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Protein

Cytochrome c oxidase subunit NDUFA4

Gene

NDUFA4

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cytochrome c oxidase (COX, complex IV) is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. Required for complex IV maintenance (By similarity).By similarity

Caution

Was initially believed to be a subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (complex I). However, was not present in all complex I preparations and presence correlated with contamination by COX6B1 (PubMed:12837546).1 Publication

GO - Molecular functioni

Keywordsi

Biological processElectron transport, Respiratory chain, Transport

Protein family/group databases

TCDBi3.D.1.6.1 the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit NDUFA4
Alternative name(s):
Complex I-MLRQ
Short name:
CI-MLRQ
NADH-ubiquinone oxidoreductase MLRQ subunit
Gene namesi
Name:NDUFA4
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 4

Organism-specific databases

VGNCiVGNC:31947 NDUFA4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001188201 – 82Cytochrome c oxidase subunit NDUFA4Add BLAST82

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei10N6-acetyllysineBy similarity1
Modified residuei67PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ01321
PeptideAtlasiQ01321
PRIDEiQ01321

Expressioni

Gene expression databases

BgeeiENSBTAG00000011145

Interactioni

Subunit structurei

Component of the cytochrome c oxidase complex (COX, complex IV).By similarity

Protein-protein interaction databases

CORUMiQ01321
IntActiQ01321, 2 interactors
STRINGi9913.ENSBTAP00000014801

Family & Domainsi

Sequence similaritiesi

Belongs to the complex IV NDUFA4 subunit family.Curated

Phylogenomic databases

eggNOGiENOG410J0TX Eukaryota
ENOG41124SW LUCA
GeneTreeiENSGT00390000010457
HOGENOMiHOG000261679
HOVERGENiHBG006548
InParanoidiQ01321
KOiK03948
OMAiRLAMFNP
OrthoDBiEOG091G1352
TreeFamiTF106383

Family and domain databases

InterProiView protein in InterPro
IPR010530 B12D
PANTHERiPTHR14256 PTHR14256, 1 hit
PfamiView protein in Pfam
PF06522 B12D, 1 hit

Sequencei

Sequence statusi: Complete.

Q01321-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRQIIGQAK RHPSLIPLFI FIGAGGTGAA LYVTRLALFN PDVSWDRKNN
60 70 80
PEPWNKLGPN DQYKFYSVNV DYSKLKKEGP DF
Length:82
Mass (Da):9,325
Last modified:July 1, 1993 - v1
Checksum:i3F9D1D228CD4E907
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64897 mRNA Translation: CAA46106.1
BC102882 mRNA Translation: AAI02883.1
PIRiS28255
RefSeqiNP_787014.1, NM_175820.3
UniGeneiBt.4819

Genome annotation databases

EnsembliENSBTAT00000014801; ENSBTAP00000014801; ENSBTAG00000011145
GeneIDi327704
KEGGibta:327704

Similar proteinsi

Entry informationi

Entry nameiNDUA4_BOVIN
AccessioniPrimary (citable) accession number: Q01321
Secondary accession number(s): Q3ZC70
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: April 25, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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