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Q01329

- PTA1_YEAST

UniProt

Q01329 - PTA1_YEAST

Protein

Pre-tRNA-processing protein PTA1

Gene

PTA1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 1 (01 Apr 1993)
      Previous versions | rss
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    Functioni

    Essential in pre-tRNA processing. Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. Component of the APT complex, which may be involved in polyadenylation-independent transcript 3'-end formation.

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. mRNA cleavage Source: SGD
    2. mRNA polyadenylation Source: SGD
    3. termination of RNA polymerase II transcription, exosome-dependent Source: SGD
    4. termination of RNA polymerase II transcription, poly(A)-coupled Source: SGD
    5. tRNA processing Source: SGD

    Keywords - Biological processi

    mRNA processing, tRNA processing

    Enzyme and pathway databases

    BioCyciYEAST:G3O-28851-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pre-tRNA-processing protein PTA1
    Gene namesi
    Name:PTA1
    Ordered Locus Names:YAL043C
    ORF Names:FUN39
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome I

    Organism-specific databases

    CYGDiYAL043c.
    SGDiS000000041. PTA1.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. mRNA cleavage and polyadenylation specificity factor complex Source: SGD
    2. mRNA cleavage factor complex Source: SGD

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 785785Pre-tRNA-processing protein PTA1PRO_0000097086Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei500 – 5001Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ01329.
    PaxDbiQ01329.
    PeptideAtlasiQ01329.

    Expressioni

    Gene expression databases

    GenevestigatoriQ01329.

    Interactioni

    Subunit structurei

    Component of the cleavage and polyadenylation factor (CPF) complex, which is composed of PTI1, SYC1, SSU72, GLC7, MPE1, REF2, PFS2, PTA1, YSH1/BRR5, SWD2, CFT2/YDH1, YTH1, CFT1/YHH1, FIP1 and PAP1. Component of the APT complex, which is a subcomplex of CPF, and is composed of PTI1, SYC1, SSU72, GLC7, REF2, PTA1 and SWD2.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    PAP1P2946810EBI-14145,EBI-12917

    Protein-protein interaction databases

    BioGridi31784. 113 interactions.
    DIPiDIP-2469N.
    IntActiQ01329. 28 interactions.
    MINTiMINT-375412.
    STRINGi4932.YAL043C.

    Structurei

    3D structure databases

    ProteinModelPortaliQ01329.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG322107.
    HOGENOMiHOG000115754.
    KOiK06100.
    OMAiSTIPDNH.
    OrthoDBiEOG78M09C.

    Family and domain databases

    InterProiIPR021850. Symplekin/Pta1.
    [Graphical view]
    PANTHERiPTHR15245:SF20. PTHR15245:SF20. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q01329-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSAEMEQLL QAKTLAMHNN PTEMLPKVLE TTASMYHNGN LSKLKLPLAK    50
    FFTQLVLDVV SMDSPIANTE RPFIAAQYLP LLLAMAQSTA DVLVYKNIVL 100
    IMCASYPLVL DLVAKTSNQE MFDQLCMLKK FVLSHWRTAY PLRATVDDET 150
    DVEQWLAQID QNIGVKLATI KFISEVVLSQ TKSPSGNEIN SSTIPDNHPV 200
    LNKPALESEA KRLLDMLLNY LIEEQYMVSS VFIGIINSLS FVIKRRPQTT 250
    IRILSGLLRF NVDAKFPLEG KSDLNYKLSK RFVERAYKNF VQFGLKNQII 300
    TKSLSSGSGS SIYSKLTKIS QTLHVIGEET KSKGILNFDP SKGNSKKTLS 350
    RQDKLKYISL WKRQLSALLS TLGVSTKTPT PVSAPATGSS TENMLDQLKI 400
    LQKYTLNKAS HQGNTFFNNS PKPISNTYSS VYSLMNSSNS NQDVTQLPND 450
    ILIKLSTEAI LQMDSTKLIT GLSIVASRYT DLMNTYINSV PSSSSSKRKS 500
    DDDDDGNDNE EVGNDGPTAN SKKIKMETEP LAEEPEEPED DDRMQKMLQE 550
    EESAQEISGD ANKSTSAIKE IAPPFEPDSL TQDEKLKYLS KLTKKLFELS 600
    GRQDTTRAKS SSSSSILLDD DDSSSWLHVL IRLVTRGIEA QEASDLIREE 650
    LLGFFIQDFE QRVSLIIEWL NEEWFFQTSL HQDPSNYKKW SLRVLESLGP 700
    FLENKHRRFF IRLMSELPSL QSDHLEALKP ICLDPARSSL GFQTLKFLIM 750
    FRPPVQDTVR DLLHQLKQED EGLHKQCDSL LDRLK 785
    Length:785
    Mass (Da):88,473
    Last modified:April 1, 1993 - v1
    Checksum:iE2AB1F468B7BC8D0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M95673 Genomic DNA. Translation: AAA34919.1.
    U12980 Genomic DNA. Translation: AAC04988.1.
    BK006935 Genomic DNA. Translation: DAA06943.1.
    PIRiS31299.
    RefSeqiNP_009356.1. NM_001178188.1.

    Genome annotation databases

    EnsemblFungiiYAL043C; YAL043C; YAL043C.
    GeneIDi851255.
    KEGGisce:YAL043C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M95673 Genomic DNA. Translation: AAA34919.1 .
    U12980 Genomic DNA. Translation: AAC04988.1 .
    BK006935 Genomic DNA. Translation: DAA06943.1 .
    PIRi S31299.
    RefSeqi NP_009356.1. NM_001178188.1.

    3D structure databases

    ProteinModelPortali Q01329.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 31784. 113 interactions.
    DIPi DIP-2469N.
    IntActi Q01329. 28 interactions.
    MINTi MINT-375412.
    STRINGi 4932.YAL043C.

    Proteomic databases

    MaxQBi Q01329.
    PaxDbi Q01329.
    PeptideAtlasi Q01329.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YAL043C ; YAL043C ; YAL043C .
    GeneIDi 851255.
    KEGGi sce:YAL043C.

    Organism-specific databases

    CYGDi YAL043c.
    SGDi S000000041. PTA1.

    Phylogenomic databases

    eggNOGi NOG322107.
    HOGENOMi HOG000115754.
    KOi K06100.
    OMAi STIPDNH.
    OrthoDBi EOG78M09C.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-28851-MONOMER.

    Miscellaneous databases

    NextBioi 968207.

    Gene expression databases

    Genevestigatori Q01329.

    Family and domain databases

    InterProi IPR021850. Symplekin/Pta1.
    [Graphical view ]
    PANTHERi PTHR15245:SF20. PTHR15245:SF20. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "PTA1, an essential gene of Saccharomyces cerevisiae affecting pre-tRNA processing."
      O'Connor J.P., Peebles C.L.
      Mol. Cell. Biol. 12:3843-3856(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. "Organization and function of APT, a subcomplex of the yeast cleavage and polyadenylation factor involved in the formation of mRNA and small nucleolar RNA 3'-ends."
      Nedea E., He X., Kim M., Pootoolal J., Zhong G., Canadien V., Hughes T., Buratowski S., Moore C.L., Greenblatt J.
      J. Biol. Chem. 278:33000-33010(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE CPF COMPLEX, COMPOSITION OF THE APT COMPLEX, SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY.
    5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    6. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-500, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiPTA1_YEAST
    AccessioniPrimary (citable) accession number: Q01329
    Secondary accession number(s): D6VPH3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: April 1, 1993
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 3730 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    2. Yeast chromosome I
      Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

    External Data

    Dasty 3