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Q01338

- ADA2A_MOUSE

UniProt

Q01338 - ADA2A_MOUSE

Protein

Alpha-2A adrenergic receptor

Gene

Adra2a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 125 (01 Oct 2014)
      Sequence version 1 (01 Apr 1993)
      Previous versions | rss
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    Functioni

    Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei113 – 1131Implicated in ligand bindingBy similarity
    Sitei200 – 2001Implicated in catechol agonist bindingBy similarity
    Sitei204 – 2041Implicated in catechol agonist bindingBy similarity

    GO - Molecular functioni

    1. alpha2-adrenergic receptor activity Source: Ensembl
    2. epinephrine binding Source: Ensembl
    3. norepinephrine binding Source: Ensembl
    4. protein binding Source: IntAct

    GO - Biological processi

    1. activation of MAPK activity by adrenergic receptor signaling pathway Source: Ensembl
    2. activation of protein kinase B activity Source: Ensembl
    3. acute inflammatory response Source: Ensembl
    4. adenylate cyclase-inhibiting adrenergic receptor signaling pathway Source: Ensembl
    5. cellular response to hormone stimulus Source: Ensembl
    6. DNA replication Source: Ensembl
    7. epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway Source: Ensembl
    8. female pregnancy Source: Ensembl
    9. glucose homeostasis Source: Ensembl
    10. negative regulation of calcium ion-dependent exocytosis Source: Ensembl
    11. negative regulation of insulin secretion involved in cellular response to glucose stimulus Source: Ensembl
    12. negative regulation of lipid catabolic process Source: Ensembl
    13. negative regulation of uterine smooth muscle contraction Source: Ensembl
    14. phospholipase C-activating adrenergic receptor signaling pathway Source: Ensembl
    15. platelet activation Source: InterPro
    16. positive regulation of cell migration Source: Ensembl
    17. positive regulation of cytokine production Source: Ensembl
    18. positive regulation of membrane protein ectodomain proteolysis Source: Ensembl
    19. positive regulation of vasodilation Source: Ensembl
    20. positive regulation of wound healing Source: Ensembl
    21. regulation of vasoconstriction Source: InterPro
    22. thermoception Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha-2A adrenergic receptor
    Alternative name(s):
    Alpha-2A adrenoreceptor
    Short name:
    Alpha-2A adrenoceptor
    Short name:
    Alpha-2AAR
    Gene namesi
    Name:Adra2a
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:87934. Adra2a.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. integral component of plasma membrane Source: Ensembl
    3. receptor complex Source: Ensembl
    4. synapse Source: Ensembl

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 450450Alpha-2A adrenergic receptorPRO_0000069081Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi10 – 101N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi14 – 141N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi106 ↔ 188PROSITE-ProRule annotation
    Lipidationi442 – 4421S-palmitoyl cysteineBy similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PRIDEiQ01338.

    PTM databases

    PhosphoSiteiQ01338.

    Expressioni

    Gene expression databases

    ArrayExpressiQ01338.
    BgeeiQ01338.
    CleanExiMM_ADRA2A.
    GenevestigatoriQ01338.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    EIF2B1Q142322EBI-491073,EBI-491065From a different organism.

    Protein-protein interaction databases

    IntActiQ01338. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ01338.
    SMRiQ01338. Positions 39-229, 368-441.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3333ExtracellularBy similarityAdd
    BLAST
    Topological domaini60 – 7011CytoplasmicBy similarityAdd
    BLAST
    Topological domaini97 – 10610ExtracellularBy similarity
    Topological domaini130 – 14920CytoplasmicBy similarityAdd
    BLAST
    Topological domaini174 – 19219ExtracellularBy similarityAdd
    BLAST
    Topological domaini218 – 374157CytoplasmicBy similarityAdd
    BLAST
    Topological domaini400 – 40910ExtracellularBy similarity
    Topological domaini431 – 45020CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei34 – 5926Helical; Name=1By similarityAdd
    BLAST
    Transmembranei71 – 9626Helical; Name=2By similarityAdd
    BLAST
    Transmembranei107 – 12923Helical; Name=3By similarityAdd
    BLAST
    Transmembranei150 – 17324Helical; Name=4By similarityAdd
    BLAST
    Transmembranei193 – 21725Helical; Name=5By similarityAdd
    BLAST
    Transmembranei375 – 39925Helical; Name=6By similarityAdd
    BLAST
    Transmembranei410 – 43021Helical; Name=7By similarityAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2A sub-subfamily.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG249628.
    HOVERGENiHBG106962.
    InParanoidiQ01338.
    PhylomeDBiQ01338.

    Family and domain databases

    Gene3Di1.20.1070.10. 2 hits.
    InterProiIPR002233. ADR_fam.
    IPR001946. ADRA2A_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24248:SF24. PTHR24248:SF24. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR01103. ADRENERGICR.
    PR00558. ADRENRGCA2AR.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q01338-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGSLQPDAGN SSWNGTEAPG GGTRATPYSL QVTLTLVCLA GLLMLFTVFG    50
    NVLVIIAVFT SRALKAPQNL FLVSLASADI LVATLVIPFS LANEVMGYWY 100
    FGKVWCEIYL ALDVLFCTSS IVHLCAISLD RYWSITQAIE YNLKRTPRRI 150
    KAIIVTVWVI SAVISFPPLI SIEKKGAGGG QQPAEPSCKI NDQKWYVISS 200
    SIGSFFAPCL IMILVYVRIY QIAKRRTRVP PSRRGPDACS APPGGADRRP 250
    NGLGPERGAG PTGAEAEPLP TQLNGAPGEP APAGPRDGDA LDLEESSSSE 300
    HAERPPGPRR PDRGPRAKGK TRASQVKPGD SLPRRGPGAA GPGASGSGHG 350
    EERGGGAKAS RWRGRQNREK RFTFVLAVVI GVFVVCWFPF FFTYTLIAVG 400
    CPVPSQLFNF FFWFGYCNSS LNPVIYTIFN HDFRRAFKKI LCRGDRKRIV 450
    Length:450
    Mass (Da):48,865
    Last modified:April 1, 1993 - v1
    Checksum:iF07E225393AFA93B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M99377 Genomic DNA. Translation: AAA37213.1.
    PIRiI49481.
    UniGeneiMm.235195.
    Mm.489007.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M99377 Genomic DNA. Translation: AAA37213.1 .
    PIRi I49481.
    UniGenei Mm.235195.
    Mm.489007.

    3D structure databases

    ProteinModelPortali Q01338.
    SMRi Q01338. Positions 39-229, 368-441.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q01338. 1 interaction.

    Chemistry

    BindingDBi Q01338.
    ChEMBLi CHEMBL2111338.
    GuidetoPHARMACOLOGYi 25.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q01338.

    Proteomic databases

    PRIDEi Q01338.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:87934. Adra2a.

    Phylogenomic databases

    eggNOGi NOG249628.
    HOVERGENi HBG106962.
    InParanoidi Q01338.
    PhylomeDBi Q01338.

    Miscellaneous databases

    PROi Q01338.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q01338.
    Bgeei Q01338.
    CleanExi MM_ADRA2A.
    Genevestigatori Q01338.

    Family and domain databases

    Gene3Di 1.20.1070.10. 2 hits.
    InterProi IPR002233. ADR_fam.
    IPR001946. ADRA2A_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24248:SF24. PTHR24248:SF24. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR01103. ADRENERGICR.
    PR00558. ADRENRGCA2AR.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of two mouse genes encoding alpha 2-adrenergic receptor subtypes and identification of a single amino acid in the mouse alpha 2-C10 homolog responsible for an interspecies variation in antagonist binding."
      Link R.E., Daunt D.A., Barsh G., Chruscinski A.J., Kobilka B.K.
      Mol. Pharmacol. 42:16-27(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiADA2A_MOUSE
    AccessioniPrimary (citable) accession number: Q01338
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: April 1, 1993
    Last modified: October 1, 2014
    This is version 125 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3