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Protein

Alpha-2C adrenergic receptor

Gene

Adra2c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei131Implicated in ligand bindingBy similarity1
Sitei214Implicated in catechol agonist binding and receptor activationBy similarity1
Sitei218Implicated in catechol agonist binding and receptor activationBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-390696 Adrenoceptors
R-MMU-392023 Adrenaline signalling through Alpha-2 adrenergic receptor
R-MMU-400042 Adrenaline,noradrenaline inhibits insulin secretion
R-MMU-418594 G alpha (i) signalling events
R-MMU-418597 G alpha (z) signalling events
R-MMU-5683826 Surfactant metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-2C adrenergic receptor
Alternative name(s):
Alpha-2 adrenergic receptor subtype C4
Alpha-2C adrenoreceptor
Short name:
Alpha-2C adrenoceptor
Short name:
Alpha-2CAR
Gene namesi
Name:Adra2c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:87936 Adra2c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 51ExtracellularBy similarityAdd BLAST51
Transmembranei52 – 76Helical; Name=1By similarityAdd BLAST25
Topological domaini77 – 88CytoplasmicBy similarityAdd BLAST12
Transmembranei89 – 114Helical; Name=2By similarityAdd BLAST26
Topological domaini115 – 124ExtracellularBy similarity10
Transmembranei125 – 147Helical; Name=3By similarityAdd BLAST23
Topological domaini148 – 168CytoplasmicBy similarityAdd BLAST21
Transmembranei169 – 191Helical; Name=4By similarityAdd BLAST23
Topological domaini192 – 207ExtracellularBy similarityAdd BLAST16
Transmembranei208 – 231Helical; Name=5By similarityAdd BLAST24
Topological domaini232 – 379CytoplasmicBy similarityAdd BLAST148
Transmembranei380 – 403Helical; Name=6By similarityAdd BLAST24
Topological domaini404 – 416ExtracellularBy similarityAdd BLAST13
Transmembranei417 – 437Helical; Name=7By similarityAdd BLAST21
Topological domaini438 – 458CytoplasmicBy similarityAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2111338

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000691061 – 458Alpha-2C adrenergic receptorAdd BLAST458

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi19N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi33N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi124 ↔ 202PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ01337
PRIDEiQ01337

PTM databases

iPTMnetiQ01337
PhosphoSitePlusiQ01337

Expressioni

Gene expression databases

BgeeiENSMUSG00000045318
CleanExiMM_ADRA2C
GenevisibleiQ01337 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ01337, 1 interactor
STRINGi10090.ENSMUSP00000059705

Structurei

3D structure databases

ProteinModelPortaliQ01337
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi291 – 305Arg-rich (basic)Add BLAST15

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2C sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00890000139331
HOGENOMiHOG000239242
HOVERGENiHBG106962
InParanoidiQ01337
KOiK04140
OMAiELMNYWY
OrthoDBiEOG091G06VI
PhylomeDBiQ01337
TreeFamiTF316350

Family and domain databases

InterProiView protein in InterPro
IPR002233 ADR_fam
IPR000735 ADRA2C_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR24248:SF25 PTHR24248:SF25, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01103 ADRENERGICR
PR00560 ADRENRGCA2CR
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q01337-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASPALAAAL AAAAAEGPNG SDAGEWGSGG GANASGTDWV PPPGQYSAGA
60 70 80 90 100
VAGLAAVVGF LIVFTVVGNV LVVIAVLTSR ALRAPQNLFL VSLASADILV
110 120 130 140 150
ATLVMPFSLA NELMAYWYFG QVWCGVYLAL DVLFCTSSIV HLCAISLDRY
160 170 180 190 200
WSVTQAVEYN LKRTPRRVKA TIVAVWLISA VISFPPLVSF YRRPDGAAYP
210 220 230 240 250
QCGLNDETWY ILSSCIGSFF APCLIMGLVY ARIYRVAKLR TRTLSEKRGP
260 270 280 290 300
AGPDGASPTT ENGLGKAAGE NGHCAPPRTE VEPDESSAAE RRRRRGALRR
310 320 330 340 350
GGRRREGAEG DTGSADGPGP GLAAEQGART ASRSPGPGGR LSRASSRSVE
360 370 380 390 400
FFLSRRRRAR SSVCRRKVAQ AREKRFTFVL AVVMGVFVLC WFPFFFSYSL
410 420 430 440 450
YGICREACQL PEPLFKFFFW IGYCNSSLNP VIYTVFNQDF RRSFKHILFR

RRRRGFRQ
Length:458
Mass (Da):49,906
Last modified:April 1, 1993 - v1
Checksum:iC0A8BDF0302BF1FB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti196G → V in AAA37183 (PubMed:8387367).Curated1
Sequence conflicti296G → A (PubMed:8387367).Curated1
Sequence conflicti298L → V (PubMed:8387367).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M99376 Genomic DNA Translation: AAA37212.1
M97516 Genomic DNA Translation: AAA37183.1
CCDSiCCDS19226.1
PIRiA48392
I49480
RefSeqiNP_031444.2, NM_007418.3
UniGeneiMm.407152
Mm.57205

Genome annotation databases

EnsembliENSMUST00000049545; ENSMUSP00000059705; ENSMUSG00000045318
GeneIDi11553
KEGGimmu:11553
UCSCiuc009vdd.1 mouse

Similar proteinsi

Entry informationi

Entry nameiADA2C_MOUSE
AccessioniPrimary (citable) accession number: Q01337
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: April 25, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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