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Q01339 (APOH_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 118. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-2-glycoprotein 1
Alternative name(s):
APC inhibitor
Activated protein C-binding protein
Apolipoprotein H
Short name=Apo-H
Beta-2-glycoprotein I
Short name=B2GPI
Short name=Beta(2)GPI
Gene names
Name:Apoh
Synonyms:B2gp1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length345 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.

Subcellular location

Secreted.

Tissue specificity

Expressed by the liver and secreted in plasma.

Sequence similarities

Contains 4 Sushi (CCP/SCR) domains.

Ontologies

Keywords
   Cellular componentSecreted
   DomainRepeat
Signal
Sushi
   LigandHeparin-binding
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processblood coagulation, intrinsic pathway

Inferred from electronic annotation. Source: Ensembl

negative regulation of angiogenesis

Inferred from electronic annotation. Source: Ensembl

negative regulation of blood coagulation

Inferred from electronic annotation. Source: Ensembl

negative regulation of endothelial cell migration

Inferred from electronic annotation. Source: Ensembl

negative regulation of endothelial cell proliferation

Inferred from electronic annotation. Source: Ensembl

negative regulation of fibrinolysis

Inferred from electronic annotation. Source: Ensembl

negative regulation of myeloid cell apoptotic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of smooth muscle cell apoptotic process

Inferred from electronic annotation. Source: Ensembl

plasminogen activation

Inferred from electronic annotation. Source: Ensembl

positive regulation of lipoprotein lipase activity

Inferred from electronic annotation. Source: Ensembl

regulation of blood coagulation

Inferred from mutant phenotype PubMed 11145969. Source: MGI

triglyceride metabolic process

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcell surface

Inferred from electronic annotation. Source: Ensembl

chylomicron

Inferred from electronic annotation. Source: Ensembl

extracellular matrix

Inferred from electronic annotation. Source: Ensembl

extracellular space

Inferred from direct assay PubMed 11145969. Source: MGI

high-density lipoprotein particle

Inferred from electronic annotation. Source: Ensembl

very-low-density lipoprotein particle

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionheparin binding

Inferred from electronic annotation. Source: UniProtKB-KW

lipoprotein lipase activator activity

Inferred from electronic annotation. Source: Ensembl

phospholipid binding

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919
Chain20 – 345326Beta-2-glycoprotein 1
PRO_0000002060

Regions

Domain21 – 8161Sushi 1
Domain82 – 13958Sushi 2
Domain140 – 20263Sushi 3
Domain203 – 26260Sushi 4
Region263 – 34583Sushi-like

Amino acid modifications

Glycosylation1051N-linked (GlcNAc...) Ref.6
Glycosylation1171N-linked (GlcNAc...) Ref.5 Ref.6
Glycosylation1621N-linked (GlcNAc...) Ref.5 Ref.6
Glycosylation1831N-linked (GlcNAc...) Ref.6
Glycosylation1931N-linked (GlcNAc...) Ref.6
Disulfide bond23 ↔ 66 By similarity
Disulfide bond51 ↔ 79 By similarity
Disulfide bond84 ↔ 124 By similarity
Disulfide bond110 ↔ 137 By similarity
Disulfide bond142 ↔ 188 By similarity
Disulfide bond174 ↔ 200 By similarity
Disulfide bond205 ↔ 248 By similarity
Disulfide bond234 ↔ 260 By similarity
Disulfide bond264 ↔ 315 By similarity
Disulfide bond300 ↔ 325 By similarity
Disulfide bond307 ↔ 345 By similarity

Experimental info

Sequence conflict2521G → R in AAB30789. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q01339 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: C83F8A6EBD51C940

FASTA34538,619
        10         20         30         40         50         60 
MVSPVLALFS AFLCHVAIAG RICPKPDDLP FATVVPLKTS YDPGEQIVYS CKPGYVSRGG 

        70         80         90        100        110        120 
MRRFTCPLTG MWPINTLRCV PRVCPFAGIL ENGIVRYTSF EYPKNISFAC NPGFFLNGTS 

       130        140        150        160        170        180 
SSKCTEEGKW SPDIPACARI TCPPPPVPKF ALLKDYRPSA GNNSLYQDTV VFKCLPHFAM 

       190        200        210        220        230        240 
IGNDTVMCTE QGNWTRLPEC LEVKCPFPPR PENGYVNYPA KPVLLYKDKA TFGCHETYKL 

       250        260        270        280        290        300 
DGPEEAECTK TGTWSFLPTC RESCKLPVKK ATVLYQGMRV KIQEQFKNGM MHGDKIHFYC 

       310        320        330        340 
KNKEKKCSYT VEAHCRDGTI EIPSCFKEHS SLAFWKTDAS ELTPC 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning of mouse beta 2-glycoprotein I and mapping of the gene to chromosome 11."
Nonaka M., Matsuda Y., Shiroishi T., Moriwak K., Natsuume-Sakai S.
Genomics 13:1082-1087(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Characterization, expression and evolution of mouse beta 2-glycoprotein I (apolipoprotein H)."
Sellar G.C., Steel D.M., Zafiropoulos A., Seery L.T., Whitehead A.S.
Biochem. Biophys. Res. Commun. 200:1521-1528(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: CBA/J.
Tissue: Liver.
[3]"Structure of the human beta-2-glycoprotein I gene."
Kristensen T.
Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
Tissue: Liver.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Liver.
[5]"Proteome-wide characterization of N-glycosylation events by diagonal chromatography."
Ghesquiere B., Van Damme J., Martens L., Vandekerckhove J., Gevaert K.
J. Proteome Res. 5:2438-2447(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-117 AND ASN-162.
Strain: C57BL/6.
Tissue: Plasma.
[6]"Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides."
Bernhard O.K., Kapp E.A., Simpson R.J.
J. Proteome Res. 6:987-995(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-105; ASN-117; ASN-162; ASN-183 AND ASN-193.
Strain: C57BL/6.
Tissue: Plasma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D10056 mRNA. Translation: BAA00945.1.
S70439 mRNA. Translation: AAB30789.1.
Y11356 mRNA. Translation: CAA72190.1.
BC019811 mRNA. Translation: AAH19811.1.
BC053338 mRNA. Translation: AAH53338.1.
CCDSCCDS25574.1.
PIRNBMS. A43286.
RefSeqNP_038503.4. NM_013475.4.
UniGeneMm.2266.

3D structure databases

ProteinModelPortalQ01339.
SMRQ01339. Positions 20-345.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ01339. 1 interaction.

PTM databases

PhosphoSiteQ01339.

Proteomic databases

MaxQBQ01339.
PaxDbQ01339.
PRIDEQ01339.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000000049; ENSMUSP00000000049; ENSMUSG00000000049.
GeneID11818.
KEGGmmu:11818.
UCSCuc007mbp.2. mouse.

Organism-specific databases

CTD350.
MGIMGI:88058. Apoh.

Phylogenomic databases

eggNOGNOG323950.
GeneTreeENSGT00750000117418.
HOGENOMHOG000034008.
HOVERGENHBG004271.
InParanoidQ01339.
KOK17305.
OMARFTCPLT.
PhylomeDBQ01339.
TreeFamTF334137.

Gene expression databases

ArrayExpressQ01339.
BgeeQ01339.
CleanExMM_APOH.
GenevestigatorQ01339.

Family and domain databases

InterProIPR015104. Sushi_2.
IPR000436. Sushi_SCR_CCP.
[Graphical view]
PfamPF00084. Sushi. 4 hits.
PF09014. Sushi_2. 1 hit.
[Graphical view]
ProDomPD012422. Sushi_2. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00032. CCP. 5 hits.
[Graphical view]
SUPFAMSSF57535. SSF57535. 5 hits.
PROSITEPS50923. SUSHI. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio279707.
PROQ01339.
SOURCESearch...

Entry information

Entry nameAPOH_MOUSE
AccessionPrimary (citable) accession number: Q01339
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: July 9, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot