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Protein

Alpha-2C adrenergic receptor

Gene

Adra2c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei131 – 1311Implicated in ligand bindingBy similarity
Sitei214 – 2141Implicated in catechol agonist binding and receptor activationBy similarity
Sitei218 – 2181Implicated in catechol agonist binding and receptor activationBy similarity

GO - Molecular functioni

  1. alpha-2A adrenergic receptor binding Source: MGI
  2. alpha2-adrenergic receptor activity Source: MGI
  3. epinephrine binding Source: MGI
  4. G-protein coupled receptor activity Source: MGI
  5. protein heterodimerization activity Source: MGI
  6. protein homodimerization activity Source: MGI

GO - Biological processi

  1. activation of MAPK activity by adrenergic receptor signaling pathway Source: MGI
  2. activation of protein kinase B activity Source: MGI
  3. epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway Source: MGI
  4. female pregnancy Source: Ensembl
  5. G-protein coupled receptor signaling pathway Source: MGI
  6. negative regulation of uterine smooth muscle contraction Source: Ensembl
  7. platelet activation Source: InterPro
  8. positive regulation of neuron differentiation Source: MGI
  9. positive regulation of vasoconstriction Source: Ensembl
  10. regulation of sensory perception of pain Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_250376. G alpha (i) signalling events.
REACT_250590. Adrenaline,noradrenaline inhibits insulin secretion.
REACT_255413. Adrenoceptors.
REACT_256826. Adrenaline signalling through Alpha-2 adrenergic receptor.
REACT_258013. G alpha (z) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-2C adrenergic receptor
Alternative name(s):
Alpha-2 adrenergic receptor subtype C4
Alpha-2C adrenoreceptor
Short name:
Alpha-2C adrenoceptor
Short name:
Alpha-2CAR
Gene namesi
Name:Adra2c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:87936. Adra2c.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5151ExtracellularBy similarityAdd
BLAST
Transmembranei52 – 7625Helical; Name=1By similarityAdd
BLAST
Topological domaini77 – 8812CytoplasmicBy similarityAdd
BLAST
Transmembranei89 – 11426Helical; Name=2By similarityAdd
BLAST
Topological domaini115 – 12410ExtracellularBy similarity
Transmembranei125 – 14723Helical; Name=3By similarityAdd
BLAST
Topological domaini148 – 16821CytoplasmicBy similarityAdd
BLAST
Transmembranei169 – 19123Helical; Name=4By similarityAdd
BLAST
Topological domaini192 – 20716ExtracellularBy similarityAdd
BLAST
Transmembranei208 – 23124Helical; Name=5By similarityAdd
BLAST
Topological domaini232 – 379148CytoplasmicBy similarityAdd
BLAST
Transmembranei380 – 40324Helical; Name=6By similarityAdd
BLAST
Topological domaini404 – 41613ExtracellularBy similarityAdd
BLAST
Transmembranei417 – 43721Helical; Name=7By similarityAdd
BLAST
Topological domaini438 – 45821CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

  1. axon terminus Source: Ensembl
  2. cytoplasm Source: MGI
  3. integral component of plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 458458Alpha-2C adrenergic receptorPRO_0000069106Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi19 – 191N-linked (GlcNAc...)Sequence Analysis
Glycosylationi33 – 331N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi124 ↔ 202PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ01337.

PTM databases

PhosphoSiteiQ01337.

Expressioni

Gene expression databases

BgeeiQ01337.
CleanExiMM_ADRA2C.
GenevestigatoriQ01337.

Interactioni

Protein-protein interaction databases

IntActiQ01337. 1 interaction.
STRINGi10090.ENSMUSP00000059705.

Structurei

3D structure databases

ProteinModelPortaliQ01337.
SMRiQ01337. Positions 52-450.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi291 – 30515Arg-rich (basic)Add
BLAST

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2C sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG249628.
GeneTreeiENSGT00760000118795.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiQ01337.
KOiK04140.
OMAiQPQCELN.
OrthoDBiEOG7J9VPT.
PhylomeDBiQ01337.
TreeFamiTF316350.

Family and domain databases

InterProiIPR002233. ADR_fam.
IPR000735. ADRA2C_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24248:SF25. PTHR24248:SF25. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01103. ADRENERGICR.
PR00560. ADRENRGCA2CR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q01337-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASPALAAAL AAAAAEGPNG SDAGEWGSGG GANASGTDWV PPPGQYSAGA
60 70 80 90 100
VAGLAAVVGF LIVFTVVGNV LVVIAVLTSR ALRAPQNLFL VSLASADILV
110 120 130 140 150
ATLVMPFSLA NELMAYWYFG QVWCGVYLAL DVLFCTSSIV HLCAISLDRY
160 170 180 190 200
WSVTQAVEYN LKRTPRRVKA TIVAVWLISA VISFPPLVSF YRRPDGAAYP
210 220 230 240 250
QCGLNDETWY ILSSCIGSFF APCLIMGLVY ARIYRVAKLR TRTLSEKRGP
260 270 280 290 300
AGPDGASPTT ENGLGKAAGE NGHCAPPRTE VEPDESSAAE RRRRRGALRR
310 320 330 340 350
GGRRREGAEG DTGSADGPGP GLAAEQGART ASRSPGPGGR LSRASSRSVE
360 370 380 390 400
FFLSRRRRAR SSVCRRKVAQ AREKRFTFVL AVVMGVFVLC WFPFFFSYSL
410 420 430 440 450
YGICREACQL PEPLFKFFFW IGYCNSSLNP VIYTVFNQDF RRSFKHILFR

RRRRGFRQ
Length:458
Mass (Da):49,906
Last modified:April 1, 1993 - v1
Checksum:iC0A8BDF0302BF1FB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti196 – 1961G → V in AAA37183. (PubMed:8387367)Curated
Sequence conflicti296 – 2961G → A(PubMed:8387367)Curated
Sequence conflicti298 – 2981L → V(PubMed:8387367)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M99376 Genomic DNA. Translation: AAA37212.1.
M97516 Genomic DNA. Translation: AAA37183.1.
CCDSiCCDS19226.1.
PIRiA48392.
I49480.
RefSeqiNP_031444.2. NM_007418.3.
UniGeneiMm.407152.
Mm.57205.

Genome annotation databases

EnsembliENSMUST00000049545; ENSMUSP00000059705; ENSMUSG00000045318.
GeneIDi11553.
KEGGimmu:11553.
UCSCiuc009vdd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M99376 Genomic DNA. Translation: AAA37212.1.
M97516 Genomic DNA. Translation: AAA37183.1.
CCDSiCCDS19226.1.
PIRiA48392.
I49480.
RefSeqiNP_031444.2. NM_007418.3.
UniGeneiMm.407152.
Mm.57205.

3D structure databases

ProteinModelPortaliQ01337.
SMRiQ01337. Positions 52-450.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ01337. 1 interaction.
STRINGi10090.ENSMUSP00000059705.

Chemistry

ChEMBLiCHEMBL2111338.
GuidetoPHARMACOLOGYi27.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ01337.

Proteomic databases

PRIDEiQ01337.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000049545; ENSMUSP00000059705; ENSMUSG00000045318.
GeneIDi11553.
KEGGimmu:11553.
UCSCiuc009vdd.1. mouse.

Organism-specific databases

CTDi152.
MGIiMGI:87936. Adra2c.

Phylogenomic databases

eggNOGiNOG249628.
GeneTreeiENSGT00760000118795.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiQ01337.
KOiK04140.
OMAiQPQCELN.
OrthoDBiEOG7J9VPT.
PhylomeDBiQ01337.
TreeFamiTF316350.

Enzyme and pathway databases

ReactomeiREACT_250376. G alpha (i) signalling events.
REACT_250590. Adrenaline,noradrenaline inhibits insulin secretion.
REACT_255413. Adrenoceptors.
REACT_256826. Adrenaline signalling through Alpha-2 adrenergic receptor.
REACT_258013. G alpha (z) signalling events.

Miscellaneous databases

NextBioi279046.
PROiQ01337.
SOURCEiSearch...

Gene expression databases

BgeeiQ01337.
CleanExiMM_ADRA2C.
GenevestigatoriQ01337.

Family and domain databases

InterProiIPR002233. ADR_fam.
IPR000735. ADRA2C_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24248:SF25. PTHR24248:SF25. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01103. ADRENERGICR.
PR00560. ADRENRGCA2CR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning of two mouse genes encoding alpha 2-adrenergic receptor subtypes and identification of a single amino acid in the mouse alpha 2-C10 homolog responsible for an interspecies variation in antagonist binding."
    Link R.E., Daunt D.A., Barsh G., Chruscinski A.J., Kobilka B.K.
    Mol. Pharmacol. 42:16-27(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Molecular characterization of a murine homologue of alpha 2C4 adrenoceptor subtype gene."
    Chang Y.-H., Chang A.C., Chen W.-M., Chang N.-C.A.
    Biochem. Mol. Biol. Int. 29:467-474(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: DBA/2.

Entry informationi

Entry nameiADA2C_MOUSE
AccessioniPrimary (citable) accession number: Q01337
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: February 4, 2015
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.