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Protein

Alpha-2A adrenergic receptor

Gene

Adra2a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei113 – 1131Implicated in ligand bindingBy similarity
Sitei200 – 2001Implicated in catechol agonist bindingBy similarity
Sitei204 – 2041Implicated in catechol agonist bindingBy similarity

GO - Molecular functioni

  1. alpha2-adrenergic receptor activity Source: Ensembl
  2. epinephrine binding Source: Ensembl
  3. norepinephrine binding Source: Ensembl

GO - Biological processi

  1. activation of MAPK activity by adrenergic receptor signaling pathway Source: Ensembl
  2. activation of protein kinase B activity Source: Ensembl
  3. acute inflammatory response Source: Ensembl
  4. adenylate cyclase-inhibiting adrenergic receptor signaling pathway Source: Ensembl
  5. cellular response to hormone stimulus Source: Ensembl
  6. DNA replication Source: Ensembl
  7. epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway Source: Ensembl
  8. female pregnancy Source: Ensembl
  9. glucose homeostasis Source: Ensembl
  10. negative regulation of calcium ion-dependent exocytosis Source: Ensembl
  11. negative regulation of insulin secretion involved in cellular response to glucose stimulus Source: Ensembl
  12. negative regulation of lipid catabolic process Source: Ensembl
  13. negative regulation of uterine smooth muscle contraction Source: Ensembl
  14. phospholipase C-activating adrenergic receptor signaling pathway Source: Ensembl
  15. platelet activation Source: InterPro
  16. positive regulation of cell migration Source: Ensembl
  17. positive regulation of cytokine production Source: Ensembl
  18. positive regulation of membrane protein ectodomain proteolysis Source: Ensembl
  19. positive regulation of vasodilation Source: Ensembl
  20. positive regulation of wound healing Source: Ensembl
  21. regulation of vasoconstriction Source: InterPro
  22. thermoception Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_272374. Adrenaline,noradrenaline inhibits insulin secretion.
REACT_292251. Adrenoceptors.
REACT_296380. G alpha (z) signalling events.
REACT_305269. Adrenaline signalling through Alpha-2 adrenergic receptor.
REACT_331048. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-2A adrenergic receptor
Alternative name(s):
Alpha-2A adrenoreceptor
Short name:
Alpha-2A adrenoceptor
Short name:
Alpha-2AAR
Gene namesi
Name:Adra2a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:87934. Adra2a.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3333ExtracellularBy similarityAdd
BLAST
Transmembranei34 – 5926Helical; Name=1By similarityAdd
BLAST
Topological domaini60 – 7011CytoplasmicBy similarityAdd
BLAST
Transmembranei71 – 9626Helical; Name=2By similarityAdd
BLAST
Topological domaini97 – 10610ExtracellularBy similarity
Transmembranei107 – 12923Helical; Name=3By similarityAdd
BLAST
Topological domaini130 – 14920CytoplasmicBy similarityAdd
BLAST
Transmembranei150 – 17324Helical; Name=4By similarityAdd
BLAST
Topological domaini174 – 19219ExtracellularBy similarityAdd
BLAST
Transmembranei193 – 21725Helical; Name=5By similarityAdd
BLAST
Topological domaini218 – 374157CytoplasmicBy similarityAdd
BLAST
Transmembranei375 – 39925Helical; Name=6By similarityAdd
BLAST
Topological domaini400 – 40910ExtracellularBy similarity
Transmembranei410 – 43021Helical; Name=7By similarityAdd
BLAST
Topological domaini431 – 45020CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. integral component of plasma membrane Source: Ensembl
  3. receptor complex Source: Ensembl
  4. synapse Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 450450Alpha-2A adrenergic receptorPRO_0000069081Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi10 – 101N-linked (GlcNAc...)Sequence Analysis
Glycosylationi14 – 141N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi106 ↔ 188PROSITE-ProRule annotation
Lipidationi442 – 4421S-palmitoyl cysteineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

MaxQBiQ01338.
PRIDEiQ01338.

PTM databases

PhosphoSiteiQ01338.

Expressioni

Gene expression databases

BgeeiQ01338.
CleanExiMM_ADRA2A.
ExpressionAtlasiQ01338. baseline and differential.
GenevestigatoriQ01338.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
EIF2B1Q142322EBI-491073,EBI-491065From a different organism.

Protein-protein interaction databases

IntActiQ01338. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ01338.
SMRiQ01338. Positions 33-442.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2A sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG249628.
HOVERGENiHBG106962.
InParanoidiQ01338.
PhylomeDBiQ01338.

Family and domain databases

InterProiIPR002233. ADR_fam.
IPR001946. ADRA2A_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24248:SF24. PTHR24248:SF24. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01103. ADRENERGICR.
PR00558. ADRENRGCA2AR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q01338-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSLQPDAGN SSWNGTEAPG GGTRATPYSL QVTLTLVCLA GLLMLFTVFG
60 70 80 90 100
NVLVIIAVFT SRALKAPQNL FLVSLASADI LVATLVIPFS LANEVMGYWY
110 120 130 140 150
FGKVWCEIYL ALDVLFCTSS IVHLCAISLD RYWSITQAIE YNLKRTPRRI
160 170 180 190 200
KAIIVTVWVI SAVISFPPLI SIEKKGAGGG QQPAEPSCKI NDQKWYVISS
210 220 230 240 250
SIGSFFAPCL IMILVYVRIY QIAKRRTRVP PSRRGPDACS APPGGADRRP
260 270 280 290 300
NGLGPERGAG PTGAEAEPLP TQLNGAPGEP APAGPRDGDA LDLEESSSSE
310 320 330 340 350
HAERPPGPRR PDRGPRAKGK TRASQVKPGD SLPRRGPGAA GPGASGSGHG
360 370 380 390 400
EERGGGAKAS RWRGRQNREK RFTFVLAVVI GVFVVCWFPF FFTYTLIAVG
410 420 430 440 450
CPVPSQLFNF FFWFGYCNSS LNPVIYTIFN HDFRRAFKKI LCRGDRKRIV
Length:450
Mass (Da):48,865
Last modified:March 31, 1993 - v1
Checksum:iF07E225393AFA93B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M99377 Genomic DNA. Translation: AAA37213.1.
PIRiI49481.
UniGeneiMm.235195.
Mm.489007.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M99377 Genomic DNA. Translation: AAA37213.1.
PIRiI49481.
UniGeneiMm.235195.
Mm.489007.

3D structure databases

ProteinModelPortaliQ01338.
SMRiQ01338. Positions 33-442.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ01338. 1 interaction.

Chemistry

BindingDBiQ01338.
ChEMBLiCHEMBL2111338.
GuidetoPHARMACOLOGYi25.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ01338.

Proteomic databases

MaxQBiQ01338.
PRIDEiQ01338.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:87934. Adra2a.

Phylogenomic databases

eggNOGiNOG249628.
HOVERGENiHBG106962.
InParanoidiQ01338.
PhylomeDBiQ01338.

Enzyme and pathway databases

ReactomeiREACT_272374. Adrenaline,noradrenaline inhibits insulin secretion.
REACT_292251. Adrenoceptors.
REACT_296380. G alpha (z) signalling events.
REACT_305269. Adrenaline signalling through Alpha-2 adrenergic receptor.
REACT_331048. G alpha (i) signalling events.

Miscellaneous databases

PROiQ01338.
SOURCEiSearch...

Gene expression databases

BgeeiQ01338.
CleanExiMM_ADRA2A.
ExpressionAtlasiQ01338. baseline and differential.
GenevestigatoriQ01338.

Family and domain databases

InterProiIPR002233. ADR_fam.
IPR001946. ADRA2A_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24248:SF24. PTHR24248:SF24. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01103. ADRENERGICR.
PR00558. ADRENRGCA2AR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning of two mouse genes encoding alpha 2-adrenergic receptor subtypes and identification of a single amino acid in the mouse alpha 2-C10 homolog responsible for an interspecies variation in antagonist binding."
    Link R.E., Daunt D.A., Barsh G., Chruscinski A.J., Kobilka B.K.
    Mol. Pharmacol. 42:16-27(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiADA2A_MOUSE
AccessioniPrimary (citable) accession number: Q01338
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 31, 1993
Last sequence update: March 31, 1993
Last modified: March 31, 2015
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.