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Protein

Cytochrome c oxidase subunit NDUFA4

Gene

NDUFA4

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Cytochrome c oxidase (COX, complex IV) is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. Required for complex IV maintenance (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Protein family/group databases

TCDBi3.D.1.6.1. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit NDUFA4
Alternative name(s):
Complex I-MLRQ
Short name:
CI-MLRQ
NADH-ubiquinone oxidoreductase MLRQ subunit
Gene namesi
Name:NDUFA4
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 4

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8282Cytochrome c oxidase subunit NDUFA4PRO_0000118820Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei10 – 101N6-acetyllysineBy similarity
Modified residuei67 – 671PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ01321.
PeptideAtlasiQ01321.
PRIDEiQ01321.

Interactioni

Subunit structurei

Component of the cytochrome c oxidase complex (COX, complex IV).By similarity

Protein-protein interaction databases

IntActiQ01321. 2 interactions.
STRINGi9913.ENSBTAP00000014801.

Family & Domainsi

Sequence similaritiesi

Belongs to the complex IV NDUFA4 subunit family.Curated

Phylogenomic databases

eggNOGiENOG410J0TX. Eukaryota.
ENOG41124SW. LUCA.
GeneTreeiENSGT00390000010457.
HOGENOMiHOG000261679.
HOVERGENiHBG006548.
InParanoidiQ01321.
KOiK03948.
OMAiYKFYAVN.
OrthoDBiEOG71P2DD.
TreeFamiTF106383.

Family and domain databases

InterProiIPR010530. B12D.
[Graphical view]
PANTHERiPTHR14256. PTHR14256. 1 hit.
PfamiPF06522. B12D. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q01321-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRQIIGQAK RHPSLIPLFI FIGAGGTGAA LYVTRLALFN PDVSWDRKNN
60 70 80
PEPWNKLGPN DQYKFYSVNV DYSKLKKEGP DF
Length:82
Mass (Da):9,325
Last modified:July 1, 1993 - v1
Checksum:i3F9D1D228CD4E907
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64897 mRNA. Translation: CAA46106.1.
BC102882 mRNA. Translation: AAI02883.1.
PIRiS28255.
RefSeqiNP_787014.1. NM_175820.3.
UniGeneiBt.4819.

Genome annotation databases

EnsembliENSBTAT00000014801; ENSBTAP00000014801; ENSBTAG00000011145.
GeneIDi327704.
KEGGibta:327704.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64897 mRNA. Translation: CAA46106.1.
BC102882 mRNA. Translation: AAI02883.1.
PIRiS28255.
RefSeqiNP_787014.1. NM_175820.3.
UniGeneiBt.4819.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ01321. 2 interactions.
STRINGi9913.ENSBTAP00000014801.

Protein family/group databases

TCDBi3.D.1.6.1. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Proteomic databases

PaxDbiQ01321.
PeptideAtlasiQ01321.
PRIDEiQ01321.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000014801; ENSBTAP00000014801; ENSBTAG00000011145.
GeneIDi327704.
KEGGibta:327704.

Organism-specific databases

CTDi4697.

Phylogenomic databases

eggNOGiENOG410J0TX. Eukaryota.
ENOG41124SW. LUCA.
GeneTreeiENSGT00390000010457.
HOGENOMiHOG000261679.
HOVERGENiHBG006548.
InParanoidiQ01321.
KOiK03948.
OMAiYKFYAVN.
OrthoDBiEOG71P2DD.
TreeFamiTF106383.

Family and domain databases

InterProiIPR010530. B12D.
[Graphical view]
PANTHERiPTHR14256. PTHR14256. 1 hit.
PfamiPF06522. B12D. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequences of 20 subunits of NADH:ubiquinone oxidoreductase from bovine heart mitochondria. Application of a novel strategy for sequencing proteins using the polymerase chain reaction."
    Walker J.E., Arizmendi J.M., Dupuis A., Fearnley I.M., Finel M., Medd S.M., Pilkington S.J., Runswick M.J., Skehel J.M.
    J. Mol. Biol. 226:1051-1072(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 1-39 AND 49-74.
    Tissue: Heart.
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.
  3. "The nuclear encoded subunits of complex I from bovine heart mitochondria."
    Hirst J., Carroll J., Fearnley I.M., Shannon R.J., Walker J.E.
    Biochim. Biophys. Acta 1604:135-150(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: MASS SPECTROMETRY, INITIAL IDENTIFICATION AS SUBUNIT OF THE NADH-UBIQUINONE OXIDOREDUCTASE COMPLEX.

Entry informationi

Entry nameiNDUA4_BOVIN
AccessioniPrimary (citable) accession number: Q01321
Secondary accession number(s): Q3ZC70
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: July 6, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Was initially believed to be a subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (complex I). However, was not present in all complex I preparations and presence correlated with contamination by COX6B1 (PubMed:12837546).1 Publication

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.