSMUSP00000000049; ENSMUSG00000000049.
    GeneIDi11818.
    KEGGimmu:11818.
    UCSCiuc007mbp.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D10056 mRNA. Translation: BAA00945.1 .
    S70439 mRNA. Translation: AAB30789.1 .
    Y11356 mRNA. Translation: CAA72190.1 .
    BC019811 mRNA. Translation: AAH19811.1 .
    BC053338 mRNA. Translation: AAH53338.1 .
    CCDSi CCDS25574.1.
    PIRi A43286. NBMS.
    RefSeqi NP_038503.4. NM_013475.4.
    UniGenei Mm.2266.

    3D structure databases

    ProteinModelPortali Q01339.
    SMRi Q01339. Positions 20-345.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q01339. 1 interaction.

    PTM databases

    PhosphoSitei Q01339.

    Proteomic databases

    MaxQBi Q01339.
    PaxDbi Q01339.
    PRIDEi Q01339.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000000049 ; ENSMUSP00000000049 ; ENSMUSG00000000049 .
    GeneIDi 11818.
    KEGGi mmu:11818.
    UCSCi uc007mbp.2. mouse.

    Organism-specific databases

    CTDi 350.
    MGIi MGI:88058. Apoh.

    Phylogenomic databases

    eggNOGi NOG323950.
    GeneTreei ENSGT00750000117418.
    HOGENOMi HOG000034008.
    HOVERGENi HBG004271.
    InParanoidi Q01339.
    KOi K17305.
    OMAi RFTCPLT.
    PhylomeDBi Q01339.
    TreeFami TF334137.

    Miscellaneous databases

    NextBioi 279707.
    PROi Q01339.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q01339.
    Bgeei Q01339.
    CleanExi MM_APOH.
    Genevestigatori Q01339.

    Family and domain databases

    InterProi IPR015104. Sushi_2.
    IPR000436. Sushi_SCR_CCP.
    [Graphical view ]
    Pfami PF00084. Sushi. 4 hits.
    PF09014. Sushi_2. 1 hit.
    [Graphical view ]
    ProDomi PD012422. Sushi_2. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00032. CCP. 5 hits.
    [Graphical view ]
    SUPFAMi SSF57535. SSF57535. 5 hits.
    PROSITEi PS50923. SUSHI. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of mouse beta 2-glycoprotein I and mapping of the gene to chromosome 11."
      Nonaka M., Matsuda Y., Shiroishi T., Moriwak K., Natsuume-Sakai S.
      Genomics 13:1082-1087(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Characterization, expression and evolution of mouse beta 2-glycoprotein I (apolipoprotein H)."
      Sellar G.C., Steel D.M., Zafiropoulos A., Seery L.T., Whitehead A.S.
      Biochem. Biophys. Res. Commun. 200:1521-1528(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: CBA/J.
      Tissue: Liver.
    3. "Structure of the human beta-2-glycoprotein I gene."
      Kristensen T.
      Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Liver.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Liver.
    5. "Proteome-wide characterization of N-glycosylation events by diagonal chromatography."
      Ghesquiere B., Van Damme J., Martens L., Vandekerckhove J., Gevaert K.
      J. Proteome Res. 5:2438-2447(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-117 AND ASN-162.
      Strain: C57BL/6.
      Tissue: Plasma.
    6. "Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides."
      Bernhard O.K., Kapp E.A., Simpson R.J.
      J. Proteome Res. 6:987-995(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-105; ASN-117; ASN-162; ASN-183 AND ASN-193.
      Strain: C57BL/6.
      Tissue: Plasma.

    Entry informationi

    Entry nameiAPOH_MOUSE
    AccessioniPrimary (citable) accession number: Q01339
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: April 1, 1993
    Last modified: October 1, 2014
    This is version 119 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3