##gff-version 3 Q01320 UniProtKB Chain 1 1528 . . . ID=PRO_0000145364;Note=DNA topoisomerase 2-alpha Q01320 UniProtKB Domain 454 571 . . . Note=Toprim;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00995 Q01320 UniProtKB Domain 714 1168 . . . Note=Topo IIA-type catalytic;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01384 Q01320 UniProtKB Region 341 343 . . . Note=Interaction with DNA;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11388 Q01320 UniProtKB Region 989 998 . . . Note=Interaction with DNA;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11388 Q01320 UniProtKB Region 1090 1118 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q01320 UniProtKB Region 1183 1211 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q01320 UniProtKB Region 1229 1528 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q01320 UniProtKB Region 1429 1435 . . . Note=Interaction with PLSCR1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11388 Q01320 UniProtKB Compositional bias 1229 1245 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q01320 UniProtKB Compositional bias 1254 1272 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q01320 UniProtKB Compositional bias 1312 1328 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q01320 UniProtKB Compositional bias 1329 1344 . . . Note=Acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q01320 UniProtKB Compositional bias 1363 1377 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q01320 UniProtKB Compositional bias 1403 1428 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q01320 UniProtKB Compositional bias 1461 1520 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q01320 UniProtKB Active site 804 804 . . . Note=O-(5'-phospho-DNA)-tyrosine intermediate;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01384 Q01320 UniProtKB Binding site 90 90 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11388 Q01320 UniProtKB Binding site 119 119 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11388 Q01320 UniProtKB Binding site 147 149 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11388 Q01320 UniProtKB Binding site 160 167 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11388 Q01320 UniProtKB Binding site 375 377 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11388 Q01320 UniProtKB Binding site 460 460 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00995 Q01320 UniProtKB Binding site 540 540 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00995 Q01320 UniProtKB Binding site 540 540 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00995 Q01320 UniProtKB Binding site 542 542 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00995 Q01320 UniProtKB Site 488 488 . . . Note=Interaction with DNA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00995 Q01320 UniProtKB Site 491 491 . . . Note=Interaction with DNA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00995 Q01320 UniProtKB Site 660 660 . . . Note=Interaction with DNA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00995 Q01320 UniProtKB Site 661 661 . . . Note=Interaction with DNA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00995 Q01320 UniProtKB Site 722 722 . . . Note=Interaction with DNA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00995 Q01320 UniProtKB Site 756 756 . . . Note=Interaction with DNA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00995 Q01320 UniProtKB Site 762 762 . . . Note=Interaction with DNA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00995 Q01320 UniProtKB Site 803 803 . . . Note=Transition state stabilizer;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P06786 Q01320 UniProtKB Site 855 855 . . . Note=Important for DNA bending%3B intercalates between base pairs of target DNA;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P06786 Q01320 UniProtKB Site 930 930 . . . Note=Interaction with DNA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00995 Q01320 UniProtKB Modified residue 1 1 . . . Note=N-acetylmethionine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11388 Q01320 UniProtKB Modified residue 4 4 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11388 Q01320 UniProtKB Modified residue 281 281 . . . Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11388 Q01320 UniProtKB Modified residue 1105 1105 . . . Note=Phosphoserine%3B by CK1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11388 Q01320 UniProtKB Modified residue 1211 1211 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:21183079;Dbxref=PMID:21183079 Q01320 UniProtKB Modified residue 1245 1245 . . . Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:21183079;Dbxref=PMID:21183079 Q01320 UniProtKB Modified residue 1291 1291 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11388 Q01320 UniProtKB Modified residue 1293 1293 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11388 Q01320 UniProtKB Modified residue 1295 1295 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11388 Q01320 UniProtKB Modified residue 1298 1298 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11388 Q01320 UniProtKB Modified residue 1323 1323 . . . Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:21183079;Dbxref=PMID:21183079 Q01320 UniProtKB Modified residue 1328 1328 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:21183079;Dbxref=PMID:21183079 Q01320 UniProtKB Modified residue 1333 1333 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:21183079;Dbxref=PMID:21183079 Q01320 UniProtKB Modified residue 1350 1350 . . . Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:21183079;Dbxref=PMID:21183079 Q01320 UniProtKB Modified residue 1370 1370 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11388 Q01320 UniProtKB Modified residue 1373 1373 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:21183079;Dbxref=PMID:21183079 Q01320 UniProtKB Modified residue 1384 1384 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11388 Q01320 UniProtKB Modified residue 1388 1388 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:21183079;Dbxref=PMID:21183079 Q01320 UniProtKB Modified residue 1418 1418 . . . Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23806337;Dbxref=PMID:23806337 Q01320 UniProtKB Modified residue 1438 1438 . . . Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23806337;Dbxref=PMID:23806337 Q01320 UniProtKB Modified residue 1465 1465 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11388 Q01320 UniProtKB Modified residue 1467 1467 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11388 Q01320 UniProtKB Modified residue 1470 1470 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11388 Q01320 UniProtKB Modified residue 1472 1472 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11388 Q01320 UniProtKB Modified residue 1521 1521 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:21183079;Dbxref=PMID:21183079 Q01320 UniProtKB Cross-link 17 17 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11388 Q01320 UniProtKB Cross-link 155 155 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11388 Q01320 UniProtKB Cross-link 156 156 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11388 Q01320 UniProtKB Cross-link 351 351 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11388 Q01320 UniProtKB Cross-link 385 385 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11388 Q01320 UniProtKB Cross-link 396 396 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11388 Q01320 UniProtKB Cross-link 415 415 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11388 Q01320 UniProtKB Cross-link 417 417 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11388 Q01320 UniProtKB Cross-link 424 424 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11388 Q01320 UniProtKB Cross-link 439 439 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11388 Q01320 UniProtKB Cross-link 465 465 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11388 Q01320 UniProtKB Cross-link 479 479 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11388 Q01320 UniProtKB Cross-link 528 528 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11388 Q01320 UniProtKB Cross-link 583 583 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11388 Q01320 UniProtKB Cross-link 598 598 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11388 Q01320 UniProtKB Cross-link 613 613 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11388 Q01320 UniProtKB Cross-link 621 621 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11388 Q01320 UniProtKB Cross-link 624 624 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11388 Q01320 UniProtKB Cross-link 631 631 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11388 Q01320 UniProtKB Cross-link 638 638 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11388 Q01320 UniProtKB Cross-link 654 654 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11388 Q01320 UniProtKB Cross-link 661 661 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11388 Q01320 UniProtKB Cross-link 675 675 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11388 Q01320 UniProtKB Cross-link 1074 1074 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11388 Q01320 UniProtKB Cross-link 1193 1193 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11388 Q01320 UniProtKB Cross-link 1201 1201 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11388 Q01320 UniProtKB Cross-link 1226 1226 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11388 Q01320 UniProtKB Cross-link 1238 1238 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11388 Q01320 UniProtKB Cross-link 1238 1238 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11388 Q01320 UniProtKB Cross-link 1272 1272 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11388 Q01320 UniProtKB Cross-link 1279 1279 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11388 Q01320 UniProtKB Cross-link 1282 1282 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11388 Q01320 UniProtKB Cross-link 1359 1359 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11388 Q01320 UniProtKB Cross-link 1363 1363 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11388 Q01320 UniProtKB Cross-link 1382 1382 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11388 Q01320 UniProtKB Cross-link 1418 1418 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11388 Q01320 UniProtKB Cross-link 1438 1438 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11388 Q01320 UniProtKB Cross-link 1450 1450 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11388 Q01320 UniProtKB Cross-link 1455 1455 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11388 Q01320 UniProtKB Cross-link 1480 1480 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11388 Q01320 UniProtKB Cross-link 1488 1488 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11388 Q01320 UniProtKB Sequence conflict 184 184 . . . Note=E->A;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q01320 UniProtKB Sequence conflict 260 260 . . . Note=S->M;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q01320 UniProtKB Sequence conflict 640 640 . . . Note=S->P;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q01320 UniProtKB Sequence conflict 841 841 . . . Note=I->N;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q01320 UniProtKB Sequence conflict 844 845 . . . Note=IP->NT;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q01320 UniProtKB Sequence conflict 1316 1316 . . . Note=A->R;Ontology_term=ECO:0000305;evidence=ECO:0000305