Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Beta-2-glycoprotein 1

Gene

Apoh

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHeparin-binding

Enzyme and pathway databases

ReactomeiR-MMU-114608 Platelet degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-2-glycoprotein 1
Alternative name(s):
APC inhibitor
Activated protein C-binding protein
Apolipoprotein H
Short name:
Apo-H
Beta-2-glycoprotein I
Short name:
B2GPI
Short name:
Beta(2)GPI
Gene namesi
Name:Apoh
Synonyms:B2gp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:88058 Apoh

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Add BLAST19
ChainiPRO_000000206020 – 345Beta-2-glycoprotein 1Add BLAST326

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi23 ↔ 66PROSITE-ProRule annotation
Glycosylationi33O-linked (GalNAc...) threonineBy similarity1
Disulfide bondi51 ↔ 79PROSITE-ProRule annotation
Disulfide bondi84 ↔ 124PROSITE-ProRule annotation
Glycosylationi105N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi110 ↔ 137PROSITE-ProRule annotation
Glycosylationi117N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi142 ↔ 188PROSITE-ProRule annotation
Glycosylationi162N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi174 ↔ 200PROSITE-ProRule annotation
Glycosylationi183N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi193N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi205 ↔ 248PROSITE-ProRule annotation
Disulfide bondi234 ↔ 260PROSITE-ProRule annotation
Disulfide bondi264 ↔ 315PROSITE-ProRule annotation
Disulfide bondi300 ↔ 325PROSITE-ProRule annotation
Disulfide bondi307 ↔ 345PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ01339
PaxDbiQ01339
PeptideAtlasiQ01339
PRIDEiQ01339

PTM databases

GlyConnecti652
iPTMnetiQ01339
PhosphoSitePlusiQ01339
SwissPalmiQ01339

Expressioni

Tissue specificityi

Expressed by the liver and secreted in plasma.

Gene expression databases

BgeeiENSMUSG00000000049
CleanExiMM_APOH
ExpressionAtlasiQ01339 baseline and differential
GenevisibleiQ01339 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198165, 1 interactor
IntActiQ01339, 1 interactor
STRINGi10090.ENSMUSP00000000049

Structurei

3D structure databases

ProteinModelPortaliQ01339
SMRiQ01339
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 81Sushi 1PROSITE-ProRule annotationAdd BLAST61
Domaini82 – 139Sushi 2PROSITE-ProRule annotationAdd BLAST58
Domaini140 – 202Sushi 3PROSITE-ProRule annotationAdd BLAST63
Domaini203 – 262Sushi 4PROSITE-ProRule annotationAdd BLAST60

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni263 – 345Sushi-likeAdd BLAST83

Keywords - Domaini

Repeat, Signal, Sushi

Phylogenomic databases

eggNOGiKOG4297 Eukaryota
ENOG410XPJ1 LUCA
GeneTreeiENSGT00910000143999
HOGENOMiHOG000034008
HOVERGENiHBG004271
InParanoidiQ01339
KOiK17305
OMAiKNKEKKC
OrthoDBiEOG091G0AFE
PhylomeDBiQ01339
TreeFamiTF334137

Family and domain databases

CDDicd00033 CCP, 4 hits
InterProiView protein in InterPro
IPR035976 Sushi/SCR/CCP_sf
IPR015104 Sushi_2
IPR000436 Sushi_SCR_CCP_dom
PfamiView protein in Pfam
PF00084 Sushi, 4 hits
PF09014 Sushi_2, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD012422 Sushi_2, 1 hit
SMARTiView protein in SMART
SM00032 CCP, 5 hits
SUPFAMiSSF57535 SSF57535, 5 hits
PROSITEiView protein in PROSITE
PS50923 SUSHI, 4 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q01339-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSPVLALFS AFLCHVAIAG RICPKPDDLP FATVVPLKTS YDPGEQIVYS
60 70 80 90 100
CKPGYVSRGG MRRFTCPLTG MWPINTLRCV PRVCPFAGIL ENGIVRYTSF
110 120 130 140 150
EYPKNISFAC NPGFFLNGTS SSKCTEEGKW SPDIPACARI TCPPPPVPKF
160 170 180 190 200
ALLKDYRPSA GNNSLYQDTV VFKCLPHFAM IGNDTVMCTE QGNWTRLPEC
210 220 230 240 250
LEVKCPFPPR PENGYVNYPA KPVLLYKDKA TFGCHETYKL DGPEEAECTK
260 270 280 290 300
TGTWSFLPTC RESCKLPVKK ATVLYQGMRV KIQEQFKNGM MHGDKIHFYC
310 320 330 340
KNKEKKCSYT VEAHCRDGTI EIPSCFKEHS SLAFWKTDAS ELTPC
Length:345
Mass (Da):38,619
Last modified:April 1, 1993 - v1
Checksum:iC83F8A6EBD51C940
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti252G → R in AAB30789 (PubMed:7514402).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10056 mRNA Translation: BAA00945.1
S70439 mRNA Translation: AAB30789.1
Y11356 mRNA Translation: CAA72190.1
BC019811 mRNA Translation: AAH19811.1
BC053338 mRNA Translation: AAH53338.1
CCDSiCCDS25574.1
PIRiA43286 NBMS
RefSeqiNP_038503.4, NM_013475.4
UniGeneiMm.2266

Genome annotation databases

EnsembliENSMUST00000000049; ENSMUSP00000000049; ENSMUSG00000000049
GeneIDi11818
KEGGimmu:11818
UCSCiuc007mbp.2 mouse

Similar proteinsi

Entry informationi

Entry nameiAPOH_MOUSE
AccessioniPrimary (citable) accession number: Q01339
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: April 25, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health