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Q01337 (ADA2C_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alpha-2C adrenergic receptor
Alternative name(s):
Alpha-2 adrenergic receptor subtype C4
Alpha-2C adrenoreceptor
Short name=Alpha-2C adrenoceptor
Short name=Alpha-2CAR
Gene names
Name:Adra2c
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length458 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2C sub-subfamily.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processG-protein coupled receptor signaling pathway

Inferred from direct assay PubMed 14712229. Source: MGI

activation of MAPK activity by adrenergic receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

activation of protein kinase B activity

Inferred from electronic annotation. Source: Ensembl

epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

female pregnancy

Inferred from electronic annotation. Source: Ensembl

negative regulation of uterine smooth muscle contraction

Inferred from electronic annotation. Source: Ensembl

platelet activation

Inferred from electronic annotation. Source: InterPro

positive regulation of neuron differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of vasoconstriction

Inferred from electronic annotation. Source: Ensembl

regulation of sensory perception of pain

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentaxon terminus

Inferred from electronic annotation. Source: Ensembl

cytoplasm

Inferred from electronic annotation. Source: Ensembl

integral component of plasma membrane

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionG-protein coupled receptor activity

Inferred from direct assay PubMed 14712229. Source: MGI

alpha2-adrenergic receptor activity

Traceable author statement PubMed 12068299. Source: MGI

epinephrine binding

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 458458Alpha-2C adrenergic receptor
PRO_0000069106

Regions

Topological domain1 – 5151Extracellular By similarity
Transmembrane52 – 7625Helical; Name=1; By similarity
Topological domain77 – 8812Cytoplasmic By similarity
Transmembrane89 – 11426Helical; Name=2; By similarity
Topological domain115 – 12410Extracellular By similarity
Transmembrane125 – 14723Helical; Name=3; By similarity
Topological domain148 – 16821Cytoplasmic By similarity
Transmembrane169 – 19123Helical; Name=4; By similarity
Topological domain192 – 20716Extracellular By similarity
Transmembrane208 – 23124Helical; Name=5; By similarity
Topological domain232 – 379148Cytoplasmic By similarity
Transmembrane380 – 40324Helical; Name=6; By similarity
Topological domain404 – 41613Extracellular By similarity
Transmembrane417 – 43721Helical; Name=7; By similarity
Topological domain438 – 45821Cytoplasmic By similarity
Compositional bias291 – 30515Arg-rich (basic)

Sites

Site1311Implicated in ligand binding By similarity
Site2141Implicated in catechol agonist binding and receptor activation By similarity
Site2181Implicated in catechol agonist binding and receptor activation By similarity

Amino acid modifications

Glycosylation191N-linked (GlcNAc...) Potential
Glycosylation331N-linked (GlcNAc...) Potential
Disulfide bond124 ↔ 202 By similarity

Experimental info

Sequence conflict1961G → V in AAA37183. Ref.2
Sequence conflict2961G → A Ref.2
Sequence conflict2981L → V Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q01337 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: C0A8BDF0302BF1FB

FASTA45849,906
        10         20         30         40         50         60 
MASPALAAAL AAAAAEGPNG SDAGEWGSGG GANASGTDWV PPPGQYSAGA VAGLAAVVGF 

        70         80         90        100        110        120 
LIVFTVVGNV LVVIAVLTSR ALRAPQNLFL VSLASADILV ATLVMPFSLA NELMAYWYFG 

       130        140        150        160        170        180 
QVWCGVYLAL DVLFCTSSIV HLCAISLDRY WSVTQAVEYN LKRTPRRVKA TIVAVWLISA 

       190        200        210        220        230        240 
VISFPPLVSF YRRPDGAAYP QCGLNDETWY ILSSCIGSFF APCLIMGLVY ARIYRVAKLR 

       250        260        270        280        290        300 
TRTLSEKRGP AGPDGASPTT ENGLGKAAGE NGHCAPPRTE VEPDESSAAE RRRRRGALRR 

       310        320        330        340        350        360 
GGRRREGAEG DTGSADGPGP GLAAEQGART ASRSPGPGGR LSRASSRSVE FFLSRRRRAR 

       370        380        390        400        410        420 
SSVCRRKVAQ AREKRFTFVL AVVMGVFVLC WFPFFFSYSL YGICREACQL PEPLFKFFFW 

       430        440        450 
IGYCNSSLNP VIYTVFNQDF RRSFKHILFR RRRRGFRQ 

« Hide

References

[1]"Cloning of two mouse genes encoding alpha 2-adrenergic receptor subtypes and identification of a single amino acid in the mouse alpha 2-C10 homolog responsible for an interspecies variation in antagonist binding."
Link R.E., Daunt D.A., Barsh G., Chruscinski A.J., Kobilka B.K.
Mol. Pharmacol. 42:16-27(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Molecular characterization of a murine homologue of alpha 2C4 adrenoceptor subtype gene."
Chang Y.-H., Chang A.C., Chen W.-M., Chang N.-C.A.
Biochem. Mol. Biol. Int. 29:467-474(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: DBA/2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M99376 Genomic DNA. Translation: AAA37212.1.
M97516 Genomic DNA. Translation: AAA37183.1.
CCDSCCDS19226.1.
PIRA48392.
I49480.
RefSeqNP_031444.2. NM_007418.3.
UniGeneMm.407152.
Mm.57205.

3D structure databases

ProteinModelPortalQ01337.
SMRQ01337. Positions 52-450.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ01337. 1 interaction.
STRING10090.ENSMUSP00000059705.

Chemistry

BindingDBQ01337.
ChEMBLCHEMBL2111338.
GuidetoPHARMACOLOGY27.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ01337.

Proteomic databases

PRIDEQ01337.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000049545; ENSMUSP00000059705; ENSMUSG00000045318.
GeneID11553.
KEGGmmu:11553.
UCSCuc009vdd.1. mouse.

Organism-specific databases

CTD152.
MGIMGI:87936. Adra2c.

Phylogenomic databases

eggNOGNOG249628.
GeneTreeENSGT00750000117640.
HOGENOMHOG000239242.
HOVERGENHBG106962.
InParanoidQ01337.
KOK04140.
OMAQPQCELN.
OrthoDBEOG7J9VPT.
PhylomeDBQ01337.
TreeFamTF316350.

Gene expression databases

BgeeQ01337.
CleanExMM_ADRA2C.
GenevestigatorQ01337.

Family and domain databases

Gene3D1.20.1070.10. 2 hits.
InterProIPR002233. ADR_fam.
IPR000735. ADRA2C_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERPTHR24248:SF25. PTHR24248:SF25. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR01103. ADRENERGICR.
PR00560. ADRENRGCA2CR.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio279046.
PROQ01337.
SOURCESearch...

Entry information

Entry nameADA2C_MOUSE
AccessionPrimary (citable) accession number: Q01337
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: July 9, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries