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Q01329

- PTA1_YEAST

UniProt

Q01329 - PTA1_YEAST

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Protein
Pre-tRNA-processing protein PTA1
Gene
PTA1, YAL043C, FUN39
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Essential in pre-tRNA processing. Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. Component of the APT complex, which may be involved in polyadenylation-independent transcript 3'-end formation.

GO - Molecular functioni

  1. protein binding Source: IntAct
Complete GO annotation...

GO - Biological processi

  1. mRNA cleavage Source: SGD
  2. mRNA polyadenylation Source: SGD
  3. tRNA processing Source: SGD
  4. termination of RNA polymerase II transcription, exosome-dependent Source: SGD
  5. termination of RNA polymerase II transcription, poly(A)-coupled Source: SGD
Complete GO annotation...

Keywords - Biological processi

mRNA processing, tRNA processing

Enzyme and pathway databases

BioCyciYEAST:G3O-28851-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-tRNA-processing protein PTA1
Gene namesi
Name:PTA1
Ordered Locus Names:YAL043C
ORF Names:FUN39
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome I

Organism-specific databases

CYGDiYAL043c.
SGDiS000000041. PTA1.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. mRNA cleavage and polyadenylation specificity factor complex Source: SGD
  2. mRNA cleavage factor complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 785785Pre-tRNA-processing protein PTA1
PRO_0000097086Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei500 – 5001Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ01329.
PaxDbiQ01329.
PeptideAtlasiQ01329.

Expressioni

Gene expression databases

GenevestigatoriQ01329.

Interactioni

Subunit structurei

Component of the cleavage and polyadenylation factor (CPF) complex, which is composed of PTI1, SYC1, SSU72, GLC7, MPE1, REF2, PFS2, PTA1, YSH1/BRR5, SWD2, CFT2/YDH1, YTH1, CFT1/YHH1, FIP1 and PAP1. Component of the APT complex, which is a subcomplex of CPF, and is composed of PTI1, SYC1, SSU72, GLC7, REF2, PTA1 and SWD2.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PAP1P2946810EBI-14145,EBI-12917

Protein-protein interaction databases

BioGridi31784. 113 interactions.
DIPiDIP-2469N.
IntActiQ01329. 28 interactions.
MINTiMINT-375412.
STRINGi4932.YAL043C.

Structurei

3D structure databases

ProteinModelPortaliQ01329.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG322107.
HOGENOMiHOG000115754.
KOiK06100.
OMAiSTIPDNH.
OrthoDBiEOG78M09C.

Family and domain databases

InterProiIPR021850. Symplekin/Pta1.
[Graphical view]
PANTHERiPTHR15245:SF20. PTHR15245:SF20. 1 hit.

Sequencei

Sequence statusi: Complete.

Q01329-1 [UniParc]FASTAAdd to Basket

« Hide

MSSAEMEQLL QAKTLAMHNN PTEMLPKVLE TTASMYHNGN LSKLKLPLAK    50
FFTQLVLDVV SMDSPIANTE RPFIAAQYLP LLLAMAQSTA DVLVYKNIVL 100
IMCASYPLVL DLVAKTSNQE MFDQLCMLKK FVLSHWRTAY PLRATVDDET 150
DVEQWLAQID QNIGVKLATI KFISEVVLSQ TKSPSGNEIN SSTIPDNHPV 200
LNKPALESEA KRLLDMLLNY LIEEQYMVSS VFIGIINSLS FVIKRRPQTT 250
IRILSGLLRF NVDAKFPLEG KSDLNYKLSK RFVERAYKNF VQFGLKNQII 300
TKSLSSGSGS SIYSKLTKIS QTLHVIGEET KSKGILNFDP SKGNSKKTLS 350
RQDKLKYISL WKRQLSALLS TLGVSTKTPT PVSAPATGSS TENMLDQLKI 400
LQKYTLNKAS HQGNTFFNNS PKPISNTYSS VYSLMNSSNS NQDVTQLPND 450
ILIKLSTEAI LQMDSTKLIT GLSIVASRYT DLMNTYINSV PSSSSSKRKS 500
DDDDDGNDNE EVGNDGPTAN SKKIKMETEP LAEEPEEPED DDRMQKMLQE 550
EESAQEISGD ANKSTSAIKE IAPPFEPDSL TQDEKLKYLS KLTKKLFELS 600
GRQDTTRAKS SSSSSILLDD DDSSSWLHVL IRLVTRGIEA QEASDLIREE 650
LLGFFIQDFE QRVSLIIEWL NEEWFFQTSL HQDPSNYKKW SLRVLESLGP 700
FLENKHRRFF IRLMSELPSL QSDHLEALKP ICLDPARSSL GFQTLKFLIM 750
FRPPVQDTVR DLLHQLKQED EGLHKQCDSL LDRLK 785
Length:785
Mass (Da):88,473
Last modified:April 1, 1993 - v1
Checksum:iE2AB1F468B7BC8D0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M95673 Genomic DNA. Translation: AAA34919.1.
U12980 Genomic DNA. Translation: AAC04988.1.
BK006935 Genomic DNA. Translation: DAA06943.1.
PIRiS31299.
RefSeqiNP_009356.1. NM_001178188.1.

Genome annotation databases

EnsemblFungiiYAL043C; YAL043C; YAL043C.
GeneIDi851255.
KEGGisce:YAL043C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M95673 Genomic DNA. Translation: AAA34919.1 .
U12980 Genomic DNA. Translation: AAC04988.1 .
BK006935 Genomic DNA. Translation: DAA06943.1 .
PIRi S31299.
RefSeqi NP_009356.1. NM_001178188.1.

3D structure databases

ProteinModelPortali Q01329.
ModBasei Search...

Protein-protein interaction databases

BioGridi 31784. 113 interactions.
DIPi DIP-2469N.
IntActi Q01329. 28 interactions.
MINTi MINT-375412.
STRINGi 4932.YAL043C.

Proteomic databases

MaxQBi Q01329.
PaxDbi Q01329.
PeptideAtlasi Q01329.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YAL043C ; YAL043C ; YAL043C .
GeneIDi 851255.
KEGGi sce:YAL043C.

Organism-specific databases

CYGDi YAL043c.
SGDi S000000041. PTA1.

Phylogenomic databases

eggNOGi NOG322107.
HOGENOMi HOG000115754.
KOi K06100.
OMAi STIPDNH.
OrthoDBi EOG78M09C.

Enzyme and pathway databases

BioCyci YEAST:G3O-28851-MONOMER.

Miscellaneous databases

NextBioi 968207.

Gene expression databases

Genevestigatori Q01329.

Family and domain databases

InterProi IPR021850. Symplekin/Pta1.
[Graphical view ]
PANTHERi PTHR15245:SF20. PTHR15245:SF20. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "PTA1, an essential gene of Saccharomyces cerevisiae affecting pre-tRNA processing."
    O'Connor J.P., Peebles C.L.
    Mol. Cell. Biol. 12:3843-3856(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "Organization and function of APT, a subcomplex of the yeast cleavage and polyadenylation factor involved in the formation of mRNA and small nucleolar RNA 3'-ends."
    Nedea E., He X., Kim M., Pootoolal J., Zhong G., Canadien V., Hughes T., Buratowski S., Moore C.L., Greenblatt J.
    J. Biol. Chem. 278:33000-33010(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE CPF COMPLEX, COMPOSITION OF THE APT COMPLEX, SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY.
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-500, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPTA1_YEAST
AccessioniPrimary (citable) accession number: Q01329
Secondary accession number(s): D6VPH3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: June 11, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 3730 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome I
    Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

External Data

Dasty 3

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