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Q01337

- ADA2C_MOUSE

UniProt

Q01337 - ADA2C_MOUSE

Protein

Alpha-2C adrenergic receptor

Gene

Adra2c

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 1 (01 Apr 1993)
      Previous versions | rss
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    Functioni

    Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei131 – 1311Implicated in ligand bindingBy similarity
    Sitei214 – 2141Implicated in catechol agonist binding and receptor activationBy similarity
    Sitei218 – 2181Implicated in catechol agonist binding and receptor activationBy similarity

    GO - Molecular functioni

    1. alpha2-adrenergic receptor activity Source: MGI
    2. epinephrine binding Source: Ensembl
    3. G-protein coupled receptor activity Source: MGI

    GO - Biological processi

    1. activation of MAPK activity by adrenergic receptor signaling pathway Source: Ensembl
    2. activation of protein kinase B activity Source: Ensembl
    3. epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway Source: Ensembl
    4. female pregnancy Source: Ensembl
    5. G-protein coupled receptor signaling pathway Source: MGI
    6. negative regulation of uterine smooth muscle contraction Source: Ensembl
    7. platelet activation Source: InterPro
    8. positive regulation of neuron differentiation Source: Ensembl
    9. positive regulation of vasoconstriction Source: Ensembl
    10. regulation of sensory perception of pain Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha-2C adrenergic receptor
    Alternative name(s):
    Alpha-2 adrenergic receptor subtype C4
    Alpha-2C adrenoreceptor
    Short name:
    Alpha-2C adrenoceptor
    Short name:
    Alpha-2CAR
    Gene namesi
    Name:Adra2c
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:87936. Adra2c.

    Subcellular locationi

    GO - Cellular componenti

    1. axon terminus Source: Ensembl
    2. cytoplasm Source: Ensembl
    3. integral component of plasma membrane Source: Ensembl

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 458458Alpha-2C adrenergic receptorPRO_0000069106Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi19 – 191N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi33 – 331N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi124 ↔ 202PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ01337.

    PTM databases

    PhosphoSiteiQ01337.

    Expressioni

    Gene expression databases

    BgeeiQ01337.
    CleanExiMM_ADRA2C.
    GenevestigatoriQ01337.

    Interactioni

    Protein-protein interaction databases

    IntActiQ01337. 1 interaction.
    STRINGi10090.ENSMUSP00000059705.

    Structurei

    3D structure databases

    ProteinModelPortaliQ01337.
    SMRiQ01337. Positions 52-450.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 5151ExtracellularBy similarityAdd
    BLAST
    Topological domaini77 – 8812CytoplasmicBy similarityAdd
    BLAST
    Topological domaini115 – 12410ExtracellularBy similarity
    Topological domaini148 – 16821CytoplasmicBy similarityAdd
    BLAST
    Topological domaini192 – 20716ExtracellularBy similarityAdd
    BLAST
    Topological domaini232 – 379148CytoplasmicBy similarityAdd
    BLAST
    Topological domaini404 – 41613ExtracellularBy similarityAdd
    BLAST
    Topological domaini438 – 45821CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei52 – 7625Helical; Name=1By similarityAdd
    BLAST
    Transmembranei89 – 11426Helical; Name=2By similarityAdd
    BLAST
    Transmembranei125 – 14723Helical; Name=3By similarityAdd
    BLAST
    Transmembranei169 – 19123Helical; Name=4By similarityAdd
    BLAST
    Transmembranei208 – 23124Helical; Name=5By similarityAdd
    BLAST
    Transmembranei380 – 40324Helical; Name=6By similarityAdd
    BLAST
    Transmembranei417 – 43721Helical; Name=7By similarityAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi291 – 30515Arg-rich (basic)Add
    BLAST

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2C sub-subfamily.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG249628.
    GeneTreeiENSGT00750000117640.
    HOGENOMiHOG000239242.
    HOVERGENiHBG106962.
    InParanoidiQ01337.
    KOiK04140.
    OMAiQPQCELN.
    OrthoDBiEOG7J9VPT.
    PhylomeDBiQ01337.
    TreeFamiTF316350.

    Family and domain databases

    Gene3Di1.20.1070.10. 2 hits.
    InterProiIPR002233. ADR_fam.
    IPR000735. ADRA2C_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24248:SF25. PTHR24248:SF25. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR01103. ADRENERGICR.
    PR00560. ADRENRGCA2CR.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q01337-1 [UniParc]FASTAAdd to Basket

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    MASPALAAAL AAAAAEGPNG SDAGEWGSGG GANASGTDWV PPPGQYSAGA    50
    VAGLAAVVGF LIVFTVVGNV LVVIAVLTSR ALRAPQNLFL VSLASADILV 100
    ATLVMPFSLA NELMAYWYFG QVWCGVYLAL DVLFCTSSIV HLCAISLDRY 150
    WSVTQAVEYN LKRTPRRVKA TIVAVWLISA VISFPPLVSF YRRPDGAAYP 200
    QCGLNDETWY ILSSCIGSFF APCLIMGLVY ARIYRVAKLR TRTLSEKRGP 250
    AGPDGASPTT ENGLGKAAGE NGHCAPPRTE VEPDESSAAE RRRRRGALRR 300
    GGRRREGAEG DTGSADGPGP GLAAEQGART ASRSPGPGGR LSRASSRSVE 350
    FFLSRRRRAR SSVCRRKVAQ AREKRFTFVL AVVMGVFVLC WFPFFFSYSL 400
    YGICREACQL PEPLFKFFFW IGYCNSSLNP VIYTVFNQDF RRSFKHILFR 450
    RRRRGFRQ 458
    Length:458
    Mass (Da):49,906
    Last modified:April 1, 1993 - v1
    Checksum:iC0A8BDF0302BF1FB
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti196 – 1961G → V in AAA37183. (PubMed:8387367)Curated
    Sequence conflicti296 – 2961G → A(PubMed:8387367)Curated
    Sequence conflicti298 – 2981L → V(PubMed:8387367)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M99376 Genomic DNA. Translation: AAA37212.1.
    M97516 Genomic DNA. Translation: AAA37183.1.
    CCDSiCCDS19226.1.
    PIRiA48392.
    I49480.
    RefSeqiNP_031444.2. NM_007418.3.
    UniGeneiMm.407152.
    Mm.57205.

    Genome annotation databases

    EnsembliENSMUST00000049545; ENSMUSP00000059705; ENSMUSG00000045318.
    GeneIDi11553.
    KEGGimmu:11553.
    UCSCiuc009vdd.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M99376 Genomic DNA. Translation: AAA37212.1 .
    M97516 Genomic DNA. Translation: AAA37183.1 .
    CCDSi CCDS19226.1.
    PIRi A48392.
    I49480.
    RefSeqi NP_031444.2. NM_007418.3.
    UniGenei Mm.407152.
    Mm.57205.

    3D structure databases

    ProteinModelPortali Q01337.
    SMRi Q01337. Positions 52-450.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q01337. 1 interaction.
    STRINGi 10090.ENSMUSP00000059705.

    Chemistry

    BindingDBi Q01337.
    ChEMBLi CHEMBL2111338.
    GuidetoPHARMACOLOGYi 27.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q01337.

    Proteomic databases

    PRIDEi Q01337.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000049545 ; ENSMUSP00000059705 ; ENSMUSG00000045318 .
    GeneIDi 11553.
    KEGGi mmu:11553.
    UCSCi uc009vdd.1. mouse.

    Organism-specific databases

    CTDi 152.
    MGIi MGI:87936. Adra2c.

    Phylogenomic databases

    eggNOGi NOG249628.
    GeneTreei ENSGT00750000117640.
    HOGENOMi HOG000239242.
    HOVERGENi HBG106962.
    InParanoidi Q01337.
    KOi K04140.
    OMAi QPQCELN.
    OrthoDBi EOG7J9VPT.
    PhylomeDBi Q01337.
    TreeFami TF316350.

    Miscellaneous databases

    NextBioi 279046.
    PROi Q01337.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q01337.
    CleanExi MM_ADRA2C.
    Genevestigatori Q01337.

    Family and domain databases

    Gene3Di 1.20.1070.10. 2 hits.
    InterProi IPR002233. ADR_fam.
    IPR000735. ADRA2C_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24248:SF25. PTHR24248:SF25. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR01103. ADRENERGICR.
    PR00560. ADRENRGCA2CR.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of two mouse genes encoding alpha 2-adrenergic receptor subtypes and identification of a single amino acid in the mouse alpha 2-C10 homolog responsible for an interspecies variation in antagonist binding."
      Link R.E., Daunt D.A., Barsh G., Chruscinski A.J., Kobilka B.K.
      Mol. Pharmacol. 42:16-27(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Molecular characterization of a murine homologue of alpha 2C4 adrenoceptor subtype gene."
      Chang Y.-H., Chang A.C., Chen W.-M., Chang N.-C.A.
      Biochem. Mol. Biol. Int. 29:467-474(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: DBA/2.

    Entry informationi

    Entry nameiADA2C_MOUSE
    AccessioniPrimary (citable) accession number: Q01337
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: April 1, 1993
    Last modified: October 1, 2014
    This is version 120 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3